Objective
Early diagnosis of diseases, including tumors, is the ultimate goal of biomedical imaging. Magnetic resonance imaging (MRI) is a technique for non-destructive and non-invasive diagnosis of a number of diseases including cancer. Recently, contrast agents bearing 19F have been introduced as an attractive alternative to purely hydrogenated compounds, because of their high signal to noise ratio as result of their unique spectroscopic signature. This project aims to design, synthesize and characterize a series of novel fluorinated amphiphilic structures based on a fluoropolymer and a dendrimer (so called DendriGrafts, DGLs) based on poly-L-lysine. DGLs are a new type of arborescent biosynthetic polymer of regular and controlled structure. They have been shown to be biocompatible and non-immunogenic. It proposed that these DGLs to have potential as a powerful platform for the functionalization of hydrophobic polymers and to afford fluoropolymers for applications in 19F MRI. Combining DGLs and fluoropolymers in a good solvent for one of the blocks, is proposed to enable self-assembly of the amphiphiles into a variety of morphologies and molecular aggregates (including micelles, vesicles or cylinders). Increasing attention has been given to this type of supramolecular organization and to their potential use in applications such as coatings, drug delivery systems, nanoparticles or nanoreactors. Thus, this project will not only study the fundamental phenomena of self-organization of these novel copolymers but will also result in new materials suitable for application as novel agents in 19F MRI. Combining the complementary expertise from the Experienced Researcher in dendritic polymers, the host team in polymerization techniques and polymer self-assembly, a series of novel copolymer systems will be originally created in this project and finally studied by in vitro and in vivo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy electron microscopy
- natural sciences chemical sciences polymer sciences
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- natural sciences chemical sciences inorganic chemistry halogens
- natural sciences chemical sciences catalysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.