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Scaling-up biodegradable nanomedicines for multimodal for multimodal precision cancer immunotherapy

Objective

PRECIOUS aims at scaling-up biodegradable nanomedicines for multimodal precision cancer immunotherapy.
With 3.5 million cancer patients in Europe every year, new cancer medicines are eagerly awaited, notably for prostate and ovarian cancer.
Systemically applied new immunotherapies are promising, but their toxicity is a hurdle. Vaccination against cancer is safe but rather the efficacy can be disappointing, i.e. the microenvironment shuts down anti-tumour immunity.

PRECIOUS will tackle 2 bottlenecks:
1. Production of non toxic multimodal nanomedicines, which induce vigorous immune responses, and at the same time reverse immunosuppression
2. Large scale GMP production of nanomedicines, and initiate a multimodal immunotherapy Phase I trial.

We want to solve these bottlenecks by:
Objective 1: Two types of GMP biodegradable nanoparticles: 1) a nanovaccine, containing tumour antigens and immune activators, and 2) a nanoparticle composed of compounds, which reverses the suppression and reactivates immunity in the tumour.
Objective 2: Clinical Phase I trial to show efficacy. Nanomedicines will be used by 1) injection of vaccines to evoke immune responses and 2) injection of nanoparticles in the tumour microenvironment, which slowly release compounds that reverse suppression.

To achieve this, a platform is formed with 6 leading industrial partners to produce large scale GMP nanomedicines and an excellent immunomodulator track record, together with 5 renowned academic partners to perform clinical studies.
Relevance to call: Large scale GMP production, industrial leadership, nanotechnology and advanced manufacturing KET technologies, translation to the clinic, marketing development.

Call for proposal

H2020-NMP-2014-2015

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Sub call

H2020-NMP-2015-two-stage

Coordinator

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Net EU contribution
€ 637 983,39
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Netherlands

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (11)

EVONIK OPERATIONS GMBH
Germany
Net EU contribution
€ 835 737,70
Address
Rellinghauser Strasse 1-11
45128 Essen

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Region
Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ITEOS THERAPEUTICS
Belgium
Net EU contribution
€ 949 029,64
Address
Rue Des Freres Wright 29
6041 Gosselies

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Région wallonne Prov. Hainaut Arr. Charleroi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
IOX THERAPEUTICS LIMITED
United Kingdom
Net EU contribution
€ 241 483,37
Address
200 Strand
WC2R 1DJ London

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Region
London Inner London — West Westminster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MOLECURE SPOLKA AKCYJNA
Poland
Net EU contribution
€ 615 782,59
Address
Ul Zwirki I Wigury 101
02-089 Warszawa

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SPECIALIZED MEDICAL SERVICES-ONCOLOGY BV
Netherlands
Net EU contribution
€ 720 266,41
Address
Walaardt Sacrestraat 401
1117 BM Schiphol

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITAT KONSTANZ
Germany
Net EU contribution
€ 735 651,02
Address
Universitatsstrasse 10
78464 Konstanz

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
USTAV MAKROMOLEKULARNI CHEMIE AV CRVVI
Czechia
Net EU contribution
€ 463 854,63
Address
Heyrovsky Sq 2
162 06 Praha 6

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Region
Praha Hlavní město Praha
Activity type
Research Organisations
Non-EU contribution
€ 0,00
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 712 254,34
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
Net EU contribution
€ 448 416,81
Address
Via Venezian 1
20133 Milan

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Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Non-EU contribution
€ 0,00
TTOPSTART BV
Netherlands
Net EU contribution
€ 159 062,18
Address
Euclideslaan 1
3584 BL Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
Net EU contribution
€ 1 771 695,42
Address
Houtlaan 4
6525 XZ Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00