Rezultaty
Benchmark the performance in peptide and protein identifications of EThcD versus HCD peptides from complex mixtures, whereby the Mw of the peptides is in the range between 2.5 and 10 kDa (middle-down proteomics)
Software module for comprehensive identification of PTMs, mutations and splice variantsImplement genome-informed proteomics platform that incorporates knowledge on human natural variations, disease mutations and alternative splicing. Ensure efficiency of search algorithm in huge protein/peptide spaces further inflated by multiple PTMs.
Software module for multiplexed quantification of clinical samplesDevelop and test software module that enables low variance quantification in body fluid and tissue samples for MS1 and MS2 label and label free quantification for hundreds of patients simultaneously.
Extension of software module to novel/hybrid fragmentation methodsDevelop peptide identification algorithms for EThcD, UVPD and other novel techniques with competitive identification rates. Incorporation in the MaxQuant software.
Industrialized workflow with low CVsDevelop and test a workflow that enables robust analysis of hundreds of tissue and body fluid samples with minimal intervention and CVs in the smaller than 20% range for proteins of interest
Feasibility study in cancer tissue proteomicsPerform large-scale quantitative phosphoproteomics of patient samples from ovarian cancer, colon cancer and prostate cancer samples using the protocols and MS acquisition strategies established in D5.1
Construction/coupling of UVPD to the latest Orbitrap instrumentsAn UVPD laser will be coupled to the latest Q-Exactive mass analyzer and/or other Orbitrap instruments
Software modules implemented for MS/MS based analysis of unconven-tional peptide and protein sequencesImplementation and benchmarking of all algorithms needed for the identification of peptide and proteins measured with the novel and hybrid fragmentation techniques including top and middle down proteomics.
LCMS time-scale compatible top- and middle-down proteomics workflows using hybrid fragmentation methodsBenchmark the performance in protein identifications of HCD, ETD and EThcD for proteins in the range between 10 and 100 kDa (top-down proteomics)
Top- and middle-down software moduleFurther develop the MaxQuant platform in order to analyze and quality control the top and middle down data generated in this project.
Machine learning module for biomarker discovery and classification of clinical samplesDevelop and benchmark a machine learning platform using support vector machines and deep learning networks for making robust decisions on patient treatment based on clinical samples.
LCMS time-scale compatible UV-PD peptide and protein sequencingBenchmark the performance in peptide and protein identifications of UVPD versus HCD using a cellular lysate on a Q-Exactive instrument (bottom-up proteomics)
Ethics checkAll relevant ethical approvals, consent forms and patient information sheets will be uploaded as deliverable 6.12. This will also include an up to date approval from The Central Denmark Region Committees on Health Research Ethics stating the ethical approvals for Aarhus University Hospital are also valid for project MSmed.
Develop and implement high-performance offline high-pH reversed-phase chromatography prior to high-resolution mass spectrometry for parallel analysis of major PTMs without enrichment and apply this to cancer cell lines treated with chemotherapeutic agents.
MaxQuant summer school 2The annual MaxQuant Summer School (host: MPIB, over 160 participants) provides an introduction into the MaxQuant software and application examples. Projeect results will be included into the School’s curriculum.
Data Management PlanDescribes the strategy for depositing and curating MSmed experimental data in publicly accessible proteomic data bases, the use of proteomic standard formats, and exceptions made as required to protect personal data and intellectual property to be patented
Robust and reproducible sample prepa¬ration protocols including MS instru¬mentation and acquisition strat-egies for large-scale, quantitative PTM analysis from primary tissue samples such as patient biopsy materialEstablish tissue sample preparation protocol based on heat-inactivation of biopsies, efficient protein extraction by ceramic bead milling, in-solution digestion and optimized nanoflow LC-MS/MS acquisition strategies. Benchmark the performance versus established protocols.
MaxQuant summer schoolThe annual MaxQuant Summer School (host: MPIB, over 160 participants) provides an introduction into the MaxQuant software and application examples. Projeect results will be included into the School’s curriculum.
Protocol for hyper-multiplexingDevelop labeling protocols and test them for multiplexing and analyzing) more than 10 patient samples at a time (goal is up to 20)
Scientific outreach meetingInternational scientific outreach meeting on Next Generation Proteomics linked to an annual Progress Meeting of the Netherlands Proteomics Center. Dissemination of project results to the broader community of proteomics researchers in Europe.
