Breaking the Nonuniqueness Barrier in Electromagnetic Neuroimaging

Project Information

BREAKBEN

Grant agreement ID: 686865

DOI 10.3030/686865

Project closed

EC signature date 16 November 2015

Start date 1 January 2016

End date 31 May 2019

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 3 998 793,00

EU contribution € 3 998 793,00

Coordinated by

AALTO KORKEAKOULUSAATIO SR
Finland

Deliverables

Demonstrators, pilots, prototypes (2)

Demonstration of CDI in vivo

Demonstration of CDI in vivo.

MEG-MRI on healthy subjects

MEG-MRI on healthy subjects.

Documents, reports (4)

Guidelines for safety and regulatory requirements

Guidelines for safety and regulatory requirements.

Connectivity maps from human subject data

Connectivity maps from human subject data.

Dissemination activities

A report on dissemination activities during the project.

Analysis of the value of a priori information

Analysis of the value of a priori information.

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan will be submitted in M6 and checked and updated for M36 and as appropriate during the project.

Websites, patent fillings, videos etc. (1)

External web-site

External web-site.

Publications

Conference proceedings (27)

Ultra-sensitive SQUID instrumentation for MEG and NCI by ULF MRI

Author(s): Rainer Körber
Published in: EMBEC & NBC 2017, IFMBE Proceedings, Issue 65, 2017, Page(s) 795-798
Publisher: Springer Singapore
DOI: 10.1007/978-981-10-5122-7_199

Towards direct neuronal current imaging via ultra-low-field MR

Author(s): Nora Höfner and Rainer Körber and Marting Burghoff
Published in: Proceedings of the workshop Biosignal Processing 2016, 2016
Publisher: Physikalisch-Technische Bundesanstalt

Calcified cortical tubers influence single dipole source localization

Author(s): Alexander Hunold, Stephan Lau, Yoshio Okada, Christos Papadelis, Jens Haueisen
Published in: BIOMAG2016 Poster Session, Issue biennial, 2016
Publisher: Biomag

Comparison of dipole localization to interictal spikesin individual and standardized BEM upon three different age group

Author(s): Corinna Horn, Alexander Hunold, Jens Haueisen, Michael Funke
Published in: BIOMAG2016 Poster Session, Issue biennial, 2016
Publisher: Biomag

A modular and field tolerant ultra-low-noise multichannel SQUID system for ULF MRI and high frequency MEG

Author(s): Rainer Körber, Jan-Hendrik Storm, Dietmar Drung and Martin Burghoff
Published in: BIOMAG2016 Poster Session, Issue biennial, 2016
Publisher: Biomag

Neuronal current imaging (NCI) by Ultra-Low-Field MRI

Author(s): Nora Höfner, Rainer Körber, Jens Haueisen, Peter Hömmen and Martin Burghoff
Published in: BIOMAG2016 Poster Session, Issue biennial, 2016
Publisher: Biomag

Optimized pipeline for the 3D co-registration of Low- and High-Field MRI

Author(s): Guidotti R., Sinibaldi R., De Luca C., Conti A., Ilmoniemi R. J., Zevenhonen K. C. J., Magnelind P., Pizzella V., Romani G. L. and Della Penna S.
Published in: BIOMAG 2016 Poster session, Issue biannual, 2016
Publisher: BIOMAG

Identifying pairwise interacting sources from the antisymmetric cross-bispectrum of EEG/MEG data

Author(s): Federico Chella, Vittorio Pizzella, Filippo Zappasodi, Guido Nolte, Laura Marzetti
Published in: OHBM 2016 Poster session, Issue annual, 2016
Publisher: OHBM

Accurate mapping of magnetic fields generated by an ultra-low-field MRI device

Author(s): Aino E Tervo, Antti J Mäkinen, Risto J Ilmoniemi, and Koos C J Zevenhoven
Published in: BIOMAG2016 poster/abstract, Issue biennial, 2016, Page(s) 407
Publisher: Biomag

Breaking the Nonuniqueness Barrier in Electromagnetic Neuroimaging: the BREAKBEN project

Author(s): Risto Ilmoniemi, Jens Haueisen, Mikko Kiviranta, Rainer Körber, Jyrki Mäkelä, Jukka Nenonen, Gian Luca Romani, and Koos Zevenhoven
Published in: BIOMAG2016 poster/abstract, Issue biennial, 2016, Page(s) 409
Publisher: Biomag

Recent advances in ultra-low-field MRI and its compatibility with other modalities

Author(s): Koos C. J. Zevenhoven and Risto J. Ilmoniemi
Published in: BIOMAG2016 poster/abstract, Issue biennial, 2016, Page(s) 410
Publisher: Biomag

