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Laser and Ultrasound Co-Analyzer for thyroid nodules

Deliverables

Dissemination and communication plan

Definition of LUCA dissemination plan.

Report on the dissemination activity Y3

Detailed annual reports describing the WP6 activities.

Preliminary Report on clinical validation

A report containing the final evaluation of the proposed LUCA system from a clinical view-point.

Project management and quality assurance plan

This document presents the project coordination aspects and the project supporting procedures. More specifically, it describes the knowledge base, which consists of procedures, tools and information needed to manage and support the project work activities. Finally, it contains sections devoted to Quality Plan and to the Risk Management Plan respectively. A risk register is presented.

Project Presentation

Project presentation and publishable report

Report on the dissemination activity Y4

Detailed annual reports describing the WP6 activities.

Preliminary Data analysis of healthy subjects

A report containing the scientific description of the measurement performed and of the results obtained with the proper data analysis procedures.

Report on the dissemination activity Y1

Detailed annual reports describing the WP6 activities.

Report on the dissemination activity Y2

Detailed annual reports describing the WP6 activities.

Data Management Plan

Data Management plan

Preliminary Data analysis of subjects with thyroid nodules

A report containing the scientific description of the measurement performed and of the results obtained with the proper data analysis procedures.

Communication kit update

Update of the leaflet presenting the main objectives of the project, the consortium, the activities and results and it will be distributed to national and international events as well as to the local workshops and the international conference.

Final communication kit

Final leaflet presenting the main objectives of the project, the consortium, the activities and results and it will be distributed to national and international events as well as to the local workshops and the international conference.

Approval by ethical committees

The official approvals by the local Ethics Committee.

Data Management Plan_new

A data management plan will be produced within the first three months of the project. The plan will include the following categories: Administrative data; type of data and collection method; documentation and metadata; ethics and legal compliance; storage and backup; deletion and preservation; data sharing, responsibilities and resources.

Provision of a optical-ultrasound phantom kit

A kit of phantoms that could be utilized for testing the probe and the systems.

Fully functional LUCA system

The fully functional LUCA system to be used as demonstrator.

Final LUCA demonstrator with upgrades

Demonstrator with upgrades

Project web site

Create and maintain a project web site in a .EU domain that will be regularly updated. It offers general information about the project, its partners and the ICT-Programme. LUCA website is used for the Consortium (Reserved Area), for dissemination towards stakeholders (Registered Area) and for public dissemination (Public Area).

Video

The video provides an overview of the LUCA project.

Dissemination material

Design and production of dissemination material (logo, templates, fact-sheet, project presentation, leaflet, poster) with a unified “look and feel”, establishing a “strong” project identity. The leaflet - presenting the main objectives of the project, the consortium, the activities and results - will be updated and it will be distributed to national and international events as well as to the local workshops and the international conference.

LUCA international innovation conference

(Before M48) International innovation conference in the field of 'Biomedical optics for Cancer Screening and Monitoring'.

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Publications

Monitoring the motor cortex hemodynamic response function in freely moving walking subjects: a time-domain fNIRS pilot study

Author(s): Michele Lacerenza, Lorenzo Spinelli, Mauro Buttafava, Alberto Dalla Mora, Franco Zappa, Antonio Pifferi, Alberto Tosi, Bruno Cozzi, Alessandro Torricelli, Davide Contini
Published in: Neurophotonics, Issue 8/01, 2021, ISSN 2329-423X
DOI: 10.1117/1.nph.8.1.015006

Instrument response function acquisition in reflectance geometry for time-resolved diffuse optical measurements

Author(s): Ileana Pirovano, Rebecca Re, Alessia Candeo, Davide Contini, Alessandro Torricelli, Lorenzo Spinelli
Published in: Biomedical Optics Express, Issue 11/1, 2020, Page(s) 240, ISSN 2156-7085
DOI: 10.1364/boe.11.000240

