Chromatin Adaptations through Interactions of Chaperones in Time

Informazioni relative al progetto

ChromADICT

ID dell’accordo di sovvenzione: 694694

DOI

10.3030/694694

Progetto chiuso

Data della firma CE 13 Giugno 2016

Data di avvio 1 Luglio 2016

Data di completamento 30 Giugno 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 697,00

Contributo UE

€ 2 499 697,00

Coordinato da

INSTITUT CURIE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (31)

CENP-A Regulation and Cancer

Autori: Charlène Renaud-Pageot, Jean-Pierre Quivy, Marina Lochhead, Geneviève Almouzni
Pubblicato in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.907120

JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability

Autori: Francisco Saavedra, Zachary A. Gurard-Levin, Camila Rojas-Villalobos, Isabelle Vassias, Raquel Quatrini, Geneviève Almouzni, Alejandra Loyola
Pubblicato in: Epigenetics & Chromatin, Numero 13/1, 2020, ISSN 1756-8935
Editore: BioMed Central
DOI: 10.1186/s13072-020-00331-1

Regulation of replicative histone RNA metabolism by the histone chaperone ASF1

Autori: Shweta Mendiratta, Dominique Ray-Gallet, Sébastien Lemaire, Alberto Gatto, Audrey Forest, Maciej A. Kerlin, Geneviève Almouzni
Pubblicato in: Molecular Cell, 2024, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2023.12.038

The cell-cycle choreography of H3 variants shapes the genome

Autori: Kamila Delaney, Nicole Weiss , Geneviève Almouzni
Pubblicato in: Mollecular Cell, 2023, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2023.08.030

HIRA-dependent boundaries between H3 variants shape early replication in mammals

Autori: Alberto Gatto, Audrey Forest, Jean-Pierre Quivy, Geneviève Almouzni
Pubblicato in: Molecular Cell, 2022, ISSN 1097-4172
Editore: Cell Press
DOI: 10.1016/j.molcel.2022.03.017

Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription

Autori: Júlia Torné, Dominique Ray-Gallet, Ekaterina Boyarchuk, Mickaël Garnier, Patricia Le Baccon, Antoine Coulon, Guillermo A. Orsi, Geneviève Almouzni
Pubblicato in: Nature Structural & Molecular Biology, Numero 27/11, 2020, Pagina/e 1057-1068, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-020-0492-7

Transcription-coupled H3.3 recycling: A link with chromatin states

Autori: Kamila Delaney, Geneviève Almouzni
Pubblicato in: Seminars in Cell and Developmental Biology, 2023, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2022.05.003

Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise

Autori: Daphné Morel, Daniel Jeffery, Sandrine Aspeslagh, Geneviève Almouzni, Sophie Postel-Vinay
Pubblicato in: Nature Reviews Clinical Oncology, Numero 17/2, 2020, Pagina/e 91-107, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/s41571-019-0267-4

La surexpression CENP-A entraîne des destins cellulaires distincts en fonction du statut p53

Autori: Jeffery, Daniel; Podsypanina, Katrina; Gatto, Alberto; Landete, Rebeca Ponce; Bonneville, Lorraine; Dumont, Marie; Fachinetti, Daniele; Almouzni, Geneviève
Pubblicato in: Communications Biology, Numero 1, 2021, ISSN 2399-3642
Editore: Nature
DOI: 10.1038/s42003-021-01941-5

LifeTime and improving European healthcare through cell-based interceptive medicine

Autori: Rajewsky N *, Almouzni G *, Gorski S A. *, Aerts S, Amit I, Bertero M G., Bock C, Bredenoord A L., Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernandez X M., Figlerowicz M, Gasser S M., Hubner N, Kjems J, Knoblich J A., Krabbe G, Lichter P, Linnarsson S, Marine J-C, Marioni J, Marti- Renom M A. , Netea M G., Nickel D, Nollmann M, Novak H R., Parkinson H, Piccolo S, Pinh
Pubblicato in: Nature, 2020, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2715-9

