Deliverables
Benchmark the performance in peptide and protein identifications of EThcD versus HCD peptides from complex mixtures, whereby the Mw of the peptides is in the range between 2.5 and 10 kDa (middle-down proteomics)
Software module for comprehensive identification of PTMs, mutations and splice variantsImplement genome-informed proteomics platform that incorporates knowledge on human natural variations, disease mutations and alternative splicing. Ensure efficiency of search algorithm in huge protein/peptide spaces further inflated by multiple PTMs.
Software module for multiplexed quantification of clinical samplesDevelop and test software module that enables low variance quantification in body fluid and tissue samples for MS1 and MS2 label and label free quantification for hundreds of patients simultaneously.
Extension of software module to novel/hybrid fragmentation methodsDevelop peptide identification algorithms for EThcD, UVPD and other novel techniques with competitive identification rates. Incorporation in the MaxQuant software.
Industrialized workflow with low CVsDevelop and test a workflow that enables robust analysis of hundreds of tissue and body fluid samples with minimal intervention and CVs in the smaller than 20% range for proteins of interest
Feasibility study in cancer tissue proteomicsPerform large-scale quantitative phosphoproteomics of patient samples from ovarian cancer, colon cancer and prostate cancer samples using the protocols and MS acquisition strategies established in D5.1
Construction/coupling of UVPD to the latest Orbitrap instrumentsAn UVPD laser will be coupled to the latest Q-Exactive mass analyzer and/or other Orbitrap instruments
Software modules implemented for MS/MS based analysis of unconven-tional peptide and protein sequencesImplementation and benchmarking of all algorithms needed for the identification of peptide and proteins measured with the novel and hybrid fragmentation techniques including top and middle down proteomics.
LCMS time-scale compatible top- and middle-down proteomics workflows using hybrid fragmentation methodsBenchmark the performance in protein identifications of HCD, ETD and EThcD for proteins in the range between 10 and 100 kDa (top-down proteomics)
Top- and middle-down software moduleFurther develop the MaxQuant platform in order to analyze and quality control the top and middle down data generated in this project.
Machine learning module for biomarker discovery and classification of clinical samplesDevelop and benchmark a machine learning platform using support vector machines and deep learning networks for making robust decisions on patient treatment based on clinical samples.
LCMS time-scale compatible UV-PD peptide and protein sequencingBenchmark the performance in peptide and protein identifications of UVPD versus HCD using a cellular lysate on a Q-Exactive instrument (bottom-up proteomics)
Ethics checkAll relevant ethical approvals, consent forms and patient information sheets will be uploaded as deliverable 6.12. This will also include an up to date approval from The Central Denmark Region Committees on Health Research Ethics stating the ethical approvals for Aarhus University Hospital are also valid for project MSmed.
Develop and implement high-performance offline high-pH reversed-phase chromatography prior to high-resolution mass spectrometry for parallel analysis of major PTMs without enrichment and apply this to cancer cell lines treated with chemotherapeutic agents.
MaxQuant summer school 2The annual MaxQuant Summer School (host: MPIB, over 160 participants) provides an introduction into the MaxQuant software and application examples. Projeect results will be included into the School’s curriculum.
Data Management PlanDescribes the strategy for depositing and curating MSmed experimental data in publicly accessible proteomic data bases, the use of proteomic standard formats, and exceptions made as required to protect personal data and intellectual property to be patented
Robust and reproducible sample prepa¬ration protocols including MS instru¬mentation and acquisition strat-egies for large-scale, quantitative PTM analysis from primary tissue samples such as patient biopsy materialEstablish tissue sample preparation protocol based on heat-inactivation of biopsies, efficient protein extraction by ceramic bead milling, in-solution digestion and optimized nanoflow LC-MS/MS acquisition strategies. Benchmark the performance versus established protocols.
MaxQuant summer schoolThe annual MaxQuant Summer School (host: MPIB, over 160 participants) provides an introduction into the MaxQuant software and application examples. Projeect results will be included into the School’s curriculum.
Protocol for hyper-multiplexingDevelop labeling protocols and test them for multiplexing and analyzing) more than 10 patient samples at a time (goal is up to 20)
Scientific outreach meetingInternational scientific outreach meeting on Next Generation Proteomics linked to an annual Progress Meeting of the Netherlands Proteomics Center. Dissemination of project results to the broader community of proteomics researchers in Europe.
