Objective
This project is an attempt to develop an effective bioactive wound dressing for the treatment of chronic non-healing wounds that until now depict a major challenge and financial burden to healthcare providers. We propose a zonal, multifunctional scaffold based on collagen (COL) and copper-doped mesoporous bioactive glass (Cu-MBG) serving as release system for vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF-BB). The degradable scaffold system is expected to accelerate the wound healing process due to synergy of angiogenetic, bioactivity, and antimicrobial characteristics.
This will be the first attempt to create a zonal COL-MBG scaffold system with release of three functional molecules, of which PDGF-BB has not previously been incorporated to MBG. Zonal design enables designed consecutive release profiles, e.g. immediate PDGF-BB from the outer layer and delayed VEGF release from the inner layer of the scaffold.
The structure of the scaffold as well as distribution of specific components and their functionality will be characterized using innovative in vitro models including cell culture tests.
The experienced researcher Dr. Nganga defended her PhD-thesis 2013 at University of Turku, Finland and has authored six original research papers. She has profound experience in biomaterials research based on involvement in cutting edge research at Universities in Germany, Finland and Italy.
The beneficiary the Department of Materials Science and Engineering and the Institute of Biomaterials at University of Erlangen-Nuremberg is a well-respected international player in biomaterials research with extensive experience of hosting foreign researchers, including MC fellows. Prof. A.R. Boccaccini is a highly recognised researcher in the biomaterials field with broad mentoring and research supervision experience. He has received numerous international awards and has recently been named a Highly Cited Researcher by Thomson Reuters.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering amorphous solids
- engineering and technology industrial biotechnology biomaterials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91058 ERLANGEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.