MacroAutophagy and Necrotic Neurodegeneration in Ageing

Project Information

MANNA

Grant agreement ID: 695190

DOI

10.3030/695190

Project closed

EC signature date 24 November 2016

Start date 1 January 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 254 109,00

EU contribution

€ 2 254 109,00

Coordinated by

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (48)

Editorial: Mitophagy in Health and Disease

Author(s): Konstantinos Palikaras, Evandro Fei Fang, Nektarios Tavernarakis
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2021.647036

Selective Autophagy as a Potential Therapeutic Target in Age-Associated Pathologies.

Author(s): Margarita-Elena Papandreou; Margarita-Elena Papandreou; Nektarios Tavernarakis; Nektarios Tavernarakis
Published in: Metabolites, Vol 11, Iss 588, p 588 (2021), Issue 3, 2021, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo11090588

Autophagy in healthy aging and disease

Author(s): Yahyah Aman,Tomas Schmauck-Medina, Malene Hansen, Richard I Morimoto, Anna Katharina Simon, Ivana Bjedov, Konstantinos Palikaras , Anne Simonsen, Terje Johansen, Nektarios Tavernarakis , David C Rubinsztein, Linda Partridge, Guido Kroemer, John Labbadia , Evandro F Fang
Published in: Nature Aging, 2021, ISSN 2662-8465
Publisher: Springer Nature
DOI: 10.1038/s43587-021-00098-4

The complex interplay between autophagy and cell death pathways

Author(s): Christina Ploumi, Margarita-Elena Papandreou, Nektarios Tavernarakis
Published in: The Biochemical Journal, 2022, ISSN 1470-8728
Publisher: Portland Press
DOI: 10.1042/bcj20210450

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

Author(s): Nektarios Tavernarakis; EIRINI LIONAKI; Christina Ploumi
Published in: Cells, Vol 11, Iss 214, p 214 (2022), Issue 1, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11020214

Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans

Author(s): Christina Ploumi, Emmanouil Kyriakakis & Nektarios Tavernarakis
Published in: Cell Death & Disease, 2023, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-023-05638-x

Age-dependent nuclear lipid droplet deposition is a cellular hallmark of aging in Caenorhabditis elegans

Author(s): Konstantinos Palikaras, Meropi Mari, Christina Ploumi, Andrea Princz, George Filippidis, Nektarios Tavernarakis
Published in: Aging Cell, 2023, ISSN 1474-9726
Publisher: Wiley
DOI: 10.1111/acel.13788

Mitochondrial protein import determines lifespan through metabolic reprogramming and de novoserine biosynthesis

Author(s): Eirini Lionaki, Ilias Gkikas,, Ioanna Daskalaki, Nektarios Tavernarakis
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28272-1

Sustained intracellular calcium rise mediates neuronalmitophagy in models of autosomal dominant optic atrophy

Author(s): Marta Zaninello, Konstantinos Palikaras, Aggeliki Sotiriou, Nektarios Tavernarakis and Luca Scorrano
Published in: Cell Death Differentiation, 2022, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-021-00847-3

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

Author(s): Marta Zaninello, Konstantinos Palikaras, Deborah Naon, Keiko Iwata, Stephanie Herkenne, Ruben Quintana-Cabrera, Martina Semenzato, Francesca Grespi, Fred N. Ross-Cisneros, Valerio Carelli, Alfredo A. Sadun, Nektarios Tavernarakis, Luca Scorrano
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17821-1

Mitochondrial turnover and homeostasis in ageing and neurodegeneration

Author(s): Maria Markaki, Nektarios Tavernarakis
Published in: FEBS Letters, Issue 594/15, 2020, Page(s) 2370-2379, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13802

Nucleophagy delays aging and preserves germline immortality

Author(s): Margarita-Elena Papandreou, Georgios Konstantinidis, Nektarios Tavernarakis 
Published in: Nature Aging, 2022, ISSN 2662-8465
Publisher: Springer Nature
DOI: 10.1038/s43587-022-00327-4