The epigenetic control of stemness in CD8+ T cell fate commitment

Autori: Luigia Pace, Christel Goudot, Elina Zueva, Paul Gueguen, Nina Burgdorf, Joshua J. Waterfall, Jean-Pierre Quivy, Geneviève Almouzni, Sebastian Amigorena
Pubblicato in: Science, 2018, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aah6499

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

Autori: Song My Hoang, Nicole Kaminski, Ragini Bhargava, Jonathan Barroso-González, Michelle L. Lynskey, Laura García-Expósito, Justin L. Roncaioli, Anne R. Wondisford, Callen T. Wallace, Simon C. Watkins, Dominic I. James, Ian D. Waddell, Donald Ogilvie, Kate M. Smith, Felipe da Veiga Leprevost, Dattatreya Mellacharevu, Alexey I. Nesvizhskii, Jianfeng Li, Dominique Ray-Gallet, Robert W. Sobol, Genevie
Pubblicato in: Nature Structural & Molecular Biology, Numero 27/12, 2020, Pagina/e 1152-1164, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-020-0512-7

H3–H4 histone chaperones and cancer

Autori: Dominique, Ray-Gallet; Geneviève, Almouzni
Pubblicato in: Current opinion in genetics & development, Numero 1, 2022, ISSN 0959-437X
Editore: Elsevier BV
DOI: 10.1016/j.gde.2022.101900

Essential role for centromeric factors following p53 loss and oncogenic transformation

Autori: Dan Filipescu, Monica Naughtin, Katrina Podsypanina, Vincent Lejour, Laurence Wilson, Zachary A. Gurard-Levin, Guillermo A. Orsi, Iva Simeonova, Eleonore Toufektchan, Laura D. Attardi, Franck Toledo, Geneviève Almouzni
Pubblicato in: Genes & Development, Numero 31/5, 2017, Pagina/e 463-480, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.290924.116

Shaping Chromatin in the Nucleus: The Bricks and the Architects

Autori: David Sitbon, Katrina Podsypanina, Tejas Yadav, Geneviève Almouzni
Pubblicato in: Cold Spring Harbor Symposia on Quantitative Biology, 2017, Pagina/e 033753, ISSN 0091-7451
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/sqb.2017.82.033753

PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4

Autori: Francisco Saavedra, Carlos Rivera, Elizabeth Rivas, Paola Merino, Daniel Garrido, Sergio Hernández, Ignasi Forné, Isabelle Vassias, Zachary A. Gurard-Levin, Iván E. Alfaro, Axel Imhof, Geneviève Almouzni, Alejandra Loyola
Pubblicato in: Nucleic Acids Research, Numero 45/20, 2017, Pagina/e 11700-11710, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkx775

Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

Autori: Dominique Ray-Gallet, M. Daniel Ricketts, Yukari Sato, Kushol Gupta, Ekaterina Boyarchuk, Toshiya Senda, Ronen Marmorstein, Geneviève Almouzni
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-05581-y

Chromatin plasticity: A versatile landscape that underlies cell fate and identity

Autori: Tejas Yadav, Jean-Pierre Quivy, Geneviève Almouzni
Pubblicato in: Science, Numero 361/6409, 2018, Pagina/e 1332-1336, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aat8950

High-resolution visualization of H3 variants during replication reveals their controlled recycling

Autori: Camille Clément, Guillermo A. Orsi, Alberto Gatto, Ekaterina Boyarchuk, Audrey Forest, Bassam Hajj, Judith Miné-Hattab, Mickaël Garnier, Zachary A. Gurard-Levin, Jean-Pierre Quivy, Geneviève Almouzni
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-05697-1

Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure

Autori: Marie-Therese El-Daher, Nicolas Cagnard, Marine Gil, Marie Chansel Da Cruz, Claire Leveau, Fernando Sepulveda, Mohammed Zarhrate, Frédéric Tores, Patricia Legoix, Sylvain Baulande, Jean Pierre de Villartay, Geneviève Almouzni, Jean-Pierre Quivy, Alain Fischer, Geneviève de Saint Basile
Pubblicato in: Cell Discovery, Numero 4/1, 2018, ISSN 2056-5968
Editore: Springer Nature
DOI: 10.1038/s41421-018-0061-y

Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

Autori: Paul Victor Sauer, Jennifer Timm, Danni Liu, David Sitbon, Elisabetta Boeri-Erba, Christophe Velours, Norbert Mücke, Jörg Langowski, Françoise Ochsenbein, Geneviève Almouzni, Daniel Panne
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.23474

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

Autori: Roberto Bellelli, Ondrej Belan, Valerie E. Pye, Camille Clement, Sarah L. Maslen, J. Mark Skehel, Peter Cherepanov, Genevieve Almouzni, Simon J. Boulton
Pubblicato in: Molecular Cell, Numero 72/1, 2018, Pagina/e 112-126.e5, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2018.08.043

Histone supply: Multitiered regulation ensures chromatin dynamics throughout the cell cycle

Autori: Shweta Mendiratta, Alberto Gatto, Genevieve Almouzni
Pubblicato in: The Journal of Cell Biology, 2018, Pagina/e jcb.201807179, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201807179

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Autori: Suk Min Jang, Annamaria Kauzlaric, Jean-Pierre Quivy, Julien Pontis, Benjamin Rauwel, Andrea Coluccio, Sandra Offner, Julien Duc, Priscilla Turelli, Geneviève Almouzni, Didier Trono
Pubblicato in: Nucleic Acids Research, Numero 46/17, 2018, Pagina/e 8788-8802, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gky580

HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes

Autori: Maëlle Locatelli; Jean-Pierre Quivy; Fleur Chapus; Maud Michelet; Judith Fresquet; Sarah Maadadi; Amel Neila Aberkane; Audrey Diederichs; Julie Lucifora; Michel Rivoire; Geneviève Almouzni; Barbara Testoni; Fabien Zoulim
Pubblicato in: "Cellular and Molecular Gastroenterology and Hepatology, 2022, 14, pp.527 - 551. ⟨10.1016/j.jcmgh.2022.05.007⟩", Numero 1, 2022, ISSN 2352-345X
Editore: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.05.007

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells

Autori: Charles Ng, Martin Aichinger, Tung Nguyen, Christy Au, Tariq Najar, Lin Wu, Kai R. Mesa, Will Liao, Jean-Pierre Quivy, Benjamin Hubert, Genevieve Almouzni, Johannes Zuber, Dan R. Littman
Pubblicato in: Genes & Development, Numero 33/11-12, 2019, Pagina/e 669-683, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.322024.118

Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches

Autori: Brendan Evano, Sara Khalilian, Gilles Le Carrou, Geneviève Almouzni, Shahragim Tajbakhsh
Pubblicato in: Cell Reports, Numero 30/10, 2020, Pagina/e 3195-3206.e7, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.01.097

Disordered regions and folded modules in CAF-1 promote histone deposition in<i>S. pombe</i>

Autori: Fouad Ouasti; Maxime Audin; Karine Freon; Jean-Pierre Quivy; Mehdi Tachekort; Elizabeth Cesard; Aurélien Thureau; Virginie Ropars; Paloma F. Varela; Gwenaelle Moal; Ibrahim Soumana Amadou; Aleksandra Uryga; Pierre Legrand; Jessica Andreani; Raphael Guerois; Geneviève Almouzni; Sarah Lambert; Francoise Ochsenbein
Pubblicato in: Elife, Numero 1, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.1101/2023.06.02.543505

CENP-A Subnuclear Localization Pattern as Marker Predicting Curability by Chemoradiation Therapy for Locally Advanced Head and Neck Cancer Patients

Autori: Pierre Verrelle; Didier Meseure; Frédérique Berger; Audrey Forest; Renaud Leclere; André Nicolas; Emilie Fortas; Xavier Sastre-Garau; Marick Laé; Sabah Boudjemaa; Rodrigue Mbagui; Valentin Calugaru; Dalila Labiod; Leanne de Koning; Geneviève Almouzni; Jean-Pierre Quivy
Pubblicato in: Cancers, Numero 1, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13163928

CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

Autori: Niborski Leticia Laura, Gueguen Paul, Ye Mengliang, Thiolat Allan, Ramos Rodrigo Nalio, Caudana Pamela, Denizeau Jordan, Colombeau Ludovic, Rodriguez Raphael, Goudot Christel, Luccarini Jean-Michel, Soude Anne, Bournique Bruno, Broqua Pierre, Pace Luigia, Baulande Sylvain, Sedlik Christine, Quivy Jean-Pierre, Almouzni Geneviève, Cohen Jose L, Zueva Elina, Waterfall Joshua J, Amigorena Sebastian,
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-31504-z

Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway

Autori: David Sitbon, Ekaterina Boyarchuk, Florent Dingli, Damarys Loew, Geneviève Almouzni
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15084-4

Book chapters (4)

Metabolic Deregulations Affecting Chromatin Architecture: One-Carbon Metabolism and Krebs Cycle Impact Histone Methylation

Autori: Francisco Saavedra, Ekaterina Boyarchuk, Francisca Alvarez, Geneviève Almouzni, Alejandra Loyola
Pubblicato in: The DNA, RNA, and Histone Methylomes, 2019, Pagina/e 573-606, ISBN 978-3-030-14791-4
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-14792-1_23

After Darwin: epigenetics and evolution - The architecture of the genome: its bricks and its plasticity

Autori: Almouzni, Geneviève
Pubblicato in: "Darwin au Collège de France XIXè-XXIè siècle, PSL/République des Savoirs, Collège de France, 2020, Passage des Disciplines, 9782722605329. &#x27E8;10.4000/books.cdf.7303&#x27E9;", Numero 1, 2020, ISSN 2261-5202
Editore: Openedition press
DOI: 10.4000/books.cdf.7381

Imaging Newly Synthesized and Old Histone Variant Dynamics Dependent on Chaperones Using the SNAP-Tag System

Autori: Júlia Torné, Guillermo A. Orsi, Dominique Ray-Gallet, Geneviève Almouzni
Pubblicato in: Histone Variants - Methods and Protocols, Numero 1832, 2018, Pagina/e 207-221, ISBN 978-1-4939-8662-0
Editore: Springer New York
DOI: 10.1007/978-1-4939-8663-7_11

Chapter 4 - Mapping histone variant genomic distribution: Exploiting SNAP-tag labeling to follow the dynamics of incorporation of H3 variants

Autori: Forest Audrey, Quivy Jean-Pierre, Almouzni Geneviève
Pubblicato in: Methods in cell biology., 2024, ISSN 0091-679X
Editore: elsevier
DOI: 10.1016/bs.mcb.2022.10.007

Other (5)

CENP-A overexpression drives distinct cell fates depending on p53 status

Autori: Jeffery, Daniel and Podsypanina, Katrina and Gatto, Alberto and Landete, Rebeca Ponce and Bonneville, Lorraine and Dumont, Marie and Fachinetti, Daniele and Almouzni Geneviève
Pubblicato in: bioRxiv, 2020
Editore: bioRxiv
DOI: 10.1101/2020.07.21.213496

Immune cells defective for suv39h1

Autori: Sebastian Amigorena, Eliane Piaggio, Christel GOUDOT, Luigia PACE, Geneviève Almouzni
Pubblicato in: Patent, 2021
Editore: World intellectual property organization

Methods and kits for diagnosis and prediction of response to treatment in cancer based on CENP-A labelling

Autori: Geneviève Almouzni, Pierre Verrelle, Didier Meseure, Jean-Pierre QUIVY, Frédérique BERGER
Pubblicato in: Patent, 2022
Editore: World intellectual property organization

Quelle que soit la voie de dépôt, l'acide aminé 31 dans le variant d'histone H3 est essentiel à la gastrulation chez Xenopus

Autori: Ekaterina Boyarchuk; Ekaterina Boyarchuk; Geneviève Almouzni; Geneviève Almouzni; David Sitbon; David Sitbon
Pubblicato in: https://hal.archives-ouvertes.fr/hal-03041039, Numero 1, 2019
Editore: bioRxiv
DOI: 10.1101/612515

Inhibiteur destiné à être utilisé dans la prévention et/ou le traitement d'une infection par le virus de l'hépatite b

Autori: Jean Pierre QUIVY, Barbara TESTONI, Fabien Zoulim, Maelle LOCATELLI
Pubblicato in: Patent, 2018
Editore: European Patent Office