Comprehensive identification of host factors involved in the early steps of HIV infection.

Información del proyecto

hRBP-virion

Identificador del acuerdo de subvención: 700184

DOI

10.3030/700184

Proyecto cerrado

Fecha de la firma de la CE 10 Marzo 2016

Fecha de inicio 3 Mayo 2017

Fecha de finalización 2 Mayo 2019

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 195 454,80

Aportación de la UE

€ 195 454,80

Coordinado por

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

Objetivo

35 million people are currently infected with Human immunodeficiency virus (HIV), causative agent of AIDS. While cocktails of anti-retrovirals can reduce viral loading to undetectable levels, drug resistance can emerge due to the high-mutation rate of the virus. Moreover, no cure is yet achieved. Therefore, it is crucial to explore complementary therapeutic strategies, a challenge that H2020 prioritizes in health. The strict dependency of HIV on host RNA-binding proteins (RBPs) represents a potential step for intervention through host-based therapies, which can be more refractory to the evolution of resistance. In some sporadic cases, host RBPs have been shown to be incorporated into virions and impact downstream early steps of infection. However, no global and systematic studies aimed to determine the scope and biological significance of host RBPs selectively packed with the HIV RNA within the virions have been reported so far. The main goal of this action, referred to as hRBP-virion, is to address this important biological question by developing an unprecedented multidisciplinary approach that combines molecular biology and virology methods with next generation proteomics and data analysis. Hence, this pioneer approach will open new avenues of research in the field of viruses that have major health and socioeconomic impact and will enhance world-class basic and applied European innovation. The hRBP-virion project requires an exclusive mix of competences. I will bring research experience in RNA and molecular virology. My supervisor will train me in cutting-edge, system-wide proteomic methods. The host institution will provide state-of-the-art facilities and pooled expertise in a broad range of disciplines. Together these will create an excellent and unique cross-disciplinary atmosphere that will ensure the successful outcome of hRBP-virion and the appropriate transfer of knowledge among the participants.

Ámbito científico (EuroSciVoc)

• ciencias naturales › ciencias biológicas › microbiología › virología
• ciencias médicas y de la salud › ciencias de la salud › enfermedad infecciosa › virus de ARN › VIH
• ciencias médicas y de la salud › medicina básica › farmacología y farmacia › farmacorresistencia
• ciencias naturales › ciencias biológicas › genética › ARN
• ciencias naturales › ciencias biológicas › biología molecular

Palabras clave

• RNA-binding proteins
• protein-RNA interaction
• interactome capture
• HIV
• AIDS

Programa(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions PROGRAMA PRINCIPAL
  
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
  

Tema(s)

• MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)
  

Régimen de financiación

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Convocatoria de propuestas

H2020-MSCA-IF-2015

Coordinador

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

• Aportación neta de la UEn: € 195 454,80
• Dirección: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford ; Reino Unido
• Región: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: € 195 454,80