Dual targeting of senescence and tumor immunity for cancer therapy

Project Information

Immune-senescence

Grant agreement ID: 683136

DOI 10.3030/683136

Project closed

EC signature date 23 June 2016

Start date 1 July 2016

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

FONDAZIONE PER L'ISTITUTO ONCOLOGICO DI RICERCA (IOR)
Switzerland

Publications

Peer reviewed articles (14)

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532)

Author(s): M. Montopoli, S. Zumerle, R. Vettor, M. Rugge, M. Zorzi, C.V. Catapano, G.M. Carbone, A. Cavalli, F. Pagano, E. Ragazzi, T. Prayer-Galetti, A. Alimonti
Published in: Annals of Oncology, Issue 31/8, 2020, Page(s) 1040-1045, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1016/j.annonc.2020.04.479

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis

Author(s): Ilaria Guccini, Ajinkya Revandkar, Mariantonietta D'Ambrosio, Manuel Colucci, Emiliano Pasquini, Simone Mosole, Martina Troiani, Daniela Brina, Raheleh Sheibani-Tezerji, Angela Rita Elia, Andrea Rinaldi, Nicolò Pernigoni, Jan Hendrik Rüschoff, Susanne Dettwiler, Angelo M. De Marzo, Emmanuel S. Antonarakis, Costanza Borrelli, Andreas E. Moor, Ramon Garcia-Escudero, Abdullah Alajati, Giuseppe Atta
Published in: Cancer Cell, Issue 39/1, 2021, Page(s) 68-82.e9, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2020.10.012

CD38 in Advanced Prostate Cancers

Author(s): Christina Guo, Mateus Crespo, Bora Gurel, David Dolling, Jan Rekowski, Adam Sharp, Antonella Petremolo, Semini Sumanasuriya, Daniel N. Rodrigues, Ana Ferreira, Rita Pereira, Ines Figueiredo, Niven Mehra, Maryou B.K. Lambros, Antje Neeb, Veronica Gil, George Seed, Leon Terstappen, Andrea Alimonti, Charles G. Drake, Wei Yuan, Johann S. de Bono, Dan Robinson, Eliezer M. Van Allen, Yi-Mi Wu, Nikolaus
Published in: European Urology, Issue 79/6, 2021, Page(s) 736-746, ISSN 0302-2838
Publisher: Elsevier BV
DOI: 10.1016/j.eururo.2021.01.017

Cellular Senescence: Defining a Path Forward

Author(s): Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, João F. Passos, Paul D. Robbins, Clemens A. Schmitt, John Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daoho
Published in: Cell, Issue 179/4, 2019, Page(s) 813-827, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.10.005

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

Author(s): Diletta Di Mitri, Michela Mirenda, Jelena Vasilevska, Arianna Calcinotto, Nicolas Delaleu, Ajinkya Revandkar, Veronica Gil, Gunther Boysen, Marco Losa, Simone Mosole, Emiliano Pasquini, Rocco D’Antuono, Michela Masetti, Elena Zagato, Giovanna Chiorino, Paola Ostano, Andrea Rinaldi, Letizia Gnetti, Mariona Graupera, Ana Raquel Martins Figueiredo Fonseca, Ricardo Pereira Mestre, David Waugh, Simon
Published in: Cell Reports, Issue 28/8, 2019, Page(s) 2156-2168.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.07.068

Epiregulation of the SASP makes good neighbors

Author(s): Maria Andrea Desbats, Sara Zumerle, Andrea Alimonti
Published in: Nature Aging, Issue 1/5, 2021, Page(s) 420-421, ISSN 2662-8465
Publisher: Nature Aging
DOI: 10.1038/s43587-021-00068-w

CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo

Author(s): Abdullah Alajati, Mariantonietta D’Ambrosio, Martina Troiani, Simone Mosole, Laura Pellegrini, Jingjing Chen, Ajinkya Revandkar, Marco Bolis, Jean-Philippe Theurillat, Ilaria Guccini, Marco Losa, Arianna Calcinotto, Gaston De Bernardis, Emiliano Pasquini, Rocco D’Antuono, Adam Sharp, Ines Figueiredo, Daniel Nava Rodrigues, Jonathan Welti, Veronica Gil, Wei Yuan, Tatjana Vlajnic, Lukas Bubendor
Published in: Journal of Clinical Investigation, Issue 130/5, 2020, Page(s) 2435-2450, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci131133