Publications
Author(s):
Kyle L. Fort, Christian N. Cramer, Valery G. Voinov, Yury V. Vasil’ev, Nathan I. Lopez, Joseph S. Beckman, Albert J. R. Heck
Published in:
Journal of Proteome Research, Issue 17/2, 2018, Page(s) 926-933, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.7b00622
Author(s):
Alba Cristobal, Fabio Marino, Harm Post, Henk W. P. van den Toorn, Shabaz Mohammed, Albert J. R. Heck
Published in:
Analytical Chemistry, Issue 89/6, 2017, Page(s) 3318-3325, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.6b03756
Author(s):
Fan Liu, Philip Lössl, Richard Scheltema, Rosa Viner, Albert J. R. Heck
Published in:
Nature Communications, Issue 8, 2017, Page(s) 15473, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/ncomms15473
Author(s):
Fan Liu, Philip Lössl, Beverley M. Rabbitts, Robert S. Balaban, Albert J. R. Heck
Published in:
Molecular & Cellular Proteomics, Issue 17/2, 2018, Page(s) 216-232, ISSN 1535-9476
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.RA117.000470
Author(s):
Chiara Francavilla, Michela Lupia, Kalliopi Tsafou, Alessandra Villa, Katarzyna Kowalczyk, Rosa Rakownikow Jersie-Christensen, Giovanni Bertalot, Stefano Confalonieri, Søren Brunak, Lars J. Jensen, Ugo Cavallaro, Jesper V. Olsen
Published in:
Cell Reports, Issue 18/13, 2017, Page(s) 3242-3256, ISSN 2211-1247
Publisher:
Cell Press
DOI:
10.1016/j.celrep.2017.03.015
Author(s):
Yang Yang, Guanbo Wang, Ting Song, Carlito B. Lebrilla, Albert J. R. Heck
Published in:
mAbs, Issue 9/4, 2017, Page(s) 638-645, ISSN 1942-0870
Publisher:
Landes Bioscience
DOI:
10.1080/19420862.2017.1290033
Author(s):
Aneika C. Leney, Karim Rafie, Daan M. F. van Aalten, Albert J. R. Heck
Published in:
ACS Chemical Biology, Issue 12/8, 2017, Page(s) 2078-2084, ISSN 1554-8929
Publisher:
American Chemical Society
DOI:
10.1021/acschembio.7b00371
Author(s):
Guanbo Wang, Rob N. de Jong, Ewald T. J. van den Bremer, Paul W. H. I. Parren, Albert J. R. Heck
Published in:
Analytical Chemistry, Issue 89/9, 2017, Page(s) 4793-4797, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.6b05129
Author(s):
Liana Tsiatsiani, Piero Giansanti, Richard A. Scheltema, Henk van den Toorn, Christopher M. Overall, A.F. Maarten Altelaar, Albert J.R. Heck
Published in:
Journal of Proteome Research, Issue 16/2, 2017, Page(s) 852-861, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.6b00825
Author(s):
Dorte B. Bekker-Jensen, Christian D. Kelstrup, Tanveer S. Batth, Sara C. Larsen, Christa Haldrup, Jesper B. Bramsen, Karina D. Sørensen, Søren Høyer, Torben F. Ørntoft, Claus L. Andersen, Michael L. Nielsen, Jesper V. Olsen
Published in:
Cell Systems, Issue 4/6, 2017, Page(s) 587-599.e4, ISSN 2211-1247
Publisher:
Cell Press
DOI:
10.1016/j.cels.2017.05.009
Author(s):
Harm Post, Renske Penning, Martin A. Fitzpatrick, Luc B. Garrigues, W. Wu, Harold D. MacGillavry, Casper C. Hoogenraad, Albert J. R. Heck, A. F. Maarten Altelaar
Published in:
Journal of Proteome Research, Issue 16/2, 2017, Page(s) 728-737, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.6b00753
Author(s):
Vojtech Franc, Yang Yang, Albert J. R. Heck
Published in:
Analytical Chemistry, Issue 89/6, 2017, Page(s) 3483-3491, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.6b04527
Author(s):
Louise von Stechow, Jesper V. Olsen
Published in:
PROTEOMICS, Issue 17/3-4, 2017, Page(s) 1600018, ISSN 1615-9853
Publisher:
John Wiley & Sons Ltd.
