Objective
Cardiovascular diseases (CVD) which include acute myocardial infarction (AMI) and stroke are the main causes of premature deaths in the EU and in Asian countries including India. Researchers have identified and reported that biomarkers can provide advance information about cardiac dysfunction which leads to acute myocardial infarction (AMI) and stroke. However technologies for sensitive and accurate detection of CVD biomarkers are not available. The nature of the CVD also demands efficient simultaneous detection of these biomarkers that the current approaches are incapable of. RECORDER aims to develop a novel biophotonic sensor methodology and technology concept for unambiguous detection of multiple biomarkers, which give confidence in the early diagnosis of CVD that in the longer term can be developed for point of care (POC) applications. The underpinning sensor principle in RECORDER is based on measureable fluorescence resonance energy transfer (FRET) from rare earth (RE) doped nanoparticles under infrared laser (wavelengths >900 nm) excitation known as upconversion fluorescence to acceptor nanoparticle with specific absorptions in the presence of very small concentrations (1-0.01ng/mL) of biomarkers. The investigation of parameters including sensitivity, specificity and speed of detection of CVD biomarkers such as cardiac troponin (mainly, cTnI), heart fatty acid binding protein (H-FABP) lipoprotein-associated phospholipase A(2) (Lp-PLA2) and myoglobin (Mb) based on upconversion and upconversion fluorescence energy transfer (UC-FRET) to overcome large noise in signal due to autofluorescence if excited with ultraviolet or visible wavelengths as in conventional FRET, will be a highly novel approach. UC-FRET applied to detect CVD biomarkers in this project will lead to a novel platform technology that will revolutionize biomarker analysis in a cost effective manner for better patient management in hospitals, primary health care and in the long term at POC.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental biotechnology biosensing
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- engineering and technology nanotechnology nano-materials
- natural sciences physical sciences optics laser physics
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
LS2 9JT Leeds
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.