The role of immune cells in Alzheimer's disease

Información del proyecto

IMMUNOALZHEIMER

Identificador del acuerdo de subvención: 695714

DOI

10.3030/695714

Proyecto cerrado

Fecha de la firma de la CE 12 Julio 2016

Fecha de inicio 1 Septiembre 2016

Fecha de finalización 31 Agosto 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

UNIVERSITA DEGLI STUDI DI VERONA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (19)

LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System.

Autores: Silvia Dusi; Stefano Angiari; Enrica Caterina Pietronigro; Nicola Lopez; Gabriele Angelini; Elena Zenaro; Vittorina Della Bianca; Gabriele Tosadori; Gabriele Tosadori; Francesca Paris; Antonella Amoruso; Tommaso Carlucci; Gabriela Constantin; Gabriela Constantin; Barbara Rossi
Publicado en: Frontiers in Immunology, Edición 4, 2019, ISSN 1664-3224
Editor: International Union of Immunological Societies
DOI: 10.3389/fimmu.2019.02436

Common Peripheral Immunity Mechanisms in Multiple Sclerosis and Alzheimer's Disease

Autores: Rossi B, Santos-Lima B, Terrabuio E, Zenaro E, Constantin G
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers

A TLR/CD44 axis regulates T cell trafficking in experimental and human multiple sclerosis

Autores: Maria Tredicine, Chiara Camponeschi, Davide Pirolli, Matteo Lucchini, Mariagrazia Valentini, Maria Concetta Geloso, Massimiliano Mirabella, Marco Fidaleo, Benedetta Righino, Camilla Moliterni, Ezio Giorda, Mario Rende, Maria Cristina De Rosa, Maria Foti, Gabriela Constantin, Francesco Ria, Gabriele Di Sante
Publicado en: iScience, 2022, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2022.103763

Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells

Autores: Alessio Montresor, Lara Toffali, Laura Fumagalli, Gabriela Constantin, Antonella Rigo, Isacco Ferrarini, Fabrizio Vinante, Carlo Laudanna
Publicado en: Journal of Immunology, 2021, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.2001462

Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis

Autores: Costa S, Bevilacqua D, Caveggion E, Gasperini S, Zenaro E, Donini M, Dusi S, Pettinella F, Constantin G, Lonardi S, Vermi W, De Sanctis F, Ugel S, Cestari T, Abram C, Lowell CA, Rodegher P, Tagliaro F, Girolomoni G, Cassatella MA and Scapini P.
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.1049079

The role of neutrophils in the dysfunction of central nervous system barriers

Autores: Bruno Santos-Lima; Enrica Caterina Pietronigro; Eleonora Terrabuio; Elena Zenaro; Gabriela Constantin
Publicado en: Frontiers in Aging Neuroscience, Edición 1, 2022, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.965169

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.

Autores: Kevin Peikert; Kevin Peikert; Enrica Federti; Alessandro Matte; Gabriela Constantin; Enrica Caterina Pietronigro; Paolo F. Fabene; Paola Defilippi; Emilia Turco; Federico Del Gallo; Pietro Pucci; Angela Amoresano; Anna Illiano; Flora Cozzolino; Maria Chiara Monti; Francesca Garello; Enzo Terreno; Seth L. Alper; Hannes Glaß; Lisann Pelzl; Katja Akgün; Tjalf Ziemssen; Rainer Ordemann; Florian Lang
Publicado en: Acta Neuropathologica Communications, 2021, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-021-01181-y

In vitro Models of Neurodegenerative Diseases

Autores: Slanzi A, Iannoto G, Rossi B, Zenaro E, Constantin G
Publicado en: Frontiers in cell and developmental biology, 2020, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2020.00328

NETosis in Alzheimer’s Disease

Autores: Enrica Caterina Pietronigro, Vittorina Della Bianca, Elena Zenaro, Gabriela Constantin
Publicado en: Frontiers in Immunology, Edición 8, 2017, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.00211

The blood-brain barrier in Alzheimer's disease

Autores: Elena Zenaro, Gennj Piacentino, Gabriela Constantin
Publicado en: Neurobiology of Disease, Edición 107, 2017, Página(s) 41-56, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2016.07.007

Functional morphology of the blood–brain barrier in health and disease

Autores: Stefan Liebner, Rick M. Dijkhuizen, Yvonne Reiss, Karl H. Plate, Dritan Agalliu, Gabriela Constantin
Publicado en: Acta Neuropathologica, Edición 135/3, 2018, Página(s) 311-336, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-018-1815-1

Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis

Autores: Rossi, Barbara; Constantin, Gabriela
Publicado en: Frontiers in Immunology, Vol 7 (2016), Edición 2, 2016, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2016.00506/full

Targeting neuroinflammation in the treatment and prevention of Alzheimer's disease

Autores: E. Zenaro, G. Constantin
Publicado en: Drugs of the Future, Edición 42/1, 2017, Página(s) 21, ISSN 0377-8282
Editor: Prous Science
DOI: 10.1358/dof.2017.042.01.2564104

Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis

Autores: Alessia Farinazzo, Stefano Angiari, Ermanna Turano, Edoardo Bistaffa, Silvia Dusi, Serena Ruggieri, Roberta Bonafede, Raffaella Mariotti, Gabriela Constantin, Bruno Bonetti
Publicado en: Scientific Reports, Edición 8/1, 2018, Página(s) 1-11, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-25676-2

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

Autores: Xingli Zhang, Yan Wang, Jia Yuan, Ni Li, Siyu Pei, Jing Xu, Xuan Luo, Chaoming Mao, Junli Liu, Tao Yu, Shucheng Gan, Qianqian Zheng, Yinming Liang, Weixiang Guo, Ju Qiu, Gabriela Constantin, Jin Jin, Jun Qin, Yichuan Xiao
Publicado en: The Journal of Experimental Medicine, Edición 215/5, 2018, Página(s) 1365-1382, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20171417

Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease

Autores: Enrica Pietronigro, Elena Zenaro, Vittorina Della Bianca, Silvia Dusi, Eleonora Terrabuio, Giulia Iannoto, Anna Slanzi, Somayehsadat Ghasemi, Rajasekar Nagarajan, Gennj Piacentino, Gabriele Tosadori, Barbara Rossi, Gabriela Constantin
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-48538-x

The emerging role of neutrophils in neurodegeneration.

Autores: Barbara Rossi; Gabriela Constantin; Elena Zenaro
Publicado en: Immunobiology, 2019, ISSN 0171-2985
Editor: Elsevier BV
DOI: 10.1016/j.imbio.2019.10.014

Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation.

Autores: Xu J, Yu T, Pietronigro EC, Yuan J, Arioli J, Pei Y, Luo X, Ye J, Constantin G, Mao C, Xiao Y.
Publicado en: Plos Biology, 2020, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.3000837

Vaccination with (1-11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice.

Autores: Francesca Mantile; Angelo Capasso; Nàdia Villacampa; Maria Donnini; Giovanna L. Liguori; Gabriela Constantin; Piergiuseppe De Berardinis; Michael T. Heneka; Antonella Prisco
Publicado en: Aging Clinical and Experimental Research, 2019, ISSN 1720-8319
Editor: Springer
DOI: 10.1007/s40520-019-01414-0