Chromatin Adaptations through Interactions of Chaperones in Time

Project Information

ChromADICT

Grant agreement ID: 694694

DOI

10.3030/694694

Project closed

EC signature date 13 June 2016

Start date 1 July 2016

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 697,00

EU contribution

€ 2 499 697,00

Coordinated by

INSTITUT CURIE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (31)

CENP-A Regulation and Cancer

Author(s): Charlène Renaud-Pageot, Jean-Pierre Quivy, Marina Lochhead, Geneviève Almouzni
Published in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.907120

JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability

Author(s): Francisco Saavedra, Zachary A. Gurard-Levin, Camila Rojas-Villalobos, Isabelle Vassias, Raquel Quatrini, Geneviève Almouzni, Alejandra Loyola
Published in: Epigenetics & Chromatin, Issue 13/1, 2020, ISSN 1756-8935
Publisher: BioMed Central
DOI: 10.1186/s13072-020-00331-1

Regulation of replicative histone RNA metabolism by the histone chaperone ASF1

Author(s): Shweta Mendiratta, Dominique Ray-Gallet, Sébastien Lemaire, Alberto Gatto, Audrey Forest, Maciej A. Kerlin, Geneviève Almouzni
Published in: Molecular Cell, 2024, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.12.038

The cell-cycle choreography of H3 variants shapes the genome

Author(s): Kamila Delaney, Nicole Weiss , Geneviève Almouzni
Published in: Mollecular Cell, 2023, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.08.030

HIRA-dependent boundaries between H3 variants shape early replication in mammals

Author(s): Alberto Gatto, Audrey Forest, Jean-Pierre Quivy, Geneviève Almouzni
Published in: Molecular Cell, 2022, ISSN 1097-4172
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.03.017

Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription

Author(s): Júlia Torné, Dominique Ray-Gallet, Ekaterina Boyarchuk, Mickaël Garnier, Patricia Le Baccon, Antoine Coulon, Guillermo A. Orsi, Geneviève Almouzni
Published in: Nature Structural & Molecular Biology, Issue 27/11, 2020, Page(s) 1057-1068, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-020-0492-7

Transcription-coupled H3.3 recycling: A link with chromatin states

Author(s): Kamila Delaney, Geneviève Almouzni
Published in: Seminars in Cell and Developmental Biology, 2023, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2022.05.003

Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise

Author(s): Daphné Morel, Daniel Jeffery, Sandrine Aspeslagh, Geneviève Almouzni, Sophie Postel-Vinay
Published in: Nature Reviews Clinical Oncology, Issue 17/2, 2020, Page(s) 91-107, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-019-0267-4

La surexpression CENP-A entraîne des destins cellulaires distincts en fonction du statut p53

Author(s): Jeffery, Daniel; Podsypanina, Katrina; Gatto, Alberto; Landete, Rebeca Ponce; Bonneville, Lorraine; Dumont, Marie; Fachinetti, Daniele; Almouzni, Geneviève
Published in: Communications Biology, Issue 1, 2021, ISSN 2399-3642
Publisher: Nature
DOI: 10.1038/s42003-021-01941-5

LifeTime and improving European healthcare through cell-based interceptive medicine

Author(s): Rajewsky N *, Almouzni G *, Gorski S A. *, Aerts S, Amit I, Bertero M G., Bock C, Bredenoord A L., Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernandez X M., Figlerowicz M, Gasser S M., Hubner N, Kjems J, Knoblich J A., Krabbe G, Lichter P, Linnarsson S, Marine J-C, Marioni J, Marti- Renom M A. , Netea M G., Nickel D, Nollmann M, Novak H R., Parkinson H, Piccolo S, Pinh
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2715-9

The epigenetic control of stemness in CD8+ T cell fate commitment

Author(s): Luigia Pace, Christel Goudot, Elina Zueva, Paul Gueguen, Nina Burgdorf, Joshua J. Waterfall, Jean-Pierre Quivy, Geneviève Almouzni, Sebastian Amigorena
Published in: Science, 2018, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aah6499

