Skip to main content

Scaling-up biodegradable nanomedicines for multimodal for multimodal precision cancer immunotherapy

Objective

PRECIOUS aims at scaling-up biodegradable nanomedicines for multimodal precision cancer immunotherapy.
With 3.5 million cancer patients in Europe every year, new cancer medicines are eagerly awaited, notably for prostate and ovarian cancer.
Systemically applied new immunotherapies are promising, but their toxicity is a hurdle. Vaccination against cancer is safe but rather the efficacy can be disappointing, i.e. the microenvironment shuts down anti-tumour immunity.

PRECIOUS will tackle 2 bottlenecks:
1. Production of non toxic multimodal nanomedicines, which induce vigorous immune responses, and at the same time reverse immunosuppression
2. Large scale GMP production of nanomedicines, and initiate a multimodal immunotherapy Phase I trial.

We want to solve these bottlenecks by:
Objective 1: Two types of GMP biodegradable nanoparticles: 1) a nanovaccine, containing tumour antigens and immune activators, and 2) a nanoparticle composed of compounds, which reverses the suppression and reactivates immunity in the tumour.
Objective 2: Clinical Phase I trial to show efficacy. Nanomedicines will be used by 1) injection of vaccines to evoke immune responses and 2) injection of nanoparticles in the tumour microenvironment, which slowly release compounds that reverse suppression.

To achieve this, a platform is formed with 6 leading industrial partners to produce large scale GMP nanomedicines and an excellent immunomodulator track record, together with 5 renowned academic partners to perform clinical studies.
Relevance to call: Large scale GMP production, industrial leadership, nanotechnology and advanced manufacturing KET technologies, translation to the clinic, marketing development.

Call for proposal

H2020-NMP-2015-two-stage
See other projects for this call

Coordinator

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 637 983,39

Participants (11)

EVONIK OPERATIONS GMBH
Germany
EU contribution
€ 835 737,70
Address
Rellinghauser Strasse 1-11
45128 Essen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ITEOS THERAPEUTICS
Belgium
EU contribution
€ 949 029,64
Address
Rue Des Freres Wright 29
6041 Gosselies
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IOX THERAPEUTICS LIMITED
United Kingdom
EU contribution
€ 241 483,37
Address
200 Strand
WC2R 1DJ London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ONCOARENDI THERAPEUTICS SPOLKA AKCYJNA
Poland
EU contribution
€ 615 782,59
Address
Uk Zwirki I Wigury 101
02 089 Warszawa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SPECIALIZED MEDICAL SERVICES-ONCOLOGY BV
Netherlands
EU contribution
€ 720 266,41
Address
Walaardt Sacrestraat 401
1117 BM Schiphol
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAT KONSTANZ
Germany
EU contribution
€ 735 651,02
Address
Universitatsstrasse 10
78457 Konstanz
Activity type
Higher or Secondary Education Establishments
USTAV MAKROMOLEKULARNI CHEMIE AV CRVVI
Czechia
EU contribution
€ 463 854,63
Address
Heyrovsky Sq 2
162 06 Praha 6
Activity type
Research Organisations
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 712 254,34
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
EU contribution
€ 448 416,81
Address
Via Venezian 1
20133 Milan
Activity type
Research Organisations
TTOPSTART BV
Netherlands
EU contribution
€ 159 062,18
Address
Euclideslaan 1
3584 BL Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING KATHOLIEKE UNIVERSITEIT

Participation ended

Netherlands
EU contribution
€ 1 771 695,42
Address
Comeniuslaan 4
6525 HP Nijmegen
Activity type
Higher or Secondary Education Establishments