Visual genetics: establishment of a new discipline to visualize neuronal nuclear functions in real-time in intact nervous system by 4D Raman spectroscopy

Livrables

Update Data Management Plan

Updates of the data management plan

Update Dissemination plan

Update of the Dissemination Plan

Action check meeting 1

Agenda of the Action check meeting 1 and presentations

Data Management Plan

Generation of Data Management Plan

Dissemination plan

D5.1. Generation of the Dissemination and Communication Plan

Action check Meeting 2

Agenda of the Action check meeting 2 and presentations

Recording

D3.1. Optimizing microscopy recording conditions

Alkyne-morpholino scale up

D2.3: Synthesise alkyne-tagged morpholinos, using newly developed methodology, on scales appropriate for the remainder of the project (up to 500 mg each)

Gene transcription detection

D34 Detection of single locus gene transcription by SRS in zebrafish embryos

SRS alkyne test

D1.5. SRS and Raman spectra of alkyne-tagged labels

Instrument support and maintenance

Report on instrument support and maintenance

Transcription hotspots

D33 Monitoring of transcription by alkyne labelled nucleotides in zebrafish

Website

Creation of the project website

Outreach

Outreach activity plan

Open Research Data Pilot

Publications

The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers

Auteurs: Richard Molnar, Laszlo Szabo, Andras Tomesz, Arpad Deutsch, Richard Darago, Bence L. Raposa, Nowrasteh Ghodratollah, Timea Varjas, Balazs Nemeth, Zsuzsanna Orsos, Eva Pozsgai, Jozsef L. Szentpeteri, Ferenc Budan, and Istvan Kiss
Publié dans: Cells, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11081300

Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons

Auteurs: Kai Du, Yu-Wei Wu, Robert Lindroos, Yu Liu, Balázs Rózsa, Gergely Katona, Jun B. Ding, and Jeanette Hellgren Kotaleski
Publié dans: Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2017, ISSN 1091-6490
Éditeur: National Academy of Science
DOI: 10.1073/pnas.1704893114

In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication

Auteurs: Polett Hajdrik, Bernadett Pályi, Zoltán Kis,Noémi Kovács, Dániel Sándor Veres, Krisztián Szigeti, Ferenc Budán, Imre Hegedüs, Tibor Kovács, Ralf Bergmann and Domokos Máthé
Publié dans: Foods, 2022, ISSN 2304-8158
Éditeur: MDPI
DOI: 10.3390/foods11050694

Transparent Thiol-ene/Acrylate-Based MicroECoG DevicesUsed for Concurrent Recording of Fluorescent CalciumSignals and Electrophysiology in Awake Animals

Auteurs: Ágnes Szabó, Miklós Madarász, Zsófia Lantos, Anita Zátonyi, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Publié dans: Advanced Materials Interfaces, 2022, ISSN 2196-7350
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/admi.202200729

Soft, Thiol-ene/Acrylate-Based Electrode Array for Long-Term Recording of Intracranial EEG Signals with ImprovedBiocompatibility in Mice

Auteurs: Flóra Zsófia Fedor, Miklós Madarász, Anita Zátonyi, Ágnes Szabó, Tibor Lőrincz, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Publié dans: Advanced Materials Technologies, 2021, ISSN 2365-709X
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/admt.202100942

Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization

Auteurs: D’Orazio, F., Balwierz, P., Jimenez-Gonzalez, A., Guo, Y., Hernández-Rodríguez, B., Wheatley, L., Hadzhev, Y., Jasiulewicz, A., Vaquerizas, JM., Cairns, B., Lenhard B. and Müller F.
Publié dans: Developmental cell, 2021, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2021.02.007

Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Auteurs: Linda Judák, Balázs Chiovini, Gábor Juhász, Dénes Pálfi, Zsolt Mezriczky, Zoltán Szadai, Gergely Katona, Benedek Szmola, Katalin Ócsai, Bernadett Martinecz, Anna Mihály, Ádám Dénes, Bálint Kerekes, Áron Szepesi, Gergely Szalay, István Ulbert, Zoltán Mucsi, Botond Roska & Balázs Rózsa
Publié dans: Nature Communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34520-1

Difference in axon diameter and myelin thickness between excitatory and inhibitory callosally projecting axons in mice

Auteurs: K.Basu, S.Appukuttan, R.Manchanda, A.Sík
Publié dans: Cerebral cortex, 2022, ISSN 1047-3211
Éditeur: Oxford University Press
DOI: 10.1093/cercor/bhac329

Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish

Auteurs: Q.Ren, D.Gao, L.Mou, S.Zhang, M.Zhang, N.Li, A.Sík, M.Jin, K.Liu
Publié dans: European journal of pharmacology, 2021, ISSN 0014-2999
Éditeur: Elsevier BV
DOI: 10.1016/j.ejphar.2021.174589

Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model

Auteurs: L.Szabo, R.Molnar, A.Tomesz, A.Deutsch, R.Darago, T.Varjas, Z.Ritter, J.L.Szentpeteri, K.Andreidesz, D.Mathe, I.Hegedüs, A.Sík, F.Budan, I.Kiss
Publié dans: Nutrients, 2022, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14040908

Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

Auteurs: Vanessa Lage-Rupprecht, Li Zhou, Gaia Bianchini, S Sara Aghvami, Max Mueller, Balázs Rózsa, Marco Sassoè-Pognetto, Veronica Egger
Publié dans: elife, 2020, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.63737

Changes in miR-124-1, miR-212, miR-132, miR-134, and miR-155 Expression Patterns after 7,12-Dimethylbenz(a)anthracene Treatment in CBA/Ca Mice

Auteurs: Andras Tomesz, Laszlo Szabo, Richard Molnar, Arpad Deutsch, Richard Darago, Bence L. Raposa, Nowrasteh Ghodratollah, Timea Varjas, Balazs Nemeth, Zsuzsanna Orsos, Eva Pozsgai, Jozsef L. Szentpeteri, Ferenc Budan, and Istvan Kiss
Publié dans: Cells, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11061020

A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation

Auteurs: Yavor Hadzhiev, Haseeb K. Qureshi, Lucy Wheatley, Ledean Cooper, Aleksandra Jasiulewicz, Huy Van Nguyen, Joseph W. Wragg, Divyasree Poovathumkadavil, Sascha Conic, Sarah Bajan, Attila Sik, György Hutvàgner, Làszlò Tora, Agnieszka Gambus, John S. Fossey, Ferenc Müller
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-08487-5

Phosphino-Triazole Ligands for Palladium-Catalyzed Cross-Coupling

Auteurs: Yiming Zhao, Huy van Nguyen, Louise Male, Philip Craven, Benjamin R. Buckley, John S. Fossey
Publié dans: Organometallics, Numéro 37/22, 2018, Page(s) 4224-4241, ISSN 0276-7333
Éditeur: American Chemical Society
DOI: 10.1021/acs.organomet.8b00539

α-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish

Auteurs: Xueliang Shang, Xiuna Ji, Jiao Dang, Lizhen Wang, Chen Sun, Kechun Liu, Attila Sik, Meng Jin
Publié dans: Toxicology Letters, Numéro 324, 2020, Page(s) 1-11, ISSN 0378-4274
Éditeur: Elsevier BV
DOI: 10.1016/j.toxlet.2020.02.003

Balancing Bulkiness in Gold(I) Phosphino-triazole Catalysis

Auteurs: Yiming Zhao, Matthew G. Wakeling, Fernanda Meloni, Tze Jing Sum, Huy van Nguyen, Benjamin R. Buckley, Paul W. Davies, John S. Fossey
Publié dans: European Journal of Organic Chemistry, Numéro 2019/31-32, 2019, Page(s) 5540-5548, ISSN 1434-193X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201900850

Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo

Auteurs: Leiron Ferrarese, Jean-Sébastien Jouhanneau, Michiel W.H. Remme, Jens Kremkow, Gergely Katona, Balázs Rózsa, Susanne Schreiber, James F.A. Poulet
Publié dans: Cell Reports, Numéro 24/13, 2018, Page(s) 3455-3465.e5, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.08.088

Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6

Auteurs: Meng Jin, Daili Gao, Rongchun Wang, Attila Sik, Kechun Liu
Publié dans: Oncology Reports, Numéro 44/2, 2020, Page(s) 555-564, ISSN 1021-335X
Éditeur: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/or.2020.7644

Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

Auteurs: Zoltán Szadai, Hyun-Jae Pi, Quentin Chevy, Katalin Ócsai, Dinu F Albeanu, Balázs Chiovini, Gergely Szalay, Gergely Katona, Adam Kepecs
Publié dans: eLife, 2022, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.78815

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