MacroAutophagy and Necrotic Neurodegeneration in Ageing

Pubblicazioni

Editorial: Mitophagy in Health and Disease

Autori: Konstantinos Palikaras, Evandro Fei Fang, Nektarios Tavernarakis
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.647036

Selective Autophagy as a Potential Therapeutic Target in Age-Associated Pathologies.

Autori: Margarita-Elena Papandreou; Margarita-Elena Papandreou; Nektarios Tavernarakis; Nektarios Tavernarakis
Pubblicato in: Metabolites, Vol 11, Iss 588, p 588 (2021), Numero 3, 2021, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo11090588

Autophagy in healthy aging and disease

Autori: Yahyah Aman,Tomas Schmauck-Medina, Malene Hansen, Richard I Morimoto, Anna Katharina Simon, Ivana Bjedov, Konstantinos Palikaras , Anne Simonsen, Terje Johansen, Nektarios Tavernarakis , David C Rubinsztein, Linda Partridge, Guido Kroemer, John Labbadia , Evandro F Fang
Pubblicato in: Nature Aging, 2021, ISSN 2662-8465
Editore: Springer Nature
DOI: 10.1038/s43587-021-00098-4

The complex interplay between autophagy and cell death pathways

Autori: Christina Ploumi, Margarita-Elena Papandreou, Nektarios Tavernarakis
Pubblicato in: The Biochemical Journal, 2022, ISSN 1470-8728
Editore: Portland Press
DOI: 10.1042/bcj20210450

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

Autori: Nektarios Tavernarakis; EIRINI LIONAKI; Christina Ploumi
Pubblicato in: Cells, Vol 11, Iss 214, p 214 (2022), Numero 1, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11020214

Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans

Autori: Christina Ploumi, Emmanouil Kyriakakis & Nektarios Tavernarakis
Pubblicato in: Cell Death & Disease, 2023, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-023-05638-x

Age-dependent nuclear lipid droplet deposition is a cellular hallmark of aging in Caenorhabditis elegans

Autori: Konstantinos Palikaras, Meropi Mari, Christina Ploumi, Andrea Princz, George Filippidis, Nektarios Tavernarakis
Pubblicato in: Aging Cell, 2023, ISSN 1474-9726
Editore: Wiley
DOI: 10.1111/acel.13788

Mitochondrial protein import determines lifespan through metabolic reprogramming and de novoserine biosynthesis

Autori: Eirini Lionaki, Ilias Gkikas,, Ioanna Daskalaki, Nektarios Tavernarakis
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28272-1

Sustained intracellular calcium rise mediates neuronalmitophagy in models of autosomal dominant optic atrophy

Autori: Marta Zaninello, Konstantinos Palikaras, Aggeliki Sotiriou, Nektarios Tavernarakis and Luca Scorrano
Pubblicato in: Cell Death Differentiation, 2022, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-021-00847-3

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

Autori: Marta Zaninello, Konstantinos Palikaras, Deborah Naon, Keiko Iwata, Stephanie Herkenne, Ruben Quintana-Cabrera, Martina Semenzato, Francesca Grespi, Fred N. Ross-Cisneros, Valerio Carelli, Alfredo A. Sadun, Nektarios Tavernarakis, Luca Scorrano
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17821-1

Mitochondrial turnover and homeostasis in ageing and neurodegeneration

Autori: Maria Markaki, Nektarios Tavernarakis
Pubblicato in: FEBS Letters, Numero 594/15, 2020, Pagina/e 2370-2379, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.13802

Nucleophagy delays aging and preserves germline immortality

Autori: Margarita-Elena Papandreou, Georgios Konstantinidis, Nektarios Tavernarakis
Pubblicato in: Nature Aging, 2022, ISSN 2662-8465
Editore: Springer Nature
DOI: 10.1038/s43587-022-00327-4

Caenorhabditis elegans as a model system for human diseases

Autori: Maria Markaki, Nektarios Tavernarakis
Pubblicato in: Current Opinion in Biotechnology, Numero 63, 2020, Pagina/e 118-125, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2019.12.011

