Nanomedicine upscaling for early clinical phases of multimodal cancer therapy

Resultado final

International workshops with main stakeholders and players, including representatives of the EC (around 80 participants)

Exploitation and dissemination Workshop II

International workshop with main stakeholders and players, including representatives of the EC (around 80 participants)

White paper on good practices for Nanotherapies scale up

This file will contain all the good practices, potential contribution standards and lessons learned in certified nanoparticle production scale up, to contribute to the deployment of nanotherapies in the EU

Public Web Site and Project Presentation

Design and maintenance of dedicated project web site with an offering of the typical electronic dissemination facilities

Publicaciones

Optomagnetic Nanoplatforms for In Situ Controlled Hyperthermia

Autores: Dirk H. Ortgies, Francisco J. Teran, Uéslen Rocha, Leonor de la Cueva, Gorka Salas, David Cabrera, Alexander S. Vanetsev, Mihkel Rähn, Väino Sammelselg, Yurii V. Orlovskii, Daniel Jaque
Publicado en: Advanced Functional Materials, Edición 28/11, 2018, Página(s) 1704434, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201704434

Iron oxide-manganese oxide nanoparticles with tunable morphology and switchable MRI contrast mode triggered by intracellular conditions

Autores: García-Soriano, D., Milán-Rois, P., Lafuente-Gómez, N., Navío, C., Gutiérrez, L., Cussó, L., Desco, M., Calle, D., Somoza, Á., Salas, G.
Publicado en: Journal of Colloid and Interface Science, 2022, Página(s) 447-460, ISSN 0021-9797
Editor: Academic Press
DOI: 10.1016/j.jcis.2022.01.070

Stimuli-responsive nanomaterials for cancer treatment: boundaries, opportunities and applications

Autores: Nuria Lafuente-Gómez; Ana Latorre; Paula Milán-Rois; Ciro Rodriguez Diaz; Álvaro Somoza
Publicado en: Chemical Communications, Edición 1, 2021, Página(s) 13662-13677, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d1cc05056g

In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments

Autores: Irene Rubia-Rodríguez; Luca Zilberti; Alessandro Arduino; Oriano Bottauscio; Mario Chiampi; Daniel Ortega; Daniel Ortega
Publicado en: International Journal of Hyperthermia, Edición 1, 2021, Página(s) 846-861, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.6084/m9.figshare.16780691.v1

Smartphone‐Based Colorimetric Method to Quantify Iron Concentration and to Determine the Nanoparticle Size from Suspensions of Magnetic Nanoparticles

Autores: Yilian Fernández‐Afonso, Gorka Salas, Irene Fernández‐Barahona, Fernando Herranz, Cordula Grüttner, Jesús Martínez de la Fuente, María Puerto Morales, Lucía Gutiérrez
Publicado en: Particle & Particle Systems Characterization, Edición 37/7, 2020, Página(s) 2000032, ISSN 0934-0866
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ppsc.202000032

Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance

Autores: S. Inder, M. Bates, N. Ni Labhrai, N. McDermott, J. Schneider, G. Erdmann, T. Jamerson, A. N. Flores, A. Prina-Mello, P. Thirion, P. R. Manecksha, D. Cormican, S. Finn, T. Lynch, L. Marignol
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-53799-7

Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives

Autores: Susann Piehler; Heidi Dähring; Julia Grandke; Julia Göring; Pierre Couleaud; Antonio Aires; Aitziber L. Cortajarena; Aitziber L. Cortajarena; José Courty; Alfonso Latorre; Álvaro Somoza; Ulf Teichgräber; Ingrid Hilger
Publicado en: Nanomaterials, Edición 1, 2021, Página(s) 1016, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano10061016

Tumor-Selective Immune Active Mild Hyperthermia Associated with Chemotherapy in Colon Peritoneal Metastasis by Photoactivation of Fluorouracil – Gold Nanoparticle Complexes

Autores: Gazeau Florence
Publicado en: ACS Nano, Edición 6, 2021, Página(s) 3330-3348, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.0c10276

