Custom architecturally defined 3D stem cell derived functional human neural networks for transformative progress in neuroscience and medicine

Informations projet

MESO_BRAIN

N° de convention de subvention: 713140

DOI 10.3030/713140

Projet clôturé

Date de signature de la CE 25 Mai 2016

Date de début 1 Septembre 2016

Date de fin 29 Février 2020

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total € 3 225 891,25

Contribution de l’UE € 3 225 890,50

Coordonné par

ASTON UNIVERSITY
United Kingdom

Livrables

Websites, patent fillings, videos etc. (5)

Use and Dissemination 3

Plan for Use and Dissemination

Website Development

Web-site developed and brand established;

Press Releases

Initial National and European press releases

Use and Dissemination 2

Plan for Use and Dissemination

Use and Dissemination 1

Plan for Use and Dissemination

Documents, reports (6)

Tools for functional connectivity analysis 2
Imaging with fast 3D imaging of neuron activity
Light sheet microscope for fast 3D imaging of neuron activity II
Optimal imaging conditions
Tools for functional connectivity analysis 1
Light sheet microscope for fast 3D imaging of neuron activity I

Demonstrators, pilots, prototypes (1)

Physiological chamber

Publications

Peer reviewed articles (8)

The Photobiomodulation of Vital Parameters of the Cancer Cell Culture by Low Dose of Near-IR Laser Irradiation

Auteurs: Anna Khokhlova, Igor Zolotovskii, Dmitrii Stoliarov, Svetlana Vorsina, Daria Liamina, Evgenia Pogodina, Andrei A. Fotiadi, Sergei G. Sokolovski, Yury Saenko, Edik U. Rafailov
Publié dans: IEEE Journal of Selected Topics in Quantum Electronics, Numéro 25/1, 2019, Page(s) 1-10, ISSN 1077-260X
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jstqe.2018.2854539

Impact of modular organization on dynamical richness in cortical networks

Auteurs: Hideaki Yamamoto, Satoshi Moriya, Katsuya Ide, Takeshi Hayakawa, Hisanao Akima, Shigeo Sato, Shigeru Kubota, Takashi Tanii, Michio Niwano, Sara Teller, Jordi Soriano, Ayumi Hirano-Iwata
Publié dans: Science Advances, Numéro 4/11, 2018, Page(s) eaau4914, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aau4914

CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons

Auteurs: Carles Calatayud, Giulia Carola, Irene Fernández-Carasa, Marco Valtorta, Senda Jiménez-Delgado, Mònica Díaz, Jordi Soriano-Fradera, Graziella Cappelletti, Javier García-Sancho, Ángel Raya, Antonella Consiglio
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-43080-2

Photodynamic opening of blood-brain barrier

Auteurs: Oxana Semyachkina-Glushkovskaya, Jürgen Kurths, Ekaterina Borisova, Sergei Sokolovski, Vanya Mantareva, Ivan Angelov, Alexander Shirokov, Nikita Navolokin, Natalia Shushunova, Alexander Khorovodov, Maria Ulanova, Madina Sagatova, Ilana Agranivich, Olga Sindeeva, Artem Gekalyuk, Anastasiya Bodrova, and Edik Rafailov
Publié dans: Biomedical Optics Express, 2017, ISSN 2156-7085
Éditeur: The Optical Society
DOI: 10.1364/boe.8.005040

Neuronal spatial arrangement shapes effective connectivity traits of in vitro cortical networks

Auteurs: Elisenda Tibau Martorell, Adriaan Alexander Ludl, Sten Rudiger, Javier G. Orlandi, Jordi Soriano
Publié dans: IEEE Transactions on Network Science and Engineering, 2017, Page(s) 1-1, ISSN 2327-4697
Éditeur: IEEE Computer Society
DOI: 10.1109/tnse.2018.2862919

7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLCγ1 pathway

Auteurs: Gerardo García-Díaz Barriga, Albert Giralt, Marta Anglada-Huguet, Nuria Gaja-Capdevila, Javier G. Orlandi, Jordi Soriano, Josep-Maria Canals, Jordi Alberch
Publié dans: Human Molecular Genetics, Numéro Vol26, No 16, 2017, Page(s) 3144–3160, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddx198

STED imaging performance estimation by means of Fourier transform analysis

Auteurs: David Merino, Arrate Mallabiabarrena, Jordi Andilla, David Artigas, Timo Zimmermann, Pablo Loza-Alvarez
Publié dans: Biomedical Optics Express, Numéro 8/5, 2017, Page(s) 2472, ISSN 2156-7085
Éditeur: The Optical Society
DOI: 10.1364/BOE.8.002472

Sub-diffraction discrimination with polarization-resolved two-photon excited fluorescence microscopy

Auteurs: David Artigas, David Merino, Christoph Polzer, Pablo Loza-Alvarez
Publié dans: Optica, Numéro 4/8, 2017, Page(s) 911, ISSN 2334-2536
Éditeur: OSA Publishing
DOI: 10.1364/optica.4.000911