Publikacje
Autorzy:
Kyle L. Fort, Christian N. Cramer, Valery G. Voinov, Yury V. Vasil’ev, Nathan I. Lopez, Joseph S. Beckman, Albert J. R. Heck
Opublikowane w:
Journal of Proteome Research, Numer 17/2, 2018, Strona(/y) 926-933, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.7b00622
Autorzy:
Alba Cristobal, Fabio Marino, Harm Post, Henk W. P. van den Toorn, Shabaz Mohammed, Albert J. R. Heck
Opublikowane w:
Analytical Chemistry, Numer 89/6, 2017, Strona(/y) 3318-3325, ISSN 0003-2700
Wydawca:
American Chemical Society
DOI:
10.1021/acs.analchem.6b03756
Autorzy:
Fan Liu, Philip Lössl, Richard Scheltema, Rosa Viner, Albert J. R. Heck
Opublikowane w:
Nature Communications, Numer 8, 2017, Strona(/y) 15473, ISSN 2041-1723
Wydawca:
Nature Publishing Group
DOI:
10.1038/ncomms15473
Autorzy:
Fan Liu, Philip Lössl, Beverley M. Rabbitts, Robert S. Balaban, Albert J. R. Heck
Opublikowane w:
Molecular & Cellular Proteomics, Numer 17/2, 2018, Strona(/y) 216-232, ISSN 1535-9476
Wydawca:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.RA117.000470
Autorzy:
Chiara Francavilla, Michela Lupia, Kalliopi Tsafou, Alessandra Villa, Katarzyna Kowalczyk, Rosa Rakownikow Jersie-Christensen, Giovanni Bertalot, Stefano Confalonieri, Søren Brunak, Lars J. Jensen, Ugo Cavallaro, Jesper V. Olsen
Opublikowane w:
Cell Reports, Numer 18/13, 2017, Strona(/y) 3242-3256, ISSN 2211-1247
Wydawca:
Cell Press
DOI:
10.1016/j.celrep.2017.03.015
Autorzy:
Yang Yang, Guanbo Wang, Ting Song, Carlito B. Lebrilla, Albert J. R. Heck
Opublikowane w:
mAbs, Numer 9/4, 2017, Strona(/y) 638-645, ISSN 1942-0870
Wydawca:
Landes Bioscience
DOI:
10.1080/19420862.2017.1290033
Autorzy:
Aneika C. Leney, Karim Rafie, Daan M. F. van Aalten, Albert J. R. Heck
Opublikowane w:
ACS Chemical Biology, Numer 12/8, 2017, Strona(/y) 2078-2084, ISSN 1554-8929
Wydawca:
American Chemical Society
DOI:
10.1021/acschembio.7b00371
Autorzy:
Guanbo Wang, Rob N. de Jong, Ewald T. J. van den Bremer, Paul W. H. I. Parren, Albert J. R. Heck
Opublikowane w:
Analytical Chemistry, Numer 89/9, 2017, Strona(/y) 4793-4797, ISSN 0003-2700
Wydawca:
American Chemical Society
DOI:
10.1021/acs.analchem.6b05129
Autorzy:
Liana Tsiatsiani, Piero Giansanti, Richard A. Scheltema, Henk van den Toorn, Christopher M. Overall, A.F. Maarten Altelaar, Albert J.R. Heck
Opublikowane w:
Journal of Proteome Research, Numer 16/2, 2017, Strona(/y) 852-861, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.6b00825
Autorzy:
Dorte B. Bekker-Jensen, Christian D. Kelstrup, Tanveer S. Batth, Sara C. Larsen, Christa Haldrup, Jesper B. Bramsen, Karina D. Sørensen, Søren Høyer, Torben F. Ørntoft, Claus L. Andersen, Michael L. Nielsen, Jesper V. Olsen
Opublikowane w:
Cell Systems, Numer 4/6, 2017, Strona(/y) 587-599.e4, ISSN 2211-1247
Wydawca:
Cell Press
DOI:
10.1016/j.cels.2017.05.009
Autorzy:
Harm Post, Renske Penning, Martin A. Fitzpatrick, Luc B. Garrigues, W. Wu, Harold D. MacGillavry, Casper C. Hoogenraad, Albert J. R. Heck, A. F. Maarten Altelaar
Opublikowane w:
Journal of Proteome Research, Numer 16/2, 2017, Strona(/y) 728-737, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.6b00753
Autorzy:
Vojtech Franc, Yang Yang, Albert J. R. Heck
Opublikowane w:
Analytical Chemistry, Numer 89/6, 2017, Strona(/y) 3483-3491, ISSN 0003-2700
Wydawca:
American Chemical Society
DOI:
10.1021/acs.analchem.6b04527
Autorzy:
Louise von Stechow, Jesper V. Olsen
Opublikowane w:
PROTEOMICS, Numer 17/3-4, 2017, Strona(/y) 1600018, ISSN 1615-9853
Wydawca:
John Wiley & Sons Ltd.
