Chromatin Adaptations through Interactions of Chaperones in Time

Información del proyecto

ChromADICT

Identificador del acuerdo de subvención: 694694

DOI

10.3030/694694

Proyecto cerrado

Fecha de la firma de la CE 13 Junio 2016

Fecha de inicio 1 Julio 2016

Fecha de finalización 30 Junio 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 697,00

Aportación de la UE

€ 2 499 697,00

Coordinado por

INSTITUT CURIE
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (31)

CENP-A Regulation and Cancer

Autores: Charlène Renaud-Pageot, Jean-Pierre Quivy, Marina Lochhead, Geneviève Almouzni
Publicado en: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.907120

JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability

Autores: Francisco Saavedra, Zachary A. Gurard-Levin, Camila Rojas-Villalobos, Isabelle Vassias, Raquel Quatrini, Geneviève Almouzni, Alejandra Loyola
Publicado en: Epigenetics & Chromatin, Edición 13/1, 2020, ISSN 1756-8935
Editor: BioMed Central
DOI: 10.1186/s13072-020-00331-1

Regulation of replicative histone RNA metabolism by the histone chaperone ASF1

Autores: Shweta Mendiratta, Dominique Ray-Gallet, Sébastien Lemaire, Alberto Gatto, Audrey Forest, Maciej A. Kerlin, Geneviève Almouzni
Publicado en: Molecular Cell, 2024, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2023.12.038

The cell-cycle choreography of H3 variants shapes the genome

Autores: Kamila Delaney, Nicole Weiss , Geneviève Almouzni
Publicado en: Mollecular Cell, 2023, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2023.08.030

HIRA-dependent boundaries between H3 variants shape early replication in mammals

Autores: Alberto Gatto, Audrey Forest, Jean-Pierre Quivy, Geneviève Almouzni
Publicado en: Molecular Cell, 2022, ISSN 1097-4172
Editor: Cell Press
DOI: 10.1016/j.molcel.2022.03.017

Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription

Autores: Júlia Torné, Dominique Ray-Gallet, Ekaterina Boyarchuk, Mickaël Garnier, Patricia Le Baccon, Antoine Coulon, Guillermo A. Orsi, Geneviève Almouzni
Publicado en: Nature Structural & Molecular Biology, Edición 27/11, 2020, Página(s) 1057-1068, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-020-0492-7

Transcription-coupled H3.3 recycling: A link with chromatin states

Autores: Kamila Delaney, Geneviève Almouzni
Publicado en: Seminars in Cell and Developmental Biology, 2023, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2022.05.003

Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise

Autores: Daphné Morel, Daniel Jeffery, Sandrine Aspeslagh, Geneviève Almouzni, Sophie Postel-Vinay
Publicado en: Nature Reviews Clinical Oncology, Edición 17/2, 2020, Página(s) 91-107, ISSN 1759-4774
Editor: Nature Publishing Group
DOI: 10.1038/s41571-019-0267-4

La surexpression CENP-A entraîne des destins cellulaires distincts en fonction du statut p53

Autores: Jeffery, Daniel; Podsypanina, Katrina; Gatto, Alberto; Landete, Rebeca Ponce; Bonneville, Lorraine; Dumont, Marie; Fachinetti, Daniele; Almouzni, Geneviève
Publicado en: Communications Biology, Edición 1, 2021, ISSN 2399-3642
Editor: Nature
DOI: 10.1038/s42003-021-01941-5

LifeTime and improving European healthcare through cell-based interceptive medicine

Autores: Rajewsky N *, Almouzni G *, Gorski S A. *, Aerts S, Amit I, Bertero M G., Bock C, Bredenoord A L., Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernandez X M., Figlerowicz M, Gasser S M., Hubner N, Kjems J, Knoblich J A., Krabbe G, Lichter P, Linnarsson S, Marine J-C, Marioni J, Marti- Renom M A. , Netea M G., Nickel D, Nollmann M, Novak H R., Parkinson H, Piccolo S, Pinh
Publicado en: Nature, 2020, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2715-9