MitoSNARE Assembly and Disassembly Factors Regulate Basal Autophagy and Aging in C. elegans

Autori: Ilias Gkikas, Ioanna Daskalaki, Konstantinos Kounakis, Nektarios Tavernarakis and Eirini Lionaki
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24044230

Mitochondrial biogenesis in organismal senescence and neurodegeneration

Autori: Ioanna Daskalaki, Nektarios Tavernarakis
Pubblicato in: Mechanisms of Ageing and Development, Numero 191, 2020, Pagina/e 111345, ISSN 0047-6374
Editore: Elsevier BV
DOI: 10.1016/j.mad.2020.111345

Molecular Interventions towards Multiple Sclerosis Treatment

Autori: Athanasios Metaxakis, Dionysia Petratou, Nektarios Tavernarakis
Pubblicato in: Brain Sciences, Numero 10/5, 2020, Pagina/e 299, ISSN 2076-3425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci10050299

Autophagy of the Nucleus in Health and Disease

Autori: Georgios Konstantinidis , Nektarios Tavernarakis
Pubblicato in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2021.814955

Oxidative Stress in Age-Related Neurodegenerative Diseases: An Overview of Recent Tools and Findings

Autori: Dimitris Korovesis, Teresa Rubio-Tomás, Nektarios Tavernarakis
Pubblicato in: Antioxidants, 2023, ISSN 2076-3921
Editore: MDPI
DOI: 10.3390/antiox12010131

Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans

Autori: Georgios Konstantinidis, Nektarios Tavernarakis
Pubblicato in: Cells, Numero 10/3, 2021, Pagina/e 694, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10030694

Research Briefing: Nuclear autophagy promotes longevity and germline immortality.

Autori: Nektarios Tavernarakis
Pubblicato in: Nature Aging, 2022, ISSN 2662-8465
Editore: Springer-Nature
DOI: 10.1038/s43587-022-00336-3

The interplay between selective types of (macro)autophagy: Mitophagy and xenophagy

Autori: Teresa Rubio-Tomás, Aggeliki Sotiriou, Nektarios Tavernarakis
Pubblicato in: International Review of Cell and Molecular Biology, 2022, ISSN 1937-6448
Editore: Elsevier BV
DOI: 10.1016/bs.ircmb.2022.10.003

The Role of Mitophagy in Innate Immunity

Autori: Ilias Gkikas, Konstantinos Palikaras, Nektarios Tavernarakis
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01283

Chapter Five - Novel Insights Into the Anti-aging Role of Mitophagy

Autori: Maria Markaki, Konstantinos Palikaras, Nektarios Tavernarakis
Pubblicato in: International Review of Cell and Molecular Biology, 2018, Pagina/e 169-208, ISSN 1937-6448
Editore: Elsevier BV
DOI: 10.1016/bs.ircmb.2018.05.005

Mitochondrial contributions to neuronal development and function

Autori: Andrea Princz, Konstantinos Kounakis, Nektarios Tavernarakis
Pubblicato in: Biological Chemistry, Numero 399/7, 2018, Pagina/e 723-739, ISSN 1431-6730
Editore: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2017-0333

Multimodal sensory processing in Caenorhabditis elegans

Autori: Athanasios Metaxakis, Dionysia Petratou, Nektarios Tavernarakis
Pubblicato in: Open Biology, Numero 8/6, 2018, Pagina/e 180049, ISSN 2046-2441
Editore: Royal Society Publishing
DOI: 10.1098/rsob.180049

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

Autori: Konstantinos Palikaras, Ioanna Daskalaki, Maria Markaki, Nektarios Tavernarakis
Pubblicato in: Pharmacology & Therapeutics, Numero 178, 2017, Pagina/e 157-174, ISSN 0163-7258
Editore: Pergamon Press
DOI: 10.1016/j.pharmthera.2017.04.005

Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans

Autori: Emmanouil Kyriakakis, Nikolaos Charmpilas, Nektarios Tavernarakis
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-05276-2

