Objective
The formation of carbon-carbon bonds in an asymmetric fashion is a very useful process in synthetic chemistry, since it generates single enantiomers of chiral molecules at the same time as the molecular framework is being assembled. In this context, two strategies for the generation of single enantiomer compounds using enantioselective catalysis have been widely emabraced: on the one hand, the use of prochiral substrates, and on the other hand, the use of racemic substrates in enantiomer resolution processes, which limits the yields up to 50%. An efficient variation of this second strategy is to couple enantiomer differentiation with interconversion of enantiomers. However, these dynamic kinetic asymmetric transformations (DYKAT) have been limited to the use of stabilized nucleophiles. Very recently, the group of Fletcher reported that alkylzirconium reagents can be employed as non-stabilized nucleophiles in combination with a copper-based catalytic system for this class of processes. Subsequently, the same group demonstrated that arylboronic acids are also suitable substrates in rhodium-catalyzed DYKATs. The project presented in this application aims to expand the scope of this powerful transformation by using vinyl- and heteroarylboronic acids as non-stabilized nucleophiles in the rhodium-catalyzed DYKAT. Moreover, a thorough study of the reaction mechanism will be conducted, as well as the investigation on alternative procedures for this process (catalytic systems, nature of the substrates, etc) that might result in useful applications for organic synthesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences organic chemistry hydrocarbons
- natural sciences chemical sciences polymer sciences
- natural sciences chemical sciences catalysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.