DOI:
10.1002/pmic.201600018
Autorzy:
Adán Alpízar, Fabio Marino, Antonio Ramos-Fernández, Manuel Lombardía, Anita Jeko, Florencio Pazos, Alberto Paradela, César Santiago, Albert J. R. Heck, Miguel Marcilla
Opublikowane w:
Molecular & Cellular Proteomics, Numer 16/2, 2017, Strona(/y) 181-193, ISSN 1535-9476
Wydawca:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.M116.063800
Autorzy:
Stephanie Munk, Jón Otti Sigurðsson, Zhenyu Xiao, Tanveer Singh Batth, Giulia Franciosa, Louise von Stechow, Andres Joaquin Lopez-Contreras, Alfred Cornelis Otto Vertegaal, Jesper Velgaard Olsen
Opublikowane w:
Cell Reports, Numer 21/2, 2017, Strona(/y) 546-558, ISSN 2211-1247
Wydawca:
Cell Press
DOI:
10.1016/j.celrep.2017.09.059
Autorzy:
Christian D. Kelstrup, Dorte B. Bekker-Jensen, Tabiwang N. Arrey, Alexander Hogrebe, Alexander Harder, Jesper V. Olsen
Opublikowane w:
Journal of Proteome Research, Numer 17/1, 2017, Strona(/y) 727-738, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.7b00602
Autorzy:
Tanveer S. Batth, Moreno Papetti, Anamarija Pfeiffer, Maxim A.X. Tollenaere, Chiara Francavilla, Jesper V. Olsen
Opublikowane w:
Cell Reports, Numer 22/10, 2018, Strona(/y) 2784-2796, ISSN 2211-1247
Wydawca:
Cell Press
DOI:
10.1016/j.celrep.2018.02.038
Autorzy:
Alexander Hogrebe, Louise von Stechow, Dorte B. Bekker-Jensen, Brian T. Weinert, Christian D. Kelstrup, Jesper V. Olsen
Opublikowane w:
Nature Communications, Numer 9/1, 2018, Strona(/y) 1045, ISSN 2041-1723
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41467-018-03309-6
Autorzy:
Sem Tamara, Richard A. Scheltema, Albert J. R. Heck, Aneika C. Leney
Opublikowane w:
Angewandte Chemie International Edition, Numer 56/44, 2017, Strona(/y) 13641-13644, ISSN 1433-7851
Wydawca:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.201706749
Autorzy:
Michiel van de Waterbeemd, Kyle L Fort, Dmitriy Boll, Maria Reinhardt-Szyba, Andrew Routh, Alexander Makarov, Albert J R Heck
Opublikowane w:
Nature Methods, Numer 14/3, 2017, Strona(/y) 283-286, ISSN 1548-7091
Wydawca:
Nature Publishing Group
DOI:
10.1038/nmeth.4147
Autorzy:
Yang Yang, Vojtech Franc, Albert J.R. Heck
Opublikowane w:
Trends in Biotechnology, Numer 35/7, 2017, Strona(/y) 598-609, ISSN 0167-7799
Wydawca:
Elsevier BV
DOI:
10.1016/j.tibtech.2017.04.010
Autorzy:
Kyle L. Fort, Michiel van de Waterbeemd, Dmitriy Boll, Maria Reinhardt-Szyba, Mikhail E. Belov, Eita Sasaki, Reinhard Zschoche, Donald Hilvert, Alexander A. Makarov, Albert J. R. Heck
Opublikowane w:
The Analyst, Numer 143/1, 2018, Strona(/y) 100-105, ISSN 0003-2654
Wydawca:
Royal Society of Chemistry
DOI:
10.1039/c7an01629h
Autorzy:
Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck
Opublikowane w:
Journal of Proteome Research, Numer 17/3, 2018, Strona(/y) 1216-1226, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.7b00839
Autorzy:
James D. Sanders, Dmitry Grinfeld, Konstantin Aizikov, Alexander Makarov, Dustin D. Holden, Jennifer S. Brodbelt
Opublikowane w:
Analytical Chemistry, Numer 90/9, 2018, Strona(/y) 5896-5902, ISSN 0003-2700
Wydawca:
American Chemical Society
DOI:
