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Nanomedicine upscaling for early clinical phases of multimodal cancer therapy

Leistungen

Exploitation & Dissemination Workshop I

International workshops with main stakeholders and players, including representatives of the EC (around 80 participants)

Exploitation and dissemination Workshop II

International workshop with main stakeholders and players, including representatives of the EC (around 80 participants)

White paper on good practices for Nanotherapies scale up

This file will contain all the good practices, potential contribution standards and lessons learned in certified nanoparticle production scale up, to contribute to the deployment of nanotherapies in the EU

Public Web Site and Project Presentation

Design and maintenance of dedicated project web site with an offering of the typical electronic dissemination facilities

Suche nach OpenAIRE-Daten ...

Veröffentlichungen

Optomagnetic Nanoplatforms for In Situ Controlled Hyperthermia

Autoren: Dirk H. Ortgies, Francisco J. Teran, Uéslen Rocha, Leonor de la Cueva, Gorka Salas, David Cabrera, Alexander S. Vanetsev, Mihkel Rähn, Väino Sammelselg, Yurii V. Orlovskii, Daniel Jaque
Veröffentlicht in: Advanced Functional Materials, 28/11, 2018, Page(s) 1704434, ISSN 1616-301X
Herausgeber: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201704434

Iron oxide-manganese oxide nanoparticles with tunable morphology and switchable MRI contrast mode triggered by intracellular conditions

Autoren: García-Soriano, D., Milán-Rois, P., Lafuente-Gómez, N., Navío, C., Gutiérrez, L., Cussó, L., Desco, M., Calle, D., Somoza, Á., Salas, G.
Veröffentlicht in: Journal of Colloid and Interface Science, 2022, Page(s) 447-460, ISSN 0021-9797
Herausgeber: Academic Press
DOI: 10.1016/j.jcis.2022.01.070

Stimuli-responsive nanomaterials for cancer treatment: boundaries, opportunities and applications

Autoren: Nuria Lafuente-Gómez; Ana Latorre; Paula Milán-Rois; Ciro Rodriguez Diaz; Álvaro Somoza
Veröffentlicht in: Chemical Communications, 1, 2021, Page(s) 13662-13677, ISSN 1359-7345
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d1cc05056g

In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments

Autoren: Irene Rubia-Rodríguez; Luca Zilberti; Alessandro Arduino; Oriano Bottauscio; Mario Chiampi; Daniel Ortega; Daniel Ortega
Veröffentlicht in: International Journal of Hyperthermia, 1, 2021, Page(s) 846-861, ISSN 0265-6736
Herausgeber: Taylor & Francis
DOI: 10.6084/m9.figshare.16780691.v1

Smartphone‐Based Colorimetric Method to Quantify Iron Concentration and to Determine the Nanoparticle Size from Suspensions of Magnetic Nanoparticles

Autoren: Yilian Fernández‐Afonso, Gorka Salas, Irene Fernández‐Barahona, Fernando Herranz, Cordula Grüttner, Jesús Martínez de la Fuente, María Puerto Morales, Lucía Gutiérrez
Veröffentlicht in: Particle & Particle Systems Characterization, 37/7, 2020, Page(s) 2000032, ISSN 0934-0866
Herausgeber: John Wiley & Sons Ltd.
DOI: 10.1002/ppsc.202000032

Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance

Autoren: S. Inder, M. Bates, N. Ni Labhrai, N. McDermott, J. Schneider, G. Erdmann, T. Jamerson, A. N. Flores, A. Prina-Mello, P. Thirion, P. R. Manecksha, D. Cormican, S. Finn, T. Lynch, L. Marignol
Veröffentlicht in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-019-53799-7

Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives

Autoren: Susann Piehler; Heidi Dähring; Julia Grandke; Julia Göring; Pierre Couleaud; Antonio Aires; Aitziber L. Cortajarena; Aitziber L. Cortajarena; José Courty; Alfonso Latorre; Álvaro Somoza; Ulf Teichgräber; Ingrid Hilger
Veröffentlicht in: Nanomaterials, 1, 2021, Page(s) 1016, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano10061016

Tumor-Selective Immune Active Mild Hyperthermia Associated with Chemotherapy in Colon Peritoneal Metastasis by Photoactivation of Fluorouracil – Gold Nanoparticle Complexes

Autoren: Gazeau Florence
Veröffentlicht in: ACS Nano, 6, 2021, Page(s) 3330-3348, ISSN 1936-0851
Herausgeber: American Chemical Society
DOI: 10.1021/acsnano.0c10276

