Microtechnology and integrated microsystems to investigate neuronal networks across scales

Publications

Peer reviewed articles (25)

Extracellular Recording of Entire Neural Networks Using a Dual-Mode Microelectrode Array With 19,584 Electrodes and High SNR

Author(s): Xinyue Yuan, Andreas Hierlemann, Urs Frey
Published in: IEEE Journal of Solid-State Circuits, 2021, Page(s) 1-1, ISSN 0018-9200
DOI: 10.1109/jssc.2021.3066043

Massively parallel microwire arrays integrated with CMOS chips for neural recording

Author(s): Abdulmalik Obaid, Mina-Elraheb Hanna, Yu-Wei Wu, Mihaly Kollo, Romeo Racz, Matthew R. Angle, Jan Müller, Nora Brackbill, William Wray, Felix Franke, E. J. Chichilnisky, Andreas Hierlemann, Jun B. Ding, Andreas T. Schaefer, Nicholas A. Melosh
Published in: Science Advances, Issue 6/12, 2020, Page(s) eaay2789, ISSN 2375-2548
DOI: 10.1126/sciadv.aay2789

Electrophysiological Phenotype Characterization of Human iPSC‐Derived Neuronal Cell Lines by Means of High‐Density Microelectrode Arrays

Author(s): Silvia Ronchi, Alessio Paolo Buccino, Gustavo Prack, Sreedhar Saseendran Kumar, Manuel Schröter, Michele Fiscella, Andreas Hierlemann
Published in: Advanced Biology, Issue 5/3, 2021, Page(s) 2000223, ISSN 2701-0198
DOI: 10.1002/adbi.202000223

Multiple Single-Unit Long-Term Tracking on Organotypic Hippocampal Slices Using High-Density Microelectrode Arrays

Author(s): Wei Gong, Jure Senčar, Douglas J. Bakkum, David Jäckel, Marie Engelene J. Obien, Milos Radivojevic, Andreas R. Hierlemann
Published in: Frontiers in Neuroscience, Issue 10, 2016, ISSN 1662-453X
DOI: 10.3389/fnins.2016.00537

Tracking individual action potentials throughout mammalian axonal arbors

Author(s): Milos Radivojevic, Felix Franke, Michael Altermatt, Jan Müller, Andreas Hierlemann, Douglas J Bakkum
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
DOI: 10.7554/eLife.30198

<italic>In Vitro</italic> Multi-Functional Microelectrode Array Featuring 59 760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement, and Neurotransmitter Detection Channels

Author(s): Jelena Dragas, Vijay Viswam, Amir Shadmani, Yihui Chen, Raziyeh Bounik, Alexander Stettler, Milos Radivojevic, Sydney Geissler, Marie Engelene J. Obien, Jan Muller, Andreas Hierlemann
Published in: IEEE Journal of Solid-State Circuits, Issue 52/6, 2017, Page(s) 1576-1590, ISSN 0018-9200
DOI: 10.1109/JSSC.2017.2686580

Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials

Author(s): Milos Radivojevic, David Jäckel, Michael Altermatt, Jan Müller, Vijay Viswam, Andreas Hierlemann, Douglas J. Bakkum
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep31332

Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration

Author(s): David Jäckel, Douglas J. Bakkum, Thomas L. Russell, Jan Müller, Milos Radivojevic, Urs Frey, Felix Franke, Andreas Hierlemann
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-00981-4

Smart Cell Culture Systems: Integration of Sensors and Actuators into Microphysiological Systems

Author(s): Mario M. Modena, Ketki Chawla, Patrick M. Misun, Andreas Hierlemann
Published in: ACS Chemical Biology, 2018, ISSN 1554-8929
DOI: 10.1021/acschembio.7b01029

Automatic spike sorting for high-density microelectrode arrays

Author(s): Roland Diggelmann, Michele Fiscella, Andreas Hierlemann, Felix Franke
Published in: Journal of Neurophysiology, Issue 120/6, 2018, Page(s) 3155-3171, ISSN 0022-3077
DOI: 10.1152/jn.00803.2017

