Objective
The twin pandemic of obesity and diabetes is one of the greatest health challenges we face today. While fat is at the center of the problem, it may also be part of the solution. It has recently been shown that humans have brown or brown-like fat, whose primary function is to burn, rather than store, energy. This energy-consuming capacity of brown and brown-like fat has the potential to be harnessed to treat obesity and diabetes. The host supervisor has recently discovered that brown adipose tissue (BAT) metabolism is not only controlled by classic thermogenic regulation, but also by the circadian rhythm of the body’s molecular clock. During my PhD training, I observed a doubling in the size of interscapular BAT in mice that lack growth hormone receptor (GHR). I found that BAT has some of the highest levels of Ghr out of all tissues in the body. Despite this, the role of GHR in BAT remains unknown. My preliminary data suggests that GHR is a critical mediator of both thermogenic and circadian regulation. We propose to use genetic gain- and loss-of-function studies accompanied by pharmacologic modulation of GHR to determine its role in BAT. Our in vitro and in vivo work will be complemented by human studies to measure the fuel uptake and thermogenic capacity of BAT. The outcome will be highly relevant to human disease given the enormous potential of BAT activation in the treatment of obesity and diabetes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health epidemiology pandemics
- medical and health sciences clinical medicine endocrinology diabetes
- engineering and technology environmental engineering energy and fuels
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.