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Advanced MR methods for characterization of microstructural brain damage

Objective

NMR (Nuclear Magnetic Resonance)-based approaches have affirmed as extremely valuable for applications in neurosciences. Nonetheless, the exquisite flexibility of tissue contrast in magnetic resonance imaging (MRI) that can be obtained by proper manipulation of nuclear spins still offers room for technological improvements which can be quickly expanded to clinical routine. In particular, there is extreme need of imaging methods that allow a correct assessment of microstructural damage in many brain diseases, including – but not limited to – neurodegenerative diseases. Indeed, current MRI techniques suffer from poor specificity and ultimately lack the ability to identify the microscopic biophysical and biological mechanisms related to the specific features of the pathology.
This project aims at expanding the set of MR based techniques available to neuroscientists to characterize microstructural damage, assessing the usefulness of these approaches in some specific pathologies where they offer more promise. Notably, this project aims also at establishing the increased specificity and sensitivity of newly developed and current techniques when merged in a truly multiparametric analysis approach.
This project is heavily based on networking activities for exchanging the complimentary knowledge available at the different world-class academic and commercial EU and third country sites. The novel MRI pulse sequences and data analyses approaches tested and validated during the course of the project will be available at each site of the consortium, and will be made available to the scientific community as well.

Coordinator

MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI
Net EU contribution
€ 162 000,00
Address
Via Panisperna 89/A
00184 Roma
Italy

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Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (5)

ITA-SUOMEN YLIOPISTO
Finland
Net EU contribution
€ 90 000,00
Address
Yliopistonranta 1 E
70211 Kuopio

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Masarykova univerzita
Czechia
Net EU contribution
€ 90 000,00
Address
Zerotinovo Namesti 9
601 77 Brno

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Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CHARLES RIVER DISCOVERY RESEARCH SERVICES FINLAND OY
Finland
Net EU contribution
€ 54 000,00
Address
Microkatu 1
70210 Kuopio

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Czechia
Net EU contribution
€ 90 000,00
Address
Pekarska 53
656 91 Brno

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Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI SALERNO
Italy
Net EU contribution
€ 54 000,00
Address
Via Giovanni Paolo Ii 132
84084 Fisciano Sa

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Region
Sud Campania Salerno
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

REGENTS OF UNIVERSITY OF MINNESOTA
United States
Net EU contribution
€ 0,00
Address
Oak Street Se 200 Mcnamara Alumni Center 450
55455 2070 Minneapolis Mn

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00