Scaling-up biodegradable nanomedicines for multimodal for multimodal precision cancer immunotherapy

Informations projet

PRECIOUS

N° de convention de subvention: 686089

DOI

10.3030/686089

Projet clôturé

Date de signature de la CE 17 Mars 2016

Date de début 1 Mai 2016

Date de fin 30 Avril 2022

Financé au titre de

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Coût total

€ 8 291 217,50

Contribution de l’UE

€ 8 291 217,50

Coordonné par

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

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Publications

Peer reviewed articles (27)

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy

Auteurs: Julia Koerner, Dennis Horvath, Valerie L. Herrmann, Anna MacKerracher, Bruno Gander, Hideo Yagita, Jacques Rohayem, Marcus Groettrup
Publié dans: Nature Communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-23244-3

Translating the Manufacture of Immunotherapeutic PLGA Nanoparticles from Lab to Industrial Scale: Process Transfer and In Vitro Testing

Auteurs: Maria Camilla Operti, Alexander Bernhardt, Jeanette Pots, Vladimir Sincari, Eliezer Jager, Silko Grimm, Andrea Engel, Anne Benedikt, Martin Hrubý, Ingrid Jolanda M. De Vries, Carl G. Figdor and Oya Tagit
Publié dans: Pharmaceutics, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14081690

A comparative assessment of continuous production techniques to generate sub-micron size PLGA particles

Auteurs: Maria Camilla Operti, David Fecher, Eric A.W. van Dinther, Silko Grimm, Rima Jaber, Carl G.Figdor, Oya Tagit
Publié dans: International Journal of Pharmaceutics, 2018, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2018.08.044

A novel computational method for automatic segmentation, quantification and comparative analysis of immunohistochemically labeled tissue sections

Auteurs: Casiraghi, E; Huber, V; Frasca, M; Cossa, M; Tozzi, M; Rivoltini, L; Leone, B; Villa, A; Vergani, B
Publié dans: BMC Bioinformatics, Numéro 2, 2018, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-018-2302-3

PLGA Nanoparticles Co-encapsulating NY-ESO-1 Peptides and IMM60 Induce Robust CD8 and CD4 T Cell and B Cell Responses

Auteurs: Yusuf Dölen, Uzi Gileadi, Ji-Li Chen, Michael Valente, Jeroen H. A. Creemers, Eric A. W. Van Dinther, N. Koen van Riessen, Eliezer Jäger, Martin Hruby, Vincenzo Cerundolo, Mustafa Diken, Carl G. Figdor and I. Jolanda M. de Vries
Publié dans: Frontiers in Immunoloy, 2021, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2021.641703

Enhanced Antitumor Efficacy through an “AND gate” Reactive Oxygen-Species-Dependent pH-Responsive Nanomedicine Approach

Auteurs: Eliézer Jäger, Jana Humajová, Yusuf Dölen, Jan Kučka, Alessandro Jäger, Rafał Konefał, Jan Pankrác, Ewa Pavlova, Tomáš Heizer, Luděk Šefc, Martin Hrubý, Carl G. Figdor, Martijn Verdoes
Publié dans: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Éditeur: World Scientific
DOI: 10.1002/adhm.202100304

Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[N-(2-hydroxypropyl)methacrylamide]-Block-Poly[N-(2,2-difluoroethyl)acrylamide], Prominent F-19 MRI Tracer

Auteurs: David Babuka, Kristyna Kolouchova, Ondrej Groborz, Zdenek Tosner, Alexander Zhigunov, Petr Stepanek, Martin Hruby
Publié dans: Nanomaterials, 2020, ISSN 2079-4991
Éditeur: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/nano10112231

Forster Resonance Energy Transfer-Based Stability Assessment of PLGA Nanoparticles in Vitro and in Vivo

Auteurs: Edyta Swider; Sanish Maharjan; Karlijne Houkes; Nicolaas Koen van Riessen; Carl G. Figdor; Mangala Srinivas; Oya Tagit
Publié dans: ACS Applied Bio Materials, Numéro 2, 2019, ISSN 2576-6422
Éditeur: American Chemical Society
DOI: 10.1021/acsabm.8b00754

Integrated transcriptional-phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients

Auteurs: Darawan Rinchai, Elena Verzoni, Veronica Huber, Agata Cova, Paola Squarcina, Loris De Cecco, Filippo de Braud, Raffaele Ratta, Matteo Dugo, Luca Lalli, Viviana Vallacchi, Monica Rodolfo, Jessica Roelands, Chiara Castelli, Damien Chaussabel, Giuseppe Procopio, Davide Bedognetti, Licia Rivoltini
Publié dans: Clinical and Translational Medicine, 2021, ISSN 1752-8054
Éditeur: Wiley-Blackwell
DOI: 10.1002/ctm2.434

Assessment of anti-PD-1 antibody and immune complex binding to Fc gamma receptors and clinical implications

