Genetic Determinants of the Epigenome

Project Information

Gen-Epix

Grant agreement ID: 694295

DOI 10.3030/694295

Project closed

EC signature date 30 May 2016

Start date 1 June 2016

End date 30 June 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 717,00

EU contribution € 2 499 717,00

Coordinated by

THE UNIVERSITY OF EDINBURGH
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Convergent cerebrosespinal fluid proteomes and metabolic ontologies in humans and animal models of Rett Syndrome

Author(s): Bird, Adrian
Published in: iScience 25; doi: https://doi.org/10.1016/j.isci.2022.104966, 2022, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1101/2022.06.14.495968

Comparative analysis of potential broad-spectrum neuronal Cre drivers

Author(s): Paton KM, Selfridge J, Guy J and Bird A
Published in: Wellcome Open Research, Issue Wellcome Open Res 2022, 7:185, 2022, ISSN 2398-502X
Publisher: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.17965.1

The Molecular Basis of MeCP2 Function in the Brain

Author(s): Tillotson, R., Bird, A.
Published in: J Mol Biol, 2019, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.10.004

Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing.

Author(s): Kashyap Chhatbar; Justyna Cholewa-Waclaw; Ruth Shah; Adrian Bird; Guido Sanguinetti; Guido Sanguinetti
Published in: PLoS Genetics, Issue 2, 2020, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1009087

Genetic therapies for neurological disorders

Author(s): FitzPatrick, L., Bird, A.
Published in: Hum Genet, 2022, ISSN 0340-6717
Publisher: Springer Verlag
DOI: 10.1007/s00439-021-02399-5

Absence of MeCP2 binding to non-methylated GT-rich sequences in vivo

Author(s): John C. Connelly; Justyna Cholewa-Waclaw; Shaun Webb; Verdiana Steccanella; Bartlomiej Waclaw; Adrian Bird
Published in: Connelly , J C , Cholewa-waclaw , J , Webb , S , Steccanella , V , Waclaw , B & Bird , A 2020 , ' Absence of MeCP2 binding to non-methylated GT-rich sequences in vivo ' , Nucleic Acids Research . https://doi.org/10.1093/nar/gkaa102, Issue 1, 2020, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa102

CDKL5 deficiency disorder: a pathophysiology of neural maintenance

Author(s): Kind P., Bird, A
Published in: J Clin Invest, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci153606

Genetic determinants of the epigenome in development and cancer

Author(s): Bird, Adrian
Published in: Swiss Medical Weekly, Issue 147/4142, 2017, Page(s) 1-6, ISSN 1424-7860
Publisher: EMH Swiss Medical Publishers Ltd
DOI: 10.4414/smw.2017.14523

The Selfishness of Law-Abiding Genes

Author(s): Adrian Bird
Published in: Trends in Genetics, Issue 36/1, 2020, Page(s) 8-13, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2019.10.002

DNA Methylation: Mega-Year Inheritance with the Help of Darwin

Author(s): Bird, A.
Published in: Curr Biol, 2020, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.02.034

Neuronal non-CG methylation is an essential target for MeCP2 function

Author(s): Tillotson, R., Cholewa-Waclaw, J., Chhatbar, K., Connelly, J. C., Kirschner, S. A., Webb, S., Koerner, M. V., Selfridge, J., Kelly, D.A., De Sousa, D., Brown, K., Lyst, M.J., Kriaucionis, S., Bird, A.
Published in: Mol Cell, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.01.011

SALL4 controls cell fate in response to DNA base composition

Author(s): Pantier, R., Chhatbar, K., Quante, T., Skourti-Stathaki, K., Cholewa-Waclaw, J., Alston, G. Alexander-Howden, B., Lee, H. Y., Cook, A. G., Spruijt, C. G., Vermeulen, M., Selfridge, J., Bird, A.
Published in: Mol Cell, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.11.046

Evaluation of CA repeat arrays as targets for MeCP2 function in the brain

Author(s): Chhatbar, K., Bird, A.
Published in: bioRxiv 2022.04.26.489598, 2022, ISSN 2575-1077
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.04.26.489598

High-throughput sequencing SELEX for the determination of DNA-binding protein specificities in vitro

Author(s): Raphaël Pantier; Kashyap Chhatbar; Grace Alston; Heng Yang Lee; Adrian Bird
Published in: Pantier , R , Chhatbar , K , Alston , G , Lee , H Y & Bird , A 2022 , ' High-throughput sequencing SELEX for the determination of DNA-binding protein specificities in vitro ' , Star Protocols , vol. 3 , no. 3 , 101490 . https://doi.org/10.1016/j.xpro.2022.101490, Issue 2, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.xpro.2022.101490