Physical oncology: New targets for nanomedicine

Autoren: Nicolas-Boluda, A., Silva, A.K.A., Fournel, S., Gazeau, F.
Veröffentlicht in: Biomaterials, 2018, Page(s) 87-99, ISSN 0142-9612
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.10.014

Effect of Matrix-Modulating Enzymes on the Cellular Uptake of Magnetic Nanoparticles and on Magnetic Hyperthermia Treatment of Pancreatic Cancer Models In Vivo

Autoren: Felista L. Tansi; Filipp Fröbel; Wisdom O. Maduabuchi; Frank Steiniger; Martin Westermann; Rainer Quaas; Ulf Teichgräber; Ingrid Hilger
Veröffentlicht in: Nanomaterials, 1, 2021, Page(s) 438, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano11020438

Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications

Autoren: Geoffrey Cotin; Cristina Blanco-Andujar; Francis Perton; Laura Asín; Jesús M. de la Fuente; Wilfried Reichardt; Wilfried Reichardt; Denise Schaffner; Dinh-Vu Ngyen; Damien Mertz; Céline Kiefer; Florent Meyer; Simo Spassov; Ovidiu Ersen; Michael Chatzidakis; Gianluigi A. Botton; Céline Henoumont; Sophie Laurent; Jean-Marc Greneche; Francisco J. Teran; Francisco J. Teran; Daniel Ortega; Daniel O
Veröffentlicht in: Nanoscale, 1, 2021, Page(s) 14552-14571, ISSN 2040-3372
Herausgeber: RSC
DOI: 10.1039/d1nr03335b

Deep-tissue localization of magnetic field hyperthermia using pulse sequencing

Autoren: Tansi, F.L., Maduabuchi, W.O., Hirsch, M., Southern, P., Hattersley, S., Quaas, R., Teichgräber, U., Pankhurst, Q.A., Hilger, I.
Veröffentlicht in: International Journal of Hypertermia, 2021, Page(s) 743-754, ISSN 1464-5157
Herausgeber: Taylor Francis
DOI: 10.1080/02656736.2021.1912412

Unraveling viscosity effects on the hysteresis losses of magnetic nanocubes

Autoren: D. Cabrera, A. Lak, T. Yoshida, M. E. Materia, D. Ortega, F. Ludwig, P. Guardia, A. Sathya, T. Pellegrino, F. J. Teran
Veröffentlicht in: Nanoscale, 9/16, 2017, Page(s) 5094-5101, ISSN 2040-3364
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/c7nr00810d

Introduction to Nanomaterials Applied to Life Sciences

Autoren: Espinosa, A., Teran, F.J., Ortega, D.
Veröffentlicht in: Nanoscale Advances, 2021, ISSN 2516-0230
Herausgeber: RSC
DOI: 10.1039/d1na90011k

Endotoxin contamination of engineered nanomaterials: Overcoming the hurdles associated with endotoxin testing

Autoren: Hannon, G., Prina-Mello, A.
Veröffentlicht in: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021, Page(s) e1738, ISSN 1939-0041
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/wnan.1738

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma

Autoren: Alba Nicolás-Boluda, Javier Vaquero, Gautier Laurent, Gilles Renault, Rana Bazzi, Emmanuel Donnadieu, Stéphane Roux, Laura Fouassier, Florence Gazeau
Veröffentlicht in: ACS Nano, 14/5, 2020, Page(s) 5738-5753, ISSN 1936-0851
Herausgeber: American Chemical Society
DOI: 10.1021/acsnano.0c00417

The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

Autoren: David García-Soriano, Rebeca Amaro, Nuria Lafuente-Gómez, Paula Milán-Rois, Álvaro Somoza, Cristina Navío, Fernando Herranz, Lucía Gutiérrez, Gorka Salas
Veröffentlicht in: Journal of Colloid and Interface Science, 578, 2020, Page(s) 510-521, ISSN 0021-9797
Herausgeber: Academic Press
DOI: 10.1016/j.jcis.2020.06.011

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells

Autoren: Gary Hannon, Anna Bogdanska, Yuri Volkov, Adriele Prina-Mello
Veröffentlicht in: Nanomaterials, 10/3, 2020, Page(s) 593, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano10030593

Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells

Autoren: David Cabrera, Annelies Coene, Jonathan Leliaert, Emilio J. Artés-Ibáñez, Luc Dupré, Neil D. Telling, Francisco J. Teran
Veröffentlicht in: ACS Nano, 12/3, 2018, Page(s) 2741-2752, ISSN 1936-0851
Herausgeber: American Chemical Society
DOI: 10.1021/acsnano.7b08995

Nanoparticle-based hyperthermia, a local treatment modulating the tumor extracellular matrix

Autoren: Jelena Kolosnjaj-Tabi, Iris Marangon, Alba Nicolas-Boluda, Amanda K.A. Silva, Florence Gazeau
Veröffentlicht in: Pharmacological Research, 126, 2017, Page(s) 123-137, ISSN 1043-6618
Herausgeber: Academic Press
DOI: 10.1016/j.phrs.2017.07.010

Overcoming the tumor microenvironment: the role of nanohyperthermia

Autoren: Amanda K Silva, Alba Nicolas-Boluda, Laura Fouassier, Florence Gazeau
Veröffentlicht in: Nanomedicine, 12/11, 2017, Page(s) 1213-1215, ISSN 1743-5889
Herausgeber: Future Medicine Ltd.
DOI: 10.2217/nnm-2017-0096

How gastrin-releasing peptide receptor (GRPR) and αvβ3 integrin expression reflect reorganization features of tumors after hyperthermia treatments

Autoren: Sandra Hallasch, Sindy Frick, Maximilian Jung, Ingrid Hilger
Veröffentlicht in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-017-06100-7

Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models

Autoren: Paul Southern, Quentin A. Pankhurst
Veröffentlicht in: International Journal of Hyperthermia, 34/6, 2017, Page(s) 671-686, ISSN 0265-6736
Herausgeber: Taylor & Francis
DOI: 10.1080/02656736.2017.1365953

The Effects of Localized Heat on the Hallmarks of Cancer

Autoren: Gary Hannon; Felista L. Tansi; Ingrid Hilger; Adriele Prina-Mello
Veröffentlicht in: Advanced Therapeutics, 1, 2021, ISSN 2366-3987
Herausgeber: Wiley
DOI: 10.1002/adtp.202000267

Smart model of intrinsic loss power of SPIONs in hyperthermia treatment

Autoren: Marco Alberti; Adriele Prina-Mello
Veröffentlicht in: Journal of Magnetism and Magnetic Materials, 3, 2020, Page(s) 166493, ISSN 0304-8853
Herausgeber: Elsevier BV
DOI: 10.1016/j.jmmm.2020.166493

Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties.

Autoren: Nuria Lafuente-Gómez; Paula Milán-Rois; David García-Soriano; Yurena Luengo; Marco Cordani; Hernán Alarcón-Iniesta; Gorka Salas; Gorka Salas; Álvaro Somoza; Álvaro Somoza
Veröffentlicht in: Cancers, 4, 2021, Page(s) 4095, ISSN 2072-6694
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13164095

Using the ‘dispersion-retention-formulation method’ to estimate clinical and preclinical dosage limits for interstitial nanomedicines or agents

Autoren: Paul Southern, Quentin A. Pankhurst
Veröffentlicht in: Journal of Magnetism and Magnetic Materials, 473, 2019, Page(s) 74-78, ISSN 0304-8853
Herausgeber: Elsevier BV
DOI: 10.1016/j.jmmm.2018.10.019

Combining Ag and γ-Fe2O3 properties to produce effective antibacterial nanocomposites

Autoren: Yurena Luengo, Begoña Sot, Gorka Salas
Veröffentlicht in: Colloids and Surfaces B: Biointerfaces, 194, 2020, Page(s) 111178, ISSN 0927-7765
Herausgeber: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111178

Whither Magnetic Hyperthermia? A Tentative Roadmap

Autoren: Irene Rubia-Rodríguez; Antonio Santana-Otero; Simo Spassov; Etelka Tombácz; Christer Johansson; Patricia de la Presa; Patricia de la Presa; Francisco J. Teran; María del Puerto Morales; Sabino Veintemillas-Verdaguer; Nguyen T. K. Thanh; Maximilian O. Besenhard; Claire Wilhelm; Florence Gazeau; Quentin John Harmer; Eric Mayes; Bella B. Manshian; Stefaan J. Soenen; Yuanyu Gu; Ángel Millán; Elen
Veröffentlicht in: Materials, 1, 2021, Page(s) 706, ISSN 1996-1944
Herausgeber: MDPI Open Access Publishing
DOI: 10.3390/ma14040706

