Cellular and molecular mechanisms of metabolic immune activation triggering non-alcoholic steatohepatitis (NASH) and HCC

Project Information

HepatoMetaboPath

Grant agreement ID: 683000

DOI 10.3030/683000

Project closed

EC signature date 22 June 2016

Start date 1 July 2016

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 995 860,00

EU contribution € 1 995 860,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

Publications

Peer reviewed articles (10)

SpaceM reveals metabolic states of single cells

Author(s): Luca Rappez, Mira Stadler, Sergio Triana, Rose Muthoni Gathungu, Katja Ovchinnikova, Prasad Phapale, Mathias Heikenwalder, Theodore Alexandrov
Published in: Nature Methods, Issue 18/7, 2021, Page(s) 799-805, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-021-01198-0

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Author(s): Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, I
Published in: Nature, Issue 592/7854, 2021, Page(s) 450-456, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03362-0

Author Correction: Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Author(s): Michael Dudek, Dominik Pfister, Sainitin Donakonda, Pamela Filpe, Annika Schneider, Melanie Laschinger, Daniel Hartmann, Norbert Hüser, Philippa Meiser, Felix Bayerl, Donato Inverso, Jennifer Wigger, Marcial Sebode, Rupert Öllinger, Roland Rad, Silke Hegenbarth, Martina Anton, Adrien Guillot, Andrew Bowman, Danijela Heide, Florian Müller, Pierluigi Ramadori, Valentina Leone, Cristina Garcia-Cac
Published in: Nature, Issue 593/7860, 2021, Page(s) E14-E14, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03568-2

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Author(s): Aleksandra Deczkowska, Eyal David, Pierluigi Ramadori, Dominik Pfister, Michael Safran, Baoguo At the, Amir Giladi, Diego Adhemar Jaitin, Oren Barboy, Merav Cohen, Ido Yofe, Chamutal Gur, Shir Shlomi-Loubaton, Sandrine Henri, Yousuf Suhail, Mengjie Qiu, Shing Kam, Hila Hermon, Eylon Lahat, Gil Ben Yakov, Oranit Cohen-Ezra, Yana Davidov, Mariya Likhter, David Goitein, Susanne Roth, Achim Weber, Ber
Published in: Nature Medicine, Issue 27/6, 2021, Page(s) 1043-1054, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-021-01344-3

The immunological and metabolic landscape in primary and metastatic liver cancer

Author(s): Xin Li, Pierluigi Ramadori, Dominik Pfister, Marco Seehawer, Lars Zender, Mathias Heikenwalder
Published in: Nature Reviews Cancer, Issue 21/9, 2021, Page(s) 541-557, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-021-00383-9

Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer

Author(s): Steffie Revia, Agnieszka Seretny, Lena Wendler, Ana Banito, Christoph Eckert, Kersten Breuer, Anand Mayakonda, Pavlo Lutsik, Matthias Evert, Silvia Ribback, Suchira Gallage, Ismaiel Chikh Bakri, Kai Breuhahn, Peter Schirmacher, Stefan Heinrich, Matthias M Gaida, Mathias Heikenwälder, Diego F Calvisi, Christoph Plass, Scott W Lowe, Darjus F Tschaharganeh
Published in: Gut, 2021, Page(s) gutjnl-2021-325405, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-325405

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

Author(s): Thomas M. Conlon, Gerrit John-Schuster, Danijela Heide, Dominik Pfister, Mareike Lehmann, Yan Hu, Zeynep Ertüz, Martin A. Lopez, Meshal Ansari, Maximilian Strunz, Christoph Mayr, Ilias Angelidis, Chiara Ciminieri, Rita Costa, Marlene Sophia Kohlhepp, Adrien Guillot, Gizem Günes, Aicha Jeridi, Maja C. Funk, Giorgi Beroshvili, Sandra Prokosch, Jenny Hetzer, Stijn E. Verleden, Hani Alsafadi, Michae
Published in: Nature, Issue 588/7836, 2020, Page(s) 151-156, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2882-8

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Author(s): Anthony Lagnado, Jack Leslie, Marie‐Helene Ruchaud‐Sparagano, Stella Victorelli, Petra Hirsova, Mikolaj Ogrodnik, Amy L Collins, Maria Grazia Vizioli, Leena Habiballa, Gabriele Saretzki, Shane A Evans, Hanna Salmonowicz, Adam Hruby, Daniel Geh, Kevin D Pavelko, David Dolan, Helen L Reeves, Sushma Grellscheid, Colin H Wilson, Sanjay Pandanaboyana, Madison Doolittle, Thomas Zglinicki, Fiona Oakl
Published in: The EMBO Journal, Issue 40/9, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020106048

Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p

Author(s): Suzanne Faure-Dupuy, Tobias Riedl, Maude Rolland, Zoheir Hizir, Florian Reisinger, Katharina Neuhaus, Svenja Schuehle, Caroline Remouchamps, Nicolas Gillet, Maximilian Schönung, Mira Stadler, Jochen Wettengel, Romain Barnault, Romain Parent, Linda Christina Schuster, Rayan Farhat, Sandra Prokosch, Corinna Leuchtenberger, Rupert Öllinger, Thomas Engleitner, Karsten Rippe, Roland Rad, Kristian Ung
Published in: JHEP Reports, Issue 3/6, 2021, Page(s) 100354, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.100354

Immunotherapies for hepatocellular carcinoma

Author(s): Josep M. Llovet, Florian Castet, Mathias Heikenwalder, Mala K. Maini, Vincenzo Mazzaferro, David J. Pinato, Eli Pikarsky, Andrew X. Zhu, Richard S. Finn
Published in: Nature Reviews Clinical Oncology, 2021, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-021-00573-2