The epigenetic control of stemness in CD8+ T cell fate commitment

Autores: Luigia Pace, Christel Goudot, Elina Zueva, Paul Gueguen, Nina Burgdorf, Joshua J. Waterfall, Jean-Pierre Quivy, Geneviève Almouzni, Sebastian Amigorena
Publicado en: Science, 2018, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aah6499

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

Autores: Song My Hoang, Nicole Kaminski, Ragini Bhargava, Jonathan Barroso-González, Michelle L. Lynskey, Laura García-Expósito, Justin L. Roncaioli, Anne R. Wondisford, Callen T. Wallace, Simon C. Watkins, Dominic I. James, Ian D. Waddell, Donald Ogilvie, Kate M. Smith, Felipe da Veiga Leprevost, Dattatreya Mellacharevu, Alexey I. Nesvizhskii, Jianfeng Li, Dominique Ray-Gallet, Robert W. Sobol, Genevie
Publicado en: Nature Structural & Molecular Biology, Edición 27/12, 2020, Página(s) 1152-1164, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-020-0512-7

H3–H4 histone chaperones and cancer

Autores: Dominique, Ray-Gallet; Geneviève, Almouzni
Publicado en: Current opinion in genetics & development, Edición 1, 2022, ISSN 0959-437X
Editor: Elsevier BV
DOI: 10.1016/j.gde.2022.101900

Essential role for centromeric factors following p53 loss and oncogenic transformation

Autores: Dan Filipescu, Monica Naughtin, Katrina Podsypanina, Vincent Lejour, Laurence Wilson, Zachary A. Gurard-Levin, Guillermo A. Orsi, Iva Simeonova, Eleonore Toufektchan, Laura D. Attardi, Franck Toledo, Geneviève Almouzni
Publicado en: Genes & Development, Edición 31/5, 2017, Página(s) 463-480, ISSN 0890-9369
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.290924.116

Shaping Chromatin in the Nucleus: The Bricks and the Architects

Autores: David Sitbon, Katrina Podsypanina, Tejas Yadav, Geneviève Almouzni
Publicado en: Cold Spring Harbor Symposia on Quantitative Biology, 2017, Página(s) 033753, ISSN 0091-7451
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/sqb.2017.82.033753

PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4

Autores: Francisco Saavedra, Carlos Rivera, Elizabeth Rivas, Paola Merino, Daniel Garrido, Sergio Hernández, Ignasi Forné, Isabelle Vassias, Zachary A. Gurard-Levin, Iván E. Alfaro, Axel Imhof, Geneviève Almouzni, Alejandra Loyola
Publicado en: Nucleic Acids Research, Edición 45/20, 2017, Página(s) 11700-11710, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkx775

Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

Autores: Dominique Ray-Gallet, M. Daniel Ricketts, Yukari Sato, Kushol Gupta, Ekaterina Boyarchuk, Toshiya Senda, Ronen Marmorstein, Geneviève Almouzni
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-05581-y

Chromatin plasticity: A versatile landscape that underlies cell fate and identity

Autores: Tejas Yadav, Jean-Pierre Quivy, Geneviève Almouzni
Publicado en: Science, Edición 361/6409, 2018, Página(s) 1332-1336, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aat8950

High-resolution visualization of H3 variants during replication reveals their controlled recycling

Autores: Camille Clément, Guillermo A. Orsi, Alberto Gatto, Ekaterina Boyarchuk, Audrey Forest, Bassam Hajj, Judith Miné-Hattab, Mickaël Garnier, Zachary A. Gurard-Levin, Jean-Pierre Quivy, Geneviève Almouzni
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-05697-1

Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure

Autores: Marie-Therese El-Daher, Nicolas Cagnard, Marine Gil, Marie Chansel Da Cruz, Claire Leveau, Fernando Sepulveda, Mohammed Zarhrate, Frédéric Tores, Patricia Legoix, Sylvain Baulande, Jean Pierre de Villartay, Geneviève Almouzni, Jean-Pierre Quivy, Alain Fischer, Geneviève de Saint Basile
Publicado en: Cell Discovery, Edición 4/1, 2018, ISSN 2056-5968
Editor: Springer Nature
DOI: 10.1038/s41421-018-0061-y

Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

Autores: Paul Victor Sauer, Jennifer Timm, Danni Liu, David Sitbon, Elisabetta Boeri-Erba, Christophe Velours, Norbert Mücke, Jörg Langowski, Françoise Ochsenbein, Geneviève Almouzni, Daniel Panne
Publicado en: eLife, Edición 6, 2017, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.23474

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

Autores: Roberto Bellelli, Ondrej Belan, Valerie E. Pye, Camille Clement, Sarah L. Maslen, J. Mark Skehel, Peter Cherepanov, Genevieve Almouzni, Simon J. Boulton
Publicado en: Molecular Cell, Edición 72/1, 2018, Página(s) 112-126.e5, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2018.08.043

Histone supply: Multitiered regulation ensures chromatin dynamics throughout the cell cycle

Autores: Shweta Mendiratta, Alberto Gatto, Genevieve Almouzni
Publicado en: The Journal of Cell Biology, 2018, Página(s) jcb.201807179, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201807179

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Autores: Suk Min Jang, Annamaria Kauzlaric, Jean-Pierre Quivy, Julien Pontis, Benjamin Rauwel, Andrea Coluccio, Sandra Offner, Julien Duc, Priscilla Turelli, Geneviève Almouzni, Didier Trono
Publicado en: Nucleic Acids Research, Edición 46/17, 2018, Página(s) 8788-8802, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gky580

HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes

Autores: Maëlle Locatelli; Jean-Pierre Quivy; Fleur Chapus; Maud Michelet; Judith Fresquet; Sarah Maadadi; Amel Neila Aberkane; Audrey Diederichs; Julie Lucifora; Michel Rivoire; Geneviève Almouzni; Barbara Testoni; Fabien Zoulim
Publicado en: "Cellular and Molecular Gastroenterology and Hepatology, 2022, 14, pp.527 - 551. ⟨10.1016/j.jcmgh.2022.05.007⟩", Edición 1, 2022, ISSN 2352-345X
Editor: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.05.007

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells

Autores: Charles Ng, Martin Aichinger, Tung Nguyen, Christy Au, Tariq Najar, Lin Wu, Kai R. Mesa, Will Liao, Jean-Pierre Quivy, Benjamin Hubert, Genevieve Almouzni, Johannes Zuber, Dan R. Littman
Publicado en: Genes & Development, Edición 33/11-12, 2019, Página(s) 669-683, ISSN 0890-9369
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.322024.118

Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches

Autores: Brendan Evano, Sara Khalilian, Gilles Le Carrou, Geneviève Almouzni, Shahragim Tajbakhsh
Publicado en: Cell Reports, Edición 30/10, 2020, Página(s) 3195-3206.e7, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.01.097

Disordered regions and folded modules in CAF-1 promote histone deposition in<i>S. pombe</i>

Autores: Fouad Ouasti; Maxime Audin; Karine Freon; Jean-Pierre Quivy; Mehdi Tachekort; Elizabeth Cesard; Aurélien Thureau; Virginie Ropars; Paloma F. Varela; Gwenaelle Moal; Ibrahim Soumana Amadou; Aleksandra Uryga; Pierre Legrand; Jessica Andreani; Raphael Guerois; Geneviève Almouzni; Sarah Lambert; Francoise Ochsenbein
Publicado en: Elife, Edición 1, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.1101/2023.06.02.543505

CENP-A Subnuclear Localization Pattern as Marker Predicting Curability by Chemoradiation Therapy for Locally Advanced Head and Neck Cancer Patients

Autores: Pierre Verrelle; Didier Meseure; Frédérique Berger; Audrey Forest; Renaud Leclere; André Nicolas; Emilie Fortas; Xavier Sastre-Garau; Marick Laé; Sabah Boudjemaa; Rodrigue Mbagui; Valentin Calugaru; Dalila Labiod; Leanne de Koning; Geneviève Almouzni; Jean-Pierre Quivy
Publicado en: Cancers, Edición 1, 2021, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13163928

CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

Autores: Niborski Leticia Laura, Gueguen Paul, Ye Mengliang, Thiolat Allan, Ramos Rodrigo Nalio, Caudana Pamela, Denizeau Jordan, Colombeau Ludovic, Rodriguez Raphael, Goudot Christel, Luccarini Jean-Michel, Soude Anne, Bournique Bruno, Broqua Pierre, Pace Luigia, Baulande Sylvain, Sedlik Christine, Quivy Jean-Pierre, Almouzni Geneviève, Cohen Jose L, Zueva Elina, Waterfall Joshua J, Amigorena Sebastian,
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-31504-z

Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway

Autores: David Sitbon, Ekaterina Boyarchuk, Florent Dingli, Damarys Loew, Geneviève Almouzni
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15084-4

Book chapters (4)

Metabolic Deregulations Affecting Chromatin Architecture: One-Carbon Metabolism and Krebs Cycle Impact Histone Methylation

Autores: Francisco Saavedra, Ekaterina Boyarchuk, Francisca Alvarez, Geneviève Almouzni, Alejandra Loyola
Publicado en: The DNA, RNA, and Histone Methylomes, 2019, Página(s) 573-606, ISBN 978-3-030-14791-4
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-14792-1_23

After Darwin: epigenetics and evolution - The architecture of the genome: its bricks and its plasticity

Autores: Almouzni, Geneviève
Publicado en: "Darwin au Collège de France XIXè-XXIè siècle, PSL/République des Savoirs, Collège de France, 2020, Passage des Disciplines, 9782722605329. &#x27E8;10.4000/books.cdf.7303&#x27E9;", Edición 1, 2020, ISSN 2261-5202
Editor: Openedition press
DOI: 10.4000/books.cdf.7381

Imaging Newly Synthesized and Old Histone Variant Dynamics Dependent on Chaperones Using the SNAP-Tag System

Autores: Júlia Torné, Guillermo A. Orsi, Dominique Ray-Gallet, Geneviève Almouzni
Publicado en: Histone Variants - Methods and Protocols, Edición 1832, 2018, Página(s) 207-221, ISBN 978-1-4939-8662-0
Editor: Springer New York
DOI: 10.1007/978-1-4939-8663-7_11

Chapter 4 - Mapping histone variant genomic distribution: Exploiting SNAP-tag labeling to follow the dynamics of incorporation of H3 variants

Autores: Forest Audrey, Quivy Jean-Pierre, Almouzni Geneviève
Publicado en: Methods in cell biology., 2024, ISSN 0091-679X
Editor: elsevier
DOI: 10.1016/bs.mcb.2022.10.007

Other (5)

CENP-A overexpression drives distinct cell fates depending on p53 status

Autores: Jeffery, Daniel and Podsypanina, Katrina and Gatto, Alberto and Landete, Rebeca Ponce and Bonneville, Lorraine and Dumont, Marie and Fachinetti, Daniele and Almouzni Geneviève
Publicado en: bioRxiv, 2020
Editor: bioRxiv
DOI: 10.1101/2020.07.21.213496

Immune cells defective for suv39h1

Autores: Sebastian Amigorena, Eliane Piaggio, Christel GOUDOT, Luigia PACE, Geneviève Almouzni
Publicado en: Patent, 2021
Editor: World intellectual property organization

Methods and kits for diagnosis and prediction of response to treatment in cancer based on CENP-A labelling

Autores: Geneviève Almouzni, Pierre Verrelle, Didier Meseure, Jean-Pierre QUIVY, Frédérique BERGER
Publicado en: Patent, 2022
Editor: World intellectual property organization

Quelle que soit la voie de dépôt, l'acide aminé 31 dans le variant d'histone H3 est essentiel à la gastrulation chez Xenopus

Autores: Ekaterina Boyarchuk; Ekaterina Boyarchuk; Geneviève Almouzni; Geneviève Almouzni; David Sitbon; David Sitbon
Publicado en: https://hal.archives-ouvertes.fr/hal-03041039, Edición 1, 2019
Editor: bioRxiv
DOI: 10.1101/612515

Inhibiteur destiné à être utilisé dans la prévention et/ou le traitement d'une infection par le virus de l'hépatite b

Autores: Jean Pierre QUIVY, Barbara TESTONI, Fabien Zoulim, Maelle LOCATELLI
Publicado en: Patent, 2018
Editor: European Patent Office