DOI:
10.1002/pmic.201600018
Author(s):
Adán Alpízar, Fabio Marino, Antonio Ramos-Fernández, Manuel Lombardía, Anita Jeko, Florencio Pazos, Alberto Paradela, César Santiago, Albert J. R. Heck, Miguel Marcilla
Published in:
Molecular & Cellular Proteomics, Issue 16/2, 2017, Page(s) 181-193, ISSN 1535-9476
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.M116.063800
Author(s):
Stephanie Munk, Jón Otti Sigurðsson, Zhenyu Xiao, Tanveer Singh Batth, Giulia Franciosa, Louise von Stechow, Andres Joaquin Lopez-Contreras, Alfred Cornelis Otto Vertegaal, Jesper Velgaard Olsen
Published in:
Cell Reports, Issue 21/2, 2017, Page(s) 546-558, ISSN 2211-1247
Publisher:
Cell Press
DOI:
10.1016/j.celrep.2017.09.059
Author(s):
Christian D. Kelstrup, Dorte B. Bekker-Jensen, Tabiwang N. Arrey, Alexander Hogrebe, Alexander Harder, Jesper V. Olsen
Published in:
Journal of Proteome Research, Issue 17/1, 2017, Page(s) 727-738, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.7b00602
Author(s):
Tanveer S. Batth, Moreno Papetti, Anamarija Pfeiffer, Maxim A.X. Tollenaere, Chiara Francavilla, Jesper V. Olsen
Published in:
Cell Reports, Issue 22/10, 2018, Page(s) 2784-2796, ISSN 2211-1247
Publisher:
Cell Press
DOI:
10.1016/j.celrep.2018.02.038
Author(s):
Alexander Hogrebe, Louise von Stechow, Dorte B. Bekker-Jensen, Brian T. Weinert, Christian D. Kelstrup, Jesper V. Olsen
Published in:
Nature Communications, Issue 9/1, 2018, Page(s) 1045, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-018-03309-6
Author(s):
Sem Tamara, Richard A. Scheltema, Albert J. R. Heck, Aneika C. Leney
Published in:
Angewandte Chemie International Edition, Issue 56/44, 2017, Page(s) 13641-13644, ISSN 1433-7851
Publisher:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.201706749
Author(s):
Michiel van de Waterbeemd, Kyle L Fort, Dmitriy Boll, Maria Reinhardt-Szyba, Andrew Routh, Alexander Makarov, Albert J R Heck
Published in:
Nature Methods, Issue 14/3, 2017, Page(s) 283-286, ISSN 1548-7091
Publisher:
Nature Publishing Group
DOI:
10.1038/nmeth.4147
Author(s):
Yang Yang, Vojtech Franc, Albert J.R. Heck
Published in:
Trends in Biotechnology, Issue 35/7, 2017, Page(s) 598-609, ISSN 0167-7799
Publisher:
Elsevier BV
DOI:
10.1016/j.tibtech.2017.04.010
Author(s):
Kyle L. Fort, Michiel van de Waterbeemd, Dmitriy Boll, Maria Reinhardt-Szyba, Mikhail E. Belov, Eita Sasaki, Reinhard Zschoche, Donald Hilvert, Alexander A. Makarov, Albert J. R. Heck
Published in:
The Analyst, Issue 143/1, 2018, Page(s) 100-105, ISSN 0003-2654
Publisher:
Royal Society of Chemistry
DOI:
10.1039/c7an01629h
Author(s):
Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck
Published in:
Journal of Proteome Research, Issue 17/3, 2018, Page(s) 1216-1226, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.7b00839
Author(s):
James D. Sanders, Dmitry Grinfeld, Konstantin Aizikov, Alexander Makarov, Dustin D. Holden, Jennifer S. Brodbelt
Published in:
Analytical Chemistry, Issue 90/9, 2018, Page(s) 5896-5902, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.8b00724
Author(s):
Dirk Nolting, Robert Malek, Alexander Makarov
Published in:
Mass Spectrometry Reviews, 2017, ISSN 0277-7037
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/mas.21549
Author(s):
Sebastian Virreira Winter, Florian Meier, Christoph Wichmann, Juergen Cox, Matthias Mann, Felix Meissner
Published in:
Nature Methods, Issue 15, 2018, Page(s) 527–530, ISSN 1548-7091
Publisher:
Nature Publishing Group
DOI:
10.1038/s41592-018-0037-8
Author(s):
Florian Meier, Philipp E. Geyer, Sebastian Virreira Winter, Juergen Cox, Matthias Mann
Published in:
Nature Methods, Issue 15/6, 2018, Page(s) 440-448, ISSN 1548-7091
Publisher:
Nature Publishing Group
DOI:
10.1038/s41592-018-0003-5
Author(s):
Pavel Sinitcyn, Shivani Tiwary, Jan Rudolph, Petra Gutenbrunner, Christoph Wichmann, Şule Yılmaz, Hamid Hamzeiy, Favio Salinas, Jürgen Cox
