The role of immune cells in Alzheimer's disease

Project Information

IMMUNOALZHEIMER

Grant agreement ID: 695714

DOI 10.3030/695714

Project closed

EC signature date 12 July 2016

Start date 1 September 2016

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

UNIVERSITA DEGLI STUDI DI VERONA
Italy

Publications

Peer reviewed articles (19)

LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System.

Author(s): Silvia Dusi; Stefano Angiari; Enrica Caterina Pietronigro; Nicola Lopez; Gabriele Angelini; Elena Zenaro; Vittorina Della Bianca; Gabriele Tosadori; Gabriele Tosadori; Francesca Paris; Antonella Amoruso; Tommaso Carlucci; Gabriela Constantin; Gabriela Constantin; Barbara Rossi
Published in: Frontiers in Immunology, Issue 4, 2019, ISSN 1664-3224
Publisher: International Union of Immunological Societies
DOI: 10.3389/fimmu.2019.02436

Common Peripheral Immunity Mechanisms in Multiple Sclerosis and Alzheimer's Disease

Author(s): Rossi B, Santos-Lima B, Terrabuio E, Zenaro E, Constantin G
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers

A TLR/CD44 axis regulates T cell trafficking in experimental and human multiple sclerosis

Author(s): Maria Tredicine, Chiara Camponeschi, Davide Pirolli, Matteo Lucchini, Mariagrazia Valentini, Maria Concetta Geloso, Massimiliano Mirabella, Marco Fidaleo, Benedetta Righino, Camilla Moliterni, Ezio Giorda, Mario Rende, Maria Cristina De Rosa, Maria Foti, Gabriela Constantin, Francesco Ria, Gabriele Di Sante
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2022.103763

Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells

Author(s): Alessio Montresor, Lara Toffali, Laura Fumagalli, Gabriela Constantin, Antonella Rigo, Isacco Ferrarini, Fabrizio Vinante, Carlo Laudanna
Published in: Journal of Immunology, 2021, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2001462

Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis

Author(s): Costa S, Bevilacqua D, Caveggion E, Gasperini S, Zenaro E, Donini M, Dusi S, Pettinella F, Constantin G, Lonardi S, Vermi W, De Sanctis F, Ugel S, Cestari T, Abram C, Lowell CA, Rodegher P, Tagliaro F, Girolomoni G, Cassatella MA and Scapini P.
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.1049079

The role of neutrophils in the dysfunction of central nervous system barriers

Author(s): Bruno Santos-Lima; Enrica Caterina Pietronigro; Eleonora Terrabuio; Elena Zenaro; Gabriela Constantin
Published in: Frontiers in Aging Neuroscience, Issue 1, 2022, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.965169

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.

Author(s): Kevin Peikert; Kevin Peikert; Enrica Federti; Alessandro Matte; Gabriela Constantin; Enrica Caterina Pietronigro; Paolo F. Fabene; Paola Defilippi; Emilia Turco; Federico Del Gallo; Pietro Pucci; Angela Amoresano; Anna Illiano; Flora Cozzolino; Maria Chiara Monti; Francesca Garello; Enzo Terreno; Seth L. Alper; Hannes Glaß; Lisann Pelzl; Katja Akgün; Tjalf Ziemssen; Rainer Ordemann; Florian Lang
Published in: Acta Neuropathologica Communications, 2021, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-021-01181-y

In vitro Models of Neurodegenerative Diseases

Author(s): Slanzi A, Iannoto G, Rossi B, Zenaro E, Constantin G
Published in: Frontiers in cell and developmental biology, 2020, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2020.00328

NETosis in Alzheimer’s Disease

Author(s): Enrica Caterina Pietronigro, Vittorina Della Bianca, Elena Zenaro, Gabriela Constantin
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.00211

The blood-brain barrier in Alzheimer's disease

Author(s): Elena Zenaro, Gennj Piacentino, Gabriela Constantin
Published in: Neurobiology of Disease, Issue 107, 2017, Page(s) 41-56, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2016.07.007

Functional morphology of the blood–brain barrier in health and disease

Author(s): Stefan Liebner, Rick M. Dijkhuizen, Yvonne Reiss, Karl H. Plate, Dritan Agalliu, Gabriela Constantin
Published in: Acta Neuropathologica, Issue 135/3, 2018, Page(s) 311-336, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-018-1815-1

Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis

Author(s): Rossi, Barbara; Constantin, Gabriela
Published in: Frontiers in Immunology, Vol 7 (2016), Issue 2, 2016, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2016.00506/full

Targeting neuroinflammation in the treatment and prevention of Alzheimer's disease

Author(s): E. Zenaro, G. Constantin
Published in: Drugs of the Future, Issue 42/1, 2017, Page(s) 21, ISSN 0377-8282
Publisher: Prous Science
DOI: 10.1358/dof.2017.042.01.2564104

Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis

Author(s): Alessia Farinazzo, Stefano Angiari, Ermanna Turano, Edoardo Bistaffa, Silvia Dusi, Serena Ruggieri, Roberta Bonafede, Raffaella Mariotti, Gabriela Constantin, Bruno Bonetti
Published in: Scientific Reports, Issue 8/1, 2018, Page(s) 1-11, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-25676-2

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

Author(s): Xingli Zhang, Yan Wang, Jia Yuan, Ni Li, Siyu Pei, Jing Xu, Xuan Luo, Chaoming Mao, Junli Liu, Tao Yu, Shucheng Gan, Qianqian Zheng, Yinming Liang, Weixiang Guo, Ju Qiu, Gabriela Constantin, Jin Jin, Jun Qin, Yichuan Xiao
Published in: The Journal of Experimental Medicine, Issue 215/5, 2018, Page(s) 1365-1382, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20171417

Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease

Author(s): Enrica Pietronigro, Elena Zenaro, Vittorina Della Bianca, Silvia Dusi, Eleonora Terrabuio, Giulia Iannoto, Anna Slanzi, Somayehsadat Ghasemi, Rajasekar Nagarajan, Gennj Piacentino, Gabriele Tosadori, Barbara Rossi, Gabriela Constantin
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-48538-x

The emerging role of neutrophils in neurodegeneration.

Author(s): Barbara Rossi; Gabriela Constantin; Elena Zenaro
Published in: Immunobiology, 2019, ISSN 0171-2985
Publisher: Elsevier BV
DOI: 10.1016/j.imbio.2019.10.014

Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation.

Author(s): Xu J, Yu T, Pietronigro EC, Yuan J, Arioli J, Pei Y, Luo X, Ye J, Constantin G, Mao C, Xiao Y.
Published in: Plos Biology, 2020, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3000837

Vaccination with (1-11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice.

Author(s): Francesca Mantile; Angelo Capasso; Nàdia Villacampa; Maria Donnini; Giovanna L. Liguori; Gabriela Constantin; Piergiuseppe De Berardinis; Michael T. Heneka; Antonella Prisco
Published in: Aging Clinical and Experimental Research, 2019, ISSN 1720-8319
Publisher: Springer
DOI: 10.1007/s40520-019-01414-0