Pleiotropic treatment of cancer: RANK inhibitors targeting cancer stem cells and immunity

Informazioni relative al progetto

PLEIO-RANK

ID dell’accordo di sovvenzione: 682935

DOI 10.3030/682935

Progetto chiuso

Data della firma CE 26 Luglio 2016

Data di avvio 1 Ottobre 2016

Data di completamento 31 Marzo 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 999 960,00

Contributo UE € 1 999 960,00

Coordinato da

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain

Pubblicazioni

Peer reviewed articles (10)

RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer

Autori: Marina Ciscar, Eva M Trinidad, Gema Perez-Chacon, Maria Jimenez, Maria J Jimenez-Santos, Hector Perez-Montoyo, Adrian Sanz-Moreno, Andrea Vethencourt, Michael Toss, Anna Petit, Maria T Soler-Monso, Victor Lopez, Jorge Gomez-Miragaya, Clara Gomez-Aleza, Lacey E Dobrolecki, Michael T Lewis, Alejandra Bruna, Silvana Mouron, Miguel Quintela-Fandino, Fatima Al-Shahrour, Antonio Martinez-Aranda, Angels
Pubblicato in: EMBO Molecular Medicine, 2023, ISSN 1757-4684
Editore: EMBO Press
DOI: 10.15252/emmm.202216715

Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential

Autori: Alex Cordero, Patricia G. Santamaría, Eva Gonzalez-Suarez
Pubblicato in: JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2023, ISSN 1083-3021
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10911-023-09530-4

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

Autori: Sandra Benítez, Alex Cordero, Patricia G. Santamaría, Jaime Redondo-Pedraza, Ana S. Rocha, Alejandro Collado-Solé, Maria Jimenez, Adrian Sanz-Moreno, Guillermo Yoldi, Juliana C. Santos, Ilaria De Benedictis, Clara Gómez-Aleza, Sabela Da Silva-Álvarez, Kevin Troulé, Gonzalo Gómez-López, Noelia Alcazar, Ignacio Palmero, Manuel Collado, Manuel Serrano, Eva Gonzalez-Suarez,
Pubblicato in: Developmental Cell, 2021, Pagina/e 1727-1741.e7, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2021.04.022.

RANK Signaling Blockade Reduces Breast Cancer Recurrence by Inducing Tumor Cell Differentiation

Autori: Guillermo Yoldi, Pasquale Pellegrini, Eva M. Trinidad, Alex Cordero, Jorge Gomez-Miragaya, Jordi Serra-Musach, William C. Dougall, Purificación Muñoz, Miguel-Angel Pujana, Lourdes Planelles, Eva González-Suárez
Pubblicato in: Cancer Research, Numero 76/19, 2016, Pagina/e 5857-5869, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-15-2745

RANKL inhibitors for osteosarcoma treatment: hope and caution

Autori: Eva M. Trinidad, Eva González-Suárez
Pubblicato in: Annals of Translational Medicine, Numero 4/24, 2016, Pagina/e 534-534, ISSN 2305-5839
Editore: Science Translational Medicine
DOI: 10.21037/atm.2016.12.10

Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody

Autori: Roger von Moos, Luis Costa, Eva Gonzalez-Suarez, Evangelos Terpos, Daniela Niepel, Jean–Jacques Body
Pubblicato in: Cancer Treatment Reviews, 2019, ISSN 0305-7372
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2019.05.003

Interrogating open issues in cancer precision medicine with patient-derived xenografts

Autori: Annette T. Byrne, Denis G. Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas, Andrew V. Biankin, Alejandra Bruna, Eva Budinská, Carlos Caldas, David K. Chang, Robert B. Clarke, Hans Clevers, George Coukos, Virginie Dangles-Marie, S. Gail Eckhardt, Eva Gonzalez-Suarez, Els Hermans, Manuel Hidalgo, Monika A. Jarzabek, Steven de Jong, Jos Jonkers, Kristel Kemper, Luisa Lanfrancone, Gunh
Pubblicato in: Nature Reviews Cancer, Numero 17/4, 2017, Pagina/e 254-268, ISSN 1474-175X
Editore: Nature Publishing Group
DOI: 10.1038/nrc.2016.140

European Network of Breast Development and Cancer turned 10 years: a growing family of mammary gland researchers

Autori: Zuzana Koledova, Beatrice A. Howard, Johanna Englund, Karsten Bach, Mohammed Bentires-Alj, Eva Gonzalez-Suarez
Pubblicato in: Breast Cancer Research, Numero 20/1, 2018, ISSN 1465-542X
Editore: Breast Cancer Research
DOI: 10.1186/s13058-018-1032-9

RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer

Autori: Adrián Sanz-Moreno, Sonia Palomeras, Kim Pedersen, Beatriz Morancho, Tomas Pascual, Patricia Galván, Sandra Benítez, Jorge Gomez-Miragaya, Marina Ciscar, Maria Jimenez, Sonia Pernas, Anna Petit, María Teresa Soler-Monsó, Gemma Viñas, Mansour Alsaleem, Emad A. Rakha, Andrew R. Green, Patricia G. Santamaria, Celine Mulder, Simone Lemeer, Joaquin Arribas, Aleix Prat, Teresa Puig, Eva Gonzalez-S
Pubblicato in: Breast Cancer Research, Numero 23/1, 2021, ISSN 1465-542X
Editore: Springer Nature
DOI: 10.1186/s13058-021-01390-2

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells

Autori: Clara Gómez-Aleza, Bastien Nguyen, Guillermo Yoldi, Marina Ciscar, Alexandra Barranco, Enrique Hernández-Jiménez, Marion Maetens, Roberto Salgado, Maria Zafeiroglou, Pasquale Pellegrini, David Venet, Soizic Garaud, Eva M. Trinidad, Sandra Benítez, Peter Vuylsteke, Laura Polastro, Hans Wildiers, Philippe Simon, Geoffrey Lindeman, Denis Larsimont, Gert Van den Eynden, Chloé Velghe, Françoise R
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20138-8