Cellular diversity and stress-induced cell-state switches in the mammalian hypothalamus

Project Information

Secret-Cells

Grant agreement ID: 695136

DOI

10.3030/695136

Project closed

EC signature date 10 August 2016

Start date 1 September 2016

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 422 698,00

EU contribution

€ 2 422 698,00

Coordinated by

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (36)

Molecular design of hypothalamus development

Author(s): Roman A. Romanov, Evgenii O. Tretiakov, Maria Eleni Kastriti, Maja Zupancic, Martin Häring, Solomiia Korchynska, Konstantin Popadin, Marco Benevento, Patrick Rebernik, Francois Lallemend, Katsuhiko Nishimori, Frédéric Clotman, William D. Andrews, John G. Parnavelas, Matthias Farlik, Christoph Bock, Igor Adameyko, Tomas Hökfelt, Erik Keimpema, Tibor Harkany
Published in: Nature, Issue 582/7811, 2020, Page(s) 246-252, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2266-0

Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants

Author(s): Janos Fuzik, Sabah Rehman, Fatima Girach, Andras G. Miklosi, Solomiia Korchynska, Gloria Arque, Roman A. Romanov, János Hanics, Ludwig Wagner, Konstantinos Meletis, Yuchio Yanagawa, Gabor G. Kovacs, Alán Alpár, Tomas G. M. Hökfelt, Tibor Harkany
Published in: Proceedings of the National Academy of Sciences, Issue 116/51, 2019, Page(s) 25958-25967, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1904006116

Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development

Author(s): Johannes Beiersdorf, Zsofia Hevesi, Daniela Calvigioni, Jakob Pyszkowski, Roman Romanov, Edit Szodorai, Gert Lubec, Sally Shirran, Catherine H. Botting, Siegfried Kasper, Geoffrey W. Guy, Roy Gray, Vincenzo Di Marzo, Tibor Harkany, Erik Keimpema
Published in: JCI Insight, Issue 5/23, 2020, Page(s) Volume 5/Issue 23, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.135418

Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB 1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster

Author(s): Giuseppe Tortoriello, Johannes Beiersdorf, Susana Romani, Gareth Williams, Gary A. Cameron, Ken Mackie, Michael J. Williams, Vincenzo Di Marzo, Erik Keimpema, Patrick Doherty, Tibor Harkany
Published in: Cannabis and Cannabinoid Research, Issue 6/2, 2021, Page(s) 119-136, ISSN 2578-5125
Publisher: Mary Ann Liebert, Inc., publishers
DOI: 10.1089/can.2020.0010

Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy

Author(s): Valentina Cinquina, Daniela Calvigioni, Matthias Farlik, Florian Halbritter, Victoria Fife-Gernedl, Sally L. Shirran, Matthew A. Fuszard, Catherine H. Botting, Patrick Poullet, Fabiana Piscitelli, Zoltán Máté, Gábor Szabó, Yuchio Yanagawa, Siegfried Kasper, Vincenzo Di Marzo, Ken Mackie, Chris J. McBain, Christoph Bock, Erik Keimpema, Tibor Harkany
Published in: Molecular Psychiatry, Issue 25/1, 2020, Page(s) 22-36, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-019-0580-4

Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability

Author(s): Zsófia Hevesi, Dóra Zelena, Roman A. Romanov, János Hanics, Attila Ignácz, Alice Zambon, Daniela D. Pollak, Dávid Lendvai, Katalin Schlett, Miklós Palkovits, Tibor Harkany, Tomas G. M. Hökfelt, Alán Alpár
Published in: Proceedings of the National Academy of Sciences, Issue 118/7, 2021, Page(s) e1921123118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1921123118

A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation

Author(s): Stefanos Stagkourakis, Kristina O. Smiley, Paul Williams, Sarah Kakadellis, Katharina Ziegler, Joanne Bakker, Rosemary S.E. Brown, Tibor Harkany, David R. Grattan, Christian Broberger
Published in: Cell, Issue 182/4, 2020, Page(s) 960-975.e15, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.07.007

Secretagogin expression in the vertebrate brainstem with focus on the noradrenergic system and implications for Alzheimer’s disease

Author(s): Péter Zahola, János Hanics, Anna Pintér, Zoltán Máté, Anna Gáspárdy, Zsófia Hevesi, Diego Echevarria, Csaba Adori, Swapnali Barde, Beáta Törőcsik, Ferenc Erdélyi, Gábor Szabó, Ludwig Wagner, Gabor G. Kovacs, Tomas Hökfelt, Tibor Harkany, Alán Alpár
Published in: Brain Structure and Function, Issue 224/6, 2019, Page(s) 2061-2078, ISSN 1863-2653
Publisher: Springer Verlag
DOI: 10.1007/s00429-019-01886-w

Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord

Author(s): Ming-Dong Zhang, Swapnali Barde, Edit Szodorai, Anna Josephson, Nicholas Mitsios, Masahiko Watanabe, Johannes Attems, Gert Lubec, Gábor G. Kovács, Mathias Uhlén, Jan Mulder, Tibor Harkany, Tomas Hökfelt
Published in: Brain Structure and Function, Issue 221/7, 2016, Page(s) 3803-3823, ISSN 1863-2653
Publisher: Springer Verlag
DOI: 10.1007/s00429-016-1191-3

GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome

Author(s): Ivan Milenkovic, Tamara Stojanovic, Eleonora Aronica, Livia Fülöp, Zsolt Bozsó, Zoltán Máté, Yuchio Yanagawa, Homa Adle-Biassette, Gert Lubec, Gábor Szabó, Tibor Harkany, Gábor G. Kovács, Erik Keimpema
Published in: Brain Structure and Function, 2018, ISSN 1863-2653
Publisher: Springer Verlag
DOI: 10.1007/s00429-017-1563-3

Resolution Matters: Correlating Quantitative Proteomics and Nanoscale-Precision Microscopy for Reconstructing Synapse Identity

Author(s): Andras Gabor Miklosi, Giorgia Del Favero, Doris Marko, Tibor Harkany, Gert Lubec
Published in: PROTEOMICS, Issue 18/14, 2018, Page(s) 1800139, ISSN 1615-9853
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201800139

Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex

Author(s): Roman A. Romanov, Robert S. Lasher, Brigit High, Logan E. Savidge, Adam Lawson, Olga A. Rogachevskaja, Haitian Zhao, Vadim V. Rogachevsky, Marina F. Bystrova, Gleb D. Churbanov, Igor Adameyko, Tibor Harkany, Ruibiao Yang, Grahame J. Kidd, Philippe Marambaud, John C. Kinnamon, Stanislav S. Kolesnikov, Thomas E. Finger
Published in: Science Signaling, Issue 11/529, 2018, Page(s) eaao1815, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aao1815

Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity

Author(s): Ming-Dong Zhang, Jie Su, Csaba Adori, Valentina Cinquina, Katarzyna Malenczyk, Fatima Girach, Changgeng Peng, Patrik Ernfors, Peter Löw, Lotta Borgius, Ole Kiehn, Masahiko Watanabe, Mathias Uhlén, Nicholas Mitsios, Jan Mulder, Tibor Harkany, Tomas Hökfelt
Published in: Journal of Clinical Investigation, Issue 128/9, 2018, Page(s) 3757-3768, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci120913

Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification

Author(s): Katarzyna Malenczyk, Edit Szodorai, Robert Schnell, Gert Lubec, Gábor Szabó, Tomas Hökfelt, Tibor Harkany
Published in: Molecular Metabolism, Issue 14, 2018, Page(s) 108-120, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.05.019

Diversity matters: combinatorial information coding by GABA A receptor subunits during spatial learning and its allosteric modulation

Author(s): Edit Szodorai, Konstantina Bampali, Roman A. Romanov, Siegfried Kasper, Tomas Hökfelt, Margot Ernst, Gert Lubec, Tibor Harkany
Published in: Cellular Signalling, Issue 50, 2018, Page(s) 142-159, ISSN 0898-6568
Publisher: Elsevier BV
DOI: 10.1016/j.cellsig.2018.07.003

Novel insights into the spatial and temporal complexity of hypothalamic organization through precision methods allowing nanoscale resolution

Author(s): A. Alpár, T. Harkany
Published in: Journal of Internal Medicine, Issue 284/6, 2018, Page(s) 568-580, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.12815

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

Author(s): Merav Cohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit
Published in: Cell, Issue 175/4, 2018, Page(s) 1031-1044.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.09.009

Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress

Author(s): Alán Alpár, Péter Zahola, János Hanics, Zsófia Hevesi, Solomiia Korchynska, Marco Benevento, Christian Pifl, Gergely Zachar, Jessica Perugini, Ilenia Severi, Patrick Leitgeb, Joanne Bakker, Andras G Miklosi, Evgenii Tretiakov, Erik Keimpema, Gloria Arque, Ramon O Tasan, Günther Sperk, Katarzyna Malenczyk, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Gert Lubec, Miklós Palkovits, Antonio
Published in: The EMBO Journal, Issue 37/21, 2018, Page(s) e100087, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018100087

