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Microtechnology and integrated microsystems to investigate neuronal networks across scales

Objective

To advance knowledge in electrophysiology and information processing of neuronal networks, we propose employing microtechnology and microelectronics to rigorously study neural networks in vitro across scales. Across scales pertains to the spatial domain - from details of subcellular components through single neurons to entire networks - and the temporal domain - from single action potentials to long-term developmental processes. Besides our CMOS-microelectronics-based high-density microelectrode arrays for recording and stimulation, the methodology will encompass patch-clamping directly on the microelectrode chips, high-resolution microscopy, genetic methods, large-scale data handling strategies, and dedicated data analysis and modeling algorithms. We will use mammalian cortical neuron cultures and brain slices.
We will potentially have access to every neuron and every action potential. We aim at studying - at the same time in the same preparation - details of specific neurons and subcellular components (somas, axons, synapses, dendrites) in their functional context and the characteristics of the corresponding networks (functional connectivity, emergent properties, plasticity). We will study alterations of components and networks over time and upon defined perturbations and mutual interdependence of network and component characteristics.
The high-spatio-temporal-resolution methodology will enable new fundamental neuroscientific insights through, e.g. facilitating investigation of axonal and axonal initial segment signaling characteristics, with the “axonal” side of neuronal activity being largely inaccessible to established methods. It will also enable the mapping of the overall synaptic input to a specific neuron, or the high-throughput monitoring of all action potentials in a network over extended time to see developmental effects or effects of disturbances. Potential applications include research in neural diseases and pharmacology.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

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Funding Scheme

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ERC-ADG - Advanced Grant

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2015-AdG

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Host institution

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 3 495 000,00
Address
Raemistrasse 101
8092 Zuerich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 3 495 000,00

Beneficiaries (1)

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