10.1021/acs.analchem.8b00724
Autorzy:
Dirk Nolting, Robert Malek, Alexander Makarov
Opublikowane w:
Mass Spectrometry Reviews, 2017, ISSN 0277-7037
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/mas.21549
Autorzy:
Sebastian Virreira Winter, Florian Meier, Christoph Wichmann, Juergen Cox, Matthias Mann, Felix Meissner
Opublikowane w:
Nature Methods, Numer 15, 2018, Strona(/y) 527–530, ISSN 1548-7091
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41592-018-0037-8
Autorzy:
Florian Meier, Philipp E. Geyer, Sebastian Virreira Winter, Juergen Cox, Matthias Mann
Opublikowane w:
Nature Methods, Numer 15/6, 2018, Strona(/y) 440-448, ISSN 1548-7091
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41592-018-0003-5
Autorzy:
Pavel Sinitcyn, Shivani Tiwary, Jan Rudolph, Petra Gutenbrunner, Christoph Wichmann, Şule Yılmaz, Hamid Hamzeiy, Favio Salinas, Jürgen Cox
Opublikowane w:
Nature Methods, Numer 15/6, 2018, Strona(/y) 401-401, ISSN 1548-7091
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41592-018-0018-y
Autorzy:
Hamid Hamzeiy, Jürgen Cox
Opublikowane w:
Current Opinion in Biotechnology, Numer 43, 2017, Strona(/y) 141-146, ISSN 0958-1669
Wydawca:
Elsevier BV
DOI:
10.1016/j.copbio.2016.11.014
Autorzy:
Jan P. Gerlach, Ingrid Jordens, Daniele V. F. Tauriello, Ineke van ‘t Land-Kuper, Jeroen M. Bugter, Ivar Noordstra, Johanneke van der Kooij, Teck Y. Low, Felipe X. Pimentel-Muiños, Despina Xanthakis, Nicola Fenderico, Catherine Rabouille, Albert J. R. Heck, David A. Egan, Madelon M. Maurice
Opublikowane w:
Proceedings of the National Academy of Sciences, Numer 115/17, 2018, Strona(/y) E3996-E4005, ISSN 0027-8424
Wydawca:
National Academy of Sciences
DOI:
10.1073/pnas.1721321115
Autorzy:
Pavel Sinitcyn, Jan Daniel Rudolph, Jürgen Cox
Opublikowane w:
Annual Review of Biomedical Data Science, Numer 1/1, 2018, Strona(/y) 207-234, ISSN 2574-3414
Wydawca:
Annual Reviews
DOI:
10.1146/annurev-biodatasci-080917-013516
Autorzy:
Vojtech Franc, Jing Zhu, Albert J. R. Heck
Opublikowane w:
Journal of The American Society for Mass Spectrometry, Numer 29/6, 2018, Strona(/y) 1099-1110, ISSN 1044-0305
Wydawca:
Elsevier BV
DOI:
10.1007/s13361-018-1901-6
Autorzy:
Michiel van de Waterbeemd, Sem Tamara, Kyle L. Fort, Eugen Damoc, Vojtech Franc, Philipp Bieri, Martin Itten, Alexander Makarov, Nenad Ban, Albert J. R. Heck
Opublikowane w:
Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41467-018-04853-x
Autorzy:
Tomislav Čaval, Weihua Tian, Zhang Yang, Henrik Clausen, Albert J. R. Heck
Opublikowane w:
Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41467-018-05536-3
Autorzy:
Philip Lössl, Andrea M. Brunner, Fan Liu, Aneika C. Leney, Masami Yamashita, Richard A. Scheltema, Albert J. R. Heck
Opublikowane w:
ACS Central Science, Numer 2/7, 2016, Strona(/y) 445-455, ISSN 2374-7943
Wydawca:
ACS Publications
DOI:
10.1021/acscentsci.6b00053
Autorzy:
Anna Secher, Christian D. Kelstrup, Kilian W. Conde-Frieboes, Charles Pyke, Kirsten Raun, Birgitte S. Wulff, Jesper V. Olsen
Opublikowane w:
Nature Communications, Numer 7, 2016, Strona(/y) 11436, ISSN 2041-1723
Wydawca:
