Project description DEENESFRITPL Accurate detection of thyroid cancer at the point of care Thyroid nodules are lumps in the thyroid gland most often of benign origin. To exclude the possibility of thyroid cancer, these nodules are evaluated using ultrasound imaging and biopsy. The EU-funded LUCA project aims to overcome the limited accuracy of existing screening methods that lead to false positive results and unnecessary surgeries. For this purpose, the project proposes to develop an innovative and affordable diagnostic device that provides comprehensive information on tissue morphology, composition, and function. Apart from improved specificity, the LUCA device will be easy to use at the point of care. Show the project objective Hide the project objective Objective This is a trans-disciplinary project that joins endocrinologists (“end-users”), radiologists (“end-users”), physicists who areexperts in medical photonics, engineers who are experts in photonics and ultrasonics and the industry to work towards aconcentrated goal - to produce a novel, point-of-care, low-cost, screening device that combines two photonics systems(near-infrared diffuse correlation spectroscopy (DCS) and time-resolved spectroscopy (TRS)) with a multi-modal ultrasound(US) system and a probe that enables multi-modal data acquisition for the screening of thyroid nodules (TN) for thyroidcancer (TC). TN are a common pathology having a prevalence of palpable nodules around 5% in women and 1% in men,that increases to 19-76% with the use of neck US. In screening thyroid nodules, to exclude thyroid cancer which occurs in5-15% of TN, the first step is the US followed by fine needle aspiration biopsy (FNAB) of suspicious nodules. The sensitivityand specificity of this process in thyroid cancer are limited, with a large number of non-diagnostic and false positive resultsthat lead to unnecessary surgeries. A reduction in the number of surgeries with a point-of-care diagnostic procedure wouldhave an important socio-economic impact, diminishing the number of thyroidectomies and the associated comorbidities. Thisimplies savings of millions of euros per year. Evidence shows that multi-modal approaches that include hemodynamicinformation leads to better specificity while each modality on its own fails. We hypothesize that a new optical-ultrasoundprobe and integrated system enabled by the development of novel, key enabling photonic components and sub-systems toprovide synergetic information on tissue morphology, composition and function will have a large impact in this field. Ouraction is directed by end-users who participate in the proposal and will be exploited by the industrial partners who cover thewhole value-chain. Fields of science medical and health sciencesclinical medicinerheumatologymedical and health sciencesclinical medicinenephrologymedical and health sciencesclinical medicinesurgerysurgical proceduresmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineneurology Keywords Oncology Radiology Thyroid Cancer ultrasonics biomedical optics Programme(s) H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT) Main Programme Topic(s) ICT-28-2015 - Cross-cutting ICT KETs Call for proposal H2020-ICT-2015 See other projects for this call Funding Scheme IA - Innovation action Coordinator FUNDACIO INSTITUT DE CIENCIES FOTONIQUES Net EU contribution € 1 048 730,37 Address Avinguda carl friedrich gauss 3 08860 Castelldefels Spain See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,01 Participants (8) Sort alphabetically Sort by Net EU contribution Expand all Collapse all POLITECNICO DI MILANO Italy Net EU contribution € 689 700,00 Address Piazza leonardo da vinci 32 20133 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain Net EU contribution € 230 625,00 Address Carrer rossello 149 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. HOSPITAL CLINIC DE BARCELONA Spain Net EU contribution € 123 138,75 Address Calle villarroel 170 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 HEMOPHOTONICS SL Spain Net EU contribution € 402 299,63 Address Avenida carl friedrich gauss 3 oficina 346 mediterranean technology park 08860 Castelldefels See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 172 414,12 VERMON SA France Net EU contribution € 188 630,75 Address 67 rue fromentel 37000 Tours See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centre — Val de Loire Centre — Val de Loire Indre-et-Loire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 80 841,75 IMV IMAGING FRANCE France Net EU contribution € 273 542,50 Address 126 boulevard de la republique 16000 Angouleme See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nouvelle-Aquitaine Poitou-Charentes Charente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 117 232,50 THE UNIVERSITY OF BIRMINGHAM United Kingdom Net EU contribution € 297 178,75 Address Edgbaston B15 2TT Birmingham See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG Austria Net EU contribution € 375 000,00 Address Am gestade 1 1010 Wien See on map Region Ostösterreich Wien Wien Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00