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Advanced MR methods for characterization of microstructural brain damage

Objective

NMR (Nuclear Magnetic Resonance)-based approaches have affirmed as extremely valuable for applications in neurosciences. Nonetheless, the exquisite flexibility of tissue contrast in magnetic resonance imaging (MRI) that can be obtained by proper manipulation of nuclear spins still offers room for technological improvements which can be quickly expanded to clinical routine. In particular, there is extreme need of imaging methods that allow a correct assessment of microstructural damage in many brain diseases, including – but not limited to – neurodegenerative diseases. Indeed, current MRI techniques suffer from poor specificity and ultimately lack the ability to identify the microscopic biophysical and biological mechanisms related to the specific features of the pathology.
This project aims at expanding the set of MR based techniques available to neuroscientists to characterize microstructural damage, assessing the usefulness of these approaches in some specific pathologies where they offer more promise. Notably, this project aims also at establishing the increased specificity and sensitivity of newly developed and current techniques when merged in a truly multiparametric analysis approach.
This project is heavily based on networking activities for exchanging the complimentary knowledge available at the different world-class academic and commercial EU and third country sites. The novel MRI pulse sequences and data analyses approaches tested and validated during the course of the project will be available at each site of the consortium, and will be made available to the scientific community as well.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /natural sciences/biological sciences/neurobiology
  • /natural sciences/biological sciences/neurobiology/neuroscience

Call for proposal

H2020-MSCA-RISE-2015
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI
Address
Via Panisperna 89/A
00184 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 162 000

Participants (5)

ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 90 000
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Masarykova univerzita
Czechia
EU contribution
€ 90 000
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
CHARLES RIVER DISCOVERY RESEARCH SERVICES FINLAND OY
Finland
EU contribution
€ 54 000
Address
Microkatu 1
70210 Kuopio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Czechia
EU contribution
€ 90 000
Address
Pekarska 53
656 91 Brno
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI SALERNO
Italy
EU contribution
€ 54 000
Address
Via Giovanni Paolo Ii 132
84084 Fisciano Sa
Activity type
Higher or Secondary Education Establishments

Partners (1)

REGENTS OF UNIVERSITY OF MINNESOTA
United States
Address
Oak Street Se 200 Mcnamara Alumni Center 450
55455 2070 Minneapolis Mn
Activity type
Higher or Secondary Education Establishments