Nanomedicine upscaling for early clinical phases of multimodal cancer therapy

Deliverables

Other (2)

Exploitation & Dissemination Workshop I

International workshops with main stakeholders and players, including representatives of the EC (around 80 participants)

Exploitation and dissemination Workshop II

International workshop with main stakeholders and players, including representatives of the EC (around 80 participants)

Documents, reports (1)

White paper on good practices for Nanotherapies scale up

This file will contain all the good practices, potential contribution standards and lessons learned in certified nanoparticle production scale up, to contribute to the deployment of nanotherapies in the EU

Websites, patent fillings, videos etc. (1)

Public Web Site and Project Presentation

Design and maintenance of dedicated project web site with an offering of the typical electronic dissemination facilities

Publications

Peer reviewed articles (37)

Optomagnetic Nanoplatforms for In Situ Controlled Hyperthermia

Author(s): Dirk H. Ortgies, Francisco J. Teran, Uéslen Rocha, Leonor de la Cueva, Gorka Salas, David Cabrera, Alexander S. Vanetsev, Mihkel Rähn, Väino Sammelselg, Yurii V. Orlovskii, Daniel Jaque
Published in: Advanced Functional Materials, 28/11, 2018, Page(s) 1704434, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201704434

Iron oxide-manganese oxide nanoparticles with tunable morphology and switchable MRI contrast mode triggered by intracellular conditions

Author(s): García-Soriano, D., Milán-Rois, P., Lafuente-Gómez, N., Navío, C., Gutiérrez, L., Cussó, L., Desco, M., Calle, D., Somoza, Á., Salas, G.
Published in: Journal of Colloid and Interface Science, 2022, Page(s) 447-460, ISSN 0021-9797
Publisher: Academic Press
DOI: 10.1016/j.jcis.2022.01.070

Stimuli-responsive nanomaterials for cancer treatment: boundaries, opportunities and applications

Author(s): Nuria Lafuente-Gómez; Ana Latorre; Paula Milán-Rois; Ciro Rodriguez Diaz; Álvaro Somoza
Published in: Chemical Communications, 1, 2021, Page(s) 13662-13677, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc05056g

In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments

Author(s): Irene Rubia-Rodríguez; Luca Zilberti; Alessandro Arduino; Oriano Bottauscio; Mario Chiampi; Daniel Ortega; Daniel Ortega
Published in: International Journal of Hyperthermia, 1, 2021, Page(s) 846-861, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.6084/m9.figshare.16780691.v1

Smartphone‐Based Colorimetric Method to Quantify Iron Concentration and to Determine the Nanoparticle Size from Suspensions of Magnetic Nanoparticles

Author(s): Yilian Fernández‐Afonso, Gorka Salas, Irene Fernández‐Barahona, Fernando Herranz, Cordula Grüttner, Jesús Martínez de la Fuente, María Puerto Morales, Lucía Gutiérrez
Published in: Particle & Particle Systems Characterization, 37/7, 2020, Page(s) 2000032, ISSN 0934-0866
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ppsc.202000032

Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance

Author(s): S. Inder, M. Bates, N. Ni Labhrai, N. McDermott, J. Schneider, G. Erdmann, T. Jamerson, A. N. Flores, A. Prina-Mello, P. Thirion, P. R. Manecksha, D. Cormican, S. Finn, T. Lynch, L. Marignol
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-53799-7

Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives

Author(s): Susann Piehler; Heidi Dähring; Julia Grandke; Julia Göring; Pierre Couleaud; Antonio Aires; Aitziber L. Cortajarena; Aitziber L. Cortajarena; José Courty; Alfonso Latorre; Álvaro Somoza; Ulf Teichgräber; Ingrid Hilger
Published in: Nanomaterials, 1, 2021, Page(s) 1016, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10061016

Tumor-Selective Immune Active Mild Hyperthermia Associated with Chemotherapy in Colon Peritoneal Metastasis by Photoactivation of Fluorouracil – Gold Nanoparticle Complexes

Author(s): Gazeau Florence
Published in: ACS Nano, 6, 2021, Page(s) 3330-3348, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c10276

Physical oncology: New targets for nanomedicine

Author(s): Nicolas-Boluda, A., Silva, A.K.A., Fournel, S., Gazeau, F.
Published in: Biomaterials, 2018, Page(s) 87-99, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.10.014

Effect of Matrix-Modulating Enzymes on the Cellular Uptake of Magnetic Nanoparticles and on Magnetic Hyperthermia Treatment of Pancreatic Cancer Models In Vivo

Author(s): Felista L. Tansi; Filipp Fröbel; Wisdom O. Maduabuchi; Frank Steiniger; Martin Westermann; Rainer Quaas; Ulf Teichgräber; Ingrid Hilger
Published in: Nanomaterials, 1, 2021, Page(s) 438, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11020438

Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications

Author(s): Geoffrey Cotin; Cristina Blanco-Andujar; Francis Perton; Laura Asín; Jesús M. de la Fuente; Wilfried Reichardt; Wilfried Reichardt; Denise Schaffner; Dinh-Vu Ngyen; Damien Mertz; Céline Kiefer; Florent Meyer; Simo Spassov; Ovidiu Ersen; Michael Chatzidakis; Gianluigi A. Botton; Céline Henoumont; Sophie Laurent; Jean-Marc Greneche; Francisco J. Teran; Francisco J. Teran; Daniel Ortega; Daniel O
Published in: Nanoscale, 1, 2021, Page(s) 14552-14571, ISSN 2040-3372
Publisher: RSC
DOI: 10.1039/d1nr03335b

Deep-tissue localization of magnetic field hyperthermia using pulse sequencing

Author(s): Tansi, F.L., Maduabuchi, W.O., Hirsch, M., Southern, P., Hattersley, S., Quaas, R., Teichgräber, U., Pankhurst, Q.A., Hilger, I.
Published in: International Journal of Hypertermia, 2021, Page(s) 743-754, ISSN 1464-5157
Publisher: Taylor Francis
DOI: 10.1080/02656736.2021.1912412

Unraveling viscosity effects on the hysteresis losses of magnetic nanocubes

Author(s): D. Cabrera, A. Lak, T. Yoshida, M. E. Materia, D. Ortega, F. Ludwig, P. Guardia, A. Sathya, T. Pellegrino, F. J. Teran
Published in: Nanoscale, 9/16, 2017, Page(s) 5094-5101, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7nr00810d

Introduction to Nanomaterials Applied to Life Sciences

Author(s): Espinosa, A., Teran, F.J., Ortega, D.
Published in: Nanoscale Advances, 2021, ISSN 2516-0230
Publisher: RSC
DOI: 10.1039/d1na90011k

Endotoxin contamination of engineered nanomaterials: Overcoming the hurdles associated with endotoxin testing

Author(s): Hannon, G., Prina-Mello, A.
Published in: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021, Page(s) e1738, ISSN 1939-0041
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/wnan.1738

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma

Author(s): Alba Nicolás-Boluda, Javier Vaquero, Gautier Laurent, Gilles Renault, Rana Bazzi, Emmanuel Donnadieu, Stéphane Roux, Laura Fouassier, Florence Gazeau
Published in: ACS Nano, 14/5, 2020, Page(s) 5738-5753, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c00417

The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

Author(s): David García-Soriano, Rebeca Amaro, Nuria Lafuente-Gómez, Paula Milán-Rois, Álvaro Somoza, Cristina Navío, Fernando Herranz, Lucía Gutiérrez, Gorka Salas
Published in: Journal of Colloid and Interface Science, 578, 2020, Page(s) 510-521, ISSN 0021-9797
Publisher: Academic Press
DOI: 10.1016/j.jcis.2020.06.011

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells

Author(s): Gary Hannon, Anna Bogdanska, Yuri Volkov, Adriele Prina-Mello
Published in: Nanomaterials, 10/3, 2020, Page(s) 593, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10030593

Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells

Author(s): David Cabrera, Annelies Coene, Jonathan Leliaert, Emilio J. Artés-Ibáñez, Luc Dupré, Neil D. Telling, Francisco J. Teran
Published in: ACS Nano, 12/3, 2018, Page(s) 2741-2752, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.7b08995

Nanoparticle-based hyperthermia, a local treatment modulating the tumor extracellular matrix

Author(s): Jelena Kolosnjaj-Tabi, Iris Marangon, Alba Nicolas-Boluda, Amanda K.A. Silva, Florence Gazeau
Published in: Pharmacological Research, 126, 2017, Page(s) 123-137, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2017.07.010

Overcoming the tumor microenvironment: the role of nanohyperthermia

Author(s): Amanda K Silva, Alba Nicolas-Boluda, Laura Fouassier, Florence Gazeau
Published in: Nanomedicine, 12/11, 2017, Page(s) 1213-1215, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2017-0096

How gastrin-releasing peptide receptor (GRPR) and αvβ3 integrin expression reflect reorganization features of tumors after hyperthermia treatments

Author(s): Sandra Hallasch, Sindy Frick, Maximilian Jung, Ingrid Hilger
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-06100-7

Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models

Author(s): Paul Southern, Quentin A. Pankhurst
Published in: International Journal of Hyperthermia, 34/6, 2017, Page(s) 671-686, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2017.1365953

The Effects of Localized Heat on the Hallmarks of Cancer

Author(s): Gary Hannon; Felista L. Tansi; Ingrid Hilger; Adriele Prina-Mello
Published in: Advanced Therapeutics, 1, 2021, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202000267

Smart model of intrinsic loss power of SPIONs in hyperthermia treatment

Author(s): Marco Alberti; Adriele Prina-Mello
Published in: Journal of Magnetism and Magnetic Materials, 3, 2020, Page(s) 166493, ISSN 0304-8853
Publisher: Elsevier BV
DOI: 10.1016/j.jmmm.2020.166493

Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties.