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

Author(s): Song My Hoang, Nicole Kaminski, Ragini Bhargava, Jonathan Barroso-González, Michelle L. Lynskey, Laura García-Expósito, Justin L. Roncaioli, Anne R. Wondisford, Callen T. Wallace, Simon C. Watkins, Dominic I. James, Ian D. Waddell, Donald Ogilvie, Kate M. Smith, Felipe da Veiga Leprevost, Dattatreya Mellacharevu, Alexey I. Nesvizhskii, Jianfeng Li, Dominique Ray-Gallet, Robert W. Sobol, Genevie
Published in: Nature Structural & Molecular Biology, Issue 27/12, 2020, Page(s) 1152-1164, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-020-0512-7

H3–H4 histone chaperones and cancer

Author(s): Dominique, Ray-Gallet; Geneviève, Almouzni
Published in: Current opinion in genetics & development, Issue 1, 2022, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2022.101900

Essential role for centromeric factors following p53 loss and oncogenic transformation

Author(s): Dan Filipescu, Monica Naughtin, Katrina Podsypanina, Vincent Lejour, Laurence Wilson, Zachary A. Gurard-Levin, Guillermo A. Orsi, Iva Simeonova, Eleonore Toufektchan, Laura D. Attardi, Franck Toledo, Geneviève Almouzni
Published in: Genes & Development, Issue 31/5, 2017, Page(s) 463-480, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.290924.116

Shaping Chromatin in the Nucleus: The Bricks and the Architects

Author(s): David Sitbon, Katrina Podsypanina, Tejas Yadav, Geneviève Almouzni
Published in: Cold Spring Harbor Symposia on Quantitative Biology, 2017, Page(s) 033753, ISSN 0091-7451
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/sqb.2017.82.033753

PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4

Author(s): Francisco Saavedra, Carlos Rivera, Elizabeth Rivas, Paola Merino, Daniel Garrido, Sergio Hernández, Ignasi Forné, Isabelle Vassias, Zachary A. Gurard-Levin, Iván E. Alfaro, Axel Imhof, Geneviève Almouzni, Alejandra Loyola
Published in: Nucleic Acids Research, Issue 45/20, 2017, Page(s) 11700-11710, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx775

Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

Author(s): Dominique Ray-Gallet, M. Daniel Ricketts, Yukari Sato, Kushol Gupta, Ekaterina Boyarchuk, Toshiya Senda, Ronen Marmorstein, Geneviève Almouzni
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05581-y

Chromatin plasticity: A versatile landscape that underlies cell fate and identity

Author(s): Tejas Yadav, Jean-Pierre Quivy, Geneviève Almouzni
Published in: Science, Issue 361/6409, 2018, Page(s) 1332-1336, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aat8950

High-resolution visualization of H3 variants during replication reveals their controlled recycling

Author(s): Camille Clément, Guillermo A. Orsi, Alberto Gatto, Ekaterina Boyarchuk, Audrey Forest, Bassam Hajj, Judith Miné-Hattab, Mickaël Garnier, Zachary A. Gurard-Levin, Jean-Pierre Quivy, Geneviève Almouzni
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05697-1

Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure

Author(s): Marie-Therese El-Daher, Nicolas Cagnard, Marine Gil, Marie Chansel Da Cruz, Claire Leveau, Fernando Sepulveda, Mohammed Zarhrate, Frédéric Tores, Patricia Legoix, Sylvain Baulande, Jean Pierre de Villartay, Geneviève Almouzni, Jean-Pierre Quivy, Alain Fischer, Geneviève de Saint Basile
Published in: Cell Discovery, Issue 4/1, 2018, ISSN 2056-5968
Publisher: Springer Nature
DOI: 10.1038/s41421-018-0061-y

Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

Author(s): Paul Victor Sauer, Jennifer Timm, Danni Liu, David Sitbon, Elisabetta Boeri-Erba, Christophe Velours, Norbert Mücke, Jörg Langowski, Françoise Ochsenbein, Geneviève Almouzni, Daniel Panne
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.23474

