Novel natural products for healthy ageing from Mediterranean diet and food plants of other global sources

Deliverables

Websites, patent fillings, videos etc. (1)

Establishment of a website

A website for Medihealth project will be established and will publish project results and activities as well as disseminate information towards a general public and to industry. Specific web space will be available for the foreseen outreach activities of the consortium and information related to the already implemented ones.

Publications

Peer reviewed articles (7)

Phytochemical Analysis and Antioxidant Potential of the Phytonutrient-Rich Decoction of Cichorium spinosum and C. intybus

Author(s): Vincent Brieudes, Apostolis Angelis, Konstantina Vougogiannopoulou, Harris Pratsinis, Dimitris Kletsas, Sofia Mitakou, Maria Halabalaki, Leandros Skaltsounis
Published in: Planta Medica, 82/11/12, 2016, Page(s) 1070-1078, ISSN 0032-0943
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0042-107472

Inhibition of Pro-Inflammatory Functions of Human Neutrophils by Constituents of Melodorum fruticosum Leaves

Author(s): Nora S. Engels, Birgit Waltenberger, Barbara Michalak, Loi Huynh, Hung Tran, Anna K. Kiss, Hermann Stuppner
Published in: Chemistry & Biodiversity, 15/11, 2018, Page(s) e1800269, ISSN 1612-1872
Publisher: Verlag Helvetica Chimica Acta
DOI: 10.1002/cbdv.201800269

Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources—The MediHealth Project

Author(s): Waltenberger, Birgit; Halabalaki, Maria; Schwaiger, Stefan; Adamopoulos, Nicolas; Allouche, Noureddine; Fiebich, Bernd L; Hermans, Nina; Jansen-Dürr, Pidder; Kesternich, Victor; Pieters, Luc; Schönbichler, Stefan; Skaltsounis, Alexios-Leandros; Tran, Hung; Trougakos, Ioannis P; Viljoen, Alvaro; Wolfender, Jean-Luc; Wolfrum, Christian; Xynos, Nikos; Stuppner, Hermann
Published in: Molecules, 23(5), 2018, Page(s) 1097, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)

Phytochemical Composition of the Decoctions of Greek Edible Greens (Chórta) and Evaluation of Antioxidant and Cytotoxic Properties

Author(s): Eleni Mikropoulou, Konstantina Vougogiannopoulou, Eleftherios Kalpoutzakis, Aimilia Sklirou, Zoi Skaperda, Joëlle Houriet, Jean-Luc Wolfender, Ioannis Trougakos, Dimitrios Kouretas, Maria Halabalaki, Sofia Mitakou
Published in: Molecules, 23/7, 2018, Page(s) 1541, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23071541

Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing

Author(s): Sophia Wedel, Maria Manola, Maria Cavinato, Ioannis Trougakos, Pidder Jansen-Dürr
Published in: Molecules, 23/5, 2018, Page(s) 1219, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23051219

Proteome Stability as a Key Factor of Genome Integrity

Author(s): Sentiljana Gumeni, Zoi Evangelakou, Vassilis Gorgoulis, Ioannis Trougakos
Published in: International Journal of Molecular Sciences, 18/10, 2017, Page(s) 2036, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18102036

Extracts from the Mediterranean Food Plants Carthamus lanatus , Cichorium intybus , and Cichorium spinosum Enhanced GSH Levels and Increased Nrf2 Expression in Human Endothelial Cells

Author(s): Dimitrios Stagos, Dimitrios Balabanos, Salomi Savva, Zoi Skaperda, Alexandros Priftis, Efthalia Kerasioti, Eleni V. Mikropoulou, Konstantina Vougogiannopoulou, Sofia Mitakou, Maria Halabalaki, Demetrios Kouretas
Published in: Oxidative Medicine and Cellular Longevity, 2018, 2018, Page(s) 1-14, ISSN 1942-0900
Publisher: Landes Bioscience
DOI: 10.1155/2018/6594101

Conference proceedings (8)

EXPLORATION OF DIETARY PLANTS FROM WORLDWIDE BIODIVERSITY AIMING THE DISCOVERY OF ACTIVE AGENTS WITH ANTI-AGEING EFFECTS

Author(s): Maria-Eleni Sakavitsi, Zoi Evangelakou, Gabriela Belen Lemus Ringele, Amal Ghorbel, Aikaterini Argyropoulou, Victor Kesternich, Noureddine Allouche, Ioannis Trougakos, Maria Halabalaki, Leandros Skaltsounis
Published in: International Conference On Natural Products Utilization: from Plants to Farmacy Shelf (ICNPU 2017), Proceedings PP192, 2017, Page(s) 20
Publisher: ICNPU 2017

Phytochemical investigation of the Chilean berries Aristotelia chilensis and Ugni molinae. Evaluation of their anti-ageing effects employing a Drosophila model.