Published in:
Nature Methods, Issue 15/6, 2018, Page(s) 401-401, ISSN 1548-7091
Publisher:
Nature Publishing Group
DOI:
10.1038/s41592-018-0018-y
Author(s):
Hamid Hamzeiy, Jürgen Cox
Published in:
Current Opinion in Biotechnology, Issue 43, 2017, Page(s) 141-146, ISSN 0958-1669
Publisher:
Elsevier BV
DOI:
10.1016/j.copbio.2016.11.014
Author(s):
Jan P. Gerlach, Ingrid Jordens, Daniele V. F. Tauriello, Ineke van ‘t Land-Kuper, Jeroen M. Bugter, Ivar Noordstra, Johanneke van der Kooij, Teck Y. Low, Felipe X. Pimentel-Muiños, Despina Xanthakis, Nicola Fenderico, Catherine Rabouille, Albert J. R. Heck, David A. Egan, Madelon M. Maurice
Published in:
Proceedings of the National Academy of Sciences, Issue 115/17, 2018, Page(s) E3996-E4005, ISSN 0027-8424
Publisher:
National Academy of Sciences
DOI:
10.1073/pnas.1721321115
Author(s):
Pavel Sinitcyn, Jan Daniel Rudolph, Jürgen Cox
Published in:
Annual Review of Biomedical Data Science, Issue 1/1, 2018, Page(s) 207-234, ISSN 2574-3414
Publisher:
Annual Reviews
DOI:
10.1146/annurev-biodatasci-080917-013516
Author(s):
Vojtech Franc, Jing Zhu, Albert J. R. Heck
Published in:
Journal of The American Society for Mass Spectrometry, Issue 29/6, 2018, Page(s) 1099-1110, ISSN 1044-0305
Publisher:
Elsevier BV
DOI:
10.1007/s13361-018-1901-6
Author(s):
Michiel van de Waterbeemd, Sem Tamara, Kyle L. Fort, Eugen Damoc, Vojtech Franc, Philipp Bieri, Martin Itten, Alexander Makarov, Nenad Ban, Albert J. R. Heck
Published in:
Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-018-04853-x
Author(s):
Tomislav Čaval, Weihua Tian, Zhang Yang, Henrik Clausen, Albert J. R. Heck
Published in:
Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-018-05536-3
Author(s):
Philip Lössl, Andrea M. Brunner, Fan Liu, Aneika C. Leney, Masami Yamashita, Richard A. Scheltema, Albert J. R. Heck
Published in:
ACS Central Science, Issue 2/7, 2016, Page(s) 445-455, ISSN 2374-7943
Publisher:
ACS Publications
DOI:
10.1021/acscentsci.6b00053
Author(s):
Anna Secher, Christian D. Kelstrup, Kilian W. Conde-Frieboes, Charles Pyke, Kirsten Raun, Birgitte S. Wulff, Jesper V. Olsen
Published in:
Nature Communications, Issue 7, 2016, Page(s) 11436, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/ncomms11436
Author(s):
Kyle L. Fort, Andrey Dyachenko, Clement M. Potel, Eleonora Corradini, Fabio Marino, Arjan Barendregt, Alexander A. Makarov, Richard A. Scheltema, Albert J. R. Heck
Published in:
Analytical Chemistry, Issue 88/4, 2016, Page(s) 2303-2310, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.5b04162
Author(s):
Yu-Hsien Lin, Vojtech Franc, Albert J. R. Heck
Published in:
Journal of Proteome Research, Issue 17/8, 2018, Page(s) 2861-2869, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00318
Author(s):
Magnus E. Jakobsson, Jędrzej M. Małecki, Levon Halabelian, Benedikt S. Nilges, Rita Pinto, Srikanth Kudithipudi, Stephanie Munk, Erna Davydova, Fawzi R. Zuhairi, Cheryl H. Arrowsmith, Albert Jeltsch, Sebastian A. Leidel, Jesper V. Olsen, Pål Ø. Falnes
Published in:
Nature Communications, Issue 9/1, 2018, Page(s) 3411, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-018-05646-y
Author(s):
Ashley L. Comes, Sergi Papiol, Thorsten Mueller, Philipp E. Geyer, Matthias Mann, Thomas G. Schulze
Published in:
Translational Psychiatry, Issue 8/1, 2018, Page(s) 160, ISSN 2158-3188
Publisher:
Nature Publishing Group
DOI:
10.1038/s41398-018-0219-2
Author(s):
Jennie R. Lill, Peter A. van Veelen, Stefan Tenzer, Arie Admon, Etienne Caron, Joshua E. Elias, Albert J.R. Heck, Miguel Marcilla, Fabio Marino, Markus Müller, Bjoern Peters, Anthony Purcell, Alessandro Sette, Theo Sturm, Nicola Ternette, Juan Antonio Vizcaíno, Michal Bassani-Sternberg
Published in:
PROTEOMICS, Issue 18/12, 2018, Page(s) 1800110, ISSN 1615-9853
Publisher:
John Wiley & Sons Ltd.