Caenorhabditis elegans as a model system for human diseases

Author(s): Maria Markaki, Nektarios Tavernarakis
Published in: Current Opinion in Biotechnology, Issue 63, 2020, Page(s) 118-125, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2019.12.011

MitoSNARE Assembly and Disassembly Factors Regulate Basal Autophagy and Aging in C. elegans

Author(s): Ilias Gkikas, Ioanna Daskalaki, Konstantinos Kounakis, Nektarios Tavernarakis and Eirini Lionaki
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24044230

Mitochondrial biogenesis in organismal senescence and neurodegeneration

Author(s): Ioanna Daskalaki, Nektarios Tavernarakis
Published in: Mechanisms of Ageing and Development, Issue 191, 2020, Page(s) 111345, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2020.111345

Molecular Interventions towards Multiple Sclerosis Treatment

Author(s): Athanasios Metaxakis, Dionysia Petratou, Nektarios Tavernarakis
Published in: Brain Sciences, Issue 10/5, 2020, Page(s) 299, ISSN 2076-3425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci10050299

Autophagy of the Nucleus in Health and Disease

Author(s): Georgios Konstantinidis , Nektarios Tavernarakis
Published in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2021.814955

Oxidative Stress in Age-Related Neurodegenerative Diseases: An Overview of Recent Tools and Findings

Author(s): Dimitris Korovesis, Teresa Rubio-Tomás, Nektarios Tavernarakis
Published in: Antioxidants, 2023, ISSN 2076-3921
Publisher: MDPI
DOI: 10.3390/antiox12010131

Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans

Author(s): Georgios Konstantinidis, Nektarios Tavernarakis
Published in: Cells, Issue 10/3, 2021, Page(s) 694, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10030694

Research Briefing: Nuclear autophagy promotes longevity and germline immortality.

Author(s): Nektarios Tavernarakis
Published in: Nature Aging, 2022, ISSN 2662-8465
Publisher: Springer-Nature
DOI: 10.1038/s43587-022-00336-3

The interplay between selective types of (macro)autophagy: Mitophagy and xenophagy

Author(s): Teresa Rubio-Tomás, Aggeliki Sotiriou, Nektarios Tavernarakis
Published in: International Review of Cell and Molecular Biology, 2022, ISSN 1937-6448
Publisher: Elsevier BV
DOI: 10.1016/bs.ircmb.2022.10.003

The Role of Mitophagy in Innate Immunity

Author(s): Ilias Gkikas, Konstantinos Palikaras, Nektarios Tavernarakis
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01283

Chapter Five - Novel Insights Into the Anti-aging Role of Mitophagy

Author(s): Maria Markaki, Konstantinos Palikaras, Nektarios Tavernarakis
Published in: International Review of Cell and Molecular Biology, 2018, Page(s) 169-208, ISSN 1937-6448
Publisher: Elsevier BV
DOI: 10.1016/bs.ircmb.2018.05.005

Mitochondrial contributions to neuronal development and function

Author(s): Andrea Princz, Konstantinos Kounakis, Nektarios Tavernarakis
Published in: Biological Chemistry, Issue 399/7, 2018, Page(s) 723-739, ISSN 1431-6730
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2017-0333

Multimodal sensory processing in Caenorhabditis elegans

Author(s): Athanasios Metaxakis, Dionysia Petratou, Nektarios Tavernarakis
Published in: Open Biology, Issue 8/6, 2018, Page(s) 180049, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1098/rsob.180049

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

Author(s): Konstantinos Palikaras, Ioanna Daskalaki, Maria Markaki, Nektarios Tavernarakis
Published in: Pharmacology & Therapeutics, Issue 178, 2017, Page(s) 157-174, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2017.04.005

Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans

Author(s): Emmanouil Kyriakakis, Nikolaos Charmpilas, Nektarios Tavernarakis
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-05276-2