Auteurs: E. Daveri, E. Luison, V. Vallacchi, B. Vergani, B.E. Leone, M.C. Garassino, M. Figini, L. Rivoltini
Publié dans: Annals of Oncology, 2021, ISSN 0923-7534
Éditeur: Oxford University Press
DOI: 10.1016/j.annonc.2021.08.1355

The AURORA of a New Way to Value Myeloid Immunosuppression in Cancer

Auteurs: Licia Rivoltini, Claudio Vernieri, Veronica Huber
Publié dans: Cancer Research, 2019, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-1081

Industrial Scale Manufacturing and Downstream Processing of PLGA-Based Nanomedicines Suitable for Fully Continuous Operation

Auteurs: Maria Camilla Operti, Alexander Bernhardt, Vladimir Sincari, Eliezer Jager, Silko Grimm, Andrea Engel, Martin Hruby, Carl Gustav Figdor, Oya Tagit
Publié dans: Pharmaceutics, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020276

The STEAP1 262-270 peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice-A new approach to immunotherapy against prostate carcinoma

Auteurs: Valerie L. Herrmann, Daniel E. Wieland, Daniel F. Legler, Valentin Wittmann, Marcus Groettrup
Publié dans: The Prostate, Numéro 76/5, 2016, Page(s) 456-468, ISSN 0270-4137
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/pros.23136

Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

Auteurs: Giuseppe Lo Russo, Massimo Moro, Michele Sommariva, Valeria Cancila, Mattia Boeri, Giovanni Centonze, Simona Ferro, Monica Ganzinelli, Patrizia Gasparini, Veronica Huber, Massimo Milione, Luca Porcu, Claudia Proto, Giancarlo Pruneri, Diego Signorelli, Sabina Sangaletti, Lucia Sfondrini, Chiara Storti, Elena Tassi, Alberto Bardelli, Silvia Marsoni, Valter Torri, Claudio Tripodo, Mario Paolo Colombo
Publié dans: Clinical Cancer Research, 2018, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-1390

Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

Auteurs: Veronica Huber, Viviana Vallacchi, Viktor Fleming, Xiaoying Hu, Agata Cova, Matteo Dugo, Eriomina Shahaj, Roberta Sulsenti, Elisabetta Vergani, Paola Filipazzi, Angela De Laurentiis, Luca Lalli, Lorenza Di Guardo, Roberto Patuzzo, Barbara Vergani, Elena Casiraghi, Mara Cossa, Ambra Gualeni, Valentina Bollati, Flavio Arienti, Filippo De Braud, Luigi Mariani, Antonello Villa, Peter Altevogt, Viktor
Publié dans: Journal of Clinical Investigation, Numéro 128/12, 2018, Page(s) 5505-5516, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci98060

Harnessing Dendritic Cells for Poly (D,L-lactide-co-glycolide) Microspheres (PLGA MS)—Mediated Anti-tumor Therapy

Auteurs: Julia Koerner, Dennis Horvath, Marcus Groettrup
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.00707

Microfluidics-Assisted Size Tuning and Biological Evaluation of PLGA Particles

Auteurs: Maria Camilla Operti, Yusuf Dölen, Jibbe Keulen, Eric A. W. van Dinther, Carl G. Figdor, Oya Tagit
Publié dans: Pharmaceutics, Numéro 11/11, 2019, Page(s) 590, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11110590

Nanovaccine administration route is critical to obtain pertinent iNKt cell help for robust anti-tumor T and B cell responses

Auteurs: Yusuf Dölen, Michael Valente, Oya Tagit, Eliezer Jäger, Eric A. W. Van Dinther, N. Koen van Riessen, Martin Hruby, Uzi Gileadi, Vincenzo Cerundolo, Carl G. Figdor
Publié dans: OncoImmunology, Numéro 9/1, 2020, Page(s) 1738813, ISSN 2162-402X
Éditeur: OncoImmunology
DOI: 10.1080/2162402x.2020.1738813

Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4/CCL17 axis for the generation of short-lived effector cells

Auteurs: M. Valente, Y. Dölen, E. van Dinther, L. Vimeux, M. Fallet, V. Feuillet, C. G. Figdor
Publié dans: Proceedings of the National Academy of Sciences, Numéro 116/51, 2019, Page(s) 25816-25827, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1913491116

Back to simplicity: a four-marker blood cell score to quantify prognostically relevant myeloid cells in melanoma patients.

