Objective
Bacterial endosymbionts are widely distributed amongst invertebrates and have an enormous impact upon the biology of their hosts, being responsible for nutrient acquisition, predator protection and interference with the host reproductive strategies. Their ability to reduce vector competence has raised the possibility of using endosymbionts as a strategy to eliminate or diminish vector-borne pathogen transmission to humans and plants. A crucial step in manipulation of symbionts is the elucidation of the genes involved in symbiosis. Symbionts are highly adapted to hosts, thriving in highly specialised niches with little interference from competing microorganisms. The genes that permit this lifestyle are not known in any case, because most symbionts cannot be grown outside their host, thus impeding classic microbiological loss of function screens to elucidate the molecular mechanisms responsible for symbioisis. In this project, I will utilize Arsenophonus nasoniae, one of the few culturable symbionts, to establish for the first time the genes and systems required for symbiotic life. This bacterium infects the parasitoid wasp Nasonia vitripennis inducing lethality in the male offspring (son-killing = sk). The major objective of this project is to elucidate by the first time genes that are essential for the symbiosis between a bacterium and an insect using hypothesis-independent TraDis approach combined with hypothesis-dependent gene knockout approaches. Identification of the genes involved in symbiosis may allow us to modify the host range of symbionts or engineer strains that produce the desired phenotype. Additionally, this project will provide solid ground for the identification of genes involved in reproductive manipulation of arthropods allowing performing symbiont-mediated alteration of host biology. Both objectives are crucial for the development of novel biological and chemical tools against major vector-borne diseases and pests.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
- natural sciences biological sciences zoology entomology
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences zoology invertebrate zoology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
L69 7ZX LIVERPOOL
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.