Nature Publishing Group
DOI:
10.1038/ncomms11436
Autorzy:
Kyle L. Fort, Andrey Dyachenko, Clement M. Potel, Eleonora Corradini, Fabio Marino, Arjan Barendregt, Alexander A. Makarov, Richard A. Scheltema, Albert J. R. Heck
Opublikowane w:
Analytical Chemistry, Numer 88/4, 2016, Strona(/y) 2303-2310, ISSN 0003-2700
Wydawca:
American Chemical Society
DOI:
10.1021/acs.analchem.5b04162
Autorzy:
Yu-Hsien Lin, Vojtech Franc, Albert J. R. Heck
Opublikowane w:
Journal of Proteome Research, Numer 17/8, 2018, Strona(/y) 2861-2869, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00318
Autorzy:
Magnus E. Jakobsson, Jędrzej M. Małecki, Levon Halabelian, Benedikt S. Nilges, Rita Pinto, Srikanth Kudithipudi, Stephanie Munk, Erna Davydova, Fawzi R. Zuhairi, Cheryl H. Arrowsmith, Albert Jeltsch, Sebastian A. Leidel, Jesper V. Olsen, Pål Ø. Falnes
Opublikowane w:
Nature Communications, Numer 9/1, 2018, Strona(/y) 3411, ISSN 2041-1723
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41467-018-05646-y
Autorzy:
Ashley L. Comes, Sergi Papiol, Thorsten Mueller, Philipp E. Geyer, Matthias Mann, Thomas G. Schulze
Opublikowane w:
Translational Psychiatry, Numer 8/1, 2018, Strona(/y) 160, ISSN 2158-3188
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41398-018-0219-2
Autorzy:
Jennie R. Lill, Peter A. van Veelen, Stefan Tenzer, Arie Admon, Etienne Caron, Joshua E. Elias, Albert J.R. Heck, Miguel Marcilla, Fabio Marino, Markus Müller, Bjoern Peters, Anthony Purcell, Alessandro Sette, Theo Sturm, Nicola Ternette, Juan Antonio Vizcaíno, Michal Bassani-Sternberg
Opublikowane w:
PROTEOMICS, Numer 18/12, 2018, Strona(/y) 1800110, ISSN 1615-9853
Wydawca:
John Wiley & Sons Ltd.
DOI:
10.1002/pmic.201800110
Autorzy:
Sem Tamara, Andrey Dyachenko, Kyle L. Fort, Alexander A. Makarov, Richard A. Scheltema, Albert J. R. Heck
Opublikowane w:
Journal of the American Chemical Society, Numer 138/34, 2016, Strona(/y) 10860-10868, ISSN 0002-7863
Wydawca:
American Chemical Society
DOI:
10.1021/jacs.6b05147
Autorzy:
Stefka Tyanova, Tikira Temu, Pavel Sinitcyn, Arthur Carlson, Marco Y Hein, Tamar Geiger, Matthias Mann, Jürgen Cox
Opublikowane w:
Nature Methods, Numer 13/9, 2016, Strona(/y) 731-740, ISSN 1548-7091
Wydawca:
Nature Publishing Group
DOI:
10.1038/nmeth.3901
Autorzy:
Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens, Albert J. R. Heck
Opublikowane w:
Nature Communications, Numer 7, 2016, Strona(/y) 13397, ISSN 2041-1723
Wydawca:
Nature Publishing Group
DOI:
10.1038/ncomms13397
Autorzy:
Philip Lössl, Michiel van de Waterbeemd, Albert JR Heck
Opublikowane w:
The EMBO Journal, Numer 35/24, 2016, Strona(/y) 2634-2657, ISSN 0261-4189
Wydawca:
Nature Publishing Group
DOI:
10.15252/embj.201694818
Autorzy:
Chiara Francavilla, Moreno Papetti, Kristoffer T G Rigbolt, Anna-Kathrine Pedersen, Jon O Sigurdsson, Giuseppe Cazzamali, Gopal Karemore, Blagoy Blagoev, Jesper V Olsen
Opublikowane w:
Nature Structural & Molecular Biology, Numer 23/6, 2016, Strona(/y) 608-618, ISSN 1545-9993
Wydawca:
Nature Publishing Group
DOI:
10.1038/nsmb.3218
Autorzy:
