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Molecular Analytical Robotics Assays

Objective

Diagnostic tests are essential to provide a targeted treatment of infectious diseases and to contain the further spread of multidrug resistant pathogens. Current methods are based either on cultivation or on PCR and have significant limitations concerning the clinical requirements to characterise pathogens including their resistance mechanisms within 3 hours. In MARA, we will develop and combine three radically novel technologies that will lead to substantial breakthroughs in science, medicine and industry and, as proof-of principle, use them to create a DNA-based molecular toolkit characterising pathogens.
First, the detection of pathogen-associated antigens will be performed by Autonomous Detection Nucleic Acids (AUDENA) that are independent of any laboratory instruments and sophisticated processing. The realisation of the AUDENA concept will lead to an autonomous, stable, simple and very economic novel sensor class applicable for any water-soluble substances. The second revolutionary technology in MARA employs a novel approach in protein mimicry and creation of artificial enzymes, which represents a breakthrough in several disciplines, such as biotechnology, biomedical manufacturing and the energy sector. The third breakthrough in this project represents the development of a Molecular Robot (MORO) that can specifically identify target cells and destroy them. In MARA, the MORO will be used for the lysis of bacterial cells to release intracellular antibiotic resistance associated antigens, but the long-term vision anticipates an application as antibiotic replacement for infectious diseases and a therapeutic agent for cancer treatment, which would represent one of the most important breakthroughs in medicine in the recent years.
To meet the highly ambitious objectives pointed out in this proposal, MARA is driven by a complementary, multidisciplinary team of leading experts, with a young, high-profile scientist in the lead.

Call for proposal

H2020-FETOPEN-2014-2015-RIA
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Address
Giefinggasse 4
1210 Wien
Austria
Activity type
Research Organisations
EU contribution
€ 1 649 517,50

Participants (5)

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 581 250
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 647 250
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
APTA BIOSCIENCES LIMITED

Participation ended

United Kingdom
EU contribution
€ 0
Address
The Elms Courtyard Bromsberrow
HR8 1RZ Ledbury Herefordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 548 460
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Pure Biologics Spolka Akcyjna
Poland
EU contribution
€ 570 000
Address
Ul Dunska 11
54-427 Wroclaw
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)