No stress with pArg: Mechanisms of a distinct phospho-mark to coordinate stress response and protein quality control

Project Information

pArg_deg_signal

Grant agreement ID: 694978

DOI 10.3030/694978

Project closed

EC signature date 18 May 2016

Start date 1 October 2016

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 299,00

EU contribution € 2 499 299,00

Coordinated by

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Austria

Publications

Non-peer reviewed articles (2)

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

Author(s): Ahel, Juraj; Fletcher, Adam; Grabarczyk, Daniel B.; Roitinger, Elisabeth; Deszcz, Luiza; Lehner, Anita; Virdee, Satpal; Clausen, Tim
Published in: bioRxiv, Issue 26928205, 2021, ISSN 2692-8205
Publisher: CHSL
DOI: 10.1101/2021.05.10.443411

BacPROTAC-induced degradation of ClpC1 as a new strategy against drug-resistant mycobacteria

Author(s): Junk, Lukas; Schmiedel, Volker Martin; Guha, Somraj; Greb, Peter; Fischel, Katharina; Rumpel, Klaus; Kaur, Parvinder; Krishnamurthy, Ramya V.; Narayanan, Shridhar; Kofink, Christiane; Andreas Mantoulidis, Andreas; Kazmaier, Uli; Anton Meinhart; Leodolter, Julia; Hoi, David; Junker, Sabryna; Morreale, Francesca Ester; Clausen, Tim; Boehmelt, Guido; Weinstabl, Harald
Published in: ChemRxiv, Issue 25732293, 2022, ISSN 2573-2293
Publisher: Cambridge Open Engage
DOI: 10.26434/chemrxiv-2022-8hnrh

Peer reviewed articles (5)

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

Author(s): Juraj Ahel, Anita Lehner, Antonia Vogel, Alexander Schleiffer, Anton Meinhart, David Haselbach, Tim Clausen
Published in: eLife, Issue 9, 2020, Page(s) 1-23, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56185

BacPROTACs mediate targeted protein degradation in bacteria

Author(s): Morreale, F. E.; Kleine, S.; Leodolter, J.; Junker, S.; Hoi, D. M.; Ovchinnikov, S.; Okun, A.; Kley, J.; Kurzbauer, R.; Junk, L.; Guha, S.; Podlesainski, D.; Kazmaier, U.; Boehmelt, G.; Weinstabl, H.; Rumpel, K.; Schmiedel, V. M.; Hartl, M.; Haselbach, D.; Meinhart, A.; Kaiser, M.; Clausen, T.
Published in: Cell, Issue 00928674, 2022, Page(s) 2338-2353, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.05.009

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.

Author(s): Bence Hajdusits; Marcin J. Suskiewicz; Nikolas Hundt; Anton Meinhart; Anton Meinhart; Robert Kurzbauer; Julia Leodolter; Philipp Kukura; Tim Clausen; Tim Clausen
Published in: eLIVE, Issue 2050084X, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.63505

Structural basis for the disaggregase activity and regulation of Hsp104

Author(s): Alexander Heuck, Sonja Schitter-Sollner, Marcin Józef Suskiewicz, Robert Kurzbauer, Juliane Kley, Alexander Schleiffer, Pascaline Rombaut, Franz Herzog, Tim Clausen
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.21516

Structure of McsB, a protein kinase for regulated arginine phosphorylation

Author(s): Marcin J. Suskiewicz, Bence Hajdusits, Rebecca Beveridge, Alexander Heuck, Lam Dai Vu, Robert Kurzbauer, Katja Hauer, Vanessa Thoeny, Klaus Rumpel, Karl Mechtler, Anton Meinhart, Tim Clausen
Published in: Nature Chemical Biology, Issue 15/5, 2019, Page(s) 510-518, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-019-0265-y