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Scaling-up biodegradable nanomedicines for multimodal for multimodal precision cancer immunotherapy

Publications

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy

Author(s): Julia Koerner, Dennis Horvath, Valerie L. Herrmann, Anna MacKerracher, Bruno Gander, Hideo Yagita, Jacques Rohayem, Marcus Groettrup
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23244-3

A comparative assessment of continuous production techniques to generate sub-micron size PLGA particles

Author(s): Maria Camilla Operti, David Fecher, Eric A.W. van Dinther, Silko Grimm, Rima Jaber, Carl G.Figdor, Oya Tagit
Published in: International Journal of Pharmaceutics, 2018, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2018.08.044

A novel computational method for automatic segmentation, quantification and comparative analysis of immunohistochemically labeled tissue sections

Author(s): Casiraghi, E; Huber, V; Frasca, M; Cossa, M; Tozzi, M; Rivoltini, L; Leone, B; Villa, A; Vergani, B
Published in: BMC Bioinformatics, 2, 2018, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-018-2302-3

PLGA Nanoparticles Co-encapsulating NY-ESO-1 Peptides and IMM60 Induce Robust CD8 and CD4 T Cell and B Cell Responses

Author(s): Yusuf Dölen, Uzi Gileadi, Ji-Li Chen, Michael Valente, Jeroen H. A. Creemers, Eric A. W. Van Dinther, N. Koen van Riessen, Eliezer Jäger, Martin Hruby, Vincenzo Cerundolo, Mustafa Diken, Carl G. Figdor and I. Jolanda M. de Vries
Published in: Frontiers in Immunoloy, 2021, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2021.641703

Enhanced Antitumor Efficacy through an “AND gate” Reactive Oxygen-Species-Dependent pH-Responsive Nanomedicine Approach

Author(s): Eliézer Jäger, Jana Humajová, Yusuf Dölen, Jan Kučka, Alessandro Jäger, Rafał Konefał, Jan Pankrác, Ewa Pavlova, Tomáš Heizer, Luděk Šefc, Martin Hrubý, Carl G. Figdor, Martijn Verdoes
Published in: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202100304

Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[N-(2-hydroxypropyl)methacrylamide]-Block-Poly[N-(2,2-difluoroethyl)acrylamide], Prominent F-19 MRI Tracer

Author(s): David Babuka, Kristyna Kolouchova, Ondrej Groborz, Zdenek Tosner, Alexander Zhigunov, Petr Stepanek, Martin Hruby
Published in: Nanomaterials, 2020, ISSN 2079-4991
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/nano10112231

Forster Resonance Energy Transfer-Based Stability Assessment of PLGA Nanoparticles in Vitro and in Vivo

Author(s): Edyta Swider; Sanish Maharjan; Karlijne Houkes; Nicolaas Koen van Riessen; Carl G. Figdor; Mangala Srinivas; Oya Tagit
Published in: ACS Applied Bio Materials, 2, 2019, ISSN 2576-6422
Publisher: American Chemical Society
DOI: 10.1021/acsabm.8b00754

Integrated transcriptional-phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients

Author(s): Darawan Rinchai, Elena Verzoni, Veronica Huber, Agata Cova, Paola Squarcina, Loris De Cecco, Filippo de Braud, Raffaele Ratta, Matteo Dugo, Luca Lalli, Viviana Vallacchi, Monica Rodolfo, Jessica Roelands, Chiara Castelli, Damien Chaussabel, Giuseppe Procopio, Davide Bedognetti, Licia Rivoltini
Published in: Clinical and Translational Medicine, 2021, ISSN 1752-8054
Publisher: Wiley-Blackwell
DOI: 10.1002/ctm2.434

Assessment of anti-PD-1 antibody and immune complex binding to Fc gamma receptors and clinical implications

Author(s): E. Daveri, E. Luison, V. Vallacchi, B. Vergani, B.E. Leone, M.C. Garassino, M. Figini, L. Rivoltini
Published in: Annals of Oncology, 2021, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1016/j.annonc.2021.08.1355

