Cellular and molecular mechanisms of metabolic immune activation triggering non-alcoholic steatohepatitis (NASH) and HCC

Informazioni relative al progetto

HepatoMetaboPath

ID dell’accordo di sovvenzione: 683000

DOI 10.3030/683000

Progetto chiuso

Data della firma CE 22 Giugno 2016

Data di avvio 1 Luglio 2016

Data di completamento 30 Giugno 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 995 860,00

Contributo UE € 1 995 860,00

Coordinato da

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

Pubblicazioni

Peer reviewed articles (10)

SpaceM reveals metabolic states of single cells

Autori: Luca Rappez, Mira Stadler, Sergio Triana, Rose Muthoni Gathungu, Katja Ovchinnikova, Prasad Phapale, Mathias Heikenwalder, Theodore Alexandrov
Pubblicato in: Nature Methods, Numero 18/7, 2021, Pagina/e 799-805, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-021-01198-0

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Autori: Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, I
Pubblicato in: Nature, Numero 592/7854, 2021, Pagina/e 450-456, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03362-0

Author Correction: Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Autori: Michael Dudek, Dominik Pfister, Sainitin Donakonda, Pamela Filpe, Annika Schneider, Melanie Laschinger, Daniel Hartmann, Norbert Hüser, Philippa Meiser, Felix Bayerl, Donato Inverso, Jennifer Wigger, Marcial Sebode, Rupert Öllinger, Roland Rad, Silke Hegenbarth, Martina Anton, Adrien Guillot, Andrew Bowman, Danijela Heide, Florian Müller, Pierluigi Ramadori, Valentina Leone, Cristina Garcia-Cac
Pubblicato in: Nature, Numero 593/7860, 2021, Pagina/e E14-E14, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03568-2

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Autori: Aleksandra Deczkowska, Eyal David, Pierluigi Ramadori, Dominik Pfister, Michael Safran, Baoguo At the, Amir Giladi, Diego Adhemar Jaitin, Oren Barboy, Merav Cohen, Ido Yofe, Chamutal Gur, Shir Shlomi-Loubaton, Sandrine Henri, Yousuf Suhail, Mengjie Qiu, Shing Kam, Hila Hermon, Eylon Lahat, Gil Ben Yakov, Oranit Cohen-Ezra, Yana Davidov, Mariya Likhter, David Goitein, Susanne Roth, Achim Weber, Ber
Pubblicato in: Nature Medicine, Numero 27/6, 2021, Pagina/e 1043-1054, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-021-01344-3

The immunological and metabolic landscape in primary and metastatic liver cancer

Autori: Xin Li, Pierluigi Ramadori, Dominik Pfister, Marco Seehawer, Lars Zender, Mathias Heikenwalder
Pubblicato in: Nature Reviews Cancer, Numero 21/9, 2021, Pagina/e 541-557, ISSN 1474-175X
Editore: Nature Publishing Group
DOI: 10.1038/s41568-021-00383-9

Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer

Autori: Steffie Revia, Agnieszka Seretny, Lena Wendler, Ana Banito, Christoph Eckert, Kersten Breuer, Anand Mayakonda, Pavlo Lutsik, Matthias Evert, Silvia Ribback, Suchira Gallage, Ismaiel Chikh Bakri, Kai Breuhahn, Peter Schirmacher, Stefan Heinrich, Matthias M Gaida, Mathias Heikenwälder, Diego F Calvisi, Christoph Plass, Scott W Lowe, Darjus F Tschaharganeh
Pubblicato in: Gut, 2021, Pagina/e gutjnl-2021-325405, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-325405

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

Autori: Thomas M. Conlon, Gerrit John-Schuster, Danijela Heide, Dominik Pfister, Mareike Lehmann, Yan Hu, Zeynep Ertüz, Martin A. Lopez, Meshal Ansari, Maximilian Strunz, Christoph Mayr, Ilias Angelidis, Chiara Ciminieri, Rita Costa, Marlene Sophia Kohlhepp, Adrien Guillot, Gizem Günes, Aicha Jeridi, Maja C. Funk, Giorgi Beroshvili, Sandra Prokosch, Jenny Hetzer, Stijn E. Verleden, Hani Alsafadi, Michae
Pubblicato in: Nature, Numero 588/7836, 2020, Pagina/e 151-156, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2882-8

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Autori: Anthony Lagnado, Jack Leslie, Marie‐Helene Ruchaud‐Sparagano, Stella Victorelli, Petra Hirsova, Mikolaj Ogrodnik, Amy L Collins, Maria Grazia Vizioli, Leena Habiballa, Gabriele Saretzki, Shane A Evans, Hanna Salmonowicz, Adam Hruby, Daniel Geh, Kevin D Pavelko, David Dolan, Helen L Reeves, Sushma Grellscheid, Colin H Wilson, Sanjay Pandanaboyana, Madison Doolittle, Thomas Zglinicki, Fiona Oakl
Pubblicato in: The EMBO Journal, Numero 40/9, 2021, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2020106048

Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p

Autori: Suzanne Faure-Dupuy, Tobias Riedl, Maude Rolland, Zoheir Hizir, Florian Reisinger, Katharina Neuhaus, Svenja Schuehle, Caroline Remouchamps, Nicolas Gillet, Maximilian Schönung, Mira Stadler, Jochen Wettengel, Romain Barnault, Romain Parent, Linda Christina Schuster, Rayan Farhat, Sandra Prokosch, Corinna Leuchtenberger, Rupert Öllinger, Thomas Engleitner, Karsten Rippe, Roland Rad, Kristian Ung
Pubblicato in: JHEP Reports, Numero 3/6, 2021, Pagina/e 100354, ISSN 2589-5559
Editore: Elsevier
DOI: 10.1016/j.jhepr.2021.100354

Immunotherapies for hepatocellular carcinoma

Autori: Josep M. Llovet, Florian Castet, Mathias Heikenwalder, Mala K. Maini, Vincenzo Mazzaferro, David J. Pinato, Eli Pikarsky, Andrew X. Zhu, Richard S. Finn
Pubblicato in: Nature Reviews Clinical Oncology, 2021, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/s41571-021-00573-2