Physical oncology: New targets for nanomedicine

Autores: Nicolas-Boluda, A., Silva, A.K.A., Fournel, S., Gazeau, F.
Publicado en: Biomaterials, 2018, Página(s) 87-99, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.10.014

Effect of Matrix-Modulating Enzymes on the Cellular Uptake of Magnetic Nanoparticles and on Magnetic Hyperthermia Treatment of Pancreatic Cancer Models In Vivo

Autores: Felista L. Tansi; Filipp Fröbel; Wisdom O. Maduabuchi; Frank Steiniger; Martin Westermann; Rainer Quaas; Ulf Teichgräber; Ingrid Hilger
Publicado en: Nanomaterials, Edición 1, 2021, Página(s) 438, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano11020438

Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications

Autores: Geoffrey Cotin; Cristina Blanco-Andujar; Francis Perton; Laura Asín; Jesús M. de la Fuente; Wilfried Reichardt; Wilfried Reichardt; Denise Schaffner; Dinh-Vu Ngyen; Damien Mertz; Céline Kiefer; Florent Meyer; Simo Spassov; Ovidiu Ersen; Michael Chatzidakis; Gianluigi A. Botton; Céline Henoumont; Sophie Laurent; Jean-Marc Greneche; Francisco J. Teran; Francisco J. Teran; Daniel Ortega; Daniel O
Publicado en: Nanoscale, Edición 1, 2021, Página(s) 14552-14571, ISSN 2040-3372
Editor: RSC
DOI: 10.1039/d1nr03335b

Deep-tissue localization of magnetic field hyperthermia using pulse sequencing

Autores: Tansi, F.L., Maduabuchi, W.O., Hirsch, M., Southern, P., Hattersley, S., Quaas, R., Teichgräber, U., Pankhurst, Q.A., Hilger, I.
Publicado en: International Journal of Hypertermia, 2021, Página(s) 743-754, ISSN 1464-5157
Editor: Taylor Francis
DOI: 10.1080/02656736.2021.1912412

Unraveling viscosity effects on the hysteresis losses of magnetic nanocubes

Autores: D. Cabrera, A. Lak, T. Yoshida, M. E. Materia, D. Ortega, F. Ludwig, P. Guardia, A. Sathya, T. Pellegrino, F. J. Teran
Publicado en: Nanoscale, Edición 9/16, 2017, Página(s) 5094-5101, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/c7nr00810d

Introduction to Nanomaterials Applied to Life Sciences

Autores: Espinosa, A., Teran, F.J., Ortega, D.
Publicado en: Nanoscale Advances, 2021, ISSN 2516-0230
Editor: RSC
DOI: 10.1039/d1na90011k

Endotoxin contamination of engineered nanomaterials: Overcoming the hurdles associated with endotoxin testing

Autores: Hannon, G., Prina-Mello, A.
Publicado en: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021, Página(s) e1738, ISSN 1939-0041
Editor: John Wiley & Sons Inc.
DOI: 10.1002/wnan.1738

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma

Autores: Alba Nicolás-Boluda, Javier Vaquero, Gautier Laurent, Gilles Renault, Rana Bazzi, Emmanuel Donnadieu, Stéphane Roux, Laura Fouassier, Florence Gazeau
Publicado en: ACS Nano, Edición 14/5, 2020, Página(s) 5738-5753, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.0c00417

The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

Autores: David García-Soriano, Rebeca Amaro, Nuria Lafuente-Gómez, Paula Milán-Rois, Álvaro Somoza, Cristina Navío, Fernando Herranz, Lucía Gutiérrez, Gorka Salas
Publicado en: Journal of Colloid and Interface Science, Edición 578, 2020, Página(s) 510-521, ISSN 0021-9797
Editor: Academic Press
DOI: 10.1016/j.jcis.2020.06.011

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells

Autores: Gary Hannon, Anna Bogdanska, Yuri Volkov, Adriele Prina-Mello
Publicado en: Nanomaterials, Edición 10/3, 2020, Página(s) 593, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano10030593

Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells

Autores: David Cabrera, Annelies Coene, Jonathan Leliaert, Emilio J. Artés-Ibáñez, Luc Dupré, Neil D. Telling, Francisco J. Teran
Publicado en: ACS Nano, Edición 12/3, 2018, Página(s) 2741-2752, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.7b08995

