Objectif In “On the origin of species” Charles Darwin used the human eye as an example of a complex character the evolution of which would have been hard to explain. Since then the vertebrate eye and the origin of vision more broadly held a central role in evolutionary biology. Recent advances in genomics, developmental biology and physiology, have allowed some advancement in our understanding of the origin of animal vision that however, is still patchy at best. Surprisingly, modern integrative studies have largely overlooked the visual systems of the Squamata (i.e. the lizards and snakes), a group comprising ~25% of terrestrial vertebrates, displaying exceptional diversity, and with greater variation in eye morphology and retinal photoreceptors than all other vertebrates combined. I propose to use the powerful but overlooked squamate system to answer major questions in visual science. I will integrate genomic, physiological and anatomical data to understand the genomic underpinning of phenotypic variation in the vertebrate visual system the relative roles of adaptation and constraints in the origin of novel visual phenotypes, and to understand whether complex visual systems can be re-elaborated following evolutionary degeneration. This is a blue skies project however, studying the evolution of the exceptionally plastic squamate visual system, will generate information that can be applied to other animals, and perhaps most importantly, used to increase our understanding of the human visual genetic disorders under the newly emerging Phylomedicine paradigm. Champ scientifique natural sciencesbiological sciencesecologynatural sciencesbiological sciencesevolutionary biologynatural sciencesbiological sciencesdevelopmental biologynatural sciencesphysical sciencesopticsmicroscopynatural sciencesbiological sciencesgeneticsRNA Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2015-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF) Appel à propositions H2020-MSCA-IF-2015 Voir d’autres projets de cet appel Régime de financement MSCA-IF-GF - Global Fellowships Coordinateur UNIVERSITY OF BRISTOL Contribution nette de l'UE € 258 107,40 Adresse BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Royaume-Uni Voir sur la carte Région South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 258 107,40 Partenaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire Partenaire Les organisations partenaires contribuent à la mise en œuvre de l’action, mais ne signent pas la convention de subvention. THE UNIVERSITY OF ADELAIDE Australie Contribution nette de l'UE € 0,00 Adresse NORTH TERRACE 5005 Adelaide Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 166 380,00