Eliminating co-registration in MEG–MRI: automatic nonlinear calibration of ULF MRI

Author(s): Antti J. Mäkinen, Koos C. J. Zevenhoven, and Risto J. Ilmoniemi
Published in: Biomag2016 poster/abstract, Issue biennial, 2016, Page(s) 406
Publisher: Biomag

Current Density Imaging in the Head using Ultra-Low Field Magnetic Resonance - An Advanced Phantom Study

Author(s): P. Hömmen, J-H. Storm, N. Höfner, A. Hunold, R. Machts, J. Haueisen and R. Körber
Published in: Biomag 2018 Poster Session, Issue biennial, 2018
Publisher: Biomag

Computational and phantom-based evaluation of dc neuronal current imaging with ultra-low field magnetic resonance

Author(s): J-H. Storm, A. M. Cassarà, N. Höfner, P. Hömmen, E. Neufeld, R. Körber and N. Kuster
Published in: Biomag 2018 Poster Session, Issue biennial, 2018
Publisher: Biomag

Neuronal current imaging using 3D ultra-low field MRI - preliminary results

Author(s): N. Höfner, J.-H. Storm, P. Hömmen, R. Körber
Published in: Biomag 2018 Poster Session, Issue biennial, 2018
Publisher: Biomag

Simulated current density magnitudes and orientations for transcranial direct current stimulation montages used in depression studies

Author(s): Alexander Hunold, Jens Haueisen
Published in: BaCI, Issue biennial, 2017
Publisher: International Conference on Basic and Clinical Multimodal Imaging

Simulating the superposition of transcranial electric stimulations targeting the visual cortex

Author(s): Alexander Hunold, Klaus Schellhorn, Jens Haueisen
Published in: BIOMAG2018, Issue biennial, 2018
Publisher: Biomag

Flexible Stimulationshaube für TES Anwendungen: Technische Parameter und Stromdichtesimulationen

Author(s): Alexander Hunold, Uwe Graichen, Klaus Schellhorn, Jens Haueisen
Published in: 62. Jahrestagung der DGKN 2018 mit Richard-Jung-Kolleg, Issue annual, 2018
Publisher: Deutsche Gesellschaft für Klinische Neurophysiologie und funktionelle Bildgebung

Realization and Testing of a 3D Electrode Array for measuring Electric Potential Differences in a Volume Conductor

Author(s): René Machts, Alexander Hunold, Jens Haueisen
Published in: 51. Jahrestagung der Biomedizinischen Technik und Dreiländertagung der Medizinischen Physik (BMTMedPhys), Issue annual, 2017
Publisher: DGBMT im VDE

Simulation of the current density in the retina for transorbital electric current stimulation

Author(s): Alexander Hunold, Anton Kresinsky, Berd A. Sabel, Jens Haueisen
Published in: "Workshop ""Innovative Verarbeitung bioelektrischer und biomagnetischer Signale""", Issue biennial, 2018
Publisher: "Fachausschüsse ""Biosignale"" und ""Magnetische Methoden in der Medizin"" der DGBMT im VDE"

Concept of a physical head phantom MEG-MRI and NCI/CDI

Author(s): Jens Haueisen, Alexander Hunold
Published in: "#brainTC", Issue annual, 2017
Publisher: Department of Neuroscience and Biomedical Engineering @AaltoUniversity

AlexandSimulated current density and technical parameters of TES applied with a flexible cap

Author(s): Alexander Hunold, Uwe Graichen, Klaus Schellhorn, Jens Haueisen
Published in: 52. Annual Conference of the German Society for Biomedical Engineering (DGBMT within VDE), Issue annual, 2018
Publisher: DGBMT within VDE

Improving MEG–MRI co-registration for reliable MEG connectivity analysis

Author(s): Federico Chella, Laura Marzetti, Matti Stenroos, Lauri Parkkonen, Risto Ilmoniemi, Gian Luca Romani, Vittorio Pizzella
Published in: BIOMAG2018 poster session, Issue biennial, 2018
Publisher: Biomag

Understanding neural synchronization by combining good practice and novel methods in electrophysiological functional connectivity analysis

Author(s): Laura Marzetti
Published in: 19th IOP World Congress, Issue biennial, 2018
Publisher: International Organization of Psychophysiology

Effects of MEG–MRI coregistration error on functional connectivity estimates

Author(s): Federico Chella, Laura Marzetti, Matti Stenroos, Lauri Parkkonen, Risto Ilmoniemi, Gian Luca Romani, Vittorio Pizzella
Published in: OHBM 2017 poster session, Issue annual, 2017
Publisher: OHBM

Large-scale synchronization in ongoing brain activity by multidimensional connectivity