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

Author(s): Jingjing Chen, Ilaria Guccini, Diletta Di Mitri, Daniela Brina, Ajinkya Revandkar, Manuela Sarti, Emiliano Pasquini, Abdullah Alajati, Sandra Pinton, Marco Losa, Gianluca Civenni, Carlo V. Catapano, Jacopo Sgrignani, Andrea Cavalli, Rocco D’Antuono, John M. Asara, Andrea Morandi, Paola Chiarugi, Sara Crotti, Marco Agostini, Monica Montopoli, Ionica Masgras, Andrea Rasola, Ramon Garcia-Escudero,
Published in: Nature Genetics, Issue 50/2, 2018, Page(s) 219-228, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-017-0026-3

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Author(s): Ajinkya Revandkar, Maria Luna Perciato, Alberto Toso, Abdullah Alajati, Jingjing Chen, Hermeto Gerber, Mitko Dimitrov, Andrea Rinaldi, Nicolas Delaleu, Emiliano Pasquini, Rocco D’Antuono, Sandra Pinton, Marco Losa, Letizia Gnetti, Alberto Arribas, Patrick Fraering, Francesco Bertoni, Alain Nepveu, Andrea Alimonti
Published in: Nature Communications, Issue 7/1, 2016, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13719

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer

Author(s): Daniel Nava Rodrigues, Pasquale Rescigno, David Liu, Wei Yuan, Suzanne Carreira, Maryou B. Lambros, George Seed, Joaquin Mateo, Ruth Riisnaes, Stephanie Mullane, Claire Margolis, Diana Miao, Susana Miranda, David Dolling, Matthew Clarke, Claudia Bertan, Mateus Crespo, Gunther Boysen, Ana Ferreira, Adam Sharp, Ines Figueiredo, Daniel Keliher, Saud Aldubayan, Kelly P. Burke, Semini Sumanasuriya, Mar
Published in: Journal of Clinical Investigation, Issue 128/11, 2018, Page(s) 5185-5185, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci125184

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

Author(s): Arianna Calcinotto, Clarissa Spataro, Elena Zagato, Diletta Di Mitri, Veronica Gil, Mateus Crespo, Gaston De Bernardis, Marco Losa, Michela Mirenda, Emiliano Pasquini, Andrea Rinaldi, Semini Sumanasuriya, Maryou B. Lambros, Antje Neeb, Roberta Lucianò, Carlo A. Bravi, Daniel Nava-Rodrigues, David Dolling, Tommaso Prayer-Galetti, Ana Ferreira, Alberto Briganti, Antonio Esposito, Simon Barry, Wei Y
Published in: Nature, Issue 559/7714, 2018, Page(s) 363-369, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0266-0

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Author(s): Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Natalia Martín-Martín, Sonia Fernandez-Ruiz, James D. Sutherland, Michelle Clasquin, Julen Tomas-Cortazar, Jose Jimenez, Ines Torres, Phong Quang, Pilar Ximenez-Embun, Ruzica Bago, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Verónica Torrano, Diana Cabrera, Sebastiaan M. van Liempd, Ylenia Cendon, Elena
Published in: Nature, Issue 547/7661, 2017, Page(s) 109-113, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature22964

Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer

Author(s): Diletta Di Mitri, Andrea Alimonti
Published in: Trends in Cell Biology, Issue 26/3, 2016, Page(s) 215-226, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2015.10.005

Prostate carcinogenesis: inflammatory storms

Author(s): Johann S. de Bono, Christina Guo, Bora Gurel, Angelo M. De Marzo, Karen S. Sfanos, Ram S. Mani, Jesús Gil, Charles G. Drake, Andrea Alimonti
Published in: Nature Reviews Cancer, Issue 20/8, 2020, Page(s) 455-469, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-020-0267-9

Non-peer reviewed articles (1)

Cellular Senescence: Aging, Cancer, and Injury

Author(s): Arianna Calcinotto, Jaskaren Kohli, Elena Zagato, Laura Pellegrini, Marco Demaria, Andrea Alimonti
Published in: Physiological Reviews, Issue 99/2, 2019, Page(s) 1047-1078, ISSN 0031-9333
Publisher: American Physiological Society
DOI: 10.1152/physrev.00020.2018

Intellectual Property Rights

Patent (1)

ENHANCEMENT OF PROSTATE CANCER TREATMENT

Application/Publication number: 20 1916574828
Date: 2019-09-18
Applicant(s): FONDAZIONE PER L'ISTITUTO ONCOLOGICO DI RICERCA (IOR)