No stress with pArg: Mechanisms of a distinct phospho-mark to coordinate stress response and protein quality control

Informazioni relative al progetto

pArg_deg_signal

ID dell’accordo di sovvenzione: 694978

DOI 10.3030/694978

Progetto chiuso

Data della firma CE 18 Maggio 2016

Data di avvio 1 Ottobre 2016

Data di completamento 30 Settembre 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 499 299,00

Contributo UE € 2 499 299,00

Coordinato da

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Austria

Pubblicazioni

Non-peer reviewed articles (2)

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

Autori: Ahel, Juraj; Fletcher, Adam; Grabarczyk, Daniel B.; Roitinger, Elisabeth; Deszcz, Luiza; Lehner, Anita; Virdee, Satpal; Clausen, Tim
Pubblicato in: bioRxiv, Numero 26928205, 2021, ISSN 2692-8205
Editore: CHSL
DOI: 10.1101/2021.05.10.443411

BacPROTAC-induced degradation of ClpC1 as a new strategy against drug-resistant mycobacteria

Autori: Junk, Lukas; Schmiedel, Volker Martin; Guha, Somraj; Greb, Peter; Fischel, Katharina; Rumpel, Klaus; Kaur, Parvinder; Krishnamurthy, Ramya V.; Narayanan, Shridhar; Kofink, Christiane; Andreas Mantoulidis, Andreas; Kazmaier, Uli; Anton Meinhart; Leodolter, Julia; Hoi, David; Junker, Sabryna; Morreale, Francesca Ester; Clausen, Tim; Boehmelt, Guido; Weinstabl, Harald
Pubblicato in: ChemRxiv, Numero 25732293, 2022, ISSN 2573-2293
Editore: Cambridge Open Engage
DOI: 10.26434/chemrxiv-2022-8hnrh

Peer reviewed articles (5)

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

Autori: Juraj Ahel, Anita Lehner, Antonia Vogel, Alexander Schleiffer, Anton Meinhart, David Haselbach, Tim Clausen
Pubblicato in: eLife, Numero 9, 2020, Pagina/e 1-23, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.56185

BacPROTACs mediate targeted protein degradation in bacteria

Autori: Morreale, F. E.; Kleine, S.; Leodolter, J.; Junker, S.; Hoi, D. M.; Ovchinnikov, S.; Okun, A.; Kley, J.; Kurzbauer, R.; Junk, L.; Guha, S.; Podlesainski, D.; Kazmaier, U.; Boehmelt, G.; Weinstabl, H.; Rumpel, K.; Schmiedel, V. M.; Hartl, M.; Haselbach, D.; Meinhart, A.; Kaiser, M.; Clausen, T.
Pubblicato in: Cell, Numero 00928674, 2022, Pagina/e 2338-2353, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2022.05.009

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.

Autori: Bence Hajdusits; Marcin J. Suskiewicz; Nikolas Hundt; Anton Meinhart; Anton Meinhart; Robert Kurzbauer; Julia Leodolter; Philipp Kukura; Tim Clausen; Tim Clausen
Pubblicato in: eLIVE, Numero 2050084X, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.63505

Structural basis for the disaggregase activity and regulation of Hsp104

Autori: Alexander Heuck, Sonja Schitter-Sollner, Marcin Józef Suskiewicz, Robert Kurzbauer, Juliane Kley, Alexander Schleiffer, Pascaline Rombaut, Franz Herzog, Tim Clausen
Pubblicato in: eLife, Numero 5, 2016, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.21516

Structure of McsB, a protein kinase for regulated arginine phosphorylation

Autori: Marcin J. Suskiewicz, Bence Hajdusits, Rebecca Beveridge, Alexander Heuck, Lam Dai Vu, Robert Kurzbauer, Katja Hauer, Vanessa Thoeny, Klaus Rumpel, Karl Mechtler, Anton Meinhart, Tim Clausen
Pubblicato in: Nature Chemical Biology, Numero 15/5, 2019, Pagina/e 510-518, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-019-0265-y