Author(s): Laura Marzetti
Published in: BIOMAG2018, Issue biennial, 2018
Publisher: Biomag

Ultra-sensitive SQUID system for pulsed field applications

Author(s): Eva Al-Dabbagh, Peter Hömmen, Jan-Hendrik Storm, Nora Höfner, Rainer Körber
Published in: EUCAS 2017 Poster Session, Issue biennial, 2017
Publisher: EUCAS

Peer reviewed articles (19)

Ultra-sensitive SQUID Systems for Pulsed Fields—Degaussing Superconducting Pick-Up Coils

Author(s): Eva Al-Dabbagh, Jan-Hendrik Storm, Rainer Korber
Published in: IEEE Transactions on Applied Superconductivity, Issue 28/4, 2018, Page(s) 1-5, ISSN 1051-8223
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TASC.2018.2797544

SQUIDs in biomagnetism: a roadmap towards improved healthcare

Author(s): Rainer Körber, Jan-Hendrik Storm, Hugh Seton, Jyrki P Mäkelä, Ritva Paetau, Lauri Parkkonen, Christoph Pfeiffer, Bushra Riaz, Justin F Schneiderman, Hui Dong, Seong-min Hwang, Lixing You, Ben Inglis, John Clarke, Michelle A Espy, Risto J Ilmoniemi, Per E Magnelind, Andrei N Matlashov, Jaakko O Nieminen, Petr L Volegov, Koos C J Zevenhoven, Nora Höfner, Martin Burghoff, Keiji Enpuku, S Y Yang,
Published in: Superconductor Science and Technology, Issue 29/11, 2016, Page(s) 113001, ISSN 0953-2048
Publisher: Institute of Physics Publishing
DOI: 10.1088/0953-2048/29/11/113001

A modular, extendible and field-tolerant multichannel vector magnetometer based on current sensor SQUIDs

Author(s): J-H Storm, D Drung, M Burghoff, R Körber
Published in: Superconductor Science and Technology, Issue 29/9, 2016, Page(s) 094001, ISSN 0953-2048
Publisher: Institute of Physics Publishing
DOI: 10.1088/0953-2048/29/9/094001

Impact of the reference choice on scalp EEG connectivity estimation

Author(s): Federico Chella, Vittorio Pizzella, Filippo Zappasodi, Laura Marzetti
Published in: Journal of Neural Engineering, Issue 13/3, 2016, Page(s) 036016, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2560/13/3/036016

Bispectral pairwise interacting source analysis for identifying systems of cross-frequency interacting brain sources from electroencephalographic or magnetoencephalographic signals

Author(s): Federico Chella, Vittorio Pizzella, Filippo Zappasodi, Guido Nolte, Laura Marzetti
Published in: Physical Review E, Issue 93/5, 2016, ISSN 2470-0045
Publisher: American Physical Society
DOI: 10.1103/PhysRevE.93.052420

An ultra-sensitive and wideband magnetometer based on a superconducting quantum interference devic

Author(s): Jan-Hendrik Storm, Peter Hömmen, Diemtar Drung, Rainer Körber
Published in: Applied Physics Letters, Issue weekly, 2017, Page(s) 072603-1 - 072603-4, ISSN 0003-6951
Publisher: American Institute of Physics
DOI: 10.1063/1.4976823

Demonstration of full tensor current density imaging using ultra-low field MRI

Author(s): P. Hömmen, J.-H. Storm, N. Höfner, R. Körber
Published in: Magnetic Resonance Imaging, 2019, ISSN 0730-725X
Publisher: Elsevier BV
DOI: 10.1016/j.mri.2019.03.010

Theta-burst stimulation causally affects side perception in the Deutsch’s octave illusion

Author(s): Paolo Capotosto, Stefania della Penna, Vittorio Pizzella, Filippo Zappasodi, Gian Luca Romani, Risto J. Ilmoniemi, Alfredo Brancucci
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-31248-1

The impact of improved MEG–MRI co-registration on MEG connectivity analysis

Author(s): Federico Chella, Laura Marzetti, Matti Stenroos, Lauri Parkkonen, Risto J. Ilmoniemi, Gian Luca Romani, Vittorio Pizzella
Published in: NeuroImage, Issue 197, 2019, Page(s) 354-367, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2019.04.061

Alpha and alpha-beta phase synchronization mediate the recruitment of the visuospatial attention network through the Superior Longitudinal Fasciculus

Author(s): Antea D'Andrea, Federico Chella, Tom R. Marshall, Vittorio Pizzella, Gian Luca Romani, Ole Jensen, Laura Marzetti
Published in: NeuroImage, Issue 188, 2019, Page(s) 722-732, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2018.12.056

A comparative study of the robustness of frequency--domain connectivity measures to finite data length