Author(s): ME Sakavitsi, Z Evangelakou, A Faúndez Catherine, G Lemus Belen Ringele, A Argyropoulou, V Kesternich, I Trougakos, M Halabalaki, A Skaltsounis Leandros
Published in: 65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA 2017), 2017
Publisher: Georg Thieme Verlag KG
DOI: 10.1055/s-0037-1608278

Sclerocarya birrea cortex ethanolic extract – Chemical characterisation and NOX4 inhibition (anti-ageing property)

Author(s): N Mncwangi, B Waltenberger, G Baraldo, P Jansen-Dürr, A Viljoen, H Stuppner
Published in: 65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA 2017), 2017
Publisher: Georg Thieme Verlag KG
DOI: 10.1055/s-0037-1608258

MediHealth – an interdisciplinary and international research and innovation staff exchange project to identify novel natural products for healthy ageing

Author(s): B Waltenberger, N Adamopoulos, N Allouche, B Fiebich, M Halabalaki, P Jansen-Dürr, V Kesternich, L Pieters, S Schönbichler, LA Skaltsounis, H Tran, IP Trougakos, A Viljoen, J-L Wolfender, C Wolfrum, N Xynos, H Stuppner
Published in: 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP, 85(18), 2019, Page(s) 1572
Publisher: Georg Thieme Verlag KG
DOI: 10.1055/s-0039-3400404

Novel natural products for healthy ageing from Mediterranean diet and food plants of other global sources - the MediHealth project

Author(s): Waltenberger B., Adamopoulos N., Allouche N., Fiebich B., Halabalaki M., Heinke R., Jansen-Dürr P., Kesternich V., Pieters L., Queiroz E.F., Schönbichler S., Schwaiger S., Skaltsounis A.-L., Tran H., Trougakos I.P., Viljoen A., Wolfender J.-L., Wolfrum C., Xynos N., Stuppner H.
Published in: PHYTO Valley - First Austrian Summit on Natural Products, 2018
Publisher: Phytovalley

Simulating Human Gastrointestinal and colonic biotransformation pathways through and in vitro assay reveals insight on hydroxytyrosol and oleuropein metabolism

Author(s): ME Sakavitsi, A Breynaert, A Angelis, L Pieters, N Hermans, S Mitakou, M Halabalaki
Published in: Young Researchers Workshop GA 2019, 2019
Publisher: Thieme

Simulating human gastrointestinal and colonic biotranformation pathways through an in vitro assay reveals insight on hydroxytyrosol and oleuropein metabolism

Author(s): ME Sakavitsi, A Breynaert, A Angelis, L Pieters, N Hermans, S Mitakou, M Halabalaki
Published in: 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP, 2019
Publisher: © Georg Thieme Verlag KG
DOI: 10.1055/s-0039-3399660

A holistic UPLC-HRMS-based approach exploring the phytochemistry, bioactivity and metabolome impact of Cichorium spinosum’ s decoction in Drosophila melanogaster

Author(s): EV Mikropoulou, Z Evangelakou, M Manola, S Gumeni, IP Trougakos, LA Skaltsounis, M Halabalaki
Published in: 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP, 2019
Publisher: © Georg Thieme Verlag KG
DOI: 10.1055/s-0039-3399823

Other (3)

Nrf2 as a central hub in the wiring of proteostatic, mitostatic and metabolic pathways

Author(s): Ioannis P. Trougakos
Published in: 68th Panhellenic Congress of the Greek Biochemical and Molecular Biology Society, Proceedings Lecture 14, 2017, Page(s) 12
Publisher: Greek Biochemical and Molecular Biology Society

Proteostasis network deregulation as a main molecular link of ageing and carcinogenesis

Author(s): Ioannis P. Trougakos
Published in: 39th ANNUAL CONFERENCE OF THE HELLENIC SOCIETY FOR BIOLOGICAL SCIENCES, Proceedings Lecture, 2017
Publisher: HELLENIC SOCIETY FOR BIOLOGICAL SCIENCES

Nrf2 as a main hub in the wiring of proteostatic, mitostatic and metabolic pathways

Author(s): Eleni N. Tsakiri, Sentiljana Gumeni, Kalliopi K. Iliaki, Dimitra Benaki, Konstantinos Vougas, Gerasimos P. Sykiotis, Vassilis G. Gorgoulis, Emmanuel Mikros, Luca Scorrano and Ioannis P. Trougakos
Published in: COST Action BM1307 PROTEOSTASIS, Proteostatic Mechanisms in Health & Disease, Proceedings Oral Presentation, 2018
Publisher: The Final COST Action BM1307 Meeting

Book chapters (2)

Chapter 6: Impact of Loss of Proteostasis on Central Nervous System Disorders

Author(s): Sentiljana Gumeni, Eleni N. Tsakiri, Christina-Maria Cheimonidi, Zoi Evangelakou, Despoina Gianniou, Kostantinos Tallas, Eleni-Dimitra Papanagnou, Aimilia D. Sklirou, Ioannis P. Trougakos
Published in: Protein Folding Disorders of the Central Nervous System, 2017, Page(s) 131-162, ISBN 978-981-3222-95-3
Publisher: World Scientific Publishing
DOI: 10.1142/9789813222960_0006

Chapter 8: Impact of Mitostasis and the Role of the Anti-oxidant Responses on Central Nervous System Disorders

Author(s): Sentiljana Gumeni, Eleni N. Tsakiri, Christina-Maria Cheimonidi, Zoi Evangelakou, Despoina Gianniou, Kostantinos Tallas, Eleni-Dimitra Papanagnou, Aimilia D. Sklirou, Ioannis P. Trougakos
Published in: Protein Folding Disorders of the Central Nervous System, 2017, Page(s) 185-201, ISBN 978-981-3222-95-3
Publisher: World Scientific Publishing
DOI: 10.1142/9789813222960_0008