Nanoparticle-based hyperthermia, a local treatment modulating the tumor extracellular matrix

Autores: Jelena Kolosnjaj-Tabi, Iris Marangon, Alba Nicolas-Boluda, Amanda K.A. Silva, Florence Gazeau
Publicado en: Pharmacological Research, Edición 126, 2017, Página(s) 123-137, ISSN 1043-6618
Editor: Academic Press
DOI: 10.1016/j.phrs.2017.07.010

Overcoming the tumor microenvironment: the role of nanohyperthermia

Autores: Amanda K Silva, Alba Nicolas-Boluda, Laura Fouassier, Florence Gazeau
Publicado en: Nanomedicine, Edición 12/11, 2017, Página(s) 1213-1215, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm-2017-0096

How gastrin-releasing peptide receptor (GRPR) and αvβ3 integrin expression reflect reorganization features of tumors after hyperthermia treatments

Autores: Sandra Hallasch, Sindy Frick, Maximilian Jung, Ingrid Hilger
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-06100-7

Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models

Autores: Paul Southern, Quentin A. Pankhurst
Publicado en: International Journal of Hyperthermia, Edición 34/6, 2017, Página(s) 671-686, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2017.1365953

The Effects of Localized Heat on the Hallmarks of Cancer

Autores: Gary Hannon; Felista L. Tansi; Ingrid Hilger; Adriele Prina-Mello
Publicado en: Advanced Therapeutics, Edición 1, 2021, ISSN 2366-3987
Editor: Wiley
DOI: 10.1002/adtp.202000267

Smart model of intrinsic loss power of SPIONs in hyperthermia treatment

Autores: Marco Alberti; Adriele Prina-Mello
Publicado en: Journal of Magnetism and Magnetic Materials, Edición 3, 2020, Página(s) 166493, ISSN 0304-8853
Editor: Elsevier BV
DOI: 10.1016/j.jmmm.2020.166493

Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties.

Autores: Nuria Lafuente-Gómez; Paula Milán-Rois; David García-Soriano; Yurena Luengo; Marco Cordani; Hernán Alarcón-Iniesta; Gorka Salas; Gorka Salas; Álvaro Somoza; Álvaro Somoza
Publicado en: Cancers, Edición 4, 2021, Página(s) 4095, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13164095

Using the ‘dispersion-retention-formulation method’ to estimate clinical and preclinical dosage limits for interstitial nanomedicines or agents

Autores: Paul Southern, Quentin A. Pankhurst
Publicado en: Journal of Magnetism and Magnetic Materials, Edición 473, 2019, Página(s) 74-78, ISSN 0304-8853
Editor: Elsevier BV
DOI: 10.1016/j.jmmm.2018.10.019

Combining Ag and γ-Fe2O3 properties to produce effective antibacterial nanocomposites

Autores: Yurena Luengo, Begoña Sot, Gorka Salas
Publicado en: Colloids and Surfaces B: Biointerfaces, Edición 194, 2020, Página(s) 111178, ISSN 0927-7765
Editor: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111178

Whither Magnetic Hyperthermia? A Tentative Roadmap

Autores: Irene Rubia-Rodríguez; Antonio Santana-Otero; Simo Spassov; Etelka Tombácz; Christer Johansson; Patricia de la Presa; Patricia de la Presa; Francisco J. Teran; María del Puerto Morales; Sabino Veintemillas-Verdaguer; Nguyen T. K. Thanh; Maximilian O. Besenhard; Claire Wilhelm; Florence Gazeau; Quentin John Harmer; Eric Mayes; Bella B. Manshian; Stefaan J. Soenen; Yuanyu Gu; Ángel Millán; Elen
Publicado en: Materials, Edición 1, 2021, Página(s) 706, ISSN 1996-1944
Editor: MDPI Open Access Publishing
DOI: 10.3390/ma14040706

The phenotype of target pancreatic cancer cells influences cell death by magnetic hyperthermia with nanoparticles carrying gemicitabine and the pseudo-peptide NucAnt