Author(s): Sommariva, Sara; Sorrentino, Alberto; Piana, Michele; Pizzella, Vittorio; Marzetti, Laura
Published in: Brain Topography, Issue 1, 2017, ISSN 0896-0267
Publisher: Kluwer Academic/Plenum Publishers

Disclosing large-scale directed functional connections in MEG with the multivariate phase slope index

Author(s): Alessio Basti, Vittorio Pizzella, Federico Chella, Gian Luca Romani, Guido Nolte, Laura Marzetti
Published in: NeuroImage, Issue 175, 2018, Page(s) 161-175, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2018.03.004

Non-linear Analysis of Scalp EEG by Using Bispectra: The Effect of the Reference Choice

Author(s): Federico Chella, Antea D'Andrea, Alessio Basti, Vittorio Pizzella, Laura Marzetti
Published in: Frontiers in Neuroscience, Issue 11, 2017, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2017.00262

Optimized 3D co-registration of ultra-low-field and high-field magnetic resonance images

Author(s): Roberto Guidotti, Raffaele Sinibaldi, Cinzia De Luca, Allegra Conti, Risto J. Ilmoniemi, Koos C. J. Zevenhoven, Per E. Magnelind, Vittorio Pizzella, Cosimo Del Gratta, Gian Luca Romani, Stefania Della Penna
Published in: PLOS ONE, Issue 13/3, 2018, Page(s) e0193890, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0193890

Unshielded SQUID Sensors for Ultra-Low-Field Magnetic Resonance Imaging

Author(s): Juho Luomahaara, Mikko Kiviranta, Leif Gronberg, Koos C. J. Zevenhoven, Petteri Laine
Published in: IEEE Transactions on Applied Superconductivity, Issue 28/4, 2018, Page(s) 1-4, ISSN 1051-8223
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2018.2791022

Automatic Spatial Calibration of Ultra-Low-Field MRI for High-Accuracy Hybrid MEG–MRI

Author(s): Antti J. Makinen, Koos C. J. Zevenhoven, Risto J. Ilmoniemi
Published in: IEEE Transactions on Medical Imaging, Issue 38/6, 2019, Page(s) 1317-1327, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2905934

Side-wall spacer passivated sub- μ m Josephson junction fabrication process

Author(s): Leif Grönberg, Mikko Kiviranta, Visa Vesterinen, Janne Lehtinen, Slawomir Simbierowicz, Juho Luomahaara, Mika Prunnila, Juha Hassel
Published in: Superconductor Science and Technology, Issue 30/12, 2017, Page(s) 125016, ISSN 0953-2048
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6668/aa9411

Head phantoms for electroencephalography and transcranial electric stimulation: a skull material study

Author(s): Alexander Hunold, Daniel Strohmeier, Patrique Fiedler, Jens Haueisen
Published in: Biomedical Engineering / Biomedizinische Technik, Issue 63/6, 2018, Page(s) 683-689, ISSN 0013-5585
Publisher: Fachverlag Schiele and Schoen GmbH
DOI: 10.1515/bmt-2017-0069

Real-Time Clustered Multiple Signal Classification (RTC-MUSIC)

Author(s): Christoph Dinh, Lorenz Esch, Johannes Rühle, Steffen Bollmann, Daniel Güllmar, Daniel Baumgarten, Matti S. Hämäläinen, Jens Haueisen
Published in: Brain Topography, Issue 31/1, 2018, Page(s) 125-128, ISSN 0896-0267
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10548-017-0586-7

Thesis and dissertations (6)

Suprajohtavan kvantti-interferenssilaitteen automatisoitu virittäminen aivokuvantamista varten [Automated tuning of a superconducting quantum interference device for brain imaging]

Author(s): Mikko Luukinen
Published in: 2017
Publisher: NA

Superconducting prepolarization coil for ultra-low-field MRI

Author(s): Iiro Lehto
Published in: 2017
Publisher: NA

Noise optimization of multi-layer insulation in liquid-helium cryostat for brain imaging

Author(s): Aino Tervo
Published in: 2016
Publisher: NA

Assessing the value of a priori information in solving the MEG inverse problem

Author(s): Gavriela Vranou
Published in: 2019
Publisher: NA

Konstruktion eines Gestells mit stufenlosem Manipulator der z-Achse für unterschiedliche Kryostaten innerhalb eines bestehenden Messsystems zur Probanden- und Probenmessung in magnetisch geschirmten Räumen

Author(s): Sebastian Neuber
Published in: 2018
Publisher: NA

Hoch-sensitives SQUID-Messsystem für Anwendungen mit gepultsten Feldern

Author(s): Eva Al-Dabbagh
Published in: 2017
Publisher: NA