A paradigm shift in cancer therapy – using mitochondria-powered chemiluminescence to non-invasively treat inaccessible tumours

Project Information

Lumiblast

Grant agreement ID: 712921

DOI 10.3030/712921

Project closed

EC signature date 16 May 2016

Start date 1 October 2016

End date 31 January 2023

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 3 031 375,00

EU contribution € 3 031 375,00

Coordinated by

OSLO UNIVERSITETSSYKEHUS HF
Norway

Deliverables

Other (2)

Publications

At least five publications in peerreviewed open access journals

Scientific symposium

Scientific symposium (final project event) on Lumiblast Technologies.

Websites, patent fillings, videos etc. (1)

Project website

Project website including some special features.

Publications

Peer reviewed articles (6)

Building a Functionalizable, Potent Chemiluminescent Agent: A Rational Design Study on 6,8-Substituted Luminol Derivatives.

Author(s): Mikroulis T, Cuquerella MC, Giussani A, Pantelia A, Rodríguez-Muñiz GM, Rotas G, Roca-Sanjuán D, Miranda MA, Vougioukalakis GC
Published in: Journal of Organic Chemistry, 2021, ISSN 1520-6904
Publisher: Americam Cancer Society
DOI: 10.1021/acs.joc.1c00890

Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines

Author(s): Maria Mastrangelopoulou, Mantas Grigalavicius, Kristian Berg, Mathilde Ménard, Theodossis A. Theodossiou
Published in: Photochemistry and Photobiology, Issue 95/1, 2019, Page(s) 387-396, ISSN 0031-8655
Publisher: American Society for Photobiology
DOI: 10.1111/php.12997

Synthesis and Chemiluminescent Properties of Amino-Acylated luminol Derivatives Bearing Phosphonium Cations

Author(s): Pantelia, Daskalaki, Cuquerella, Rotas, Miranda, Vougioukalakis
Published in: Molecules, Issue 24/21, 2019, Page(s) 3957, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24213957

Photodynamic efficacy of cercosporin in 3D tumor cell cultures

Author(s): Mantas Grigalavicius, Maria Mastrangelopoulou, Delmon Arous, Asta Juzeniene, Mathilde Ménard, Ellen Skarpen, Kristian Berg, Theodossis A. Theodossiou
Published in: Photochemistry and Photobiology, 2020, ISSN 0031-8655
Publisher: American Society for Photobiology
DOI: 10.1111/php.13257

Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances.

Author(s): Mastrangelopoulou M, Grigalavicius M, Raabe TH, Skarpen E, Juzenas P, Peng Q, Berg K, Theodossiou TA.
Published in: Cancer Rep (Hoboken), 2020, ISSN 2573-8348
Publisher: Wiley Periodicals LLC
DOI: 10.1002/cnr2.1278

Modulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols.

Author(s): Rodríguez-Muñiz GM, Mikroulis T, Pantelia A, Rotas G, Cuquerella MC, Vougioukalakis GC, Miranda MA.
Published in: Molecules, 2022, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27041245

Intellectual Property Rights

Patent (3)

METHOD

Application/Publication number: 20 18051744
Date: 2018-06-21

METHOD

Application/Publication number: 20 18051744
Date: 2018-06-21

METHOD

Application/Publication number: 20 18051744
Date: 2018-06-21