The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening

Author(s): Lorenzo Cortese, Giuseppe Lo Presti, Marta Zanoletti, Gloria Aranda, Mauro Buttafava, Davide Contini, Alberto Dalla Mora, Hamid Dehghani, Laura Di Sieno, Sixte de Fraguier, Felicia A. Hanzu, Mireia Mora Porta, An Nguyen-Dinh, Marco Renna, Bogdan Rosinski, Mattia Squarcia, Alberto Tosi, Udo M. Weigel, Stanislaw Wojtkiewicz, Turgut Durduran
Published in: Biomedical Optics Express, Issue 12/6, 2021, Page(s) 3392, ISSN 2156-7085
DOI: 10.1364/boe.416561

Self-calibrating time-resolved near infrared spectroscopy

Author(s): Stanislaw Wojtkiewicz, Anna Gerega, Marta Zanoletti, Aleh Sudakou, Davide Contini, Adam Liebert, Turgut Durduran, Hamid Dehghani
Published in: Biomedical Optics Express, Issue 10/5, 2019, Page(s) 2657, ISSN 2156-7085
DOI: 10.1364/boe.10.002657

In vivo time-domain diffuse correlation spectroscopy above the water absorption peak

Author(s): L. Colombo, M. Pagliazzi, S. Konugolu Venkata Sekar, D. Contini, T. Durduran, A. Pifferi
Published in: Optics Letters, Issue 45/13, 2020, Page(s) 3377, ISSN 0146-9592
DOI: 10.1364/ol.392355

Recipes for diffuse correlation spectroscopy instrument design using commonly utilized hardware based on targets for signal-to-noise ratio and precision

Author(s): Lorenzo Cortese, Giuseppe Lo Presti, Marco Pagliazzi, Davide Contini, Alberto Dalla Mora, Hamid Dehghani, Fabio Ferri, Jonas B. Fischer, Martina Giovannella, Fabrizio Martelli, Udo M. Weigel, Stanislaw Wojtkiewicz, Marta Zanoletti, Turgut Durduran
Published in: Biomedical Optics Express, Issue 12/6, 2021, Page(s) 3265, ISSN 2156-7085
DOI: 10.1364/boe.423071

Systematic study of the effect of ultrasound gel on the performances of time-domain diffuse optics and diffuse correlation spectroscopy

Author(s): Laura Di Sieno, Davide Contini, Giuseppe Lo Presti, Lorenzo Cortese, Tony Mateo, Bogdan Rosinski, Elena Venturini, Pietro Panizza, Mireia Mora, Gloria Aranda, Mattia Squarcia, Andrea Farina, Turgut Durduran, Paola Taroni, Antonio Pifferi, Alberto Dalla Mora
Published in: Biomedical Optics Express, Issue 10/8, 2019, Page(s) 3899, ISSN 2156-7085
DOI: 10.1364/boe.10.003899

Non-invasive estimation of intracranial pressure by diffuse optics – a proof-of-concept study

Author(s): Jonas B. Fischer, Ameer Ghouse, Susanna Tagliabue, Federica Maruccia, Anna Rey-Perez, Marcelino Báguena, Paola Cano, Riccardo Zucca, Udo M. Weigel, Juan Sahuquillo, Maria A. Poca, Turgut Durduran
Published in: Journal of Neurotrauma, Issue 37(23), 2020, Page(s) 2569-2579, ISSN 0897-7151
DOI: 10.1101/2020.05.21.20109256

Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease

Author(s): Clara Gregori-Pla, Rickson C. Mesquita, Christopher G. Favilla, David R. Busch, Igor Blanco, Peyman Zirak, Lisa Kobayashi Frisk, Stella Avtzi, Federica Maruccia, Giacomo Giacalone, Gianluca Cotta, Pol Camps-Renom, Michael T. Mullen, Joan Martí-Fàbregas, Luís Prats-Sánchez, Alejandro Martínez-Domeño, Scott E. Kasner, Joel H. Greenberg, Chao Zhou, Brian L. Edlow, Mary E. Putt, John A. Detre, A
Published in: BMC Neurology, Issue 21/1, 2021, ISSN 1471-2377
DOI: 10.1186/s12883-021-02179-8

Time-resolved near infrared light propagation using frequency domain superposition

Author(s): Stanislaw Wojtkiewicz, Turgut Durduran, Hamid Dehghani
Published in: Biomedical Optics Express, Issue 9/1, 2018, Page(s) 41, ISSN 2156-7085
DOI: 10.1364/boe.9.000041