DOI:
10.1002/pmic.201800110
Author(s):
Sem Tamara, Andrey Dyachenko, Kyle L. Fort, Alexander A. Makarov, Richard A. Scheltema, Albert J. R. Heck
Published in:
Journal of the American Chemical Society, Issue 138/34, 2016, Page(s) 10860-10868, ISSN 0002-7863
Publisher:
American Chemical Society
DOI:
10.1021/jacs.6b05147
Author(s):
Stefka Tyanova, Tikira Temu, Pavel Sinitcyn, Arthur Carlson, Marco Y Hein, Tamar Geiger, Matthias Mann, Jürgen Cox
Published in:
Nature Methods, Issue 13/9, 2016, Page(s) 731-740, ISSN 1548-7091
Publisher:
Nature Publishing Group
DOI:
10.1038/nmeth.3901
Author(s):
Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens, Albert J. R. Heck
Published in:
Nature Communications, Issue 7, 2016, Page(s) 13397, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/ncomms13397
Author(s):
Philip Lössl, Michiel van de Waterbeemd, Albert JR Heck
Published in:
The EMBO Journal, Issue 35/24, 2016, Page(s) 2634-2657, ISSN 0261-4189
Publisher:
Nature Publishing Group
DOI:
10.15252/embj.201694818
Author(s):
Chiara Francavilla, Moreno Papetti, Kristoffer T G Rigbolt, Anna-Kathrine Pedersen, Jon O Sigurdsson, Giuseppe Cazzamali, Gopal Karemore, Blagoy Blagoev, Jesper V Olsen
Published in:
Nature Structural & Molecular Biology, Issue 23/6, 2016, Page(s) 608-618, ISSN 1545-9993
Publisher:
Nature Publishing Group
DOI:
10.1038/nsmb.3218
Author(s):
Dmitry Grinfeld, Konstantin Aizikov, Arne Kreutzmann, Eugen Damoc, Alexander Makarov
Published in:
Analytical Chemistry, Issue 89/2, 2016, Page(s) 1202-1211, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.6b03636
Author(s):
Nicolai J. Wewer Albrechtsen, Philipp E. Geyer, Sophia Doll, Peter V. Treit, Kirstine N. Bojsen-Møller, Christoffer Martinussen, Nils B. Jørgensen, Signe S. Torekov, Florian Meier, Lili Niu, Alberto Santos, Eva C. Keilhauer, Jens J. Holst, Sten Madsbad, Matthias Mann
Published in:
Cell Systems, Issue 7/6, 2018, Page(s) 601-612.e3, ISSN 2405-4712
Publisher:
Cell Press
DOI:
10.1016/j.cels.2018.10.012
Author(s):
Nicolai Bache, Philipp E. Geyer, Dorte B. Bekker-Jensen, Ole Hoerning, Lasse Falkenby, Peter V. Treit, Sophia Doll, Igor Paron, Johannes B. Müller, Florian Meier, Jesper V. Olsen, Ole Vorm, Matthias Mann
Published in:
Molecular & Cellular Proteomics, Issue 17/11, 2018, Page(s) 2284-2296, ISSN 1535-9476
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.TIR118.000853
Author(s):
Jan Daniel Rudolph, Jürgen Cox
Published in:
Journal of Proteome Research, Issue 18/5, 2019, Page(s) 2052-2064, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00927
Author(s):
Yasset Perez-Riverol, Attila Csordas, Jingwen Bai, Manuel Bernal-Llinares, Suresh Hewapathirana, Deepti J Kundu, Avinash Inuganti, Johannes Griss, Gerhard Mayer, Martin Eisenacher, Enrique Pérez, Julian Uszkoreit, Julianus Pfeuffer, Timo Sachsenberg, Şule Yılmaz, Shivani Tiwary, Jürgen Cox, Enrique Audain, Mathias Walzer, Andrew F Jarnuczak, Tobias Ternent, Alvis Brazma, Juan Antonio Vizcaíno
