Periodic Reporting for period 1 - GRO-BAT (Growth hormone: an endocrine factor that integrates thermogenic and circadian signals to regulate brown adipose tissue activity.)
Período documentado: 2016-10-01 hasta 2018-09-30
During the second year, we utilized the novel mice generated during the first year to investigate the thermogenic and circadian regulation of adipose thermogenesis in knockout animal models using state-of-the-art technologies and techniques such as telemetric temperature and activity recordings. Systemic metabolic effects were determined using indirect calorimetry and insulin and glucose tolerance tests. We also determined the potential translational potential of our discoveries using human immortal adipose cultures and primary human adipocytes. In conjunction with this, we analyzed genetic datasets to determine the impact of mutations in some of our key interest genes on human metabolism. Professional development activities continued through the second year, including attending conferences, training workshops, serving on the EYES board and co-founding and co-chairing the NNF CBMR Metabolism Association for Postdocs and Students (MAPS). We are currently writing up the results for imminent submission for publication consideration.