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Laser and Ultrasound Co-Analyzer for thyroid nodules

Objective

This is a trans-disciplinary project that joins endocrinologists (“end-users”), radiologists (“end-users”), physicists who are
experts in medical photonics, engineers who are experts in photonics and ultrasonics and the industry to work towards a
concentrated goal - to produce a novel, point-of-care, low-cost, screening device that combines two photonics systems
(near-infrared diffuse correlation spectroscopy (DCS) and time-resolved spectroscopy (TRS)) with a multi-modal ultrasound
(US) system and a probe that enables multi-modal data acquisition for the screening of thyroid nodules (TN) for thyroid
cancer (TC). TN are a common pathology having a prevalence of palpable nodules around 5% in women and 1% in men,
that increases to 19-76% with the use of neck US. In screening thyroid nodules, to exclude thyroid cancer which occurs in
5-15% of TN, the first step is the US followed by fine needle aspiration biopsy (FNAB) of suspicious nodules. The sensitivity
and specificity of this process in thyroid cancer are limited, with a large number of non-diagnostic and false positive results
that lead to unnecessary surgeries. A reduction in the number of surgeries with a point-of-care diagnostic procedure would
have an important socio-economic impact, diminishing the number of thyroidectomies and the associated comorbidities. This
implies savings of millions of euros per year. Evidence shows that multi-modal approaches that include hemodynamic
information leads to better specificity while each modality on its own fails. We hypothesize that a new optical-ultrasound
probe and integrated system enabled by the development of novel, key enabling photonic components and sub-systems to
provide synergetic information on tissue morphology, composition and function will have a large impact in this field. Our
action is directed by end-users who participate in the proposal and will be exploited by the industrial partners who cover the
whole value-chain.

Coordinator

FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Net EU contribution
€ 1 048 730,37
Address
Avinguda Carl Friedrich Gauss 3
08860 Castelldefels
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,01

Participants (8)

POLITECNICO DI MILANO
Italy
Net EU contribution
€ 689 700,00
Address
Piazza Leonardo Da Vinci 32
20133 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
Net EU contribution
€ 230 625,00
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Other
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

HOSPITAL CLINIC DE BARCELONA
Spain
Net EU contribution
€ 123 138,75
Address
Calle Villarroel 170
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
HEMOPHOTONICS SL
Spain
Net EU contribution
€ 402 299,63
Address
Avenida Carl Friedrich Gauss 3 Oficina 346 Mediterranean Technology Park
08860 Castelldefels

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 172 414,12
VERMON SA
France
Net EU contribution
€ 188 630,75
Address
67 Rue Fromentel
37000 Tours

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centre — Val de Loire Centre — Val de Loire Indre-et-Loire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 80 841,75
IMV IMAGING FRANCE
France
Net EU contribution
€ 273 542,50
Address
126 Boulevard De La Republique
16000 Angouleme

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nouvelle-Aquitaine Poitou-Charentes Charente
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 117 232,50
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Net EU contribution
€ 297 178,75
Address
Edgbaston
B15 2TT Birmingham

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Austria
Net EU contribution
€ 375 000,00
Non-EU contribution
€ 0,00