Dual targeting of senescence and tumor immunity for cancer therapy

Publicaciones

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532)

Autores: M. Montopoli, S. Zumerle, R. Vettor, M. Rugge, M. Zorzi, C.V. Catapano, G.M. Carbone, A. Cavalli, F. Pagano, E. Ragazzi, T. Prayer-Galetti, A. Alimonti
Publicado en: Annals of Oncology, Edición 31/8, 2020, Página(s) 1040-1045, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1016/j.annonc.2020.04.479

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis

Autores: Ilaria Guccini, Ajinkya Revandkar, Mariantonietta D'Ambrosio, Manuel Colucci, Emiliano Pasquini, Simone Mosole, Martina Troiani, Daniela Brina, Raheleh Sheibani-Tezerji, Angela Rita Elia, Andrea Rinaldi, Nicolò Pernigoni, Jan Hendrik Rüschoff, Susanne Dettwiler, Angelo M. De Marzo, Emmanuel S. Antonarakis, Costanza Borrelli, Andreas E. Moor, Ramon Garcia-Escudero, Abdullah Alajati, Giuseppe Atta
Publicado en: Cancer Cell, Edición 39/1, 2021, Página(s) 68-82.e9, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2020.10.012

CD38 in Advanced Prostate Cancers

Autores: Christina Guo, Mateus Crespo, Bora Gurel, David Dolling, Jan Rekowski, Adam Sharp, Antonella Petremolo, Semini Sumanasuriya, Daniel N. Rodrigues, Ana Ferreira, Rita Pereira, Ines Figueiredo, Niven Mehra, Maryou B.K. Lambros, Antje Neeb, Veronica Gil, George Seed, Leon Terstappen, Andrea Alimonti, Charles G. Drake, Wei Yuan, Johann S. de Bono, Dan Robinson, Eliezer M. Van Allen, Yi-Mi Wu, Nikolaus
Publicado en: European Urology, Edición 79/6, 2021, Página(s) 736-746, ISSN 0302-2838
Editor: Elsevier BV
DOI: 10.1016/j.eururo.2021.01.017

Cellular Senescence: Defining a Path Forward

Autores: Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, João F. Passos, Paul D. Robbins, Clemens A. Schmitt, John Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daoho
Publicado en: Cell, Edición 179/4, 2019, Página(s) 813-827, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2019.10.005

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

Autores: Diletta Di Mitri, Michela Mirenda, Jelena Vasilevska, Arianna Calcinotto, Nicolas Delaleu, Ajinkya Revandkar, Veronica Gil, Gunther Boysen, Marco Losa, Simone Mosole, Emiliano Pasquini, Rocco D’Antuono, Michela Masetti, Elena Zagato, Giovanna Chiorino, Paola Ostano, Andrea Rinaldi, Letizia Gnetti, Mariona Graupera, Ana Raquel Martins Figueiredo Fonseca, Ricardo Pereira Mestre, David Waugh, Simon
Publicado en: Cell Reports, Edición 28/8, 2019, Página(s) 2156-2168.e5, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.07.068

Epiregulation of the SASP makes good neighbors

Autores: Maria Andrea Desbats, Sara Zumerle, Andrea Alimonti
Publicado en: Nature Aging, Edición 1/5, 2021, Página(s) 420-421, ISSN 2662-8465
Editor: Nature Aging
DOI: 10.1038/s43587-021-00068-w

CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo

Autores: Abdullah Alajati, Mariantonietta D’Ambrosio, Martina Troiani, Simone Mosole, Laura Pellegrini, Jingjing Chen, Ajinkya Revandkar, Marco Bolis, Jean-Philippe Theurillat, Ilaria Guccini, Marco Losa, Arianna Calcinotto, Gaston De Bernardis, Emiliano Pasquini, Rocco D’Antuono, Adam Sharp, Ines Figueiredo, Daniel Nava Rodrigues, Jonathan Welti, Veronica Gil, Wei Yuan, Tatjana Vlajnic, Lukas Bubendor
Publicado en: Journal of Clinical Investigation, Edición 130/5, 2020, Página(s) 2435-2450, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci131133