Auteurs: Veronica Huber; Lorenza Di Guardo; Luca Lalli; Daniele Giardiello; Agata Cova; Paola Squarcina; Paola Frati; Anna Maria Di Giacomo; Lorenzo Pilla; Marcella Tazzari; Chiara Camisaschi; Flavio Arienti; Chiara Castelli; Monica Rodolfo; Valeria Beretta; Massimo Di Nicola; Michele Maio; Michele Del Vecchio; Filippo de Braud; Luigi Mariani; Licia Rivoltini
Publié dans: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021), Numéro 1, 2021, ISSN 2051-1426
Éditeur: BMJ
DOI: 10.1136/jitc-2020-001167

Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion

Auteurs: Camille Le Gall, Anna Cammarata, Lukas de Haas, Iván Ramos-Tomillero, Jorge Cuenca-Escalona, Kayleigh Schouren, Zacharias Wijfjes, Anouk M D Becker, Johanna Bödder, Yusuf Dölen, Jolanda M de Vries, Carl G Figdor, Georgina Flórez-Grau, Martijn Verdoes
Publié dans: Journal for ImmunoTherapy of Cancer, 2022, ISSN 2051-1426
Éditeur: BMJ Publishing Group
DOI: 10.1136/jitc-2021-004309

BMCMDA: a novel model for predicting human microbe-disease associations via binary matrix completion

Auteurs: Jian-Yu Shi, Hua Huang, Yan-Ning Zhang, Jiang-Bo Cao & Siu-Ming Yiu
Publié dans: BMC Bioinformatics, 2018, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-018-2274-3

Is impaired response to PD-1 blockers of high serum PD-1 patients related to immune complexes?

Auteurs: E. Daveri, E. Luison, V. Vallacchi, B. Vergani, B. E. Leone, M. C. Garassino, M. Figini, L. Rivoltini
Publié dans: annals of oncology, 2021, ISSN 0923-7534
Éditeur: Oxford University Press
DOI: 10.1016/j.annonc.2021.02.022

Assessing the safety, tolerability and efficacy of PLGA-based immunomodulatory nanoparticles in patients with advanced NY-ESO-1-positive cancers: a first-in-human phase I open-label dose-escalation study protocol.

Auteurs: Jeroen H A Creemers; Inka Pawlitzky; Konstantina Grosios; Uzi Gileadi; Mark R. Middleton; Winald R. Gerritsen; Niven Mehra; Licia Rivoltini; Ian Walters; Carl G. Figdor; Petronella B. Ottevanger; I. Jolanda M. de Vries
Publié dans: BMJ Open, Numéro 5, 2021, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-050725

PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up

Auteurs: Maria Camilla Operti, Alexander Bernhardt, Silko Grimm, Andrea Engel, Carl Gustav Figdor, Oya Tagit
Publié dans: International Journal of Pharmaceutics, 2021, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120807

Immunosuppressive circuits in tumor microenvironment and their influence on cancer treatment efficacy

Auteurs: Alessandra Tuccitto, Eriomina Shahaj, Elisabetta Vergani, Simona Ferro, Veronica Huber, Monica Rodolfo, Chiara Castelli, Licia Rivoltini, Viviana Vallacchi
Publié dans: Virchows Arch, 2019, ISSN 0945-6317
Éditeur: Springer Verlag
DOI: 10.1007/s00428-018-2477-z

microRNAs Shape Myeloid Cell-Mediated Resistance to Cancer Immunotherapy.

Auteurs: Elena Daveri; Elisabetta Vergani; Eriomina Shahaj; Laura Bergamaschi; Stefano La Magra; Michela Dosi; Chiara Castelli; Monica Rodolfo; Licia Rivoltini; Viviana Vallacchi; Veronica Huber
Publié dans: Frontiers in Immunology, Numéro 4, 2020, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.01214

Other (1)

Pazopanib induces dramatic but transient contraction of myeloid suppression compartment in favor of adaptive immunity

Auteurs: Darawan Rinchai, Elena Verzoni, Veronica Huber, Agata Cova, Paola Squarcina, Loris De Cecco, Filippo de Braud, Raffaele Ratta, Matteo Dugo, Luca Lalli, Viviana Vallacchi, Monica Rodolfo, Jessica Roelands, Chiara Castelli, Damien Chaussabel, Giuseppe Procopio, Davide Bedognetti, Licia Rivoltini
Publié dans: bioRxiv, 2020, ISSN 2692-8205
Éditeur: N/A
DOI: 10.1101/2020.05.01.071613

Droits de propriété intellectuelle

Patent (3)

ARGINASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS

Numéro de demande/publication: 15 823405
Date: 2015-12-22
Demandeur(s): MOLECURE SPOLKA AKCYJNA

PROCESS FOR PREPARING NANOPARTICLES IN THE FORM OF A POWDER COMPRISING A BIO-RESORBABLE POLYESTER

Numéro de demande/publication: 20 20076853
Date: 2020-09-25
Demandeur(s): EVONIK OPERATIONS GMBH

DIPEPTIDE PIPERIDINE DERIVATIVES

Numéro de demande/publication: 19 721812
Date: 2019-03-29
Demandeur(s): MOLECURE SPOLKA AKCYJNA