No stress with pArg: Mechanisms of a distinct phospho-mark to coordinate stress response and protein quality control

Project Information

pArg_deg_signal

Grant agreement ID: 694978

DOI

10.3030/694978

Project closed

EC signature date 18 May 2016

Start date 1 October 2016

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 299,00

EU contribution

€ 2 499 299,00

Coordinated by

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Non-peer reviewed articles (2)

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

Author(s): Ahel, Juraj; Fletcher, Adam; Grabarczyk, Daniel B.; Roitinger, Elisabeth; Deszcz, Luiza; Lehner, Anita; Virdee, Satpal; Clausen, Tim
Published in: bioRxiv, Issue 26928205, 2021, ISSN 2692-8205
Publisher: CHSL
DOI: 10.1101/2021.05.10.443411

BacPROTAC-induced degradation of ClpC1 as a new strategy against drug-resistant mycobacteria

Author(s): Junk, Lukas; Schmiedel, Volker Martin; Guha, Somraj; Greb, Peter; Fischel, Katharina; Rumpel, Klaus; Kaur, Parvinder; Krishnamurthy, Ramya V.; Narayanan, Shridhar; Kofink, Christiane; Andreas Mantoulidis, Andreas; Kazmaier, Uli; Anton Meinhart; Leodolter, Julia; Hoi, David; Junker, Sabryna; Morreale, Francesca Ester; Clausen, Tim; Boehmelt, Guido; Weinstabl, Harald
Published in: ChemRxiv, Issue 25732293, 2022, ISSN 2573-2293
Publisher: Cambridge Open Engage
DOI: 10.26434/chemrxiv-2022-8hnrh

Peer reviewed articles (5)

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

Author(s): Juraj Ahel, Anita Lehner, Antonia Vogel, Alexander Schleiffer, Anton Meinhart, David Haselbach, Tim Clausen
Published in: eLife, Issue 9, 2020, Page(s) 1-23, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56185

BacPROTACs mediate targeted protein degradation in bacteria

Author(s): Morreale, F. E.; Kleine, S.; Leodolter, J.; Junker, S.; Hoi, D. M.; Ovchinnikov, S.; Okun, A.; Kley, J.; Kurzbauer, R.; Junk, L.; Guha, S.; Podlesainski, D.; Kazmaier, U.; Boehmelt, G.; Weinstabl, H.; Rumpel, K.; Schmiedel, V. M.; Hartl, M.; Haselbach, D.; Meinhart, A.; Kaiser, M.; Clausen, T.
Published in: Cell, Issue 00928674, 2022, Page(s) 2338-2353, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.05.009

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.

Author(s): Bence Hajdusits; Marcin J. Suskiewicz; Nikolas Hundt; Anton Meinhart; Anton Meinhart; Robert Kurzbauer; Julia Leodolter; Philipp Kukura; Tim Clausen; Tim Clausen
Published in: eLIVE, Issue 2050084X, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.63505

Structural basis for the disaggregase activity and regulation of Hsp104

Author(s): Alexander Heuck, Sonja Schitter-Sollner, Marcin Józef Suskiewicz, Robert Kurzbauer, Juliane Kley, Alexander Schleiffer, Pascaline Rombaut, Franz Herzog, Tim Clausen
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.21516

Structure of McsB, a protein kinase for regulated arginine phosphorylation

Author(s): Marcin J. Suskiewicz, Bence Hajdusits, Rebecca Beveridge, Alexander Heuck, Lam Dai Vu, Robert Kurzbauer, Katja Hauer, Vanessa Thoeny, Klaus Rumpel, Karl Mechtler, Anton Meinhart, Tim Clausen
Published in: Nature Chemical Biology, Issue 15/5, 2019, Page(s) 510-518, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-019-0265-y