Hypoxia and Selective Autophagy in Cancer Development and Therapy

Author(s): Ioanna Daskalaki, Ilias Gkikas, Nektarios Tavernarakis
Published in: Frontiers in Cell and Developmental Biology, Issue 6, 2018, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2018.00104

Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

Author(s): Matthias Rieckher, Maria Markaki, Andrea Princz, Björn Schumacher, Nektarios Tavernarakis
Published in: Cell Reports, Issue 25/1, 2018, Page(s) 199-211.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.09.009

Regulation and Roles of Autophagy at Synapses

Author(s): Vassiliki Nikoletopoulou, Nektarios Tavernarakis
Published in: Trends in Cell Biology, Issue 28/8, 2018, Page(s) 646-661, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2018.03.006

Nucleophagy: from homeostasis to disease

Author(s): Margarita-Elena Papandreou, Nektarios Tavernarakis
Published in: Cell Death & Differentiation, Issue 26/4, 2019, Page(s) 630-639, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-018-0266-5

Mitochondrial maturation drives germline stem cell differentiation in Caenorhabditis elegans

Author(s): Nikolaos Charmpilas, Nektarios Tavernarakis
Published in: Cell Death & Differentiation, 2019, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-019-0375-9

Mitophagy and Neuroprotection

Author(s): Guofeng Lou, Konstantinos Palikaras, Sofie Lautrup, Morten Scheibye-Knudsen, Nektarios Tavernarakis, Evandro F. Fang
Published in: Trends in Molecular Medicine, 2019, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2019.07.002

Autophagy in Age-Associated Neurodegeneration

Author(s): Athanasios Metaxakis, Christina Ploumi, Nektarios Tavernarakis
Published in: Cells, Issue 7/5, 2018, Page(s) 37, ISSN 2073-4409
Publisher: MDPI GA
DOI: 10.3390/cells7050037

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Author(s): Konstantinos Palikaras, Eirini Lionaki, Nektarios Tavernarakis
Published in: Nature Cell Biology, Issue 20/9, 2018, Page(s) 1013-1022, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0176-2

Emerging Roles of Lipophagy in Health and Disease

Author(s): Konstantinos Kounakis, Manos Chaniotakis, Maria Markaki, Nektarios Tavernarakis
Published in: Frontiers in Cell and Developmental Biology, Issue 7, 2019, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2019.00185

SUMOylation in Neurodegenerative Diseases

Author(s): Andrea Princz, Nektarios Tavernarakis
Published in: Gerontology, 2019, Page(s) 1-9, ISSN 0304-324X
Publisher: S. Karger AG
DOI: 10.1159/000502142

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Author(s): Evandro F. Fang, Yujun Hou, Konstantinos Palikaras, Bryan A. Adriaanse, Jesse S. Kerr, Beimeng Yang, Sofie Lautrup, Md Mahdi Hasan-Olive, Domenica Caponio, Xiuli Dan, Paula Rocktäschel, Deborah L. Croteau, Mansour Akbari, Nigel H. Greig, Tormod Fladby, Hilde Nilsen, M. Zameel Cader, Mark P. Mattson, Nektarios Tavernarakis, Vilhelm A. Bohr
Published in: Nature Neuroscience, Issue 22/3, 2019, Page(s) 401-412, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0332-9

Mitochondrial protein import machinery conveys stress signals to the cytosol and beyond

Author(s): Eirini Lionaki, Ilias Gkikas, Nektarios Tavernarakis
Published in: BioEssays, 2023, ISSN 1521-1878
Publisher: Wiley
DOI: 10.1002/bies.202200160

Modeling Age-Associated Neurodegenerative Diseases in <em>Caenorhabditis elegans</em>

Author(s): Konstantinos Palikaras, Nektarios Tavernarakis
Published in: Journal of Visualized Experiments, Issue 162, 2020, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/61169