Liquid phantoms for near-infrared and diffuse correlation spectroscopies with tunable optical and dynamic properties

Author(s): Lorenzo Cortese, Giuseppe Lo Presti, Marco Pagliazzi, Davide Contini, Alberto Dalla Mora, Antonio Pifferi, Sanathana Konugolu Venkata Sekar, Lorenzo Spinelli, Paola Taroni, Marta Zanoletti, Udo M. Weigel, Sixte de Fraguier, An Nguyen-Dihn, Bogdan Rosinski, Turgut Durduran
Published in: Biomedical Optics Express, Issue 9/5, 2018, Page(s) 2068, ISSN 2156-7085
DOI: 10.1364/BOE.9.002068

Broadband (550–1350 nm) diffuse optical characterization of thyroid chromophores

Author(s): Sanathana Konugolu Venkata Sekar, Andrea Farina, Alberto Dalla Mora, Claus Lindner, Marco Pagliazzi, Mireia Mora, Gloria Aranda, Hamid Dehghani, Turgut Durduran, Paola Taroni, Antonio Pifferi
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-27684-8

Eight-Wavelength, Dual Detection Channel Instrument for Near-Infrared Time-Resolved Diffuse Optical Spectroscopy

Author(s): Marco Renna, Mauro Buttafava, Anurag Behera, Marta Zanoletti, Laura Di Sieno, Alberto Dalla Mora, Davide Contini, Alberto Tosi
Published in: IEEE Journal of Selected Topics in Quantum Electronics, Issue 25/1, 2019, Page(s) 1-11, ISSN 1077-260X
DOI: 10.1109/jstqe.2018.2863570

A Compact Two-Wavelength Time-Domain NIRS System Based on SiPM and Pulsed Diode Lasers

Author(s): Mauro Buttafava, Edoardo Martinenghi, Davide Tamborini, Davide Contini, Alberto Dalla Mora, Marco Renna, Alessandro Torricelli, Antonio Pifferi, Franco Zappa, Alberto Tosi
Published in: IEEE Photonics Journal, Issue 9/1, 2017, Page(s) 1-14, ISSN 1943-0655
DOI: 10.1109/JPHOT.2016.2632061

Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems

Author(s): E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, A. Dalla Mora
Published in: Review of Scientific Instruments, Issue 87/7, 2016, Page(s) 073101, ISSN 0034-6748
DOI: 10.1063/1.4954968

Wearable and wireless time-domain near-infrared spectroscopy system for brain and muscle hemodynamic monitoring

Author(s): Michele Lacerenza, Mauro Buttafava, Marco Renna, Alberto Dalla Mora, Lorenzo Spinelli, Franco Zappa, Antonio Pifferi, Alessandro Torricelli, Alberto Tosi, Davide Contini
Published in: Biomedical Optics Express, Issue 11/10, 2020, Page(s) 5934, ISSN 2156-7085
DOI: 10.1364/boe.403327

Coherent fluctuations in time-domain diffuse optics

Author(s): Lorenzo Colombo, Saeed Samaei, Pranav Lanka, Daniele Ancora, Marco Pagliazzi, Turgut Durduran, Piotr Sawosz, Adam Liebert, Antonio Pifferi
Published in: APL Photonics, Issue 5/7, 2020, Page(s) 071301, ISSN 2378-0967
DOI: 10.1063/5.0011838

Time resolved speckle contrast optical spectroscopy at quasi-null source-detector separation for non-invasive measurement of microvascular blood flow

Author(s): Marco Pagliazzi, Lorenzo Colombo, Ernesto E. Vidal-Rosas, Tanja Dragojević, Veronika Parfentyeva, Joseph P. Culver, Sanathana Konugolu Venkata Sekar, Laura Di Sieno, Davide Contini, Alessandro Torricelli, Antonio Pifferi, Alberto Dalla Mora, Turgut Durduran
Published in: Biomedical Optics Express, Issue 12/3, 2021, Page(s) 1499, ISSN 2156-7085
DOI: 10.1364/boe.418882