Accurate signal-source localization in brain slices by means of high-density microelectrode arrays

Author(s): Marie Engelene J. Obien, Andreas Hierlemann, Urs Frey
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-018-36895-y

Monolithic CMOS sensor platform featuring an array of 9’216 carbon-nanotube-sensor elements and low-noise, wide-bandwidth and wide-dynamic-range readout circuitry

Author(s): Alexandra Dudina, Florent Seichepine, Yihui Chen, Alexander Stettler, Andreas Hierlemann, Urs Frey
Published in: Sensors and Actuators B: Chemical, Issue 279, 2019, Page(s) 255-266, ISSN 0925-4005
DOI: 10.1016/j.snb.2018.10.004

Impedance Spectroscopy and Electrophysiological Imaging of Cells With a High-Density CMOS Microelectrode Array System

Author(s): Vijay Viswam, Raziyeh Bounik, Amir Shadmani, Jelena Dragas, Cedar Urwyler, Julia Alicia Boos, Marie Engelene J. Obien, Jan Muller, Yihui Chen, Andreas Hierlemann
Published in: IEEE Transactions on Biomedical Circuits and Systems, Issue 12/6, 2018, Page(s) 1356-1368, ISSN 1932-4545
DOI: 10.1109/tbcas.2018.2881044

Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays

Author(s): Silvia Ronchi, Michele Fiscella, Camilla Marchetti, Vijay Viswam, Jan Müller, Urs Frey, Andreas Hierlemann
Published in: Frontiers in Neuroscience, Issue 13, 2019, ISSN 1662-453X
DOI: 10.3389/fnins.2019.00208

Medullary respiratory circuit is reorganized by a seasonally-induced program in preparation for hibernation

Author(s): T. Russell, J. Zhang, M. Okoniewski, F. Franke, S. Bichet, A. Hierlemann
Published in: Frontiers in Neuroscience, 2019, ISSN 1662-453X
DOI: 10.3389/fnins.2019.00376

Optimal Electrode Size for Multi-Scale Extracellular-Potential Recording From Neuronal Assemblies

Author(s): Vijay Viswam, Marie Engelene J. Obien, Felix Franke, Urs Frey, Andreas Hierlemann
Published in: Frontiers in Neuroscience, Issue 13, 2019, ISSN 1662-453X
DOI: 10.3389/fnins.2019.00385

Stimulation and Artifact-suppression Techniques for in-vitro High-density Microelectrode Array Systems

Author(s): Amir Shadmani, Vijay Viswam, Yihui Chen, Raziyeh Bounik, Jelena Dragas, Milos Radivojevic, Sydney Geissler, Sergey Sitnikov, Jan Muller, Andreas Hierlemann
Published in: IEEE Transactions on Biomedical Engineering, 2018, Page(s) 1-1, ISSN 0018-9294
DOI: 10.1109/tbme.2018.2890530

How Diverse Retinal Functions Arise from Feedback at the First Visual Synapse

Author(s): Antonia Drinnenberg, Felix Franke, Rei K. Morikawa, Josephine Jüttner, Daniel Hillier, Peter Hantz, Andreas Hierlemann, Rava Azeredo da Silveira, Botond Roska
Published in: Neuron, Issue 99/1, 2018, Page(s) 117-134.e11, ISSN 0896-6273
DOI: 10.1016/j.neuron.2018.06.001

The Axon Initial Segment is the Dominant Contributor to the Neuron's Extracellular Electrical Potential Landscape

Author(s): Douglas J. Bakkum, Marie Engelene J. Obien, Milos Radivojevic, David Jäckel, Urs Frey, Hirokazu Takahashi, Andreas Hierlemann
Published in: Advanced Biosystems, Issue 3/2, 2019, Page(s) 1800308, ISSN 2366-7478
DOI: 10.1002/adbi.201800308