Published in:
Nucleic Acids Research, Issue 47/D1, 2018, Page(s) D442-D450, ISSN 0305-1048
Publisher:
Oxford University Press
DOI:
10.1093/nar/gky1106
Author(s):
Marta Murgia, Jing Tan, Philipp E. Geyer, Sophia Doll, Matthias Mann, Thomas Klopstock
Published in:
Cell Reports, Issue 29/12, 2019, Page(s) 3825-3834.e4, ISSN 2211-1247
Publisher:
Cell Press
DOI:
10.1016/j.celrep.2019.11.055
Author(s):
Miao-Hsia Lin, Clement M. Potel, Kamaleddin H. M. E. Tehrani, Albert J. R. Heck, Nathaniel I. Martin, Simone Lemeer
Published in:
Molecular & Cellular Proteomics, Issue 17/12, 2018, Page(s) 2496-2507, ISSN 1535-9476
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.ra118.000880
Author(s):
David Y. Chiang, Katherina M. Alsina, Eleonora Corradini, Martin Fitzpatrick, Li Ni, Satadru K. Lahiri, Julia O. Reynolds, Xiaolu Pan, Larry Scott, Albert J.R. Heck, Xander H.T. Wehrens
Published in:
Circulation, Issue 138/15, 2018, Page(s) 1569-1581, ISSN 0009-7322
Publisher:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1161/circulationaha.118.034361
Author(s):
Karli R. Reiding, Albert Bondt, Vojtech Franc, Albert J.R. Heck
Published in:
TrAC Trends in Analytical Chemistry, Issue 108, 2018, Page(s) 260-268, ISSN 0165-9936
Publisher:
Elsevier BV
DOI:
10.1016/j.trac.2018.09.007
Author(s):
Clement M. Potel, Domenico Fasci, Albert J.R. Heck
Published in:
The FEBS Journal, Issue 285/15, 2018, Page(s) 2856-2868, ISSN 1742-464X
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/febs.14525
Author(s):
Clement M. Potel, Miao-Hsia Lin, Albert J. R. Heck, Simone Lemeer
Published in:
Molecular & Cellular Proteomics, Issue 17/5, 2018, Page(s) 1028-1034, ISSN 1535-9476
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.tir117.000518
Author(s):
Clement M Potel, Miao-Hsia Lin, Albert J R Heck, Simone Lemeer
Published in:
Nature Methods, Issue 15/3, 2018, Page(s) 187-190, ISSN 1548-7091
Publisher:
Nature Publishing Group
DOI:
10.1038/nmeth.4580
Author(s):
Oleg Klykov, Barbara Steigenberger, Sibel Pektaş, Domenico Fasci, Albert J. R. Heck, Richard A. Scheltema
Published in:
Nature Protocols, Issue 13/12, 2018, Page(s) 2964-2990, ISSN 1754-2189
Publisher:
Nature Publishing Group
DOI:
10.1038/s41596-018-0074-x
Author(s):
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Published in:
Molecular & Cellular Proteomics, Issue 17/10, 2018, Page(s) 2018-2033, ISSN 1535-9476
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.ra118.000924
Author(s):
Barbara Steigenberger, Roland J. Pieters, Albert J. R. Heck, Richard A. Scheltema
Published in:
ACS Central Science, Issue 5/9, 2019, Page(s) 1514-1522, ISSN 2374-7943
Publisher:
ACS Publications
DOI:
10.1021/acscentsci.9b00416
Author(s):
Tomislav Čaval, Jing Zhu, Albert J.R. Heck
Published in:
