Cellular diversity and stress-induced cell-state switches in the mammalian hypothalamus

Información del proyecto

Secret-Cells

Identificador del acuerdo de subvención: 695136

DOI

10.3030/695136

Proyecto cerrado

Fecha de la firma de la CE 10 Agosto 2016

Fecha de inicio 1 Septiembre 2016

Fecha de finalización 31 Agosto 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 422 698,00

Aportación de la UE

€ 2 422 698,00

Coordinado por

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (36)

Molecular design of hypothalamus development

Autores: Roman A. Romanov, Evgenii O. Tretiakov, Maria Eleni Kastriti, Maja Zupancic, Martin Häring, Solomiia Korchynska, Konstantin Popadin, Marco Benevento, Patrick Rebernik, Francois Lallemend, Katsuhiko Nishimori, Frédéric Clotman, William D. Andrews, John G. Parnavelas, Matthias Farlik, Christoph Bock, Igor Adameyko, Tomas Hökfelt, Erik Keimpema, Tibor Harkany
Publicado en: Nature, Edición 582/7811, 2020, Página(s) 246-252, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2266-0

Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants

Autores: Janos Fuzik, Sabah Rehman, Fatima Girach, Andras G. Miklosi, Solomiia Korchynska, Gloria Arque, Roman A. Romanov, János Hanics, Ludwig Wagner, Konstantinos Meletis, Yuchio Yanagawa, Gabor G. Kovacs, Alán Alpár, Tomas G. M. Hökfelt, Tibor Harkany
Publicado en: Proceedings of the National Academy of Sciences, Edición 116/51, 2019, Página(s) 25958-25967, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1904006116

Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development

Autores: Johannes Beiersdorf, Zsofia Hevesi, Daniela Calvigioni, Jakob Pyszkowski, Roman Romanov, Edit Szodorai, Gert Lubec, Sally Shirran, Catherine H. Botting, Siegfried Kasper, Geoffrey W. Guy, Roy Gray, Vincenzo Di Marzo, Tibor Harkany, Erik Keimpema
Publicado en: JCI Insight, Edición 5/23, 2020, Página(s) Volume 5/Edición 23, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.135418

Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB 1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster

Autores: Giuseppe Tortoriello, Johannes Beiersdorf, Susana Romani, Gareth Williams, Gary A. Cameron, Ken Mackie, Michael J. Williams, Vincenzo Di Marzo, Erik Keimpema, Patrick Doherty, Tibor Harkany
Publicado en: Cannabis and Cannabinoid Research, Edición 6/2, 2021, Página(s) 119-136, ISSN 2578-5125
Editor: Mary Ann Liebert, Inc., publishers
DOI: 10.1089/can.2020.0010

Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy

Autores: Valentina Cinquina, Daniela Calvigioni, Matthias Farlik, Florian Halbritter, Victoria Fife-Gernedl, Sally L. Shirran, Matthew A. Fuszard, Catherine H. Botting, Patrick Poullet, Fabiana Piscitelli, Zoltán Máté, Gábor Szabó, Yuchio Yanagawa, Siegfried Kasper, Vincenzo Di Marzo, Ken Mackie, Chris J. McBain, Christoph Bock, Erik Keimpema, Tibor Harkany
Publicado en: Molecular Psychiatry, Edición 25/1, 2020, Página(s) 22-36, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-019-0580-4

Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability

Autores: Zsófia Hevesi, Dóra Zelena, Roman A. Romanov, János Hanics, Attila Ignácz, Alice Zambon, Daniela D. Pollak, Dávid Lendvai, Katalin Schlett, Miklós Palkovits, Tibor Harkany, Tomas G. M. Hökfelt, Alán Alpár
Publicado en: Proceedings of the National Academy of Sciences, Edición 118/7, 2021, Página(s) e1921123118, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1921123118

A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation

Autores: Stefanos Stagkourakis, Kristina O. Smiley, Paul Williams, Sarah Kakadellis, Katharina Ziegler, Joanne Bakker, Rosemary S.E. Brown, Tibor Harkany, David R. Grattan, Christian Broberger
Publicado en: Cell, Edición 182/4, 2020, Página(s) 960-975.e15, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.07.007

Secretagogin expression in the vertebrate brainstem with focus on the noradrenergic system and implications for Alzheimer’s disease

Autores: Péter Zahola, János Hanics, Anna Pintér, Zoltán Máté, Anna Gáspárdy, Zsófia Hevesi, Diego Echevarria, Csaba Adori, Swapnali Barde, Beáta Törőcsik, Ferenc Erdélyi, Gábor Szabó, Ludwig Wagner, Gabor G. Kovacs, Tomas Hökfelt, Tibor Harkany, Alán Alpár
Publicado en: Brain Structure and Function, Edición 224/6, 2019, Página(s) 2061-2078, ISSN 1863-2653
Editor: Springer Verlag
DOI: 10.1007/s00429-019-01886-w

Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord

Autores: Ming-Dong Zhang, Swapnali Barde, Edit Szodorai, Anna Josephson, Nicholas Mitsios, Masahiko Watanabe, Johannes Attems, Gert Lubec, Gábor G. Kovács, Mathias Uhlén, Jan Mulder, Tibor Harkany, Tomas Hökfelt
Publicado en: Brain Structure and Function, Edición 221/7, 2016, Página(s) 3803-3823, ISSN 1863-2653
Editor: Springer Verlag
DOI: 10.1007/s00429-016-1191-3

GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome

Autores: Ivan Milenkovic, Tamara Stojanovic, Eleonora Aronica, Livia Fülöp, Zsolt Bozsó, Zoltán Máté, Yuchio Yanagawa, Homa Adle-Biassette, Gert Lubec, Gábor Szabó, Tibor Harkany, Gábor G. Kovács, Erik Keimpema
Publicado en: Brain Structure and Function, 2018, ISSN 1863-2653
Editor: Springer Verlag
DOI: 10.1007/s00429-017-1563-3

Resolution Matters: Correlating Quantitative Proteomics and Nanoscale-Precision Microscopy for Reconstructing Synapse Identity

Autores: Andras Gabor Miklosi, Giorgia Del Favero, Doris Marko, Tibor Harkany, Gert Lubec
Publicado en: PROTEOMICS, Edición 18/14, 2018, Página(s) 1800139, ISSN 1615-9853
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201800139

Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex

Autores: Roman A. Romanov, Robert S. Lasher, Brigit High, Logan E. Savidge, Adam Lawson, Olga A. Rogachevskaja, Haitian Zhao, Vadim V. Rogachevsky, Marina F. Bystrova, Gleb D. Churbanov, Igor Adameyko, Tibor Harkany, Ruibiao Yang, Grahame J. Kidd, Philippe Marambaud, John C. Kinnamon, Stanislav S. Kolesnikov, Thomas E. Finger
Publicado en: Science Signaling, Edición 11/529, 2018, Página(s) eaao1815, ISSN 1937-9145
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aao1815

Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity

Autores: Ming-Dong Zhang, Jie Su, Csaba Adori, Valentina Cinquina, Katarzyna Malenczyk, Fatima Girach, Changgeng Peng, Patrik Ernfors, Peter Löw, Lotta Borgius, Ole Kiehn, Masahiko Watanabe, Mathias Uhlén, Nicholas Mitsios, Jan Mulder, Tibor Harkany, Tomas Hökfelt
Publicado en: Journal of Clinical Investigation, Edición 128/9, 2018, Página(s) 3757-3768, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci120913

Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification

Autores: Katarzyna Malenczyk, Edit Szodorai, Robert Schnell, Gert Lubec, Gábor Szabó, Tomas Hökfelt, Tibor Harkany
Publicado en: Molecular Metabolism, Edición 14, 2018, Página(s) 108-120, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.05.019

Diversity matters: combinatorial information coding by GABA A receptor subunits during spatial learning and its allosteric modulation

Autores: Edit Szodorai, Konstantina Bampali, Roman A. Romanov, Siegfried Kasper, Tomas Hökfelt, Margot Ernst, Gert Lubec, Tibor Harkany
Publicado en: Cellular Signalling, Edición 50, 2018, Página(s) 142-159, ISSN 0898-6568
Editor: Elsevier BV
DOI: 10.1016/j.cellsig.2018.07.003

Novel insights into the spatial and temporal complexity of hypothalamic organization through precision methods allowing nanoscale resolution

Autores: A. Alpár, T. Harkany
Publicado en: Journal of Internal Medicine, Edición 284/6, 2018, Página(s) 568-580, ISSN 0954-6820
Editor: Blackwell Publishing Inc.
DOI: 10.1111/joim.12815

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

Autores: Merav Cohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit
Publicado en: Cell, Edición 175/4, 2018, Página(s) 1031-1044.e18, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2018.09.009

Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress

Autores: Alán Alpár, Péter Zahola, János Hanics, Zsófia Hevesi, Solomiia Korchynska, Marco Benevento, Christian Pifl, Gergely Zachar, Jessica Perugini, Ilenia Severi, Patrick Leitgeb, Joanne Bakker, Andras G Miklosi, Evgenii Tretiakov, Erik Keimpema, Gloria Arque, Ramon O Tasan, Günther Sperk, Katarzyna Malenczyk, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Gert Lubec, Miklós Palkovits, Antonio
Publicado en: The EMBO Journal, Edición 37/21, 2018, Página(s) e100087, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2018100087

