Periodic Reporting for period 1 - LIPSYNING (Eat me microglia: lipid scrambling as a signal for synaptic pruning)
Période du rapport: 2016-09-01 au 2018-08-31
The findings of this project established a base for future investigations of neurodevelopmental refinement of brain circuitry. The unique tools developed in this project will be used to dissect further mechanisms of synaptic maturation in developing brain. Aberrant brain wiring during development is known to be defective in a wide range of neurodevelopmental disorders and understanding how circuits are formed and refined during this period will be critical for explaining their aetiology, in order to alleviate societal challenges associated with neurodevelopmental and neuropsychiatric disorders, such as autism or schizophrenia.
Scientific outcomes of this project were presented at multiple scientific conferences, including local (Conferences of Lithuanian Neuroscience Society, BaltLASA Conference of Baltic Laboratory Animal Science Association, Conference of Lithuanian Stem Cell Association), European (EMBO Microglia, FENS Forum 2020, Neuronus IBRO Neuroscience Forum) and international events (IBRO World Congress, Society for Neuroscience Global Connectome). Importantly, in addition to the dissemination of the results within the scientific community, this project included wide public engagement through different media, such as TV programs, radio interviews, the articles in the newspapers and journals, and school visits to meet both pupils and their teachers. It is estimated that the audience of the public outreach activities of this project exceeded 150 000.