Analytical Chemistry, Issue 91/16, 2019, Page(s) 10401-10406, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.9b02125
Author(s):
Jean-François Greisch, Sem Tamara, Richard A. Scheltema, Howard W. R. Maxwell, Robert D. Fagerlund, Peter C. Fineran, Stephan Tetter, Donald Hilvert, Albert J. R. Heck
Published in:
Chemical Science, Issue 10/30, 2019, Page(s) 7163-7171, ISSN 2041-6520
Publisher:
Royal Society of Chemistry
DOI:
10.1039/c9sc01857c
Author(s):
Clement M. Potel, Miao-Hsia Lin, Nadine Prust, Henk W. P. van den Toorn, Albert J. R. Heck, Simone Lemeer
Published in:
Analytical Chemistry, Issue 91/9, 2019, Page(s) 5542-5547, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.9b00734
Author(s):
Laura C. Demmers, Albert J. R. Heck, Wei Wu
Published in:
Journal of Proteome Research, Issue 18/4, 2019, Page(s) 1634-1643, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00821
Author(s):
Kelly A. Dingess, Henk W. P. van den Toorn, Marko Mank, Bernd Stahl, Albert J. R. Heck
Published in:
Analytical and Bioanalytical Chemistry, Issue 411/7, 2019, Page(s) 1351-1363, ISSN 1618-2642
Publisher:
Springer Verlag
DOI:
10.1007/s00216-018-01566-4
Author(s):
Clement M. Potel, Simone Lemeer, Albert J. R. Heck
Published in:
Analytical Chemistry, Issue 91/1, 2018, Page(s) 126-141, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.8b04746
Author(s):
Jing Zhu, Luc Garrigues, Henk Van den Toorn, Bernd Stahl, Albert J. R. Heck
Published in:
Journal of Proteome Research, Issue 18/1, 2018, Page(s) 225-238, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00550
Author(s):
Andrey Dyachenko, Sem Tamara, Albert J. R. Heck
Published in:
Journal of The American Society for Mass Spectrometry, Issue 30/1, 2019, Page(s) 7-15, ISSN 1044-0305
Publisher:
Elsevier BV
DOI:
10.1007/s13361-018-1910-5
Author(s):
Tomislav Čaval, Jing Zhu, Weihua Tian, Sanne Remmelzwaal, Zhang Yang, Henrik Clausen, Albert J.R. Heck
Published in:
Molecular & Cellular Proteomics, Issue 18/1, 2019, Page(s) 16-27, ISSN 1535-9476
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.ra118.000967
Author(s):
Sebastiaan C. de Graaf, Oleg Klykov, Henk van den Toorn, Richard A. Scheltema
Published in:
Journal of Proteome Research, Issue 18/2, 2018, Page(s) 642-651, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00725
Author(s):
Christoph Wichmann, Florian Meier, Sebastian Virreira Winter, Andreas-David Brunner, Jürgen Cox, Matthias Mann
Published in:
Molecular & Cellular Proteomics, Issue 18/5, 2019, Page(s) 982-994, ISSN 1535-9476
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.tir118.001131
Author(s):
Philipp E Geyer, Eugenia Voytik, Peter V Treit, Sophia Doll, Alisa Kleinhempel, Lili Niu, Johannes B Müller, Marie‐Luise Buchholtz, Jakob M Bader, Daniel Teupser, Lesca M Holdt, Matthias Mann
Published in:
EMBO Molecular Medicine, Issue 11/11, 2019, Page(s) e10427, ISSN 1757-4676
Publisher:
John Wiley & Sons Ltd.