Hypothalamic cell diversity: non-neuronal codes for long-distance volume transmission by neuropeptides

Autores: Alán Alpár, Marco Benevento, Roman A Romanov, Tomas Hökfelt, Tibor Harkany
Publicado en: Current Opinion in Neurobiology, Edición 56, 2019, Página(s) 16-23, ISSN 0959-4388
Editor: Elsevier BV
DOI: 10.1016/j.conb.2018.10.012

Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons

Autores: Roman A. Romanov, Alán Alpár, Tomas Hökfelt, Tibor Harkany
Publicado en: Annual Review of Neuroscience, Edición 42/1, 2019, ISSN 0147-006X
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-neuro-070918-050414

GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation

Autores: Solomiia Korchynska, Mirjam I. Lutz, Erzsébet Borók, Johannes Pammer, Valentina Cinquina, Nataliya Fedirko, Andrew J. Irving, Ken Mackie, Tibor Harkany, Erik Keimpema
Publicado en: JCI Insight, Edición 4/4, 2019, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.122947

Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex

Autores: Daniela Calvigioni, Zoltán Máté, János Fuzik, Fatima Girach, Ming-Dong Zhang, Andrea Varro, Johannes Beiersdorf, Christian Schwindling, Yuchio Yanagawa, Graham J. Dockray, Chris J. McBain, Tomas Hökfelt, Gábor Szabó, Erik Keimpema, Tibor Harkany
Publicado en: Cerebral Cortex, 2017, Página(s) bhw094, ISSN 1047-3211
Editor: Oxford University Press
DOI: 10.1093/cercor/bhw094

Artemisinins Target GABA A Receptor Signaling and Impair ? Cell Identity

Autores: Jin Li, Tamara Casteels, Thomas Frogne, Camilla Ingvorsen, Christian Honor?, Monica Courtney, Kilian V.M. Huber, Nicole Schmitner, Robin A. Kimmel, Roman A. Romanov, Caterina Sturtzel, Charles-Hugues Lardeau, Johanna Klughammer, Matthias Farlik, Sara Sdelci, Andhira Vieira, Fabio Avolio, Fran?ois Briand, Igor Baburin, Peter M?jek, Florian M. Pauler, Thomas Penz, Alexey Stukalov, Manuela Gridling,
Publicado en: Cell, Edición 168/1-2, 2017, Página(s) 86-100.e15, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2016.11.010

Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration

Autores: J?nos Hanics, Edit Szodorai, Giuseppe Tortoriello, Katarzyna Malenczyk, Erik Keimpema, Gert Lubec, Zs?fia Hevesi, Mirjam I. Lutz, M?rk Kozsurek, Zita Pusk?r, Zsuzsanna E. T?th, Ludwig Wagner, G?bor G. Kov?cs, Tomas G. M. H?kfelt, Tibor Harkany, Al?n Alp?r
Publicado en: Proceedings of the National Academy of Sciences, Edición 114/10, 2017, Página(s) E2006-E2015, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1700662114

(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity

Autores: Tibor Harkany, Tamas L. Horvath
Publicado en: Cell Metabolism, Edición 25/1, 2017, Página(s) 8-10, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2016.12.020

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Autores: S. Marques, A. Zeisel, S. Codeluppi, D. van Bruggen, A. Mendanha Falcao, L. Xiao, H. Li, M. Haring, H. Hochgerner, R. A. Romanov, D. Gyllborg, A. B. Munoz-Manchado, G. La Manno, P. Lonnerberg, E. M. Floriddia, F. Rezayee, P. Ernfors, E. Arenas, J. Hjerling-Leffler, T. Harkany, W. D. Richardson, S. Linnarsson, G. Castelo-Branco
Publicado en: Science, Edición 352/6291, 2016, Página(s) 1326-1329, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aaf6463

A TRPV1‐to‐secretagogin regulatory axis controls pancreatic β‐cell survival by modulating protein turnover

Autores: Katarzyna Malenczyk, Fatima Girach, Edit Szodorai, Petter Storm, Åsa Segerstolpe, Giuseppe Tortoriello, Robert Schnell, Jan Mulder, Roman A Romanov, Erzsébet Borók, Fabiana Piscitelli, Vincenzo Di Marzo, Gábor Szabó, Rickard Sandberg, Stefan Kubicek, Gert Lubec, Tomas Hökfelt, Ludwig Wagner, Leif Groop, Tibor Harkany
Publicado en: The EMBO Journal, 2017, Página(s) e201695347, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.201695347

Molecular diversity of corticotropin-releasing hormone mRNA-containing neurons in the hypothalamus

Autores: Roman A Romanov, Al?n Alp?r, Tomas H?kfelt, Tibor Harkany
Publicado en: Journal of Endocrinology, Edición 232/3, 2017, Página(s) R161-R172, ISSN 0022-0795
Editor: Society for Endocrinology
DOI: 10.1530/JOE-16-0256