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

Autores: Jingjing Chen, Ilaria Guccini, Diletta Di Mitri, Daniela Brina, Ajinkya Revandkar, Manuela Sarti, Emiliano Pasquini, Abdullah Alajati, Sandra Pinton, Marco Losa, Gianluca Civenni, Carlo V. Catapano, Jacopo Sgrignani, Andrea Cavalli, Rocco D’Antuono, John M. Asara, Andrea Morandi, Paola Chiarugi, Sara Crotti, Marco Agostini, Monica Montopoli, Ionica Masgras, Andrea Rasola, Ramon Garcia-Escudero,
Publicado en: Nature Genetics, Edición 50/2, 2018, Página(s) 219-228, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-017-0026-3

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Autores: Ajinkya Revandkar, Maria Luna Perciato, Alberto Toso, Abdullah Alajati, Jingjing Chen, Hermeto Gerber, Mitko Dimitrov, Andrea Rinaldi, Nicolas Delaleu, Emiliano Pasquini, Rocco D’Antuono, Sandra Pinton, Marco Losa, Letizia Gnetti, Alberto Arribas, Patrick Fraering, Francesco Bertoni, Alain Nepveu, Andrea Alimonti
Publicado en: Nature Communications, Edición 7/1, 2016, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms13719

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer

Autores: Daniel Nava Rodrigues, Pasquale Rescigno, David Liu, Wei Yuan, Suzanne Carreira, Maryou B. Lambros, George Seed, Joaquin Mateo, Ruth Riisnaes, Stephanie Mullane, Claire Margolis, Diana Miao, Susana Miranda, David Dolling, Matthew Clarke, Claudia Bertan, Mateus Crespo, Gunther Boysen, Ana Ferreira, Adam Sharp, Ines Figueiredo, Daniel Keliher, Saud Aldubayan, Kelly P. Burke, Semini Sumanasuriya, Mar
Publicado en: Journal of Clinical Investigation, Edición 128/11, 2018, Página(s) 5185-5185, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci125184

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

Autores: Arianna Calcinotto, Clarissa Spataro, Elena Zagato, Diletta Di Mitri, Veronica Gil, Mateus Crespo, Gaston De Bernardis, Marco Losa, Michela Mirenda, Emiliano Pasquini, Andrea Rinaldi, Semini Sumanasuriya, Maryou B. Lambros, Antje Neeb, Roberta Lucianò, Carlo A. Bravi, Daniel Nava-Rodrigues, David Dolling, Tommaso Prayer-Galetti, Ana Ferreira, Alberto Briganti, Antonio Esposito, Simon Barry, Wei Y
Publicado en: Nature, Edición 559/7714, 2018, Página(s) 363-369, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0266-0

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Autores: Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Natalia Martín-Martín, Sonia Fernandez-Ruiz, James D. Sutherland, Michelle Clasquin, Julen Tomas-Cortazar, Jose Jimenez, Ines Torres, Phong Quang, Pilar Ximenez-Embun, Ruzica Bago, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Verónica Torrano, Diana Cabrera, Sebastiaan M. van Liempd, Ylenia Cendon, Elena
Publicado en: Nature, Edición 547/7661, 2017, Página(s) 109-113, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature22964

Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer

Autores: Diletta Di Mitri, Andrea Alimonti
Publicado en: Trends in Cell Biology, Edición 26/3, 2016, Página(s) 215-226, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2015.10.005

Prostate carcinogenesis: inflammatory storms

Autores: Johann S. de Bono, Christina Guo, Bora Gurel, Angelo M. De Marzo, Karen S. Sfanos, Ram S. Mani, Jesús Gil, Charles G. Drake, Andrea Alimonti
Publicado en: Nature Reviews Cancer, Edición 20/8, 2020, Página(s) 455-469, ISSN 1474-175X
Editor: Nature Publishing Group
DOI: 10.1038/s41568-020-0267-9

Cellular Senescence: Aging, Cancer, and Injury

Autores: Arianna Calcinotto, Jaskaren Kohli, Elena Zagato, Laura Pellegrini, Marco Demaria, Andrea Alimonti
Publicado en: Physiological Reviews, Edición 99/2, 2019, Página(s) 1047-1078, ISSN 0031-9333
Editor: American Physiological Society
DOI: 10.1152/physrev.00020.2018

Derechos de propiedad intelectual

ENHANCEMENT OF PROSTATE CANCER TREATMENT

Número de solicitud/publicación: 20 1916574828
Fecha: 2019-09-18
Solicitante(s): FONDAZIONE PER L'ISTITUTO ONCOLOGICO DI RICERCA (IOR)

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