Hypoxia and Selective Autophagy in Cancer Development and Therapy

Autori: Ioanna Daskalaki, Ilias Gkikas, Nektarios Tavernarakis
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 6, 2018, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2018.00104

Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

Autori: Matthias Rieckher, Maria Markaki, Andrea Princz, Björn Schumacher, Nektarios Tavernarakis
Pubblicato in: Cell Reports, Numero 25/1, 2018, Pagina/e 199-211.e6, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.09.009

Regulation and Roles of Autophagy at Synapses

Autori: Vassiliki Nikoletopoulou, Nektarios Tavernarakis
Pubblicato in: Trends in Cell Biology, Numero 28/8, 2018, Pagina/e 646-661, ISSN 0962-8924
Editore: Elsevier BV
DOI: 10.1016/j.tcb.2018.03.006

Nucleophagy: from homeostasis to disease

Autori: Margarita-Elena Papandreou, Nektarios Tavernarakis
Pubblicato in: Cell Death & Differentiation, Numero 26/4, 2019, Pagina/e 630-639, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-018-0266-5

Mitochondrial maturation drives germline stem cell differentiation in Caenorhabditis elegans

Autori: Nikolaos Charmpilas, Nektarios Tavernarakis
Pubblicato in: Cell Death & Differentiation, 2019, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-019-0375-9

Mitophagy and Neuroprotection

Autori: Guofeng Lou, Konstantinos Palikaras, Sofie Lautrup, Morten Scheibye-Knudsen, Nektarios Tavernarakis, Evandro F. Fang
Pubblicato in: Trends in Molecular Medicine, 2019, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/j.molmed.2019.07.002

Autophagy in Age-Associated Neurodegeneration

Autori: Athanasios Metaxakis, Christina Ploumi, Nektarios Tavernarakis
Pubblicato in: Cells, Numero 7/5, 2018, Pagina/e 37, ISSN 2073-4409
Editore: MDPI GA
DOI: 10.3390/cells7050037

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Autori: Konstantinos Palikaras, Eirini Lionaki, Nektarios Tavernarakis
Pubblicato in: Nature Cell Biology, Numero 20/9, 2018, Pagina/e 1013-1022, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-018-0176-2

Emerging Roles of Lipophagy in Health and Disease

Autori: Konstantinos Kounakis, Manos Chaniotakis, Maria Markaki, Nektarios Tavernarakis
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 7, 2019, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2019.00185

SUMOylation in Neurodegenerative Diseases

Autori: Andrea Princz, Nektarios Tavernarakis
Pubblicato in: Gerontology, 2019, Pagina/e 1-9, ISSN 0304-324X
Editore: S. Karger AG
DOI: 10.1159/000502142

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Autori: Evandro F. Fang, Yujun Hou, Konstantinos Palikaras, Bryan A. Adriaanse, Jesse S. Kerr, Beimeng Yang, Sofie Lautrup, Md Mahdi Hasan-Olive, Domenica Caponio, Xiuli Dan, Paula Rocktäschel, Deborah L. Croteau, Mansour Akbari, Nigel H. Greig, Tormod Fladby, Hilde Nilsen, M. Zameel Cader, Mark P. Mattson, Nektarios Tavernarakis, Vilhelm A. Bohr
Pubblicato in: Nature Neuroscience, Numero 22/3, 2019, Pagina/e 401-412, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-018-0332-9

Mitochondrial protein import machinery conveys stress signals to the cytosol and beyond

Autori: Eirini Lionaki, Ilias Gkikas, Nektarios Tavernarakis
Pubblicato in: BioEssays, 2023, ISSN 1521-1878
Editore: Wiley
DOI: 10.1002/bies.202200160

Modeling Age-Associated Neurodegenerative Diseases in <em>Caenorhabditis elegans</em>

Autori: Konstantinos Palikaras, Nektarios Tavernarakis
Pubblicato in: Journal of Visualized Experiments, Numero 162, 2020, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/61169

