Periodic Reporting for period 3 - ORCHESTRATE (Building complex life through self-organization: from organ to organism)
Período documentado: 2019-10-01 hasta 2020-09-30
Society stands to benefit greatly from regenerative medicine, which is a multidisciplinary field that combines biology, engineering and medicine to replace or regenerate organs and tissues. In particular, those suffering from chronic diseases may be presented with a cure for their condition in the form of a new organ or tissue. In ORCHESTRATE, we are developing technology and know-how to advance this field.
This proposal begins with the design and development of new cell culture platforms. Building upon our proprietary fabrication and microfluidic technology, we will create advanced platforms that will control how cells aggregate and enable the application of biomolecules with spatial and temporal resolution to orchestrate self-organization. This technology will be transferred into three projects focussing on different organs or organisms. For each, we need to find the right conditions to enrich for desired phenotypes and functions, which means that we need quantitative read-outs in the form of single cell information and imaging technology.