Hypothalamic cell diversity: non-neuronal codes for long-distance volume transmission by neuropeptides

Author(s): Alán Alpár, Marco Benevento, Roman A Romanov, Tomas Hökfelt, Tibor Harkany
Published in: Current Opinion in Neurobiology, Issue 56, 2019, Page(s) 16-23, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2018.10.012

Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons

Author(s): Roman A. Romanov, Alán Alpár, Tomas Hökfelt, Tibor Harkany
Published in: Annual Review of Neuroscience, Issue 42/1, 2019, ISSN 0147-006X
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-neuro-070918-050414

GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation

Author(s): Solomiia Korchynska, Mirjam I. Lutz, Erzsébet Borók, Johannes Pammer, Valentina Cinquina, Nataliya Fedirko, Andrew J. Irving, Ken Mackie, Tibor Harkany, Erik Keimpema
Published in: JCI Insight, Issue 4/4, 2019, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.122947

Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex

Author(s): Daniela Calvigioni, Zoltán Máté, János Fuzik, Fatima Girach, Ming-Dong Zhang, Andrea Varro, Johannes Beiersdorf, Christian Schwindling, Yuchio Yanagawa, Graham J. Dockray, Chris J. McBain, Tomas Hökfelt, Gábor Szabó, Erik Keimpema, Tibor Harkany
Published in: Cerebral Cortex, 2017, Page(s) bhw094, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhw094

Artemisinins Target GABA A Receptor Signaling and Impair ? Cell Identity

Author(s): Jin Li, Tamara Casteels, Thomas Frogne, Camilla Ingvorsen, Christian Honor?, Monica Courtney, Kilian V.M. Huber, Nicole Schmitner, Robin A. Kimmel, Roman A. Romanov, Caterina Sturtzel, Charles-Hugues Lardeau, Johanna Klughammer, Matthias Farlik, Sara Sdelci, Andhira Vieira, Fabio Avolio, Fran?ois Briand, Igor Baburin, Peter M?jek, Florian M. Pauler, Thomas Penz, Alexey Stukalov, Manuela Gridling,
Published in: Cell, Issue 168/1-2, 2017, Page(s) 86-100.e15, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2016.11.010

Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration

Author(s): J?nos Hanics, Edit Szodorai, Giuseppe Tortoriello, Katarzyna Malenczyk, Erik Keimpema, Gert Lubec, Zs?fia Hevesi, Mirjam I. Lutz, M?rk Kozsurek, Zita Pusk?r, Zsuzsanna E. T?th, Ludwig Wagner, G?bor G. Kov?cs, Tomas G. M. H?kfelt, Tibor Harkany, Al?n Alp?r
Published in: Proceedings of the National Academy of Sciences, Issue 114/10, 2017, Page(s) E2006-E2015, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1700662114

(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity

Author(s): Tibor Harkany, Tamas L. Horvath
Published in: Cell Metabolism, Issue 25/1, 2017, Page(s) 8-10, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2016.12.020

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Author(s): S. Marques, A. Zeisel, S. Codeluppi, D. van Bruggen, A. Mendanha Falcao, L. Xiao, H. Li, M. Haring, H. Hochgerner, R. A. Romanov, D. Gyllborg, A. B. Munoz-Manchado, G. La Manno, P. Lonnerberg, E. M. Floriddia, F. Rezayee, P. Ernfors, E. Arenas, J. Hjerling-Leffler, T. Harkany, W. D. Richardson, S. Linnarsson, G. Castelo-Branco
Published in: Science, Issue 352/6291, 2016, Page(s) 1326-1329, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaf6463

A TRPV1‐to‐secretagogin regulatory axis controls pancreatic β‐cell survival by modulating protein turnover

Author(s): Katarzyna Malenczyk, Fatima Girach, Edit Szodorai, Petter Storm, Åsa Segerstolpe, Giuseppe Tortoriello, Robert Schnell, Jan Mulder, Roman A Romanov, Erzsébet Borók, Fabiana Piscitelli, Vincenzo Di Marzo, Gábor Szabó, Rickard Sandberg, Stefan Kubicek, Gert Lubec, Tomas Hökfelt, Ludwig Wagner, Leif Groop, Tibor Harkany
Published in: The EMBO Journal, 2017, Page(s) e201695347, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201695347

Molecular diversity of corticotropin-releasing hormone mRNA-containing neurons in the hypothalamus

Author(s): Roman A Romanov, Al?n Alp?r, Tomas H?kfelt, Tibor Harkany
Published in: Journal of Endocrinology, Issue 232/3, 2017, Page(s) R161-R172, ISSN 0022-0795
Publisher: Society for Endocrinology
DOI: 10.1530/JOE-16-0256

