CLONAL AND CELLULAR HETEROGENEITY OF BREAST CANCER AND ITS DYNAMIC EVOLUTION WITH TREATMENT

Project Information

CLONCELLBREAST

Grant agreement ID: 694620

DOI 10.3030/694620

Project closed

EC signature date 10 May 2016

Start date 1 January 2017

End date 30 June 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 497 660,00

EU contribution € 2 497 660,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Publications

Peer reviewed articles (9)

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

Author(s): Rajbir Nath Batra, Aviezer Lifshitz, Ana Tufegdzic Vidakovic, Suet-Feung Chin, Ankita Sati-Batra, Stephen-John Sammut, Elena Provenzano, H. Raza Ali, Ali Dariush, Alejandra Bruna, Leigh Murphy, Arnie Purushotham, Ian Ellis, Andrew Green, Francine E. Garrett-Bakelman, Chris Mason, Ari Melnick, Samuel A. J. R. Aparicio, Oscar M. Rueda, Amos Tanay, Carlos Caldas
Published in: Nature Communications, Issue 12, 2021, Page(s) 5406, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25661-w

Tumor diversity and the trade-off between universal cancer tasks

Author(s): Jean Hausser, Pablo Szekely, Noam Bar, Anat Zimmer, Hila Sheftel, Carlos Caldas, Uri Alon
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13195-1

Functional genomics approaches to improve pre-clinical drug screening and biomarker discovery

Author(s): Long V Nguyen, Carlos Caldas
Published in: EMBO Molecular Medicine, Issue 13, 2021, Page(s) e13189, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013189

Deciphering the signaling network of breast cancer improves drug sensitivity prediction

Author(s): Marco Tognetti, Attila Gabor, Mi Yang, Valentina Cappelletti, Jonas Windhager, Oscar M. Rueda, Konstantina Charmpi, Elham Esmaeilishirazifard, Alejandra Bruna, Natalie de Souza, Carlos Caldas, Andreas Beyer, Paola Picotti, Julio Saez-Rodriguez, Bernd Bodenmiller
Published in: Cell Systems, Issue 12/5, 2021, Page(s) 401-418.e12, ISSN 2405-4712
Publisher: Cell
DOI: 10.1016/j.cels.2021.04.002

Multi-omic machine learning predictor of breast cancer therapy response

Author(s): Stephen-John Sammut, Mireia Crispin-Ortuzar, Suet-Feung Chin, Elena Provenzano, Helen A. Bardwell, Wenxin Ma, Wei Cope, Ali Dariush, Sarah-Jane Dawson, Jean E. Abraham, Janet Dunn, Louise Hiller, Jeremy Thomas, David A. Cameron, John M. S. Bartlett, Larry Hayward, Paul D. Pharoah, Florian Markowetz, Oscar M. Rueda, Helena M. Earl , Carlos Caldas
Published in: Nature, Issue 601, 2022, Page(s) 623-629, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04278-5

Breast tumor microenvironment structures are associated with genomic features and clinical outcome

Author(s): Esther Danenberg, Helen Bardwell, Vito R. T. Zanotelli, Elena Provenzano, Suet-Feung Chin, Oscar M. Rueda, Andrew Green, Emad Rakha, Samuel Aparicio, Ian O. Ellis, Bernd Bodenmiller, Carlos Caldas, H. Raza Ali
Published in: Nature Genetics, Issue 54, 2022, Page(s) 660-669, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01041-y

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

Author(s): Dimitra Georgopoulou, Maurizio Callari, Oscar M. Rueda, Abigail Shea, Alistair Martin, Agnese Giovannetti, Fatime Qosaj, Ali Dariush, Suet-Feung Chin, Larissa S. Carnevalli, Elena Provenzano, Wendy Greenwood, Giulia Lerda, Elham Esmaeilishirazifard, Martin O’Reilly, Violeta Serra, Dario Bressan, Gordon B. Mills, H. Raza Ali, Sabina S. Cosulich, Gregory J. Hannon, Alejandra Bruna, Carlos Caldas
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22303-z

TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis

Author(s): Mary L. Uribe, Maik Dahlhoff, Rajbir N. Batra, Nishanth B. Nataraj, Yuya Haga, Diana Drago-Garcia, Ilaria Marrocco, Arunachalam Sekar, Soma Ghosh, Itay Vaknin, Sacha Lebon, Lior Kramarski, Yasuo Tsutsumi, Inpyo Choi, Oscar M. Rueda, Carlos Caldas, Yosef Yarden
Published in: Science Signaling, Issue 14/688, 2021, Page(s) eabe6156, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abe6156

The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

Author(s): Leticia De Mattos-Arruda, Stephen-John Sammut, Edith M Ross, Rachael Bashford-Rogers, Erez Greenstein, Havell Markus, Sandro Morganella, Yvonne Teng, Yosef Maruvka, Bernard Pereira, Oscar M Rueda, Suet-Feung Chin, Tania Contente-Cuomo, Regina Mayor, Alexandra Arias, H Raza Ali, Wei Cope, Daniel Tiezzi, Aliakbar Dariush, Tauanne Dias Amarante, Dan Reshef, Nikaoly Ciriaco, Elena Martinez-Saez, Vicen
Published in: Cell Reports, Issue 27, 2019, Page(s) 2690-2708, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.04.098