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

Author(s): Roberto Bellelli, Ondrej Belan, Valerie E. Pye, Camille Clement, Sarah L. Maslen, J. Mark Skehel, Peter Cherepanov, Genevieve Almouzni, Simon J. Boulton
Published in: Molecular Cell, Issue 72/1, 2018, Page(s) 112-126.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.08.043

Histone supply: Multitiered regulation ensures chromatin dynamics throughout the cell cycle

Author(s): Shweta Mendiratta, Alberto Gatto, Genevieve Almouzni
Published in: The Journal of Cell Biology, 2018, Page(s) jcb.201807179, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201807179

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Author(s): Suk Min Jang, Annamaria Kauzlaric, Jean-Pierre Quivy, Julien Pontis, Benjamin Rauwel, Andrea Coluccio, Sandra Offner, Julien Duc, Priscilla Turelli, Geneviève Almouzni, Didier Trono
Published in: Nucleic Acids Research, Issue 46/17, 2018, Page(s) 8788-8802, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky580

HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes

Author(s): Maëlle Locatelli; Jean-Pierre Quivy; Fleur Chapus; Maud Michelet; Judith Fresquet; Sarah Maadadi; Amel Neila Aberkane; Audrey Diederichs; Julie Lucifora; Michel Rivoire; Geneviève Almouzni; Barbara Testoni; Fabien Zoulim
Published in: "Cellular and Molecular Gastroenterology and Hepatology, 2022, 14, pp.527 - 551. ⟨10.1016/j.jcmgh.2022.05.007⟩", Issue 1, 2022, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.05.007

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells

Author(s): Charles Ng, Martin Aichinger, Tung Nguyen, Christy Au, Tariq Najar, Lin Wu, Kai R. Mesa, Will Liao, Jean-Pierre Quivy, Benjamin Hubert, Genevieve Almouzni, Johannes Zuber, Dan R. Littman
Published in: Genes & Development, Issue 33/11-12, 2019, Page(s) 669-683, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.322024.118

Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches

Author(s): Brendan Evano, Sara Khalilian, Gilles Le Carrou, Geneviève Almouzni, Shahragim Tajbakhsh
Published in: Cell Reports, Issue 30/10, 2020, Page(s) 3195-3206.e7, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.01.097

Disordered regions and folded modules in CAF-1 promote histone deposition in<i>S. pombe</i>

Author(s): Fouad Ouasti; Maxime Audin; Karine Freon; Jean-Pierre Quivy; Mehdi Tachekort; Elizabeth Cesard; Aurélien Thureau; Virginie Ropars; Paloma F. Varela; Gwenaelle Moal; Ibrahim Soumana Amadou; Aleksandra Uryga; Pierre Legrand; Jessica Andreani; Raphael Guerois; Geneviève Almouzni; Sarah Lambert; Francoise Ochsenbein
Published in: Elife, Issue 1, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2023.06.02.543505

CENP-A Subnuclear Localization Pattern as Marker Predicting Curability by Chemoradiation Therapy for Locally Advanced Head and Neck Cancer Patients

Author(s): Pierre Verrelle; Didier Meseure; Frédérique Berger; Audrey Forest; Renaud Leclere; André Nicolas; Emilie Fortas; Xavier Sastre-Garau; Marick Laé; Sabah Boudjemaa; Rodrigue Mbagui; Valentin Calugaru; Dalila Labiod; Leanne de Koning; Geneviève Almouzni; Jean-Pierre Quivy
Published in: Cancers, Issue 1, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13163928

CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

Author(s): Niborski Leticia Laura, Gueguen Paul, Ye Mengliang, Thiolat Allan, Ramos Rodrigo Nalio, Caudana Pamela, Denizeau Jordan, Colombeau Ludovic, Rodriguez Raphael, Goudot Christel, Luccarini Jean-Michel, Soude Anne, Bournique Bruno, Broqua Pierre, Pace Luigia, Baulande Sylvain, Sedlik Christine, Quivy Jean-Pierre, Almouzni Geneviève, Cohen Jose L, Zueva Elina, Waterfall Joshua J, Amigorena Sebastian,
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-31504-z

Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway

Author(s): David Sitbon, Ekaterina Boyarchuk, Florent Dingli, Damarys Loew, Geneviève Almouzni
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15084-4

Book chapters (4)

Metabolic Deregulations Affecting Chromatin Architecture: One-Carbon Metabolism and Krebs Cycle Impact Histone Methylation

Author(s): Francisco Saavedra, Ekaterina Boyarchuk, Francisca Alvarez, Geneviève Almouzni, Alejandra Loyola
Published in: The DNA, RNA, and Histone Methylomes, 2019, Page(s) 573-606, ISBN 978-3-030-14791-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-14792-1_23

After Darwin: epigenetics and evolution - The architecture of the genome: its bricks and its plasticity

Author(s): Almouzni, Geneviève
Published in: "Darwin au Collège de France XIXè-XXIè siècle, PSL/République des Savoirs, Collège de France, 2020, Passage des Disciplines, 9782722605329. &#x27E8;10.4000/books.cdf.7303&#x27E9;", Issue 1, 2020, ISSN 2261-5202
Publisher: Openedition press
DOI: 10.4000/books.cdf.7381

Imaging Newly Synthesized and Old Histone Variant Dynamics Dependent on Chaperones Using the SNAP-Tag System

Author(s): Júlia Torné, Guillermo A. Orsi, Dominique Ray-Gallet, Geneviève Almouzni
Published in: Histone Variants - Methods and Protocols, Issue 1832, 2018, Page(s) 207-221, ISBN 978-1-4939-8662-0
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8663-7_11

Chapter 4 - Mapping histone variant genomic distribution: Exploiting SNAP-tag labeling to follow the dynamics of incorporation of H3 variants

Author(s): Forest Audrey, Quivy Jean-Pierre, Almouzni Geneviève
Published in: Methods in cell biology., 2024, ISSN 0091-679X
Publisher: elsevier
DOI: 10.1016/bs.mcb.2022.10.007

Other (5)

CENP-A overexpression drives distinct cell fates depending on p53 status

Author(s): Jeffery, Daniel and Podsypanina, Katrina and Gatto, Alberto and Landete, Rebeca Ponce and Bonneville, Lorraine and Dumont, Marie and Fachinetti, Daniele and Almouzni Geneviève
Published in: bioRxiv, 2020
Publisher: bioRxiv
DOI: 10.1101/2020.07.21.213496

Immune cells defective for suv39h1

Author(s): Sebastian Amigorena, Eliane Piaggio, Christel GOUDOT, Luigia PACE, Geneviève Almouzni
Published in: Patent, 2021
Publisher: World intellectual property organization

Methods and kits for diagnosis and prediction of response to treatment in cancer based on CENP-A labelling

Author(s): Geneviève Almouzni, Pierre Verrelle, Didier Meseure, Jean-Pierre QUIVY, Frédérique BERGER
Published in: Patent, 2022
Publisher: World intellectual property organization

Quelle que soit la voie de dépôt, l'acide aminé 31 dans le variant d'histone H3 est essentiel à la gastrulation chez Xenopus

Author(s): Ekaterina Boyarchuk; Ekaterina Boyarchuk; Geneviève Almouzni; Geneviève Almouzni; David Sitbon; David Sitbon
Published in: https://hal.archives-ouvertes.fr/hal-03041039, Issue 1, 2019
Publisher: bioRxiv
DOI: 10.1101/612515

Inhibiteur destiné à être utilisé dans la prévention et/ou le traitement d'une infection par le virus de l'hépatite b

Author(s): Jean Pierre QUIVY, Barbara TESTONI, Fabien Zoulim, Maelle LOCATELLI
Published in: Patent, 2018
Publisher: European Patent Office