Author(s): Nuria Lafuente-Gómez; Paula Milán-Rois; David García-Soriano; Yurena Luengo; Marco Cordani; Hernán Alarcón-Iniesta; Gorka Salas; Gorka Salas; Álvaro Somoza; Álvaro Somoza
Published in: Cancers, 4, 2021, Page(s) 4095, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13164095

Using the ‘dispersion-retention-formulation method’ to estimate clinical and preclinical dosage limits for interstitial nanomedicines or agents

Author(s): Paul Southern, Quentin A. Pankhurst
Published in: Journal of Magnetism and Magnetic Materials, 473, 2019, Page(s) 74-78, ISSN 0304-8853
Publisher: Elsevier BV
DOI: 10.1016/j.jmmm.2018.10.019

Combining Ag and γ-Fe2O3 properties to produce effective antibacterial nanocomposites

Author(s): Yurena Luengo, Begoña Sot, Gorka Salas
Published in: Colloids and Surfaces B: Biointerfaces, 194, 2020, Page(s) 111178, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111178

Whither Magnetic Hyperthermia? A Tentative Roadmap

Author(s): Irene Rubia-Rodríguez; Antonio Santana-Otero; Simo Spassov; Etelka Tombácz; Christer Johansson; Patricia de la Presa; Patricia de la Presa; Francisco J. Teran; María del Puerto Morales; Sabino Veintemillas-Verdaguer; Nguyen T. K. Thanh; Maximilian O. Besenhard; Claire Wilhelm; Florence Gazeau; Quentin John Harmer; Eric Mayes; Bella B. Manshian; Stefaan J. Soenen; Yuanyu Gu; Ángel Millán; Elen
Published in: Materials, 1, 2021, Page(s) 706, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma14040706

The phenotype of target pancreatic cancer cells influences cell death by magnetic hyperthermia with nanoparticles carrying gemicitabine and the pseudo-peptide NucAnt

Author(s): Mourad Sanhaji, Julia Göring, Pierre Couleaud, Antonio Aires, Aitziber L. Cortajarena, José Courty, Adriele Prina-Mello, Marcus Stapf, Robert Ludwig, Yuri Volkov, Alfonso Latorre, Álvaro Somoza, Rodolfo Miranda, Ingrid Hilger
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, 20, 2019, Page(s) 101983, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2018.12.019

A study focused on macrophages modulation induced by the Polymeric Electrospun Matrices (EL-Ms) for application in tissue regeneration: in vitro proof of concept.

Author(s): Silvia Pisani; Rossella Dorati; Ida Genta; Marco Benazzo; Bice Conti; Adriele Prina Mello
Published in: International Journal of Pharmaceutics, 1, 2021, Page(s) 120712, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120712

Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment

Author(s): Marco Cordani, Álvaro Somoza
Published in: Cellular and Molecular Life Sciences, 76/7, 2019, Page(s) 1215-1242, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-018-2973-y

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment.

Author(s): Alba Nicolas-Boluda; Javier Vaquero; Lene Vimeux; Thomas Guilbert; Sarah Barrin; Chahrazade Kantari-Mimoun; Matteo Ponzo; Gilles Renault; Piotr Deptuła; Katarzyna Pogoda; Robert Bucki; Ilaria Cascone; José Courty; Laura Fouassier; Florence Gazeau; Emmanuel Donnadieu
Published in: "eLife, eLife Sciences Publication, 2021, 10 (32), pp.322001. ⟨10.7554/eLife.58688⟩", 1, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.58688

Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells

Author(s): Ana Lazaro-Carrillo, Macarena Calero, Antonio Aires, Aitziber L. Cortajarena, Bruno M. Simões, Alfonso Latorre, Álvaro Somoza, Robert B. Clarke, Rodolfo Miranda, Angeles Villanueva
Published in: Cancers, 12/6, 2020, Page(s) 1397, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061397

Individual particle heating of interacting magnetic nanoparticles at nonzero temperature

Author(s): Jonathan Leliaert; Javier Ortega-Julia; Daniel Ortega; Daniel Ortega
Published in: Nanoscale, 2021, Page(s) 14734-14744, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr05311f

3D volume segmentation and reconstruction. Supervised image classification and automated quantification of superparamagnetic iron oxide nanoparticles in histology slides for safety assessment.

Author(s): Anna Bogdanska; Oliviero L. Gobbo; Yuri Volkov; Adriele Prina-Mello
Published in: Nanotoxicology, 1, 2021, Page(s) 1151-1167, ISSN 1743-5390
Publisher: Informa Healthcare
DOI: 10.1080/17435390.2021.1991502

Self‐Assemblies of Fe 3 O 4 Nanocrystals: Toward Nanoscale Precision of Photothermal Effects in the Tumor Microenvironment

Author(s): Alba Nicolas‐Boluda, Zhijie Yang, Thomas Guilbert, Laura Fouassier, Florent Carn, Florence Gazeau, Marie Paule Pileni
Published in: Advanced Functional Materials, 2020, Page(s) 2006824, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202006824

Non-peer reviewed articles (1)

Two step promotion of a hot tumor immune environment by gold decorated iron oxide nanoflowers and light-triggered mild hyperthermia

Author(s): Gazeau Florence
Published in: Nanoscale, 6, 2021, Page(s) 18483-18497, ISSN 2040-3372
Publisher: RSC
DOI: 10.1039/d1nr03201a