DOI:
10.15252/emmm.201910427
Author(s):
Lili Niu, Philipp E Geyer, Nicolai J Wewer Albrechtsen, Lise L Gluud, Alberto Santos, Sophia Doll, Peter V Treit, Jens J Holst, Filip K Knop, Tina Vilsbøll, Anders Junker, Stephan Sachs, Kerstin Stemmer, Timo D Müller, Matthias H Tschöp, Susanna M Hofmann, Matthias Mann
Published in:
Molecular Systems Biology, Issue 15/3, 2019, Page(s) e8793, ISSN 1744-4292
Publisher:
Nature Publishing Group
DOI:
10.15252/msb.20188793
Author(s):
Alicia Lundby, Giulia Franciosa, Kristina B. Emdal, Jan C. Refsgaard, Sebastian P. Gnosa, Dorte B. Bekker-Jensen, Anna Secher, Svetlana R. Maurya, Indranil Paul, Blanca L. Mendez, Christian D. Kelstrup, Chiara Francavilla, Marie Kveiborg, Guillermo Montoya, Lars J. Jensen, Jesper V. Olsen
Published in:
Cell, Issue 179/2, 2019, Page(s) 543-560.e26, ISSN 0092-8674
Publisher:
Cell Press
DOI:
10.1016/j.cell.2019.09.008
Author(s):
Tanveer S. Batth, Maxim A. X. Tollenaere, Patrick Rüther, Alba Gonzalez-Franquesa, Bhargav S. Prabhakar, Simon Bekker-Jensen, Atul S. Deshmukh, Jesper V. Olsen
Published in:
Molecular & Cellular Proteomics, Issue 18/5, 2019, Page(s) 1027-1035, ISSN 1535-9476
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.tir118.001270
Author(s):
Kristina B. Emdal, Anna-Kathrine Pedersen, Dorte B. Bekker-Jensen, Alicia Lundby, Shana Claeys, Katleen De Preter, Frank Speleman, Chiara Francavilla, Jesper V. Olsen
Published in:
Science Signaling, Issue 11/557, 2018, Page(s) eaap9752, ISSN 1937-9145
Publisher:
American Association for the Advancement of Science
DOI:
10.1126/scisignal.aap9752
Author(s):
Christian D. Kelstrup, Konstantin Aizikov, Tanveer S. Batth, Arne Kreutzman, Dmitry Grinfeld, Oliver Lange, Daniel Mourad, Alexander A. Makarov, Jesper V. Olsen
Published in:
Journal of Proteome Research, Issue 17/11, 2018, Page(s) 4008-4016, ISSN 1535-3893
Publisher:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00381
Author(s):
Vyacheslav Akimov, Inigo Barrio-Hernandez, Sten V. F. Hansen, Philip Hallenborg, Anna-Kathrine Pedersen, Dorte B. Bekker-Jensen, Michele Puglia, Stine D. K. Christensen, Jens T. Vanselow, Mogens M. Nielsen, Irina Kratchmarova, Christian D. Kelstrup, Jesper V. Olsen, Blagoy Blagoev
Published in:
Nature Structural & Molecular Biology, Issue 25/7, 2018, Page(s) 631-640, ISSN 1545-9993
Publisher:
Nature Publishing Group
DOI:
10.1038/s41594-018-0084-y
Author(s):
Miia R. Mäkelä, Ourdia Bouzid, Diogo Robl, Harm Post, Mao Peng, Albert Heck, Maarten Altelaar, Ronald P. de Vries
Published in:
New Biotechnology, Issue 37, 2017, Page(s) 162-171, ISSN 1871-6784
Publisher:
Elsevier BV
DOI:
10.1016/j.nbt.2017.02.002
Author(s):
Hecht, E.S., Scigelova, M., Eliuk, S. and Makarov, A.
Published in:
Encyclopedia of Analytical Chemistry, 2019
Publisher:
Wiley Online Library
Author(s):
Fabian Coscia, Sophia Doll, Jacob Mathias Bech, Andreas Mund, Ernst Lengyel, Jan Lindebjerg, Gunvor Iben Madsen, José M. A. Moreira, Matthias Mann
Published in:
bioRxiv, 2019
Publisher:
Cold Spring Harbor Laboratory
DOI:
10.1101/779009
Author(s):
Dorte B. Bekker-Jensen, Ana Martínez del Val, Sophia Steigerwald, Patrick Rüther, Kyle Fort, Tabiwang N. Arrey, Alexander Harder, Alexander Makarov, Jesper V. Olsen
Published in:
bioRxiv, 2019
Publisher:
Cold Spring Harbor Laboratory
DOI:
10.1101/860643
Author(s):
Dorte B. Bekker-Jensen, Oliver M. Bernhardt, Alexander Hogrebe, Ana Martinez del Val, Lynn Verbeke, Tejas Gandhi, Christian D. Kelstrup, Lukas Reiter, Jesper V. Olsen
Published in:
bioRxiv, 2019
Publisher:
Cold Spring Harbor Laboratory
DOI:
10.1101/657858
Intellectual Property Rights
Application/Publication number:
25
69639
Date:
1939-09-13
Application/Publication number:
EP
15165127
Date:
2015-04-24
Application/Publication number:
GB
1618595.1
Date:
2016-11-04
Application/Publication number:
EP
17158299
Date:
2017-02-28
Application/Publication number:
19
175643
Date:
2017-06-02
Application/Publication number:
17
174330
Date:
2017-06-02
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