Regulation and roles of mitophagy at synapses

Author(s): Konstantinos Palikaras, Nektarios Tavernarakis
Published in: Mechanisms of Ageing and Development, Issue 187, 2020, Page(s) 111216, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2020.111216

Assessment of de novo Protein Synthesis Rates in <em>Caenorhabditis elegans</em>

Author(s): Margarita Elena Papandreou, Konstantinos Palikaras, Nektarios Tavernarakis
Published in: Journal of Visualized Experiments, Issue 163, 2020, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/61170

Assessment of dopaminergic neuron degeneration in a C. elegans model of Parkinson’s disease

Author(s): Konstantinos Palikaras,Tanima SenGupta, Hilde Nilsen,Nektarios Tavernarakis
Published in: STAR Protocols, 2022, ISSN 2666-1667
Publisher: Science Direct/ Elsevier
DOI: 10.1016/j.xpro.2022.101264

Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay

Author(s): Teresa Rubio-Tomás; Nektarios Tavernarakis
Published in: Biogerontology, Issue 4, 2022, ISSN 1573-6768
Publisher: Springer, Netherlands
DOI: 10.1007/s10522-022-09989-4

Acyl-CoA-binding protein (ACBP): a phylogenetically conserved appetite stimulator

Author(s): Nikolaos Charmpilas, Christoph Ruckenstuhl, Valentina Sica, Sabrina Büttner, Lukas Habernig, Silvia Dichtinger, Frank Madeo, Nektarios Tavernarakis, José M. Bravo-San Pedro, Guido Kroemer
Published in: Cell Death & Disease, Issue 11/1, 2020, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-019-2205-x

Base excision repair causes age-dependent accumulation of single-stranded DNA breaks thatcontribute to Parkinson disease pathology

Author(s): SenGupta T., Palikaras K., Esbensen Y. Q., Konstantinidis G., Naranjo Galindo F. J., Achanta K., Kassahun H., Stavgiannoudaki I., Bohr V. A., Akbari M., Gaare J., Tzoulis C., Tavernarakis N. and Nilsen H.
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109668

SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans

Author(s): Andrea Princz, Federico Pelisch, Nektarios Tavernarakis
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-72637-9

Mitophagy mechanisms in neuronal physiology and pathology during ageing

Author(s): Maria Markaki; Dikaia Tsagkari; Nektarios Tavernarakis; Nektarios Tavernarakis
Published in: Biophys Rev, Issue 5, 2021, ISSN 1867-2469
Publisher: Springer
DOI: 10.1007/s12551-021-00894-7

Book chapters (4)

Assessing polyglutamine tract aggregation in the nematode Caenorhabditis elegans

Author(s): Aggeliki Sotiriou; Christina Ploumi; Nikolaos Charmpilas; Nektarios Tavernarakis
Published in: Methods in Cell Biology, Issue 3, 2022, ISSN 0091-679X
Publisher: Elsevier Inc.
DOI: 10.1016/bs.mcb.2022.09.003

Monitoring autophagic flux in Caenorhabditis elegans using a p62/SQST-1 reporter

Author(s): Christina Ploumi, Aggeliki Sotiriou, Nektarios Tavernarakis
Published in: Methods in Cell Biology, 2020
Publisher: Elsevier
DOI: 10.1016/bs.mcb.2020.10.011

The Cytoskeleton as a Modulator of Aging and Neurodegeneration

Author(s): Konstantinos Kounakis, Nektarios Tavernarakis
Published in: Reviews on Biomarker Studies in Aging and Anti-Aging Research, Issue 1178, 2019, Page(s) 227-245, ISBN 978-3-030-25649-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-25650-0_12

Assessment of Neuronal Cell Death in Caenorhabditis elegans

Author(s): Konstantinos Kounakis and Nektarios Tavernarakis
Published in: Methods in Molecular Biology, 2022
Publisher: Springer Nature
DOI: 10.1007/978-1-0716-2409-8_19