Dmitry Grinfeld, Konstantin Aizikov, Arne Kreutzmann, Eugen Damoc, Alexander Makarov
Opublikowane w:
Analytical Chemistry, Numer 89/2, 2016, Strona(/y) 1202-1211, ISSN 0003-2700
Wydawca:
American Chemical Society
DOI:
10.1021/acs.analchem.6b03636
Autorzy:
Nicolai J. Wewer Albrechtsen, Philipp E. Geyer, Sophia Doll, Peter V. Treit, Kirstine N. Bojsen-Møller, Christoffer Martinussen, Nils B. Jørgensen, Signe S. Torekov, Florian Meier, Lili Niu, Alberto Santos, Eva C. Keilhauer, Jens J. Holst, Sten Madsbad, Matthias Mann
Opublikowane w:
Cell Systems, Numer 7/6, 2018, Strona(/y) 601-612.e3, ISSN 2405-4712
Wydawca:
Cell Press
DOI:
10.1016/j.cels.2018.10.012
Autorzy:
Nicolai Bache, Philipp E. Geyer, Dorte B. Bekker-Jensen, Ole Hoerning, Lasse Falkenby, Peter V. Treit, Sophia Doll, Igor Paron, Johannes B. Müller, Florian Meier, Jesper V. Olsen, Ole Vorm, Matthias Mann
Opublikowane w:
Molecular & Cellular Proteomics, Numer 17/11, 2018, Strona(/y) 2284-2296, ISSN 1535-9476
Wydawca:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.TIR118.000853
Autorzy:
Jan Daniel Rudolph, Jürgen Cox
Opublikowane w:
Journal of Proteome Research, Numer 18/5, 2019, Strona(/y) 2052-2064, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00927
Autorzy:
Yasset Perez-Riverol, Attila Csordas, Jingwen Bai, Manuel Bernal-Llinares, Suresh Hewapathirana, Deepti J Kundu, Avinash Inuganti, Johannes Griss, Gerhard Mayer, Martin Eisenacher, Enrique Pérez, Julian Uszkoreit, Julianus Pfeuffer, Timo Sachsenberg, Şule Yılmaz, Shivani Tiwary, Jürgen Cox, Enrique Audain, Mathias Walzer, Andrew F Jarnuczak, Tobias Ternent, Alvis Brazma, Juan Antonio Vizcaíno
Opublikowane w:
Nucleic Acids Research, Numer 47/D1, 2018, Strona(/y) D442-D450, ISSN 0305-1048
Wydawca:
Oxford University Press
DOI:
10.1093/nar/gky1106
Autorzy:
Marta Murgia, Jing Tan, Philipp E. Geyer, Sophia Doll, Matthias Mann, Thomas Klopstock
Opublikowane w:
Cell Reports, Numer 29/12, 2019, Strona(/y) 3825-3834.e4, ISSN 2211-1247
Wydawca:
Cell Press
DOI:
10.1016/j.celrep.2019.11.055
Autorzy:
Miao-Hsia Lin, Clement M. Potel, Kamaleddin H. M. E. Tehrani, Albert J. R. Heck, Nathaniel I. Martin, Simone Lemeer
Opublikowane w:
Molecular & Cellular Proteomics, Numer 17/12, 2018, Strona(/y) 2496-2507, ISSN 1535-9476
Wydawca:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.ra118.000880
Autorzy:
David Y. Chiang, Katherina M. Alsina, Eleonora Corradini, Martin Fitzpatrick, Li Ni, Satadru K. Lahiri, Julia O. Reynolds, Xiaolu Pan, Larry Scott, Albert J.R. Heck, Xander H.T. Wehrens
Opublikowane w:
Circulation, Numer 138/15, 2018, Strona(/y) 1569-1581, ISSN 0009-7322
Wydawca:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1161/circulationaha.118.034361
Autorzy:
Karli R. Reiding, Albert Bondt, Vojtech Franc, Albert J.R. Heck
Opublikowane w:
TrAC Trends in Analytical Chemistry, Numer 108, 2018, Strona(/y) 260-268, ISSN 0165-9936
Wydawca:
Elsevier BV
DOI:
10.1016/j.trac.2018.09.007
Autorzy:
Clement M. Potel, Domenico Fasci, Albert J.R. Heck
Opublikowane w:
The FEBS Journal, Numer 285/15, 2018, Strona(/y) 2856-2868, ISSN 1742-464X
Wydawca:
Blackwell Publishing Inc.