Technologies to Study Action Potential Propagation With a Focus on HD-MEAs

Author(s): Vishalini Emmenegger, Marie Engelene J. Obien, Felix Franke, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 13, 2019, ISSN 1662-5102
DOI: 10.3389/fncel.2019.00159

Carbon-Nanotube-Based Monolithic CMOS Platform for Electrochemical Detection of Neurotransmitter Glutamate

Author(s): Alexandra Dudina, Urs Frey, Andreas Hierlemann
Published in: Sensors, Issue 19/14, 2019, Page(s) 3080, ISSN 1424-8220
DOI: 10.3390/s19143080

Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays

Author(s): Torsten Bullmann, Milos Radivojevic, Stefan T. Huber, Kosmas Deligkaris, Andreas Hierlemann, Urs Frey
Published in: Frontiers in Cellular Neuroscience, Issue 13, 2019, ISSN 1662-5102
DOI: 10.3389/fncel.2019.00404

A 15-Channel 30-V Neural Stimulator for Spinal Cord Repair

Author(s): Yonghong Tao, Andreas Hierlemann
Published in: IEEE Transactions on Very Large Scale Integration (VLSI) Systems, Issue 26/10, 2018, Page(s) 2185-2189, ISSN 1063-8210
DOI: 10.1109/tvlsi.2018.2832051

CHIME: CMOS-Hosted in vivo Microelectrodes for Massively Scalable Neuronal Recordings

Author(s): Mihaly Kollo, Romeo Racz, Mina-Elraheb Hanna, Abdulmalik Obaid, Matthew R. Angle, William Wray, Yifan Kong, Jan Müller, Andreas Hierlemann, Nicholas A. Melosh, Andreas T. Schaefer
Published in: Frontiers in Neuroscience, Issue 14, 2020, ISSN 1662-453X
DOI: 10.3389/fnins.2020.00834

Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level

Author(s): Xinyue Yuan, Manuel Schröter, Marie Engelene J. Obien, Michele Fiscella, Wei Gong, Tetsuhiro Kikuchi, Aoi Odawara, Shuhei Noji, Ikuro Suzuki, Jun Takahashi, Andreas Hierlemann, Urs Frey
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-​020-18620-4

Conference proceedings (29)

Electrophysiological characterization of α-synuclein function in human iPSC-derived dopaminergic neurons using high-density microelectrode arrays

Author(s): Hornauer, Philipp; Prack, Gustavo; Fiscella, Michele; Donner, Christian; Roqueiro, Damian Sabas; id_orcid0000-0002-9195-5915; Taylor, Verdon; Borgwardt, Karsten; Hierlemann, Andreas; id_orcid0000-0002-3838-2468; Schröter, Manuel
Published in: ISSCR 2020 Poster Abstract Guide, Issue 8, 2020

Integration of Discrete Sensors and Microelectrode Arrays Into Open Microfluidic Hanging-Drop Networks

Author(s): Raziyeh Bounik, Massimiliano Gusmaroli, Patrick M. Misun, Vijay Viswam, Andreas Hierlemann, Mario M. Modena
Published in: 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS), 2019, Page(s) 441-444
DOI: 10.1109/memsys.2019.8870732

High-density mapping of brain slices using a large multi-functional high-density CMOS microelectrode array system

Author(s): Vijay Viswam, Raziyeh Bounik, Amir Shadmani, Jelena Dragas, Marie Obien, Jan Muller, Yihui Chen, Andreas Hierlemann
Published in: 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2017, Page(s) 135-138
DOI: 10.1109/TRANSDUCERS.2017.7994006

Acquisition of bioelectrical signals with small electrodes

Author(s): Vijay Viswam, Marie Obien, Urs Frey, Felix Franke, Andreas Hierlemann
Published in: 2017 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2017, Page(s) 1-4
DOI: 10.1109/BIOCAS.2017.8325216

