Objective
To advance knowledge in electrophysiology and information processing of neuronal networks, we propose employing microtechnology and microelectronics to rigorously study neural networks in vitro across scales. Across scales pertains to the spatial domain - from details of subcellular components through single neurons to entire networks - and the temporal domain - from single action potentials to long-term developmental processes. Besides our CMOS-microelectronics-based high-density microelectrode arrays for recording and stimulation, the methodology will encompass patch-clamping directly on the microelectrode chips, high-resolution microscopy, genetic methods, large-scale data handling strategies, and dedicated data analysis and modeling algorithms. We will use mammalian cortical neuron cultures and brain slices.
We will potentially have access to every neuron and every action potential. We aim at studying - at the same time in the same preparation - details of specific neurons and subcellular components (somas, axons, synapses, dendrites) in their functional context and the characteristics of the corresponding networks (functional connectivity, emergent properties, plasticity). We will study alterations of components and networks over time and upon defined perturbations and mutual interdependence of network and component characteristics.
The high-spatio-temporal-resolution methodology will enable new fundamental neuroscientific insights through, e.g. facilitating investigation of axonal and axonal initial segment signaling characteristics, with the “axonal” side of neuronal activity being largely inaccessible to established methods. It will also enable the mapping of the overall synaptic input to a specific neuron, or the high-throughput monitoring of all action potentials in a network over extended time to see developmental effects or effects of disturbances. Potential applications include research in neural diseases and pharmacology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences physical sciences electromagnetism and electronics microelectronics
- natural sciences physical sciences optics microscopy confocal microscopy
- natural sciences computer and information sciences data science data processing
- natural sciences computer and information sciences artificial intelligence computational intelligence
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-ADG - Advanced Grant
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-AdG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.