DOI:
10.1111/febs.14525
Autorzy:
Clement M. Potel, Miao-Hsia Lin, Albert J. R. Heck, Simone Lemeer
Opublikowane w:
Molecular & Cellular Proteomics, Numer 17/5, 2018, Strona(/y) 1028-1034, ISSN 1535-9476
Wydawca:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.tir117.000518
Autorzy:
Clement M Potel, Miao-Hsia Lin, Albert J R Heck, Simone Lemeer
Opublikowane w:
Nature Methods, Numer 15/3, 2018, Strona(/y) 187-190, ISSN 1548-7091
Wydawca:
Nature Publishing Group
DOI:
10.1038/nmeth.4580
Autorzy:
Oleg Klykov, Barbara Steigenberger, Sibel Pektaş, Domenico Fasci, Albert J. R. Heck, Richard A. Scheltema
Opublikowane w:
Nature Protocols, Numer 13/12, 2018, Strona(/y) 2964-2990, ISSN 1754-2189
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41596-018-0074-x
Autorzy:
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Opublikowane w:
Molecular & Cellular Proteomics, Numer 17/10, 2018, Strona(/y) 2018-2033, ISSN 1535-9476
Wydawca:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.ra118.000924
Autorzy:
Barbara Steigenberger, Roland J. Pieters, Albert J. R. Heck, Richard A. Scheltema
Opublikowane w:
ACS Central Science, Numer 5/9, 2019, Strona(/y) 1514-1522, ISSN 2374-7943
Wydawca:
ACS Publications
DOI:
10.1021/acscentsci.9b00416
Autorzy:
Tomislav Čaval, Jing Zhu, Albert J.R. Heck
Opublikowane w:
Analytical Chemistry, Numer 91/16, 2019, Strona(/y) 10401-10406, ISSN 0003-2700
Wydawca:
American Chemical Society
DOI:
10.1021/acs.analchem.9b02125
Autorzy:
Jean-François Greisch, Sem Tamara, Richard A. Scheltema, Howard W. R. Maxwell, Robert D. Fagerlund, Peter C. Fineran, Stephan Tetter, Donald Hilvert, Albert J. R. Heck
Opublikowane w:
Chemical Science, Numer 10/30, 2019, Strona(/y) 7163-7171, ISSN 2041-6520
Wydawca:
Royal Society of Chemistry
DOI:
10.1039/c9sc01857c
Autorzy:
Clement M. Potel, Miao-Hsia Lin, Nadine Prust, Henk W. P. van den Toorn, Albert J. R. Heck, Simone Lemeer
Opublikowane w:
Analytical Chemistry, Numer 91/9, 2019, Strona(/y) 5542-5547, ISSN 0003-2700
Wydawca:
American Chemical Society
DOI:
10.1021/acs.analchem.9b00734
Autorzy:
Laura C. Demmers, Albert J. R. Heck, Wei Wu
Opublikowane w:
Journal of Proteome Research, Numer 18/4, 2019, Strona(/y) 1634-1643, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00821
Autorzy:
Kelly A. Dingess, Henk W. P. van den Toorn, Marko Mank, Bernd Stahl, Albert J. R. Heck
Opublikowane w:
Analytical and Bioanalytical Chemistry, Numer 411/7, 2019, Strona(/y) 1351-1363, ISSN 1618-2642
Wydawca:
Springer Verlag
DOI:
10.1007/s00216-018-01566-4
Autorzy:
Clement M. Potel, Simone Lemeer, Albert J. R. Heck
Opublikowane w:
Analytical Chemistry, Numer 91/1, 2018, Strona(/y) 126-141, ISSN 0003-2700
Wydawca:
American Chemical Society
DOI:
10.1021/acs.analchem.8b04746
Autorzy:
Jing Zhu, Luc Garrigues, Henk Van den Toorn, Bernd Stahl, Albert J. R. Heck
Opublikowane w:
Journal of Proteome Research, Numer 18/1, 2018, Strona(/y) 225-238, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00550
Autorzy:
Andrey Dyachenko, Sem Tamara, Albert J. R. Heck
Opublikowane w:
Journal of The American Society for Mass Spectrometry, Numer 30/1, 2019, Strona(/y) 7-15, ISSN 1044-0305
Wydawca:
Elsevier BV
DOI:
10.1007/s13361-018-1910-5
Autorzy:
Tomislav Čaval, Jing Zhu, Weihua Tian, Sanne Remmelzwaal, Zhang Yang, Henrik Clausen, Albert J.R. Heck
Opublikowane w:
Molecular & Cellular Proteomics, Numer 18/1, 2019, Strona(/y) 16-27, ISSN 1535-9476
Wydawca:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.ra118.000967
Autorzy:
Sebastiaan C. de Graaf, Oleg Klykov, Henk van den Toorn, Richard A. Scheltema
Opublikowane w:
Journal of Proteome Research, Numer 18/2, 2018, Strona(/y) 642-651, ISSN 1535-3893
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jproteome.8b00725
Autorzy:
Christoph Wichmann, Florian Meier, Sebastian Virreira Winter, Andreas-David Brunner, Jürgen Cox, Matthias Mann
Opublikowane w:
Molecular & Cellular Proteomics, Numer 18/5, 2019, Strona(/y) 982-994, ISSN 1535-9476
Wydawca:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1074/mcp.tir118.001131
Autorzy:
Philipp E Geyer, Eugenia Voytik, Peter V Treit, Sophia Doll, Alisa Kleinhempel, Lili Niu, Johannes B Müller, Marie‐Luise Buchholtz, Jakob M Bader, Daniel Teupser, Lesca M Holdt, Matthias Mann
Opublikowane w:
EMBO Molecular Medicine, Numer 11/11, 2019, Strona(/y) e10427, ISSN 1757-4676
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John Wiley & Sons Ltd.