The phenotype of target pancreatic cancer cells influences cell death by magnetic hyperthermia with nanoparticles carrying gemicitabine and the pseudo-peptide NucAnt

Autoren: Mourad Sanhaji, Julia Göring, Pierre Couleaud, Antonio Aires, Aitziber L. Cortajarena, José Courty, Adriele Prina-Mello, Marcus Stapf, Robert Ludwig, Yuri Volkov, Alfonso Latorre, Álvaro Somoza, Rodolfo Miranda, Ingrid Hilger
Veröffentlicht in: Nanomedicine: Nanotechnology, Biology and Medicine, 20, 2019, Page(s) 101983, ISSN 1549-9634
Herausgeber: Elsevier BV
DOI: 10.1016/j.nano.2018.12.019

A study focused on macrophages modulation induced by the Polymeric Electrospun Matrices (EL-Ms) for application in tissue regeneration: in vitro proof of concept.

Autoren: Silvia Pisani; Rossella Dorati; Ida Genta; Marco Benazzo; Bice Conti; Adriele Prina Mello
Veröffentlicht in: International Journal of Pharmaceutics, 1, 2021, Page(s) 120712, ISSN 0378-5173
Herausgeber: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120712

Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment

Autoren: Marco Cordani, Álvaro Somoza
Veröffentlicht in: Cellular and Molecular Life Sciences, 76/7, 2019, Page(s) 1215-1242, ISSN 1420-682X
Herausgeber: Birkhauser Verlag
DOI: 10.1007/s00018-018-2973-y

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment.

Autoren: Alba Nicolas-Boluda; Javier Vaquero; Lene Vimeux; Thomas Guilbert; Sarah Barrin; Chahrazade Kantari-Mimoun; Matteo Ponzo; Gilles Renault; Piotr Deptuła; Katarzyna Pogoda; Robert Bucki; Ilaria Cascone; José Courty; Laura Fouassier; Florence Gazeau; Emmanuel Donnadieu
Veröffentlicht in: "eLife, eLife Sciences Publication, 2021, 10 (32), pp.322001. ⟨10.7554/eLife.58688⟩", 1, 2021, ISSN 2050-084X
Herausgeber: eLife Sciences Publications
DOI: 10.7554/elife.58688

Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells

Autoren: Ana Lazaro-Carrillo, Macarena Calero, Antonio Aires, Aitziber L. Cortajarena, Bruno M. Simões, Alfonso Latorre, Álvaro Somoza, Robert B. Clarke, Rodolfo Miranda, Angeles Villanueva
Veröffentlicht in: Cancers, 12/6, 2020, Page(s) 1397, ISSN 2072-6694
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061397

Individual particle heating of interacting magnetic nanoparticles at nonzero temperature

Autoren: Jonathan Leliaert; Javier Ortega-Julia; Daniel Ortega; Daniel Ortega
Veröffentlicht in: Nanoscale, 2021, Page(s) 14734-14744, ISSN 2040-3372
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d1nr05311f

3D volume segmentation and reconstruction. Supervised image classification and automated quantification of superparamagnetic iron oxide nanoparticles in histology slides for safety assessment.

Autoren: Anna Bogdanska; Oliviero L. Gobbo; Yuri Volkov; Adriele Prina-Mello
Veröffentlicht in: Nanotoxicology, 1, 2021, Page(s) 1151-1167, ISSN 1743-5390
Herausgeber: Informa Healthcare
DOI: 10.1080/17435390.2021.1991502

Self‐Assemblies of Fe 3 O 4 Nanocrystals: Toward Nanoscale Precision of Photothermal Effects in the Tumor Microenvironment

Autoren: Alba Nicolas‐Boluda, Zhijie Yang, Thomas Guilbert, Laura Fouassier, Florent Carn, Florence Gazeau, Marie Paule Pileni
Veröffentlicht in: Advanced Functional Materials, 2020, Page(s) 2006824, ISSN 1616-301X
Herausgeber: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202006824

Two step promotion of a hot tumor immune environment by gold decorated iron oxide nanoflowers and light-triggered mild hyperthermia

Autoren: Gazeau Florence
Veröffentlicht in: Nanoscale, 6, 2021, Page(s) 18483-18497, ISSN 2040-3372
Herausgeber: RSC
DOI: 10.1039/d1nr03201a