Regulation and roles of mitophagy at synapses

Autori: Konstantinos Palikaras, Nektarios Tavernarakis
Pubblicato in: Mechanisms of Ageing and Development, Numero 187, 2020, Pagina/e 111216, ISSN 0047-6374
Editore: Elsevier BV
DOI: 10.1016/j.mad.2020.111216

Assessment of de novo Protein Synthesis Rates in <em>Caenorhabditis elegans</em>

Autori: Margarita Elena Papandreou, Konstantinos Palikaras, Nektarios Tavernarakis
Pubblicato in: Journal of Visualized Experiments, Numero 163, 2020, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/61170

Assessment of dopaminergic neuron degeneration in a C. elegans model of Parkinson’s disease

Autori: Konstantinos Palikaras,Tanima SenGupta, Hilde Nilsen,Nektarios Tavernarakis
Pubblicato in: STAR Protocols, 2022, ISSN 2666-1667
Editore: Science Direct/ Elsevier
DOI: 10.1016/j.xpro.2022.101264

Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay

Autori: Teresa Rubio-Tomás; Nektarios Tavernarakis
Pubblicato in: Biogerontology, Numero 4, 2022, ISSN 1573-6768
Editore: Springer, Netherlands
DOI: 10.1007/s10522-022-09989-4

Acyl-CoA-binding protein (ACBP): a phylogenetically conserved appetite stimulator

Autori: Nikolaos Charmpilas, Christoph Ruckenstuhl, Valentina Sica, Sabrina Büttner, Lukas Habernig, Silvia Dichtinger, Frank Madeo, Nektarios Tavernarakis, José M. Bravo-San Pedro, Guido Kroemer
Pubblicato in: Cell Death & Disease, Numero 11/1, 2020, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-019-2205-x

Base excision repair causes age-dependent accumulation of single-stranded DNA breaks thatcontribute to Parkinson disease pathology

Autori: SenGupta T., Palikaras K., Esbensen Y. Q., Konstantinidis G., Naranjo Galindo F. J., Achanta K., Kassahun H., Stavgiannoudaki I., Bohr V. A., Akbari M., Gaare J., Tzoulis C., Tavernarakis N. and Nilsen H.
Pubblicato in: Cell Reports, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109668

SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans

Autori: Andrea Princz, Federico Pelisch, Nektarios Tavernarakis
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-72637-9

Mitophagy mechanisms in neuronal physiology and pathology during ageing

Autori: Maria Markaki; Dikaia Tsagkari; Nektarios Tavernarakis; Nektarios Tavernarakis
Pubblicato in: Biophys Rev, Numero 5, 2021, ISSN 1867-2469
Editore: Springer
DOI: 10.1007/s12551-021-00894-7

Assessing polyglutamine tract aggregation in the nematode Caenorhabditis elegans

Autori: Aggeliki Sotiriou; Christina Ploumi; Nikolaos Charmpilas; Nektarios Tavernarakis
Pubblicato in: Methods in Cell Biology, Numero 3, 2022, ISSN 0091-679X
Editore: Elsevier Inc.
DOI: 10.1016/bs.mcb.2022.09.003

Monitoring autophagic flux in Caenorhabditis elegans using a p62/SQST-1 reporter

Autori: Christina Ploumi, Aggeliki Sotiriou, Nektarios Tavernarakis
Pubblicato in: Methods in Cell Biology, 2020
Editore: Elsevier
DOI: 10.1016/bs.mcb.2020.10.011

The Cytoskeleton as a Modulator of Aging and Neurodegeneration

Autori: Konstantinos Kounakis, Nektarios Tavernarakis
Pubblicato in: Reviews on Biomarker Studies in Aging and Anti-Aging Research, Numero 1178, 2019, Pagina/e 227-245, ISBN 978-3-030-25649-4
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-25650-0_12

Assessment of Neuronal Cell Death in Caenorhabditis elegans

Autori: Konstantinos Kounakis and Nektarios Tavernarakis
Pubblicato in: Methods in Molecular Biology, 2022
Editore: Springer Nature
DOI: 10.1007/978-1-0716-2409-8_19

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