The AURORA of a New Way to Value Myeloid Immunosuppression in Cancer

Author(s): Licia Rivoltini, Claudio Vernieri, Veronica Huber
Published in: Cancer Research, 2019, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-1081

Industrial Scale Manufacturing and Downstream Processing of PLGA-Based Nanomedicines Suitable for Fully Continuous Operation

Author(s): Maria Camilla Operti, Alexander Bernhardt, Vladimir Sincari, Eliezer Jager, Silko Grimm, Andrea Engel, Martin Hruby, Carl Gustav Figdor, Oya Tagit
Published in: Pharmaceutics, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020276

The STEAP1 262-270 peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice-A new approach to immunotherapy against prostate carcinoma

Author(s): Valerie L. Herrmann, Daniel E. Wieland, Daniel F. Legler, Valentin Wittmann, Marcus Groettrup
Published in: The Prostate, 76/5, 2016, Page(s) 456-468, ISSN 0270-4137
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pros.23136

Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

Author(s): Giuseppe Lo Russo, Massimo Moro, Michele Sommariva, Valeria Cancila, Mattia Boeri, Giovanni Centonze, Simona Ferro, Monica Ganzinelli, Patrizia Gasparini, Veronica Huber, Massimo Milione, Luca Porcu, Claudia Proto, Giancarlo Pruneri, Diego Signorelli, Sabina Sangaletti, Lucia Sfondrini, Chiara Storti, Elena Tassi, Alberto Bardelli, Silvia Marsoni, Valter Torri, Claudio Tripodo, Mario Paolo Colombo
Published in: Clinical Cancer Research, 2018, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-1390

Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

Author(s): Veronica Huber, Viviana Vallacchi, Viktor Fleming, Xiaoying Hu, Agata Cova, Matteo Dugo, Eriomina Shahaj, Roberta Sulsenti, Elisabetta Vergani, Paola Filipazzi, Angela De Laurentiis, Luca Lalli, Lorenza Di Guardo, Roberto Patuzzo, Barbara Vergani, Elena Casiraghi, Mara Cossa, Ambra Gualeni, Valentina Bollati, Flavio Arienti, Filippo De Braud, Luigi Mariani, Antonello Villa, Peter Altevogt, Viktor
Published in: Journal of Clinical Investigation, 128/12, 2018, Page(s) 5505-5516, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci98060

Harnessing Dendritic Cells for Poly (D,L-lactide-co-glycolide) Microspheres (PLGA MS)—Mediated Anti-tumor Therapy

Author(s): Julia Koerner, Dennis Horvath, Marcus Groettrup
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.00707

Microfluidics-Assisted Size Tuning and Biological Evaluation of PLGA Particles

Author(s): Maria Camilla Operti, Yusuf Dölen, Jibbe Keulen, Eric A. W. van Dinther, Carl G. Figdor, Oya Tagit
Published in: Pharmaceutics, 11/11, 2019, Page(s) 590, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11110590

Nanovaccine administration route is critical to obtain pertinent iNKt cell help for robust anti-tumor T and B cell responses

Author(s): Yusuf Dölen, Michael Valente, Oya Tagit, Eliezer Jäger, Eric A. W. Van Dinther, N. Koen van Riessen, Martin Hruby, Uzi Gileadi, Vincenzo Cerundolo, Carl G. Figdor
Published in: OncoImmunology, 9/1, 2020, Page(s) 1738813, ISSN 2162-402X
Publisher: OncoImmunology
DOI: 10.1080/2162402x.2020.1738813

Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4/CCL17 axis for the generation of short-lived effector cells

Author(s): M. Valente, Y. Dölen, E. van Dinther, L. Vimeux, M. Fallet, V. Feuillet, C. G. Figdor
Published in: Proceedings of the National Academy of Sciences, 116/51, 2019, Page(s) 25816-25827, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1913491116

Back to simplicity: a four-marker blood cell score to quantify prognostically relevant myeloid cells in melanoma patients.