Direct interfacing of neurons to highly integrated microsystems

Author(s): Andreas Hierlemann
Published in: 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS), 2017, Page(s) 199-204
DOI: 10.1109/MEMSYS.2017.7863375

High-resolution Microelectrode Array Platform for Biomarker Discovery and Novel Functional Assays in Human iPSC-derived Neurons

Author(s): Fiscella, Michele; Müller, Jan; Hierlemann, Andreas
Published in: Poster Abstract Book ISSCR 2017, Issue 1, 2017

Single-Cell Electrical Stimulation with CMOS-based High-Density Microelectrode Arrays

Author(s): Silvia Ronchi, Michele Fiscella, Jan Müller, Vijay Viswam, Urs Frey, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
DOI: 10.3389/conf.fncel.2018.38.00086

Mapping neuronal network dynamics in developing cerebral organoids

Author(s): Manuel Schröter, Monika Girr, Julia Boos, Magdalena Renner, Mahshid Gazorpak, Wei Gong, Julian Bartram, Jan Müller, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
DOI: 10.3389/conf.fncel.2018.38.00066

Dual-mode Microelectrode Array with 20k-electrodes and High SNR for High-Throughput Extracellular Recording and Stimulation

Author(s): Xinyue Yuan, Andreas Hierlemann, Urs Frey
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
DOI: 10.3389/conf.fncel.2018.38.00088

Mechanisms of homeostatic synaptic plasticity

Author(s): Bartram, Julian; Schröter, Manuel; Ronchi, Silvia; Emmenegger, Vishalini; Müller, Jan; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: Neuroscience 2018 Abstracts, Issue 7, 2018

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelectrode array

Author(s): Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: Neuroscience 2018 Abstracts, Issue 7, 2018

Single-neuron sub-cellular-resolution electrical stimulation with high-density microelectrode arrays

Author(s): Ronchi, Silvia; Fiscella, Michele; Marchetti, C.; Viswam, Vijay; Müller, Jan; Frey, Urs; id_orcid0000-0003-4026-1259; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: Neuroscience 2018 Abstracts, Issue 1, 2018

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays

Author(s): Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas; id_orcid0000-0002-3838-2468
Published in: Poster Abstract Book of the ISSCR 2018 Annual Meeting, Issue 6, 2018

ELECTROPHYSIOLOGICAL PHENOTYPE CHARACTERIZATION OF HUMAN IPSC-DERIVED DOPAMINERGIC NEURONAL LINES BY MEANS OF HIGH-RESOLUTION MICROELECTRODE ARRAYS

Author(s): Michele Fiscella, Noelle Leary, Ebru Acun, Silvia Ronchi, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
DOI: 10.3389/conf.fncel.2018.38.00014

Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons

Author(s): Marie Engelene Obien, Giulio Zorzi, Michele Fiscella, Noelle Leary, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
DOI: 10.3389/conf.fncel.2018.38.00095

Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons

Author(s): Giulio Zorzi, Marie Engelene Obien, Michele Fiscella, Noelle Leary, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
DOI: 10.3389/conf.fncel.2018.38.00049

Effective benchmarking of high-density MEA spike-sorters

Author(s): Roland Diggelmann, Andreas Hierlemann, Felix Franke
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
DOI: 10.3389/conf.fncel.2018.38.00092

Investigating the analog modulation of action-potential waveforms in axonal arbors of cortical neurons using whole-cell patch-clamp recordings and high-density microelectrode arrays

Author(s): V. Emmenegger, J. Bartram, S. Sitnikov, A. Hierlemann
Published in: Neuroscience 2018 Abstracts, 2018

Dual-mode Microelectrode Array Featuring 20k Electrodes and High SNR for Extracellular Recording of Neural Networks

Author(s): Xinyue Yuan, Vishalini Emmenegger, Marie Engelene J. Obien, Andreas Hierlemann, Urs Frey
Published in: 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2018, Page(s) 1-4
DOI: 10.1109/biocas.2018.8584735

