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Dual targeting of senescence and tumor immunity for cancer therapy

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Publications

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

Author(s): Jingjing Chen, Ilaria Guccini, Diletta Di Mitri, Daniela Brina, Ajinkya Revandkar, Manuela Sarti, Emiliano Pasquini, Abdullah Alajati, Sandra Pinton, Marco Losa, Gianluca Civenni, Carlo V. Catapano, Jacopo Sgrignani, Andrea Cavalli, Rocco D’Antuono, John M. Asara, Andrea Morandi, Paola Chiarugi, Sara Crotti, Marco Agostini, Monica Montopoli, Ionica Masgras, Andrea Rasola, Ramon Garcia-Escudero,
Published in: Nature Genetics, Issue 50/2, 2018, Page(s) 219-228, ISSN 1061-4036
DOI: 10.1038/s41588-017-0026-3

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Author(s): Ajinkya Revandkar, Maria Luna Perciato, Alberto Toso, Abdullah Alajati, Jingjing Chen, Hermeto Gerber, Mitko Dimitrov, Andrea Rinaldi, Nicolas Delaleu, Emiliano Pasquini, Rocco D’Antuono, Sandra Pinton, Marco Losa, Letizia Gnetti, Alberto Arribas, Patrick Fraering, Francesco Bertoni, Alain Nepveu, Andrea Alimonti
Published in: Nature Communications, Issue 7/1, 2016, ISSN 2041-1723
DOI: 10.1038/ncomms13719

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer

Author(s): Daniel Nava Rodrigues, Pasquale Rescigno, David Liu, Wei Yuan, Suzanne Carreira, Maryou B. Lambros, George Seed, Joaquin Mateo, Ruth Riisnaes, Stephanie Mullane, Claire Margolis, Diana Miao, Susana Miranda, David Dolling, Matthew Clarke, Claudia Bertan, Mateus Crespo, Gunther Boysen, Ana Ferreira, Adam Sharp, Ines Figueiredo, Daniel Keliher, Saud Aldubayan, Kelly P. Burke, Semini Sumanasuriya, Mar
Published in: Journal of Clinical Investigation, Issue 128/11, 2018, Page(s) 5185-5185, ISSN 0021-9738
DOI: 10.1172/jci125184

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

Author(s): Arianna Calcinotto, Clarissa Spataro, Elena Zagato, Diletta Di Mitri, Veronica Gil, Mateus Crespo, Gaston De Bernardis, Marco Losa, Michela Mirenda, Emiliano Pasquini, Andrea Rinaldi, Semini Sumanasuriya, Maryou B. Lambros, Antje Neeb, Roberta Lucianò, Carlo A. Bravi, Daniel Nava-Rodrigues, David Dolling, Tommaso Prayer-Galetti, Ana Ferreira, Alberto Briganti, Antonio Esposito, Simon Barry, Wei Y
Published in: Nature, Issue 559/7714, 2018, Page(s) 363-369, ISSN 0028-0836
DOI: 10.1038/s41586-018-0266-0

Cellular Senescence: Aging, Cancer, and Injury

Author(s): Arianna Calcinotto, Jaskaren Kohli, Elena Zagato, Laura Pellegrini, Marco Demaria, Andrea Alimonti
Published in: Physiological Reviews, Issue 99/2, 2019, Page(s) 1047-1078, ISSN 0031-9333
DOI: 10.1152/physrev.00020.2018

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Author(s): Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Natalia Martín-Martín, Sonia Fernandez-Ruiz, James D. Sutherland, Michelle Clasquin, Julen Tomas-Cortazar, Jose Jimenez, Ines Torres, Phong Quang, Pilar Ximenez-Embun, Ruzica Bago, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Verónica Torrano, Diana Cabrera, Sebastiaan M. van Liempd, Ylenia Cendon, Elena
Published in: Nature, Issue 547/7661, 2017, Page(s) 109-113, ISSN 0028-0836
DOI: 10.1038/nature22964