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10.15252/emmm.201910427
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Opublikowane w:
Molecular Systems Biology, Numer 15/3, 2019, Strona(/y) e8793, ISSN 1744-4292
Wydawca:
Nature Publishing Group
DOI:
10.15252/msb.20188793
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Alicia Lundby, Giulia Franciosa, Kristina B. Emdal, Jan C. Refsgaard, Sebastian P. Gnosa, Dorte B. Bekker-Jensen, Anna Secher, Svetlana R. Maurya, Indranil Paul, Blanca L. Mendez, Christian D. Kelstrup, Chiara Francavilla, Marie Kveiborg, Guillermo Montoya, Lars J. Jensen, Jesper V. Olsen
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Cell, Numer 179/2, 2019, Strona(/y) 543-560.e26, ISSN 0092-8674
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Cell Press
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10.1016/j.cell.2019.09.008
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Tanveer S. Batth, Maxim A. X. Tollenaere, Patrick Rüther, Alba Gonzalez-Franquesa, Bhargav S. Prabhakar, Simon Bekker-Jensen, Atul S. Deshmukh, Jesper V. Olsen
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Molecular & Cellular Proteomics, Numer 18/5, 2019, Strona(/y) 1027-1035, ISSN 1535-9476
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American Society for Biochemistry and Molecular Biology Inc.
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10.1074/mcp.tir118.001270
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Kristina B. Emdal, Anna-Kathrine Pedersen, Dorte B. Bekker-Jensen, Alicia Lundby, Shana Claeys, Katleen De Preter, Frank Speleman, Chiara Francavilla, Jesper V. Olsen
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Science Signaling, Numer 11/557, 2018, Strona(/y) eaap9752, ISSN 1937-9145
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American Association for the Advancement of Science
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10.1126/scisignal.aap9752
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Christian D. Kelstrup, Konstantin Aizikov, Tanveer S. Batth, Arne Kreutzman, Dmitry Grinfeld, Oliver Lange, Daniel Mourad, Alexander A. Makarov, Jesper V. Olsen
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Journal of Proteome Research, Numer 17/11, 2018, Strona(/y) 4008-4016, ISSN 1535-3893
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American Chemical Society
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10.1021/acs.jproteome.8b00381
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Vyacheslav Akimov, Inigo Barrio-Hernandez, Sten V. F. Hansen, Philip Hallenborg, Anna-Kathrine Pedersen, Dorte B. Bekker-Jensen, Michele Puglia, Stine D. K. Christensen, Jens T. Vanselow, Mogens M. Nielsen, Irina Kratchmarova, Christian D. Kelstrup, Jesper V. Olsen, Blagoy Blagoev
Opublikowane w:
Nature Structural & Molecular Biology, Numer 25/7, 2018, Strona(/y) 631-640, ISSN 1545-9993
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Nature Publishing Group
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10.1038/s41594-018-0084-y
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Miia R. Mäkelä, Ourdia Bouzid, Diogo Robl, Harm Post, Mao Peng, Albert Heck, Maarten Altelaar, Ronald P. de Vries
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New Biotechnology, Numer 37, 2017, Strona(/y) 162-171, ISSN 1871-6784
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Elsevier BV
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10.1016/j.nbt.2017.02.002
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Opublikowane w:
Encyclopedia of Analytical Chemistry, 2019
Wydawca:
Wiley Online Library
Autorzy:
Fabian Coscia, Sophia Doll, Jacob Mathias Bech, Andreas Mund, Ernst Lengyel, Jan Lindebjerg, Gunvor Iben Madsen, José M. A. Moreira, Matthias Mann
Opublikowane w:
bioRxiv, 2019
Wydawca:
Cold Spring Harbor Laboratory
DOI:
10.1101/779009
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bioRxiv, 2019
Wydawca:
Cold Spring Harbor Laboratory
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10.1101/860643
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Opublikowane w:
bioRxiv, 2019
Wydawca:
Cold Spring Harbor Laboratory
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10.1101/657858
Prawa własności intelektualnej
Numer wniosku/publikacji:
25
69639
Data:
1939-09-13
Numer wniosku/publikacji:
EP
15165127
Data:
2015-04-24
Numer wniosku/publikacji:
GB
1618595.1
Data:
2016-11-04
Numer wniosku/publikacji:
EP
17158299
Data:
2017-02-28
Numer wniosku/publikacji:
19
175643
Data:
2017-06-02
Numer wniosku/publikacji:
17
174330
Data:
2017-06-02
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