Objective
Traumatic stressors are important and prevalent risk factors for psychiatric disorders, such as post-traumatic stress disorder (PTSD). People differ strikingly in their susceptibility to develop PTSD after traumatic stress, however the exact underlying biological mechanisms of differential susceptibility are unknown. The identification of biomarkers that distinguish between persons at high and low risk of developing PTSD following trauma exposure would enable more effective preventive strategies and early interventions. Epigenetic mechanisms have been proposed to underlie the relationship between exposure to traumatic stress and the susceptibility to develop PTSD. Recent work carried out by the host laboratory demonstrated that DNA methylation might regulate the impact of traumatic stress on gene expression and ultimately brain function. Based on this and the emerging role of miRNA as key epigenetic players in psychiatric disorders, I hypothesize that (i) susceptibility to traumatic stress exposure is associated with distinct miRNAs expression profiles with blood-brain correlation, (ii) experimental manipulation of miRNA expression levels in animals alters their susceptibility to traumatic stress. These hypotheses will be tested by a unique set of epigenetic epidemiological studies using prospective cohorts with longitudinal sampling schemes of military soldiers deployed to war, next to experimental animal studies. The proposed multidisciplinary and translational project will open the possibility of tapping into the mechanisms underlying differential susceptibility to traumatic stress through blood profiling. It has excellent prospects for yielding clinically relevant and usable biomarkers for the prediction of susceptibility to traumatic stressors. Moreover, the project will reinforce my foundation as a highly promising early career researcher by broadening my knowledge, skills, professional experience and network necessary to launch my own research group.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine psychiatry sleep disorders
- medical and health sciences clinical medicine psychiatry posttraumatic stress disorder
- medical and health sciences clinical medicine oncology
- engineering and technology medical engineering medical laboratory technology laboratory samples analysis
- medical and health sciences clinical medicine nephrology kidney diseases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6200 MD Maastricht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.