Author(s): Veronica Huber; Lorenza Di Guardo; Luca Lalli; Daniele Giardiello; Agata Cova; Paola Squarcina; Paola Frati; Anna Maria Di Giacomo; Lorenzo Pilla; Marcella Tazzari; Chiara Camisaschi; Flavio Arienti; Chiara Castelli; Monica Rodolfo; Valeria Beretta; Massimo Di Nicola; Michele Maio; Michele Del Vecchio; Filippo de Braud; Luigi Mariani; Licia Rivoltini
Published in: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021), 1, 2021, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2020-001167

Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion

Author(s): Camille Le Gall, Anna Cammarata, Lukas de Haas, Iván Ramos-Tomillero, Jorge Cuenca-Escalona, Kayleigh Schouren, Zacharias Wijfjes, Anouk M D Becker, Johanna Bödder, Yusuf Dölen, Jolanda M de Vries, Carl G Figdor, Georgina Flórez-Grau, Martijn Verdoes
Published in: Journal for ImmunoTherapy of Cancer, 2022, ISSN 2051-1426
Publisher: BMJ Publishing Group
DOI: 10.1136/jitc-2021-004309

BMCMDA: a novel model for predicting human microbe-disease associations via binary matrix completion

Author(s): Jian-Yu Shi, Hua Huang, Yan-Ning Zhang, Jiang-Bo Cao & Siu-Ming Yiu
Published in: BMC Bioinformatics, 2018, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-018-2274-3

Is impaired response to PD-1 blockers of high serum PD-1 patients related to immune complexes?

Author(s): E. Daveri, E. Luison, V. Vallacchi, B. Vergani, B. E. Leone, M. C. Garassino, M. Figini, L. Rivoltini
Published in: annals of oncology, 2021, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1016/j.annonc.2021.02.022

Assessing the safety, tolerability and efficacy of PLGA-based immunomodulatory nanoparticles in patients with advanced NY-ESO-1-positive cancers: a first-in-human phase I open-label dose-escalation study protocol.

Author(s): Jeroen H A Creemers; Inka Pawlitzky; Konstantina Grosios; Uzi Gileadi; Mark R. Middleton; Winald R. Gerritsen; Niven Mehra; Licia Rivoltini; Ian Walters; Carl G. Figdor; Petronella B. Ottevanger; I. Jolanda M. de Vries
Published in: BMJ Open, 5, 2021, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-050725

PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up

Author(s): Maria Camilla Operti, Alexander Bernhardt, Silko Grimm, Andrea Engel, Carl Gustav Figdor, Oya Tagit
Published in: International Journal of Pharmaceutics, 2021, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120807

Immunosuppressive circuits in tumor microenvironment and their influence on cancer treatment efficacy

Author(s): Alessandra Tuccitto, Eriomina Shahaj, Elisabetta Vergani, Simona Ferro, Veronica Huber, Monica Rodolfo, Chiara Castelli, Licia Rivoltini, Viviana Vallacchi
Published in: Virchows Arch, 2019, ISSN 0945-6317
Publisher: Springer Verlag
DOI: 10.1007/s00428-018-2477-z

microRNAs Shape Myeloid Cell-Mediated Resistance to Cancer Immunotherapy.

Author(s): Elena Daveri; Elisabetta Vergani; Eriomina Shahaj; Laura Bergamaschi; Stefano La Magra; Michela Dosi; Chiara Castelli; Monica Rodolfo; Licia Rivoltini; Viviana Vallacchi; Veronica Huber
Published in: Frontiers in Immunology, 4, 2020, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.01214

Pazopanib induces dramatic but transient contraction of myeloid suppression compartment in favor of adaptive immunity

Author(s): Darawan Rinchai, Elena Verzoni, Veronica Huber, Agata Cova, Paola Squarcina, Loris De Cecco, Filippo de Braud, Raffaele Ratta, Matteo Dugo, Luca Lalli, Viviana Vallacchi, Monica Rodolfo, Jessica Roelands, Chiara Castelli, Damien Chaussabel, Giuseppe Procopio, Davide Bedognetti, Licia Rivoltini
Published in: bioRxiv, 2020, ISSN 2692-8205
Publisher: N/A
DOI: 10.1101/2020.05.01.071613