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

Author(s): Roman A Romanov, Amit Zeisel, Joanne Bakker, Fatima Girach, Arash Hellysaz, Raju Tomer, Al?n Alp?r, Jan Mulder, Fr?d?ric Clotman, Erik Keimpema, Brian Hsueh, Ailey K Crow, Henrik Martens, Christian Schwindling, Daniela Calvigioni, Jaideep S Bains, Zolt?n M?t?, G?bor Szab?, Yuchio Yanagawa, Ming-Dong Zhang, Andre Rendeiro, Matthias Farlik, Mathias Uhl?n, Peer Wulff, Christoph Bock, Christian Brober
Published in: Nature Neuroscience, Issue 20/2, 2016, Page(s) 176-188, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/nn.4462

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

Author(s): Pia Rivetti di Val Cervo, Roman A Romanov, Giada Spigolon, D?bora Masini, Elisa Mart?n-Monta?ez, Enrique M Toledo, Gioele La Manno, Michael Feyder, Christian Pifl, Yi-Han Ng, Sara Padrell S?nchez, Sten Linnarsson, Marius Wernig, Tibor Harkany, Gilberto Fisone, Ernest Arenas
Published in: Nature Biotechnology, Issue 35/5, 2017, Page(s) 444-452, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/nbt.3835

miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes

Author(s): Changgeng Peng, Lili Li, Ming-Dong Zhang, Carolina Bengtsson Gonzales, Marc Parisien, Inna Belfer, Dmitry Usoskin, Hind Abdo, Alessandro Furlan, Martin Häring, Francois Lallemend, Tibor Harkany, Luda Diatchenko, Tomas Hökfelt, Jens Hjerling-Leffler, Patrik Ernfors
Published in: Science, Issue 356/6343, 2017, Page(s) 1168-1171, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aam7671

Selective silencing of hippocampal parvalbumin interneurons induces development of recurrent spontaneous limbic seizures in mice

Author(s): Meinrad Drexel, Roman A. Romanov, James Wood, Stefan Weger, Regine Heilbronn, Peer Wulff, Ramon O. Tasan, Tibor Harkany, Günther Sperk
Published in: The Journal of Neuroscience, 2017, Page(s) 3456-16, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.3456-16.2017

Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease

Author(s): Ágoston Patthy, János Murai, János Hanics, Anna Pintér, Péter Zahola, Tomas G. M. Hökfelt, Tibor Harkany, Alán Alpár
Published in: Journal of Clinical Medicine, Issue 10/8, 2021, Page(s) 1555, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10081555

The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity

Author(s): Tayyaba Qureshi, Christina Sørensen, Paul Berghuis, Vidar Jensen, Marton B Dobszay, Tamás Farkas, Knut Tomas Dalen, Caiying Guo, Bjørnar Hassel, Tor Paaske Utheim, Øivind Hvalby, Torkel Hafting, Tibor Harkany, Marianne Fyhn, Farrukh Abbas Chaudhry
Published in: Cerebral Cortex, Issue 29/12, 2019, Page(s) 5166-5179, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhz055

Life‐long impairment of glucose homeostasis upon prenatal exposure to psychostimulants

Author(s): Solomiia Korchynska, Maria Krassnitzer, Katarzyna Malenczyk, Rashmi B Prasad, Evgenii O Tretiakov, Sabah Rehman, Valentina Cinquina, Victoria Gernedl, Matthias Farlik, Julian Petersen, Sophia Hannes, Julia Schachenhofer, Sonali N Reisinger, Alice Zambon, Olof Asplund, Isabella Artner, Erik Keimpema, Gert Lubec, Jan Mulder, Christoph Bock, Daniela D Pollak, Roman A Romanov, Christian Pifl, Leif Gro
Published in: The EMBO Journal, Issue 39/1, 2020, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018100882

Identification of ALK in Thinness

Author(s): Michael Orthofer, Armand Valsesia, Reedik Mägi, Qiao-Ping Wang, Joanna Kaczanowska, Ivona Kozieradzki, Alexandra Leopoldi, Domagoj Cikes, Lydia M. Zopf, Evgenii O. Tretiakov, Egon Demetz, Richard Hilbe, Anna Boehm, Melita Ticevic, Margit Nõukas, Alexander Jais, Katrin Spirk, Teleri Clark, Sabine Amann, Maarja Lepamets, Christoph Neumayr, Cosmas Arnold, Zhengchao Dou, Volker Kuhn, Maria Novatchko
Published in: Cell, Issue 181/6, 2020, Page(s) 1246-1262.e22, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.04.034