Blood Vessel Development and Homeostasis: Identification and Functional Analysis of Genetic Modifiers

Project Information

ZMOD

Grant agreement ID: 694455

DOI

10.3030/694455

Project closed

EC signature date 21 June 2016

Start date 1 October 2016

End date 30 September 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

Author(s): Giulia LM Boezio, Anabela Bensimon-Brito, Janett Piesker, Stefan Guenther, Christian SM Helker, Didier YR Stainier
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.57603

Parental mutations influence wild-type offspring via transcriptional adaptation

Author(s): Zhen Jiang, Mohamed A El-Brolosy, Vahan Serobyan, Jordan M Welker, Nicholas Retzer, Christopher M Dooley, Gabrielius Jakutis, Thomas Juan, Nana Fukuda, Hans-Martin Maischein, Darius Balciunas, Didier Y R Stainier
Published in: Science Advances, Issue 8, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science - AAAS
DOI: 10.1126/sciadv.abj2029

Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state

Author(s): Christian S.M. Helker, Jean Eberlein, Kerstin Wilhelm, Toshiya Sugino, Julian Malchow, Annika Schuermann, Stefan Baumeister, Hyouk-Bum Kwon, Hans-Martin Maischein, Michael Potente, Wiebke Herzog, Didier Y.R. Stainier
Published in: eLife, Issue 10, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55589

Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures.

Author(s): Konstantinos Gkatzis, Paolo Panza, Sofia Peruzzo, Didier Y.R. Stainier
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.65811

Partial sequence identity in a 25-nucleotide long element is sufficient for transcriptional adaptation in the Caenorhabditis elegans act-5/act-3 model

Author(s): Jordan M. Welker, Vahan Serobyan, Elhamalsadat Zaker Esfahani, Didier Y. R. Stainier
Published in: PLoS Genetics, Issue 19, 2023, ISSN 1553-7404
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1010806

Induction of interferon-stimulated genes and cellular stress pathways by morpholinos in zebrafish

Author(s): Jason K.H. Lai, Kristina K. Gagalova, Carsten Kuenne, Mohamed A. El-Brolosy, Didier Y.R. Stainier
Published in: Developmental Biology, 2019, ISSN 0012-1606
Publisher: Academic Press
DOI: 10.1016/j.ydbio.2019.06.008

Genetic compensation triggered by mutant mRNA degradation

Author(s): Mohamed A. El-Brolosy, Zacharias Kontarakis, Andrea Rossi, Carsten Kuenne, Stefan Günther, Nana Fukuda, Khrievono Kikhi, Giulia L. M. Boezio, Carter M. Takacs, Shih-Lei Lai, Ryuichi Fukuda, Claudia Gerri, Antonio J. Giraldez, Didier Y. R. Stainier
Published in: Nature, Issue 568/7751, 2019, Page(s) 193-197, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1064-z

Immune responses in cardiac repair and regeneration: a comparative point of view

Author(s): Shih-Lei Lai, Rubén Marín-Juez, Didier Y. R. Stainier
Published in: Cellular and Molecular Life Sciences, Issue 76/7, 2019, Page(s) 1365-1380, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-018-2995-5

The Max Planck Institute for Heart and Lung Research Curiosity-Driven Basic Research to Fight Cardio-Pulmonary Diseases

Author(s): Thomas Braun, Stefan Offermanns, Didier Y.R. Stainier, Werner Seeger
Published in: Circulation Research, Issue 120/9, 2017, Page(s) 1386-1389, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.310763

Transcriptional adaptation in Caenorhabditis elegans

Author(s): Vahan Serobyan, Zacharias Kontarakis, Mohamed A El-Brolosy, Jordan M Welker, Oleg Tolstenkov, Amr M Saadeldein, Nicholas Retzer, Alexander Gottschalk, Ann M Wehman, Didier YR Stainier
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.50014

Tek (Tie2) is not required for cardiovascular development in zebrafish

Author(s): Zhen Jiang, Claudia Carlantoni, Srinivas Allanki, Ingo Ebersberger, Didier Y.R. Stainier
Published in: Development, Issue 147, 2020, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.193029

Other (6)

Genetics in Light of Transcriptional Adaptation.

Author(s): Zacharias Kontarakis, Didier Y.R. Stainier
Published in: Trends in Genetics, Issue 36, 2020, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2020.08.008

Genotype–Phenotype Relationships in the Context of Transcriptional Adaptation and Genetic Robustness

Author(s): Gabrielius Jakutis, Didier Y.R. Stainier
Published in: Annual Review of Genetics, Issue 55/1, 2021, Page(s) 71-91, ISSN 0066-4197
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-genet-071719-020342

Genetic compensation: A phenomenon in search of mechanisms

Author(s): Mohamed A. El-Brolosy, Didier Y. R. Stainier
Published in: PLOS Genetics, Issue 13/7, 2017, Page(s) e1006780, ISSN 1553-7404
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1006780

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

Author(s): Benjamin E. Housden, Matthias Muhar, Matthew Gemberling, Charles A. Gersbach, Didier Y. R. Stainier, Geraldine Seydoux, Stephanie E. Mohr, Johannes Zuber, Norbert Perrimon
Published in: Nature Reviews Genetics, Issue 18/1, 2017, Page(s) 24-40, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/nrg.2016.118

Recent insights into vascular development from studies in zebrafish

Author(s): Ryota L. Matsuoka, Didier Y.R. Stainier
Published in: Current Opinion in Hematology, 2018, Page(s) 1, ISSN 1065-6251
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/moh.0000000000000420

Transcriptional adaptation: a mechanism underlying genetic robustness

Author(s): Tamar E. Sztal, Didier Y. R. Stainier
Published in: Development, Issue 147/15, 2020, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.186452