The SiPM revolution in time-domain diffuse optics

Author(s): Alberto Dalla Mora, Laura Di Sieno, Anurag Behera, Paola Taroni, Davide Contini, Alessandro Torricelli, Antonio Pifferi
Published in: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Issue 978, 2020, Page(s) 164411, ISSN 0168-9002
DOI: 10.1016/j.nima.2020.164411

Neurodevelopmental profile in children with benign external hydrocephalus syndrome. A pilot cohort study

Author(s): Federica Maruccia, Laura Gomáriz, Katiuska Rosas, Turgut Durduran, Fernando Paredes-Carmona, Juan Sahuquillo, Maria A. Poca
Published in: Child's Nervous System, 2021, ISSN 0256-7040
DOI: 10.1007/s00381-021-05201-z

Novel Technologies for Time-Domain Diffuse Optics: Miniaturized Wearable Devices and Bioresorbable Optical Fibers

Author(s): Alberto Dalla Mora, Laura Di Sieno, Sanathana Konugolu Venkata Sekar, Andrea Farina, Davide Contini, Nadia G. Boetti, Daniel Milanese, Jan Nissinen, Antonio Pifferi
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) OF2D.6
DOI: 10.1364/ots.2018.of2d.6

Broadband (600-1100 nm) Diffuse Optical Characterization of Thyroid Tissue Constituents and Application to in vivo Thyroid Studies

Author(s): Sanathana Konugolu Venkata Sekar, Andrea Farina, Alberto Dalla Mora, Paola Taroni, Claus Lindner, Mireia Mora, Marco Pagliazzi, Mattia Squarcia, Irene Halperin, Felicia Hanzu, Hamid Dehghani, Turgut Durduran, Antonio Pifferi
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) CF2B.3
DOI: 10.1364/TRANSLATIONAL.2018.CF2B.3

Wearable time-domain near-infrared spectroscopy system

Author(s): Michele Lacerenza, Mauro Buttafava, Marco Renna, Alessandro Torricelli, Alberto Tosi, Alberto Dalla Mora, Franco Zappa, Antonio Pifferi, Davide Contini
Published in: Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables, Issue 11237, 2020, Page(s) 1
DOI: 10.1117/12.2544271

In vivo time-domain diffuse correlation spectroscopy of the human muscle above 1000 nm

Author(s): Lorenzo Colombo, M. Pagliazzi, Sanathana Konugolu Venkata Sekar, Davide Contini, Alberto Dalla Mora, Lorenzo Spinelli, Alessandro Torricelli, Turgut Durduran, Antonio Pifferi
Published in: Diffuse Optical Spectroscopy and Imaging VII, Issue EB101, 2019, Page(s) 104
DOI: 10.1117/12.2527065

Effects of ultrasound impedance matching fluids on diffuse optical measurements

Author(s): Laura Di Sieno, Davide Contini, Giuseppe Lo Presti, Lorenzo Cortese, Tony Mateo, Bogdan Rosinski, Elena Venturini, Pietro Panizza, Mireia Mora, Gloria Aranda, Mattia Squarcia, Andrea Farina, Turgut Durduran, Paola Taroni, Antonio Pifferi, Alberto Dalla Mora
Published in: Diffuse Optical Spectroscopy and Imaging VII, Issue EB101, 2019, Page(s) 102
DOI: 10.1117/12.2526925

The Curse of Big Data in Diffuse Optical Spectroscopic Tomography: The LUCA approach

Author(s): Hamid Dehghani, Stanislaw Wojtkiewicz
Published in: Biophotonics Congress: Biomedical Optics 2020 (Translational, Microscopy, OCT, OTS, BRAIN), 2020, Page(s) SM2D.3
DOI: 10.1364/ots.2020.sm2d.3

Multi-wavelength, dual-detection channel system for time-resolved near-infrared spectroscopy

Author(s): Marco Renna, Mauro Buttafava, Anurag Behera, Marta Zanoletti, Laura Di Sieno, Alberto Dalla Mora, Davide Contini, Alberto Tosi
Published in: Optical Tomography and Spectroscopy of Tissue XIII, Issue 10874, 2019, Page(s) 8
DOI: 10.1117/12.2509706