Autores: Mourad Sanhaji, Julia Göring, Pierre Couleaud, Antonio Aires, Aitziber L. Cortajarena, José Courty, Adriele Prina-Mello, Marcus Stapf, Robert Ludwig, Yuri Volkov, Alfonso Latorre, Álvaro Somoza, Rodolfo Miranda, Ingrid Hilger
Publicado en: Nanomedicine: Nanotechnology, Biology and Medicine, Edición 20, 2019, Página(s) 101983, ISSN 1549-9634
Editor: Elsevier BV
DOI: 10.1016/j.nano.2018.12.019

A study focused on macrophages modulation induced by the Polymeric Electrospun Matrices (EL-Ms) for application in tissue regeneration: in vitro proof of concept.

Autores: Silvia Pisani; Rossella Dorati; Ida Genta; Marco Benazzo; Bice Conti; Adriele Prina Mello
Publicado en: International Journal of Pharmaceutics, Edición 1, 2021, Página(s) 120712, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120712

Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment

Autores: Marco Cordani, Álvaro Somoza
Publicado en: Cellular and Molecular Life Sciences, Edición 76/7, 2019, Página(s) 1215-1242, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-018-2973-y

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment.

Autores: Alba Nicolas-Boluda; Javier Vaquero; Lene Vimeux; Thomas Guilbert; Sarah Barrin; Chahrazade Kantari-Mimoun; Matteo Ponzo; Gilles Renault; Piotr Deptuła; Katarzyna Pogoda; Robert Bucki; Ilaria Cascone; José Courty; Laura Fouassier; Florence Gazeau; Emmanuel Donnadieu
Publicado en: "eLife, eLife Sciences Publication, 2021, 10 (32), pp.322001. ⟨10.7554/eLife.58688⟩", Edición 1, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.58688

Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells

Autores: Ana Lazaro-Carrillo, Macarena Calero, Antonio Aires, Aitziber L. Cortajarena, Bruno M. Simões, Alfonso Latorre, Álvaro Somoza, Robert B. Clarke, Rodolfo Miranda, Angeles Villanueva
Publicado en: Cancers, Edición 12/6, 2020, Página(s) 1397, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061397

Individual particle heating of interacting magnetic nanoparticles at nonzero temperature

Autores: Jonathan Leliaert; Javier Ortega-Julia; Daniel Ortega; Daniel Ortega
Publicado en: Nanoscale, 2021, Página(s) 14734-14744, ISSN 2040-3372
Editor: Royal Society of Chemistry
DOI: 10.1039/d1nr05311f

3D volume segmentation and reconstruction. Supervised image classification and automated quantification of superparamagnetic iron oxide nanoparticles in histology slides for safety assessment.

Autores: Anna Bogdanska; Oliviero L. Gobbo; Yuri Volkov; Adriele Prina-Mello
Publicado en: Nanotoxicology, Edición 1, 2021, Página(s) 1151-1167, ISSN 1743-5390
Editor: Informa Healthcare
DOI: 10.1080/17435390.2021.1991502

Self‐Assemblies of Fe 3 O 4 Nanocrystals: Toward Nanoscale Precision of Photothermal Effects in the Tumor Microenvironment

Autores: Alba Nicolas‐Boluda, Zhijie Yang, Thomas Guilbert, Laura Fouassier, Florent Carn, Florence Gazeau, Marie Paule Pileni
Publicado en: Advanced Functional Materials, 2020, Página(s) 2006824, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202006824

Two step promotion of a hot tumor immune environment by gold decorated iron oxide nanoflowers and light-triggered mild hyperthermia

Autores: Gazeau Florence
Publicado en: Nanoscale, Edición 6, 2021, Página(s) 18483-18497, ISSN 2040-3372
Editor: RSC
DOI: 10.1039/d1nr03201a

Derechos de propiedad intelectual

METHOD FOR DETECTION OF AN ANALYTE

Número de solicitud/publicación: 18 796477
Fecha: 2018-11-08
Solicitante(s): FUNDACION IMDEA NANOCIENCIA

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Resultado final

Publicaciones

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