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

Autores: Roman A Romanov, Amit Zeisel, Joanne Bakker, Fatima Girach, Arash Hellysaz, Raju Tomer, Al?n Alp?r, Jan Mulder, Fr?d?ric Clotman, Erik Keimpema, Brian Hsueh, Ailey K Crow, Henrik Martens, Christian Schwindling, Daniela Calvigioni, Jaideep S Bains, Zolt?n M?t?, G?bor Szab?, Yuchio Yanagawa, Ming-Dong Zhang, Andre Rendeiro, Matthias Farlik, Mathias Uhl?n, Peer Wulff, Christoph Bock, Christian Brober
Publicado en: Nature Neuroscience, Edición 20/2, 2016, Página(s) 176-188, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/nn.4462

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

Autores: Pia Rivetti di Val Cervo, Roman A Romanov, Giada Spigolon, D?bora Masini, Elisa Mart?n-Monta?ez, Enrique M Toledo, Gioele La Manno, Michael Feyder, Christian Pifl, Yi-Han Ng, Sara Padrell S?nchez, Sten Linnarsson, Marius Wernig, Tibor Harkany, Gilberto Fisone, Ernest Arenas
Publicado en: Nature Biotechnology, Edición 35/5, 2017, Página(s) 444-452, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/nbt.3835

miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes

Autores: Changgeng Peng, Lili Li, Ming-Dong Zhang, Carolina Bengtsson Gonzales, Marc Parisien, Inna Belfer, Dmitry Usoskin, Hind Abdo, Alessandro Furlan, Martin Häring, Francois Lallemend, Tibor Harkany, Luda Diatchenko, Tomas Hökfelt, Jens Hjerling-Leffler, Patrik Ernfors
Publicado en: Science, Edición 356/6343, 2017, Página(s) 1168-1171, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aam7671

Selective silencing of hippocampal parvalbumin interneurons induces development of recurrent spontaneous limbic seizures in mice

Autores: Meinrad Drexel, Roman A. Romanov, James Wood, Stefan Weger, Regine Heilbronn, Peer Wulff, Ramon O. Tasan, Tibor Harkany, Günther Sperk
Publicado en: The Journal of Neuroscience, 2017, Página(s) 3456-16, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.3456-16.2017

Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease

Autores: Ágoston Patthy, János Murai, János Hanics, Anna Pintér, Péter Zahola, Tomas G. M. Hökfelt, Tibor Harkany, Alán Alpár
Publicado en: Journal of Clinical Medicine, Edición 10/8, 2021, Página(s) 1555, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10081555

The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity

Autores: Tayyaba Qureshi, Christina Sørensen, Paul Berghuis, Vidar Jensen, Marton B Dobszay, Tamás Farkas, Knut Tomas Dalen, Caiying Guo, Bjørnar Hassel, Tor Paaske Utheim, Øivind Hvalby, Torkel Hafting, Tibor Harkany, Marianne Fyhn, Farrukh Abbas Chaudhry
Publicado en: Cerebral Cortex, Edición 29/12, 2019, Página(s) 5166-5179, ISSN 1047-3211
Editor: Oxford University Press
DOI: 10.1093/cercor/bhz055

Life‐long impairment of glucose homeostasis upon prenatal exposure to psychostimulants

Autores: Solomiia Korchynska, Maria Krassnitzer, Katarzyna Malenczyk, Rashmi B Prasad, Evgenii O Tretiakov, Sabah Rehman, Valentina Cinquina, Victoria Gernedl, Matthias Farlik, Julian Petersen, Sophia Hannes, Julia Schachenhofer, Sonali N Reisinger, Alice Zambon, Olof Asplund, Isabella Artner, Erik Keimpema, Gert Lubec, Jan Mulder, Christoph Bock, Daniela D Pollak, Roman A Romanov, Christian Pifl, Leif Gro
Publicado en: The EMBO Journal, Edición 39/1, 2020, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2018100882

Identification of ALK in Thinness

Autores: Michael Orthofer, Armand Valsesia, Reedik Mägi, Qiao-Ping Wang, Joanna Kaczanowska, Ivona Kozieradzki, Alexandra Leopoldi, Domagoj Cikes, Lydia M. Zopf, Evgenii O. Tretiakov, Egon Demetz, Richard Hilbe, Anna Boehm, Melita Ticevic, Margit Nõukas, Alexander Jais, Katrin Spirk, Teleri Clark, Sabine Amann, Maarja Lepamets, Christoph Neumayr, Cosmas Arnold, Zhengchao Dou, Volker Kuhn, Maria Novatchko
Publicado en: Cell, Edición 181/6, 2020, Página(s) 1246-1262.e22, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.04.034