Spontaneous neuronal activity in developing mouse cerebral organoids

Author(s): M. Girr, J. Boos, P. Misun, J. Bartram, M. Renner, M. Gazorpak, A. Hierlemann, M. Schröter
Published in: Neuroscience 2018 Abstracts, 2018

Probing synaptic connectivity and function using high-density microelectrode arrays and whole-cell patch-clamp recordings

Author(s): Julian Bartram, Manuel Schröter, Silvia Ronchi, Vishalini Emmenegger, Jan Müller, Andreas Hierlemann
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
DOI: 10.3389/conf.fncel.2018.38.00085

Pre-whitening as a means to improve dimensionality reduction and simplify clustering in spike-sorters for multi-electrode recordings

Author(s): R. Diggelmann, M. Fiscella, A. Hierlemann, F. Franke
Published in: 26th Annual Computational Neuroscience Meeting (CNS2017), July 15-20, 2017, Antwerp, Belgium, 2017, ISSN 1471-2202

How the coupling strength of horizontal cells effects the retinal processing of spatio-temporal light stimuli - Model and experiments

Author(s): Bucci, Annalisa Diggelmann, Roland Znidaric, Matej Roska, Botond da Silveira, Rava Hierlemann, Andreas Franke, Felix
Published in: Society for Neuroscience (SfN) Meeting (Neuroscience 2019), Chicago, IL, USA, October 19-23, 2019, 2019

Machine learning for deep electrophysiological phenotyping of human dopaminergic neurons

Author(s): Schröter, Manuel Roqueiro, Damian Sabas Prack, Gustavo Fiscella, Michele Borgwardt, Karsten Hierlemann, Andreas
Published in: International Society for Stem Cell Research Annual Meeting (ISSCR 2019), Los Angeles, CA, USA, June 26-29, 2019, 2019

Ex vivo mouse retinal recordings using HD-MEA systems: From characterizing single cells to analyzing populations

Author(s): Znidaric, Matejcc Diggelmann, Roland Bucci, Annalisa Hierlemann, Andreascc Franke, Felix
Published in: Society for Neuroscience (SfN) Meeting (Neuroscience 2019), Chicago, IL, USA, October 19-23, 2019, 2019

Investigating dendritic signals evoked by natural patterns of presynaptic activity

Author(s): Xue, Xiaohan Lummen, Tom T.A. Hierlemann, Andreas Bartram, Julian
Published in: Society for Neuroscience (SfN) Meeting (Neuroscience 2019), Chicago, IL, USA, October 19-23, 2019, 2019

Electrophysiological Phenotype Characterization of Human iPSC-derived Neuronal-Cell Lines by Means of High-Resolution Microelectrode Arrays

Author(s): Fiscella, Michele Zorzi, Giulio Ronchi, Silvia Prack, Gustavo Schröter, Manuel Hierlemann, Andreas
Published in: International Society for Stem Cell Research Annual Meeting (ISSCR 2019), Los Angeles, CA, USA, June 26-29, 2019, 2019

Connectivity profiling and single-cell RNA sequencing to study homeostatic plasticity in hippocampal neuronal networks in vitro

Author(s): Kim, Taehoon Bartram, Julian Hierlemann, Andreas Schröter, Manuel
Published in: Society for Neuroscience (SfN) Meeting (Neuroscience 2019), Chicago, IL, USA, October 19-23, 2019, 2019

Improved receptive-field characterization of retinal ganglion cells using a large field-of-view light stimuli

Author(s): Diggelmann, Roland Znidaric, Matej Bucci, Annalisa Hierlemann, Andreas Franke, Felix
Published in: Society for Neuroscience (SfN) Meeting, Chicago, IL, USA, October 19-23, 2019, 2019

Thesis dissertations (1)

From selective stimulation to single-spike detection: interfacing neocortical neurons with thousands of microelectrodes at subcellular spatial resolution

Author(s): Radivojevic, Milos
Published in: Issue 3, 2017
DOI: 10.3929/ethz-b-000172841